| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| JingSi Jiang, Yan Wang, Min Den. New developments and opportunities in drugs being trialed for amyotrophic lateral sclerosis from 2020 to 2022. Frontiers in pharmacology. vol 13. 2022-12-15. PMID:36518658. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disorder that primarily affects motor neurons in the brain and spinal cord. |
2022-12-15 |
2023-08-14 |
Not clear |
| Jack Humphrey, Sanan Venkatesh, Rahat Hasan, Jake T Herb, Katia de Paiva Lopes, Fahri Küçükali, Marta Byrska-Bishop, Uday S Evani, Giuseppe Narzisi, Delphine Fagegaltier, Kristel Sleegers, Hemali Phatnani, David A Knowles, Pietro Fratta, Towfique Ra. Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes. Nature neuroscience. 2022-12-09. PMID:36482247. |
integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes. |
2022-12-09 |
2023-08-14 |
Not clear |
| Jack Humphrey, Sanan Venkatesh, Rahat Hasan, Jake T Herb, Katia de Paiva Lopes, Fahri Küçükali, Marta Byrska-Bishop, Uday S Evani, Giuseppe Narzisi, Delphine Fagegaltier, Kristel Sleegers, Hemali Phatnani, David A Knowles, Pietro Fratta, Towfique Ra. Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes. Nature neuroscience. 2022-12-09. PMID:36482247. |
amyotrophic lateral sclerosis (als) is a progressively fatal neurodegenerative disease affecting motor neurons in the brain and spinal cord. |
2022-12-09 |
2023-08-14 |
Not clear |
| Ryan A Milstead, Christopher D Link, Zuoshang Xu, Charles A Hoeffe. TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord. Cerebral cortex (New York, N.Y. : 1991). 2022-11-28. PMID:36443249. |
transactive response dna binding protein 43 kilodaltons (tdp-43) is a dna and rna binding protein associated with severe neurodegenerative diseases such as amyotrophic lateral sclerosis (als), primarily affecting motor neurons in the brain and spinal cord. |
2022-11-28 |
2023-08-14 |
mouse |
| Juan José Casañas, María Luz Montesino. Proteomic characterization of spinal cord synaptoneurosomes from Tg-SOD1/G93A mice supports a role for MNK1 and local translation in the early stages of amyotrophic lateral sclerosis. Molecular and cellular neurosciences. 2022-11-13. PMID:36372157. |
proteomic characterization of spinal cord synaptoneurosomes from tg-sod1/g93a mice supports a role for mnk1 and local translation in the early stages of amyotrophic lateral sclerosis. |
2022-11-13 |
2023-08-14 |
mouse |
| Juan José Casañas, María Luz Montesino. Proteomic characterization of spinal cord synaptoneurosomes from Tg-SOD1/G93A mice supports a role for MNK1 and local translation in the early stages of amyotrophic lateral sclerosis. Molecular and cellular neurosciences. 2022-11-13. PMID:36372157. |
to characterize synaptic failure in the spinal cord (sc) in the tg-sod1/g93a mouse model of amyotrophic lateral sclerosis (als), we applied a method we originally designed to isolate cortical and hippocampal sns to sc tissue. |
2022-11-13 |
2023-08-14 |
mouse |
| Shirong Li, Junyu Lin, Chunyu Li, Yongping Chen, Bei Cao, Tianmi Yang, Qianqian Wei, Bi Zhao, Xueping Chen, Huifang Shan. Clinical and genetic study of a Chinese family affected by both amyotrophic lateral sclerosis and autosomal dominant polycystic kidney disease. Frontiers in neurology. vol 13. 2022-11-07. PMID:36341123. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disorder characterized by loss of the upper and lower motor neurons from the motor cortex, brainstem, and spinal cord. |
2022-11-07 |
2023-08-14 |
Not clear |
| Giuseppe Schirò, Vincenzo Di Stefano, Salvatore Iacono, Antonino Lupica, Filippo Brighina, Roberto Monastero, Carmela Rita Balistrer. Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis. Brain sciences. vol 12. issue 10. 2022-10-27. PMID:36291345. |
amyotrophic lateral sclerosis (als) is a fatal neuromuscular disease, characterized by the progressive degeneration of the upper and lower motor neurons in the cortex and spinal cord. |
2022-10-27 |
2023-08-14 |
human |
| Yoshitaka Tamaki, Makoto Urushitan. Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293362. |
hyperphosphorylated and ubiquitinated tdp-43-positive neuronal cytoplasmic inclusions are identified in the brain and spinal cord in most cases of amyotrophic lateral sclerosis (als) and a substantial proportion of frontotemporal lobar degeneration (ftld) cases. |
2022-10-27 |
2023-08-14 |
Not clear |
| Panlin Liao, Yanchun Yuan, Zhen Liu, Xiaorong Hou, Wanzhen Li, Jin Wen, Kexuan Zhang, Bin Jiao, Lu Shen, Hong Jiang, Jifeng Guo, Beisha Tang, Zhuohua Zhang, Zhonghua Hu, Junling Wan. Association of variants in the KIF1A gene with amyotrophic lateral sclerosis. Translational neurodegeneration. vol 11. issue 1. 2022-10-26. PMID:36284339. |
amyotrophic lateral sclerosis (als) is a devastating progressive neurodegenerative disease that affects neurons in the central nervous system and the spinal cord. |
2022-10-26 |
2023-08-14 |
Not clear |
