| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samantha Rossano, Takuya Toyonaga, Jason Bini, Nabeel Nabulsi, Jim Ropchan, Zhengxin Cai, Yiyun Huang, Richard E Carso. Feasibility of imaging synaptic density in the human spinal cord using [ EJNMMI physics. vol 9. issue 1. 2022-05-03. PMID:35503134. |
feasibility of imaging synaptic density in the human spinal cord using [ neuronal damage and synapse loss in the spinal cord (sc) have been implicated in spinal cord injury (sci) and neurodegenerative disorders such as amyotrophic lateral sclerosis (als). |
2022-05-03 |
2023-08-13 |
human |
| Caterina Peggion, Valeria Scalcon, Maria Lina Massimino, Kelly Nies, Raffaele Lopreiato, Maria Pia Rigobello, Alessandro Bertol. SOD1 in ALS: Taking Stock in Pathogenic Mechanisms and the Role of Glial and Muscle Cells. Antioxidants (Basel, Switzerland). vol 11. issue 4. 2022-04-23. PMID:35453299. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disorder characterized by the loss of motor neurons in the brain and spinal cord. |
2022-04-23 |
2023-08-13 |
Not clear |
| Riya Kulkarni, Akshata Thakur, Hemant Kuma. Microtubule Dynamics Following Central and Peripheral Nervous System Axotomy. ACS chemical neuroscience. 2022-04-22. PMID:35451811. |
understanding the neuronal mt dynamics will help develop effective therapeutic strategies in diseases where the mt network gets disrupted, such as spinal cord injury, traumatic brain injury, multiple sclerosis, and amyotrophic lateral sclerosis. |
2022-04-22 |
2023-08-13 |
Not clear |
| Yifei Dong, V Wee Yon. Oxidized phospholipids as novel mediators of neurodegeneration. Trends in neurosciences. 2022-04-08. PMID:35393134. |
oxpcs have been proposed as biomarkers of oxidative stress, where their detection in lesions in multiple sclerosis (ms), frontotemporal lobe dementia, spinal cord injury, and amyotrophic lateral sclerosis (als) implies that oxidative insult had occurred. |
2022-04-08 |
2023-08-13 |
Not clear |
| Kelby M Killoy, Benjamin A Harlan, Mariana Pehar, Marcelo R Varga. NR1D1 downregulation in astrocytes induces a phenotype that is detrimental to cocultured motor neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 4. 2022-03-23. PMID:35319791. |
amyotrophic lateral sclerosis (als) is the most common adult-onset motor neuron disease, caused by the progressive degeneration of motor neurons in the spinal cord, brain stem, and motor cortex. |
2022-03-23 |
2023-08-13 |
mouse |
| Stephanie L Rayner, Shu Yang, Natalie E Farrawell, Cyril J Jagaraj, Flora Cheng, Jennilee M Davidson, Luan Luu, Alberto G Redondo, Alberto Rábano, Daniel Borrego-Hernández, Julie D Atkin, Marco Morsch, Ian P Blair, Justin J Yerbury, Roger Chung, Albert Le. TDP-43 is a ubiquitylation substrate of the SCF Neurobiology of disease. 2022-03-01. PMID:35231559. |
tdp-43 is a ubiquitylation substrate of the scf amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease characterised by the loss of upper and lower motor neurons in the brain and spinal cord. |
2022-03-01 |
2023-08-13 |
Not clear |
| Justin You, Katarina Maksimovic, Jooyun Lee, Mashiat Khan, Rintaro Masuda, Jeehye Par. Selective Loss of MATR3 in Spinal Interneurons, Upper Motor Neurons and Hippocampal CA1 Neurons in a MATR3 S85C Knock-In Mouse Model of Amyotrophic Lateral Sclerosis. Biology. vol 11. issue 2. 2022-02-25. PMID:35205163. |
the neuropathological hallmark of amyotrophic lateral sclerosis (als) is motor neuron degeneration in the spinal cord and cortex. |
2022-02-25 |
2023-08-13 |
mouse |
