| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Murugaiah A M Subbaia. Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. Journal of medicinal chemistry. vol 61. issue 6. 2019-04-17. PMID:28731336. |
triple reuptake inhibitors (tris), which elevate dopamine in addition to serotonin and norepinephrine, may demonstrate greater efficacy, with the reversal of anhedonia and improved tolerability. |
2019-04-17 |
2023-08-13 |
Not clear |
| I V Ekimova, A R Gazizova, M N Karpenko, D V Plaksin. [Signs of anhedonia and destructive changes in the ventral tegmental area of the midbrain in the model of the preclinical Parkinson's disease stage in experiment]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 118. issue 9. 2019-03-25. PMID:30335074. |
anhedonia was combined with the death of about one third of dopamine (da)-ergic neurons in the ventral tegmental area of the midbrain and their axons in the ventral striatum; and a decrease of dopamine concentration in the ventral striatum (by 40%) and the tyrosine hydroxylase level in surviving da-ergic neurons. |
2019-03-25 |
2023-08-13 |
rat |
| Katayoun Sedaghat, Zahra Yousefian, Abbas Ali Vafaei, Ali Rashidy-Pour, Houman Parsaei, Ali Khaleghian, Sara Choobda. Mesolimbic dopamine system and its modulation by vitamin D in a chronic mild stress model of depression in the rat. Behavioural brain research. vol 356. 2019-03-22. PMID:30144460. |
depression, a common mood disorder, involves anhedonia and defects in reward circuits and mesolimbic dopamine transmission in the striatum and nucleus accumbens (nac). |
2019-03-22 |
2023-08-13 |
rat |
| Sebastian P Fernandez, Loïc Broussot, Fabio Marti, Thomas Contesse, Xavier Mouska, Mariano Soiza-Reilly, Hélène Marie, Philippe Faure, Jacques Bari. Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors. Nature communications. vol 9. issue 1. 2019-01-07. PMID:30361503. |
dysregulation of ventral tegmental area (vta) dopamine neurons has been causally linked to the appearance of social withdrawal and anhedonia, two classical manifestations of depression. |
2019-01-07 |
2023-08-13 |
Not clear |
| Steven J Lamontagne, Sofia I Melendez, Mary C Olmstea. Investigating dopamine and glucocorticoid systems as underlying mechanisms of anhedonia. Psychopharmacology. vol 235. issue 11. 2018-12-31. PMID:30136143. |
investigating dopamine and glucocorticoid systems as underlying mechanisms of anhedonia. |
2018-12-31 |
2023-08-13 |
Not clear |
| Steven J Lamontagne, Sofia I Melendez, Mary C Olmstea. Investigating dopamine and glucocorticoid systems as underlying mechanisms of anhedonia. Psychopharmacology. vol 235. issue 11. 2018-12-31. PMID:30136143. |
dopamine (da) has been implicated in anhedonia through its role in reward-related learning; glucocorticoid systems may also be involved in that anhedonia is often preceded by chronic stress. |
2018-12-31 |
2023-08-13 |
Not clear |
| Mark S Gold, Kenneth Blum, Marcelo Febo, David Baron, Edward Justin Modestino, Igor Elman, Rajendra D Badgaiya. Molecular role of dopamine in anhedonia linked to reward deficiency syndrome (RDS) and anti- reward systems. Frontiers in bioscience (Scholar edition). vol 10. 2018-11-27. PMID:29293435. |
molecular role of dopamine in anhedonia linked to reward deficiency syndrome (rds) and anti- reward systems. |
2018-11-27 |
2023-08-13 |
Not clear |
| Jan Józef Szczypiński, Mateusz Gol. Dopamine dysregulation hypothesis: the common basis for motivational anhedonia in major depressive disorder and schizophrenia? Reviews in the neurosciences. vol 29. issue 7. 2018-11-16. PMID:29573379. |
dopamine dysregulation hypothesis: the common basis for motivational anhedonia in major depressive disorder and schizophrenia? |
2018-11-16 |
2023-08-13 |
Not clear |
| Jan Józef Szczypiński, Mateusz Gol. Dopamine dysregulation hypothesis: the common basis for motivational anhedonia in major depressive disorder and schizophrenia? Reviews in the neurosciences. vol 29. issue 7. 2018-11-16. PMID:29573379. |
with regard to the similarities and differences between the neural mechanisms of mdd and sch, here we expand the current knowledge of motivation deficits and present the common underlying mechanism of motivational anhedonia - the dopamine dysregulation hypothesis - stating that any prolonged dysregulation in tonic dopamine signaling that exceeds the given equilibrium can lead to striatal dysfunction and motivational anhedonia. |
2018-11-16 |
2023-08-13 |
Not clear |
| Marta Peciña, Magdalena Sikora, Erich T Avery, Joseph Heffernan, Susana Peciña, Brian J Mickey, Jon-Kar Zubiet. Striatal dopamine D2/3 receptor-mediated neurotransmission in major depression: Implications for anhedonia, anxiety and treatment response. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 27. issue 10. 2018-05-30. PMID:28870407. |
striatal dopamine d2/3 receptor-mediated neurotransmission in major depression: implications for anhedonia, anxiety and treatment response. |
2018-05-30 |
2023-08-13 |
Not clear |
