| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karoline Santur, Elke Reinartz, Yi Lien, Markus Tusche, Tim Altendorf, Marc Sevenich, Gültekin Tamgüney, Jeannine Mohrlüder, Dieter Willbol. Ligand-Induced Stabilization of the Native Human Superoxide Dismutase 1. ACS chemical neuroscience. vol 12. issue 13. 2021-08-02. PMID:34138531. |
a common characteristic of familial (fals) and sporadic amyotrophic lateral sclerosis (sals) is the accumulation of aberrant proteinaceous species in the motor neurons and spinal cord of als patients-including aggregates of the human superoxide dismutase 1 (hsod1). |
2021-08-02 |
2023-08-13 |
human |
| P Corcia, S Beltran, S E Bakkouche, P Couratie. Therapeutic news in ALS. Revue neurologique. vol 177. issue 5. 2021-07-29. PMID:33781562. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease characterized by death of motor neurons in the cortex and the spinal cord. |
2021-07-29 |
2023-08-13 |
Not clear |
| Xiao Li, Chongyang Chen, Xu Zhan, Binyao Li, Zaijun Zhang, Shupeng Li, Yongmei Xie, Xiangrong Song, Yuanyuan Shen, Jianjun Liu, Ping Liu, Gong-Ping Liu, Xifei Yan. R13 preserves motor performance in SOD1 Theranostics. vol 11. issue 15. 2021-07-29. PMID:34158851. |
r13 preserves motor performance in sod1 amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease characterized by death of motor neurons in the brain and spinal cord. |
2021-07-29 |
2023-08-13 |
Not clear |
| Sanjay Das, A Nalini, T R Laxmi, T R Raj. ALS-CSF-induced structural changes in spinal motor neurons of rat pups cause deficits in motor behaviour. Experimental brain research. vol 239. issue 1. 2021-07-28. PMID:33170340. |
amyotrophic lateral sclerosis (als) is a late-onset, neurodegenerative disease associated with the loss of motor neurons in the spinal cord, brain stem and primary motor cortex. |
2021-07-28 |
2023-08-13 |
rat |
| Xue Bai, Rui-Jia Fu, Shuo Zhang, Shi-Jun Yue, Yan-Yan Chen, Ding-Qiao Xu, Yu-Ping Tan. Potential medicinal value of celastrol and its synthesized analogues for central nervous system diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 139. 2021-07-26. PMID:33865016. |
however, in recent years, the extensive medical value of celastrol in the treatment of cns diseases such as nervous system tumors, alzheimer's disease, parkinson's disease, cerebral ischemia, multiple sclerosis, spinal cord injury, and amyotrophic lateral sclerosis has gradually attracted intensive attention worldwide. |
2021-07-26 |
2023-08-13 |
human |
| Nadia Sadanandan, Jea-Young Lee, Svitlana Garbuzova-Davi. Extracellular vesicle-based therapy for amyotrophic lateral sclerosis. Brain circulation. vol 7. issue 1. 2021-07-21. PMID:34084973. |
amyotrophic lateral sclerosis (als) stands as a neurodegenerative disorder characterized by the rapid progression of motor neuron loss in the brain and spinal cord. |
2021-07-21 |
2023-08-13 |
mouse |
| Wenting Liu, Sharmila Venugopal, Sana Majid, In Sook Ahn, Graciel Diamante, Jason Hong, Xia Yang, Scott H Chandle. Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis. Neurobiology of disease. vol 141. 2021-07-14. PMID:32360664. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease in which motor neurons throughout the brain and spinal cord progressively degenerate resulting in muscle atrophy, paralysis and death. |
2021-07-14 |
2023-08-13 |
mouse |
| Isil Keskin, Elaheh Ekhtiari Bidhendi, Matthew Marklund, Peter M Andersen, Thomas Brännström, Stefan L Marklund, Ulrika Nordströ. Peripheral administration of SOD1 aggregates does not transmit pathogenic aggregation to the CNS of SOD1 transgenic mice. Acta neuropathologica communications. vol 9. issue 1. 2021-07-12. PMID:34158126. |
in transgenic (tg) mouse models of superoxide dismutase-1 (sod1)-linked amyotrophic lateral sclerosis (als), inoculation of minute amounts of human sod1 (hsod1) aggregates into the spinal cord or peripheral nerves induces premature als-like disease and template-directed hsod1 aggregation that spreads along the neuroaxis. |
2021-07-12 |
2023-08-13 |
mouse |
| Toshihide Takeuch. Pathogenic and protective roles of extracellular vesicles in neurodegenerative diseases. Journal of biochemistry. vol 169. issue 2. 2021-07-08. PMID:33196835. |
neurodegenerative diseases such as alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis and polyglutamine diseases are caused by aggregation and abnormal accumulation of the disease-causative proteins in brain and spinal cord. |
2021-07-08 |
2023-08-13 |
Not clear |
| Jin-Hui Hor, Shi-Yan N. Generating ventral spinal organoids from human induced pluripotent stem cells. Methods in cell biology. vol 159. 2021-07-07. PMID:32586446. |
organoids also serves as important cellular tools to model spinal cord development and motor neuron diseases such as spinal muscular atrophy and amyotrophic lateral sclerosis. |
2021-07-07 |
2023-08-13 |
human |
| Terry C Burns, Alfredo Quinones-Hinojos. Regenerative medicine for neurological diseases-will regenerative neurosurgery deliver? BMJ (Clinical research ed.). vol 373. 2021-07-05. PMID:34162530. |