| X Rosa Ma, Mercedes Prudencio, Yuka Koike, Sarat C Vatsavayai, Garam Kim, Fred Harbinski, Adam Briner, Caitlin M Rodriguez, Caiwei Guo, Tetsuya Akiyama, H Broder Schmidt, Beryl B Cummings, David W Wyatt, Katherine Kurylo, Georgiana Miller, Shila Mekhoubad, Nathan Sallee, Gemechu Mekonnen, Laura Ganser, Jack D Rubien, Karen Jansen-West, Casey N Cook, Sarah Pickles, Björn Oskarsson, Neill R Graff-Radford, Bradley F Boeve, David S Knopman, Ronald C Petersen, Dennis W Dickson, James Shorter, Sua Myong, Eric M Green, William W Seeley, Leonard Petrucelli, Aaron D Gitle. TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A. Nature. 2022-02-24. PMID:35197626. |
a hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (als) and frontotemporal dementia (ftd) is the depletion of rna-binding protein tdp-43 from the nucleus of neurons in the brain and spinal cord |
2022-02-24 |
2023-08-13 |
Not clear |
| Nidhi Puranik, Ananta Prasad Arukha, Shiv Kumar Yadav, Dhananjay Yadav, Jun O Ji. Exploring the role of stem cell therapy in treating neurodegenerative diseases: Challenges and current perspectives. Current stem cell research & therapy. 2022-02-09. PMID:35135462. |
several human neurological disorders such as parkinson's disease, alzheimer's disease, amyotrophic lateral sclerosis; huntington's disease, spinal cord injury, multiple sclerosis, and brain stroke, are caused by the injury to neurons or glial cells. |
2022-02-09 |
2023-08-13 |
human |
| Ahmed Salem, Carter J Wilson, Benjamin S Rutledge, Allison Dilliott, Sali Farhan, Wing-Yiu Choy, Martin L Duennwal. Matrin3: Disorder and ALS Pathogenesis. Frontiers in molecular biosciences. vol 8. 2022-01-27. PMID:35083279. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disorder characterized by the degeneration of both upper and lower motor neurons in the brain and spinal cord. |
2022-01-27 |
2023-08-13 |
Not clear |
| Jackson E Powell, Colin K W Lim, Ramya Krishnan, Tristan X McCallister, Christian Saporito-Magriña, Maria A Zeballos, Garrett D McPheron, Thomas Ga. Targeted gene silencing in the nervous system with CRISPR-Cas13. Science advances. vol 8. issue 3. 2022-01-19. PMID:35044815. |
intrathecally delivering an adeno-associated virus vector encoding an rfxcas13d variant programmed to target superoxide dismutase 1 (sod1), a protein whose mutation can cause amyotrophic lateral sclerosis, reduced sod1 mrna and protein in the spinal cord by >50% and improved outcomes in a mouse model of the disorder. |
2022-01-19 |
2023-08-13 |
mouse |
| Ping Li, Shiqiang Cheng, Yan Wen, Bolun Cheng, Li Liu, Xiuhua Wu, Xiang Ao, Zucheng Huang, Congrui Liao, Shaen Li, Feng Zhang, Zhongmin Zhan. Identifying Candidate Genes Associated with Sporadic Amyotrophic Lateral Sclerosis via Integrative Analysis of Transcriptome-Wide Association Study and Messenger RNA Expression Profile. Cellular and molecular neurobiology. 2022-01-17. PMID:35038056. |
amyotrophic lateral sclerosis, a fatal neurodegeneration disease affecting motor neurons in the brain and spinal cord, is difficult to diagnose and treat. |
2022-01-17 |
2023-08-13 |
Not clear |
| Chuan Liu, Michelle A Nguyen, Anabel Alvarez-Ciara, Melissa Franklin, Cassie Bennett, Justin B Domena, Noah C Kleinhenz, Gabriel A Blanco Colmenares, Sebastian Duque, Aisha F Chebbi, Brianna Bernard, Jean-Hubert Olivier, Abhishek Prasa. Surface Modifications of an Organic Polymer-Based Microwire Platform for Sustained Release of an Anti-Inflammatory Drug. ACS applied bio materials. vol 3. issue 7. 2022-01-13. PMID:35025460. |
brain machine interfaces (bmis), introduced into the daily lives of individuals with injuries or disorders of the nervous system such as spinal cord injury, stroke, or amyotrophic lateral sclerosis, can improve the quality of life. |
2022-01-13 |
2023-08-13 |