| Shuo Kang, Mariah M Wu, Roberto Galvez, Joshua M Gulle. Timing of amphetamine exposure in relation to puberty onset determines its effects on anhedonia, exploratory behavior, and dopamine D Neuroscience. vol 339. 2017-10-30. PMID:27702645. |
timing of amphetamine exposure in relation to puberty onset determines its effects on anhedonia, exploratory behavior, and dopamine d non-medical use of amphetamine (amph) among adolescents is prevalent, which is problematic given the potential consequences of developmental drug exposure on brain function and behavior. |
2017-10-30 |
2023-08-13 |
rat |
| Sarah A Eisenstein, Ryan Bogdan, Ling Chen, Stephen M Moerlein, Kevin J Black, Joel S Perlmutter, Tamara Hershey, Deanna M Barc. Preliminary evidence that negative symptom severity relates to multilocus genetic profile for dopamine signaling capacity and D2 receptor binding in healthy controls and in schizophrenia. Journal of psychiatric research. vol 86. 2017-09-12. PMID:27886638. |
deficits in central, subcortical dopamine (da) signaling may underlie negative symptom severity, particularly anhedonia, in healthy individuals and in schizophrenia. |
2017-09-12 |
2023-08-13 |
human |
| J C Felger, Z Li, E Haroon, B J Woolwine, M Y Jung, X Hu, A H Mille. Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression. Molecular psychiatry. vol 21. issue 10. 2017-09-05. PMID:26552591. |
moreover, administration of inflammatory stimuli reduces neural activity and dopamine release in reward-related brain regions in association with reduced motivation and anhedonia. |
2017-09-05 |
2023-08-13 |
Not clear |
| Jia Huang, Xin-Hua Yang, Yong Lan, Cui-Ying Zhu, Xiao-Qun Liu, Ye-Fei Wang, Eric F C Cheung, Guang-Rong Xie, Raymond C K Cha. Neural substrates of the impaired effort expenditure decision making in schizophrenia. Neuropsychology. vol 30. issue 6. 2017-08-07. PMID:27054437. |
unwillingness to expend more effort to pursue high value rewards has been associated with motivational anhedonia in schizophrenia (scz) and abnormal dopamine activity in the nucleus accumbens (nacc). |
2017-08-07 |
2023-08-13 |
Not clear |
| Aimee Zisner, Theodore P Beauchain. Neural substrates of trait impulsivity, anhedonia, and irritability: Mechanisms of heterotypic comorbidity between externalizing disorders and unipolar depression. Development and psychopathology. vol 28. issue 4pt1. 2017-07-24. PMID:27739396. |
here, we review common neural substrates of trait impulsivity, anhedonia, and irritability, which include both low tonic mesolimbic dopamine activity and low phasic mesolimbic dopamine responding to incentives during reward anticipation and associative learning. |
2017-07-24 |
2023-08-13 |
Not clear |
| Jennifer C Felge. The Role of Dopamine in Inflammation-Associated Depression: Mechanisms and Therapeutic Implications. Current topics in behavioral neurosciences. vol 31. 2017-06-20. PMID:27225499. |
findings have included inflammation-associated reductions in ventral striatal responses to hedonic reward, decreased dopamine and dopamine metabolites in cerebrospinal fluid, and decreased availability of striatal dopamine, all of which correlate with symptoms of anhedonia, fatigue, and psychomotor retardation. |
2017-06-20 |
2023-08-13 |
Not clear |
| Matthew A Albrecht, Gareth Roberts, Greg Price, Joseph Lee, Rajan Iyyalol, Mathew T Martin-Iverso. The effects of dexamphetamine on the resting-state electroencephalogram and functional connectivity. Human brain mapping. vol 37. issue 2. 2016-10-17. PMID:26577247. |
we discuss the alterations of low- and high-frequency eeg power in response to dexamphetamine within the context of disorders of dopamine regulation, in particular schizophrenia, as well as in the context of a recently hypothesized association between low-frequency power and aspects of anhedonia. |
2016-10-17 |
2023-08-13 |
human |
| Nicole M Enman, Kayti Arthur, Sara J Ward, Shane A Perrine, Ellen M Unterwal. Anhedonia, Reduced Cocaine Reward, and Dopamine Dysfunction in a Rat Model of Posttraumatic Stress Disorder. Biological psychiatry. vol 78. issue 12. 2016-08-24. PMID:26115790. |
anhedonia, reduced cocaine reward, and dopamine dysfunction in a rat model of posttraumatic stress disorder. |
2016-08-24 |
2023-08-13 |
rat |
| Nicole M Enman, Kayti Arthur, Sara J Ward, Shane A Perrine, Ellen M Unterwal. Anhedonia, Reduced Cocaine Reward, and Dopamine Dysfunction in a Rat Model of Posttraumatic Stress Disorder. Biological psychiatry. vol 78. issue 12. 2016-08-24. PMID:26115790. |
dopamine reward dysfunction also may be relevant to the mechanisms underlying the ptsd symptoms of anhedonia and emotional numbing. |
2016-08-24 |
2023-08-13 |
rat |
| Deanna M Barch, David Pagliaccio, Katherine Lukin. Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia. Current topics in behavioral neurosciences. vol 27. 2016-07-21. PMID:26026289. |
such hedonic impairments could reflect alterations in dopamine and/or opioid signaling in the striatum related to depression or specifically to anhedonia in depressed populations. |
2016-07-21 |
2023-08-13 |
Not clear |