| Alberto Albanese, Albert Christian Ludolph, Christopher J McDermott, Philippe Corcia, Philip Van Damme, Leonard H Van den Berg, Orla Hardiman, Gilberto Rinaldi, Nicola Vanacore, Brian Dicki. Tauroursodeoxycholic acid in patients with amyotrophic lateral sclerosis: The TUDCA-ALS trial protocol. Frontiers in neurology. vol 13. 2022-10-14. PMID:36237618. |
amyotrophic lateral sclerosis (als) is a chronic neurodegenerative rare disease that affects motor neurons in the brain, brainstem, and spinal cord, resulting in progressive weakness and atrophy of voluntary skeletal muscles. |
2022-10-14 |
2023-08-14 |
Not clear |
| Byung Jo Choi, Kang Ho Park, Min Hee Park, Eric J Huang, Seung Hyun Kim, Jae-Sung Bae, Hee Kyung Ji. Acid sphingomyelinase inhibition improves motor behavioral deficits and neuronal loss in an amyotrophic lateral sclerosis mouse model. BMB reports. 2022-10-13. PMID:36229415. |
amyotrophic lateral sclerosis (als) is an incurable neurodegenerative disease characterized by the degeneration of motor neurons in the spinal cord. |
2022-10-13 |
2023-08-14 |
mouse |
| Elif Kubat Oktem, Busra Aydin, Metin Yazar, Kazim Yalcin Arg. Integrative Analysis of Motor Neuron and Microglial Transcriptomes from SOD1 Journal of molecular neuroscience : MN. 2022-09-30. PMID:36178612. |
integrative analysis of motor neuron and microglial transcriptomes from sod1 amyotrophic lateral sclerosis (als) is a fatal disease of motor neurons that mainly affects the motor cortex, brainstem, and spinal cord. |
2022-09-30 |
2023-08-14 |
Not clear |
| Non-Nuoc Tran, Byung-Hoon Le. Functional implication of ubiquitinating and deubiquitinating mechanisms in TDP-43 proteinopathies. Frontiers in cell and developmental biology. vol 10. 2022-09-26. PMID:36158183. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease in which motor neurons in spinal cord and motor cortex are progressively lost. |
2022-09-26 |
2023-08-14 |
Not clear |
| b' Bel\\xc3\\xa9n Proa\\xc3\\xb1o, Julia Casani-Cubel, Mar\\xc3\\xada Benlloch, Ana Rodriguez-Mateos, Esther Navarro-Illana, Jose Mar\\xc3\\xada Lajara-Romance, Jose Enrique de la Rubia Ort\\xc3\\xa. Is Dutasteride a Therapeutic Alternative for Amyotrophic Lateral Sclerosis? Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140184.' |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease that is characterized by the loss of upper and lower motor neurons (mns) in the cerebral cortex, brainstem and spinal cord, with consequent weakness, atrophy and the progressive paralysis of all muscles. |
2022-09-23 |
2023-08-14 |
Not clear |
| Robert L Barry, Angel Torrado-Carvajal, John E Kirsch, Grae E Arabasz, Daniel S Albrecht, Zeynab Alshelh, Olivia Pijanowski, Austin J Lewis, Mackenzie Keegan, Beverly Reynolds, Paulina C Knight, Erin J Morrissey, Marco L Loggia, Nazem Atassi, Jacob M Hooker, Suma Bab. Selective atrophy of the cervical enlargement in whole spinal cord MRI of amyotrophic lateral sclerosis. NeuroImage. Clinical. vol 36. 2022-09-22. PMID:36137496. |
selective atrophy of the cervical enlargement in whole spinal cord mri of amyotrophic lateral sclerosis. |
2022-09-22 |
2023-08-14 |
human |
| Robert L Barry, Angel Torrado-Carvajal, John E Kirsch, Grae E Arabasz, Daniel S Albrecht, Zeynab Alshelh, Olivia Pijanowski, Austin J Lewis, Mackenzie Keegan, Beverly Reynolds, Paulina C Knight, Erin J Morrissey, Marco L Loggia, Nazem Atassi, Jacob M Hooker, Suma Bab. Selective atrophy of the cervical enlargement in whole spinal cord MRI of amyotrophic lateral sclerosis. NeuroImage. Clinical. vol 36. 2022-09-22. PMID:36137496. |
amyotrophic lateral sclerosis (als) is a deadly neurodegenerative disorder affecting motor neurons in the spinal cord and brain. |
2022-09-22 |
2023-08-14 |
human |
| Banaja P Dash, Axel Freischmidt, Jochen H Weishaupt, Andreas Herman. Downstream Effects of Mutations in International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077049. |
downstream effects of mutations in amyotrophic lateral sclerosis (als) is a progressive and fatal neurodegenerative disease marked by death of motor neurons (mns) present in the spinal cord, brain stem and motor cortex. |
2022-09-09 |
2023-08-14 |
human |
| Stephanie L Rayner, Alison Hogan, Jennilee M Davidson, Flora Cheng, Luan Luu, Marco Morsch, Ian Blair, Roger Chung, Albert Le. Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2022-09-05. PMID:36062310. |
amyotrophic lateral sclerosis (als) is the most common form of motor neuron disease and is characterized by the degeneration of upper and lower motor neurons of the brain and spinal cord. |
2022-09-05 |
2023-08-14 |
Not clear |
| Christoph Schweingruber, Eva Hedlun. The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in Amyotrophic Lateral Sclerosis. Biology. vol 11. issue 8. 2022-08-26. PMID:36009818. |
amyotrophic lateral sclerosis (als) is defined by the loss of upper motor neurons (mns) that project from the cerebral cortex to the brain stem and spinal cord and of lower mns in the brain stem and spinal cord which innervate skeletal muscles, leading to spasticity, muscle atrophy, and paralysis. |
2022-08-26 |
2023-08-14 |
Not clear |