Not clear |
| Sukhdev Singh, Kuleshwar Sahu, Charan Singh, Arti Sing. Lipopolysaccharide induced altered signaling pathways in various neurological disorders. Naunyn-Schmiedeberg's archives of pharmacology. 2022-01-06. PMID:34989812. |
neuroinflammation is defined as an inflammatory response within the brain or spinal cord, whereas the brain's innate immune system is triggered by various inflammatory challenges such as injury, infection, exposure to toxin (lps) and ageing, which result in cognitive impairment and neurodegenerative diseases including alzheimer's disease (ad), parkinson's disease (pd), amyotrophic lateral sclerosis (als) and multiple sclerosis (ms). |
2022-01-06 |
2023-08-13 |
Not clear |
| Defne A Amado, Beverly L Davidso. Gene therapy for ALS: A review. Molecular therapy : the journal of the American Society of Gene Therapy. vol 29. issue 12. 2021-12-11. PMID:33839324. |
amyotrophic lateral sclerosis (als) has historically posed unique challenges for gene-therapy-based approaches, due to a paucity of therapeutic targets as well as the difficulty of accessing both the brain and spinal cord. |
2021-12-11 |
2023-08-13 |
human |
| Mandana Hunter, Krista J Spiller, Myrna A Dominique, Hong Xu, Francis W Hunter, Terry C Fang, Rebecca G Canter, Christopher J Roberts, Richard M Ransohoff, John Q Trojanowski, Virginia M-Y Le. Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery. Acta neuropathologica communications. vol 9. issue 1. 2021-12-08. PMID:34412701. |
in amyotrophic lateral sclerosis (als), a syndrome characterized by cytoplasmic aggregation of tdp-43 protein and atrophy of motor neurons in the cortex and spinal cord, the transcriptomic signatures of microglia during disease progression are incompletely understood. |
2021-12-08 |
2023-08-13 |
mouse |
| Simona Rossi, Mauro Cozzolin. Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia. Cells. vol 10. issue 11. 2021-12-08. PMID:34831228. |
amyotrophic lateral sclerosis is a neurological disease that primarily affects motor neurons in the cortex, brainstem, and spinal cord. |
2021-12-08 |
2023-08-13 |
Not clear |
| Sun Hwa Lee, Mudan Cai, Eun Jin Yan. Anti-inflammatory Effects of a Novel Herbal Extract in the Muscle and Spinal Cord of an Amyotrophic Lateral Sclerosis Animal Model. Frontiers in neuroscience. vol 15. 2021-12-04. PMID:34858128. |
anti-inflammatory effects of a novel herbal extract in the muscle and spinal cord of an amyotrophic lateral sclerosis animal model. |
2021-12-04 |
2023-08-13 |
Not clear |
| Taide Wang, Doris Tomas, Nirma D Perera, Brittany Cuic, Sophia Luikinga, Aida Viden, Samantha K Barton, Catriona A McLean, André L Samson, Adam Southon, Ashley I Bush, James M Murphy, Bradley J Turne. Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis. Cell death and differentiation. 2021-12-03. PMID:34857917. |
amyotrophic lateral sclerosis (als) is caused by selective degeneration of motor neurons in the brain and spinal cord; however, the primary cell death pathway(s) mediating motor neuron demise remain elusive. |
2021-12-03 |
2023-08-13 |
mouse |
| Polina S Goncharova, Tatiana K Davydova, Tatiana E Popova, Maxim A Novitsky, Marina M Petrova, Oksana A Gavrilyuk, Mustafa Al-Zamil, Natalia G Zhukova, Regina F Nasyrova, Natalia A Shnayde. Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis. Nutrients. vol 13. issue 11. 2021-11-29. PMID:34836059. |
amyotrophic lateral sclerosis (als) is an incurable chronic progressive neurodegenerative disease with the progressive degeneration of motor neurons in the motor cortex and lower motor neurons in the spinal cord and the brain stem. |
2021-11-29 |
2023-08-13 |
Not clear |