we specifically highlight ongoing translational efforts in parkinson's disease, amyotrophic lateral sclerosis, stroke, and spinal cord injury, using these to illustrate the principles, challenges, and opportunities of regenerative neurosurgery. |
2021-07-05 |
2023-08-13 |
Not clear |
| John D Simeral, Thomas Hosman, Jad Saab, Sharlene N Flesher, Marco Vilela, Brian Franco, Jessica N Kelemen, David M Brandman, John G Ciancibello, Paymon G Rezaii, Emad N Eskandar, David M Rosler, Krishna V Shenoy, Jaimie M Henderson, Arto V Nurmikko, Leigh R Hochber. Home Use of a Percutaneous Wireless Intracortical Brain-Computer Interface by Individuals With Tetraplegia. IEEE transactions on bio-medical engineering. vol 68. issue 7. 2021-06-28. PMID:33784612. |
individuals with neurological disease or injury such as amyotrophic lateral sclerosis, spinal cord injury or stroke may become tetraplegic, unable to speak or even locked-in. |
2021-06-28 |
2023-08-13 |
human |
| Qiao Ding, Justin Chaplin, Matthew J Morris, Massimo A Hilliard, Ernst Wolvetang, Dominic C H Ng, Peter G Noake. TDP-43 Mutation Affects Stress Granule Dynamics in Differentiated NSC-34 Motoneuron-Like Cells. Frontiers in cell and developmental biology. vol 9. 2021-06-26. PMID:34169068. |
amyotrophic lateral sclerosis (als) is characterized by degeneration of motor neurons in the brain and spinal cord. |
2021-06-26 |
2023-08-13 |
Not clear |
| Kelby M Killoy, Mariana Pehar, Benjamin A Harlan, Marcelo R Varga. Altered expression of clock and clock-controlled genes in a hSOD1-linked amyotrophic lateral sclerosis mouse model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 2. 2021-06-24. PMID:33508151. |
here, we investigated the expression of clock and clock-controlled genes in multiple tissues (suprachiasmatic nucleus, spinal cord, gastrocnemius muscle, and liver) from mutant hsod1-linked amyotrophic lateral sclerosis (als) mouse models. |
2021-06-24 |
2023-08-13 |
mouse |
| Koh Tadokoro, Toru Yamashita, Jingwei Shang, Yasuyuki Ohta, Emi Nomura, Ryuta Morihara, Yoshio Omote, Mami Takemoto, Koji Ab. Switching the Proteolytic System from the Ubiquitin-Proteasome System to Autophagy in the Spinal Cord of an Amyotrophic Lateral Sclerosis Mouse Model. Neuroscience. vol 466. 2021-06-22. PMID:33974963. |
switching the proteolytic system from the ubiquitin-proteasome system to autophagy in the spinal cord of an amyotrophic lateral sclerosis mouse model. |
2021-06-22 |
2023-08-13 |
mouse |
| George S Stoyanov, Deyan L Dzhenkov, Lilyana Petkov. Histomorphology of Amyotrophic Lateral Sclerosis: An Autopsy Case Report. Cureus. vol 13. issue 5. 2021-06-22. PMID:34150370. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease affecting predominantly the motor neurons of the anterior horns of the spinal cord. |
2021-06-22 |
2023-08-13 |
Not clear |
| Jun Ma, Baofeng Feng, Desheng Kong, Jingjing He, Ruiyun Guo, Asiamah Ernest Amponsah, Wei Zhang, Shuhan Zhang, Fei Lv, Yongzhou Song, Aijing Liu, Huixian Cu. Production and validation of human induced pluripotent stem cell line from sporadic amyotrophic lateral sclerosis (SALS). Stem cell research. vol 44. 2021-06-21. PMID:32203916. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease with the loss of upper motor neurons in the cortex and lower motor neurons in the brain stem and spinal cord regressively. |
2021-06-21 |
2023-08-13 |
human |
| Pramod Kumar Pisharady, Lynn E Eberly, Ian Cheong, Georgios Manousakis, Gaurav Guliani, H Brent Clark, Mark Bathe, David Walk, Christophe Lengle. Tract-specific analysis improves sensitivity of spinal cord diffusion MRI to cross-sectional and longitudinal changes in amyotrophic lateral sclerosis. Communications biology. vol 3. issue 1. 2021-06-17. PMID:32651439. |
tract-specific analysis improves sensitivity of spinal cord diffusion mri to cross-sectional and longitudinal changes in amyotrophic lateral sclerosis. |
2021-06-17 |
2023-08-13 |
Not clear |
| Pramod Kumar Pisharady, Lynn E Eberly, Ian Cheong, Georgios Manousakis, Gaurav Guliani, H Brent Clark, Mark Bathe, David Walk, Christophe Lengle. Tract-specific analysis improves sensitivity of spinal cord diffusion MRI to cross-sectional and longitudinal changes in amyotrophic lateral sclerosis. Communications biology. vol 3. issue 1. 2021-06-17. PMID:32651439. |
amyotrophic lateral sclerosis (als) is a late-onset fatal neurodegenerative disease that causes progressive degeneration of motor neurons in the brain and the spinal cord. |
2021-06-17 |
2023-08-13 |
Not clear |
| Lucas Vu, Asmita Ghosh, Chelsea Tran, Walters Aji Tebung, Hadjara Sidibé, Krystine Garcia-Mansfield, Victoria David-Dirgo, Ritin Sharma, Patrick Pirrotte, Robert Bowser, Christine Vande Veld. Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions. Journal of proteome research. vol 20. issue 6. 2021-06-17. PMID:33939924. |
finally, we identified snrnp200 in cytoplasmic aggregates in amyotrophic lateral sclerosis (als) spinal cord and motor cortex. |
2021-06-17 |
2023-08-13 |
Not clear |