| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christine Marques, Thibaut Burg, Jelena Scekic-Zahirovic, Mathieu Fischer, Caroline Rouau. Upper and Lower Motor Neuron Degenerations Are Somatotopically Related and Temporally Ordered in the Brain sciences. vol 11. issue 3. 2021-04-13. PMID:33805792. |
upper and lower motor neuron degenerations are somatotopically related and temporally ordered in the amyotrophic lateral sclerosis (als) is a devastating and fatal neurodegenerative disease arising from the combined degeneration of upper motor neurons (umn) in the motor cortex, and lower motor neurons (lmn) in the brainstem and spinal cord. |
2021-04-13 |
2023-08-13 |
Not clear |
| Domenico Di Curzio, Mamneet Gurm, Matthew Turnbull, Marie-Josée Nadeau, Breanna Meek, Julia D Rempel, Samuel Fineblit, Michael Jonasson, Sherry Hebert, Jennifer Ferguson-Parry, Renée N Douvill. Pro-Inflammatory Signaling Upregulates a Neurotoxic Conotoxin-Like Protein Encrypted Within Human Endogenous Retrovirus-K. Cells. vol 9. issue 7. 2021-04-12. PMID:32629888. |
pro-inflammatory signaling upregulates a neurotoxic conotoxin-like protein encrypted within human endogenous retrovirus-k. motor neuron degeneration and spinal cord demyelination are hallmark pathological events in amyotrophic lateral sclerosis (als). |
2021-04-12 |
2023-08-13 |
human |
| Pilar Rojas, Ana I Ramírez, Manuel Cadena, José A Fernández-Albarral, Elena Salobrar-García, Inés López-Cuenca, Irene Santos-García, Eva de Lago, José L Urcelay-Segura, José M Ramírez, Rosa de Hoz, Juan J Salaza. Retinal Ganglion Cell Loss and Microglial Activation in a SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 22. issue 4. 2021-04-12. PMID:33562231. |
the neurodegenerative disease amyotrophic lateral sclerosis (als) affects the spinal cord, brain stem, and cerebral cortex. |
2021-04-12 |
2023-08-13 |
mouse |
| Kazuhide Asakawa, Hiroshi Handa, Koichi Kawakam. Illuminating ALS Motor Neurons With Optogenetics in Zebrafish. Frontiers in cell and developmental biology. vol 9. 2021-04-06. PMID:33816488. |
amyotrophic lateral sclerosis (als) is a fatal neurological disorder characterized by progressive degeneration of motor neurons in the brain and spinal cord. |
2021-04-06 |
2023-08-13 |
zebrafish |
| João Rodrigues Lima-Junior, David Sulzer, Cecilia S Lindestam Arlehamn, Alessandro Sett. The role of immune-mediated alterations and disorders in ALS disease. Human immunology. vol 82. issue 3. 2021-03-29. PMID:33583639. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disorder that leads to neuronal death in the brain and spinal cord. |
2021-03-29 |
2023-08-13 |
Not clear |
| Shiqi Zhang, Zhengbo Shao, Xinna Liu, Mingying Hou, Fang Cheng, Dawei Lei, Huiping Yua. The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro. Cell death discovery. vol 7. issue 1. 2021-03-29. PMID:33723228. |
in addition, we also observed increased cytoplasmic tdp-43 in the spinal cord and motor dysfunction in 24-month-old optn (e50k) mice, indicating that tdp-43 accumulation may be the common pathological mechanism of glaucoma and amyotrophic lateral sclerosis (als). |
2021-03-29 |
2023-08-13 |
mouse |
| Biyao Wang, Minghao Huang, Dehao Shang, Xu Yan, Baohong Zhao, Xinwen Zhan. Mitochondrial Behavior in Axon Degeneration and Regeneration. Frontiers in aging neuroscience. vol 13. 2021-03-26. PMID:33762926. |
in this paper, we focus on the biological behavior of axonal mitochondria in aging, injury (e.g., traumatic brain and spinal cord injury), and neurodegenerative diseases (alzheimer's disease, ad; parkinson's disease, pd; amyotrophic lateral sclerosis, als) and consider the role of mitochondria in axon regeneration. |
2021-03-26 |
2023-08-13 |
Not clear |
| Seth Jarvis, Nicol Birsa, Maria Secrier, Pietro Fratta, Vincent Plagno. A Comparison of Low Read Depth QuantSeq 3' Sequencing to Total RNA-Seq in FUS Mutant Mice. Frontiers in genetics. vol 11. 2021-03-17. PMID:33329699. |
we applied both quantseq at low read depth and total rna-seq to the same two sets of mouse spinal cord rnas, each comprised by four controls and four mutants related to the neurodegenerative disease amyotrophic lateral sclerosis. |
2021-03-17 |
2023-08-13 |
mouse |
| Zachary C E Hawley, Danae Campos-Melo, Michael J Stron. Evidence of A Negative Feedback Network Between TDP-43 and miRNAs Dependent on TDP-43 Nuclear Localization. Journal of molecular biology. vol 432. issue 24. 2021-03-04. PMID:33137311. |
it has been previously shown that there is a general reduction in mirna levels within the spinal cord and spinal motor neurons of amyotrophic lateral sclerosis (als) patients. |
2021-03-04 |
2023-08-13 |
Not clear |
| Isidro Ferrer, Pol Andrés-Benito, Margarita Carmona, Abdelilah Assialioui, Mónica Povedan. TDP-43 Vasculopathy in the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis (sALS) and Frontal Cortex in sALS/FTLD-TDP. Journal of neuropathology and experimental neurology. vol 80. issue 3. 2021-02-26. PMID:33421065. |
tdp-43 vasculopathy in the spinal cord in sporadic amyotrophic lateral sclerosis (sals) and frontal cortex in sals/ftld-tdp. |
2021-02-26 |
2023-08-13 |
Not clear |
| HaEun Cho, Surabhi Shukl. Role of Edaravone as a Treatment Option for Patients with Amyotrophic Lateral Sclerosis. Pharmaceuticals (Basel, Switzerland). vol 14. issue 1. 2021-02-18. PMID:33396271. |
amyotrophic lateral sclerosis (als), also known as lou gehrig's disease, is a progressive and fatal neurodegenerative disease that leads to a loss of muscle control due to nerve cells being affected in the brain and spinal cord. |
2021-02-18 |
2023-08-13 |
Not clear |
| Yeomin Yun, Yoon H. CRISPR/Cas9-Mediated Gene Correction to Understand ALS. International journal of molecular sciences. vol 21. issue 11. 2021-02-16. PMID:32471232. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease caused by the death of motor neurons in the spinal cord and brainstem. |
2021-02-16 |
2023-08-13 |
Not clear |
| Emiliano Vicencio, Sebastián Beltrán, Luis Labrador, Patricio Manque, Melissa Nassif, Ute Woehlbie. Implications of Selective Autophagy Dysfunction for ALS Pathology. Cells. vol 9. issue 2. 2021-02-12. PMID:32046060. |
amyotrophic lateral sclerosis (als) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. |
2021-02-12 |
2023-08-13 |
Not clear |
| Matteo Bordoni, Eveljn Scarian, Federica Rey, Stella Gagliardi, Stephana Carelli, Orietta Pansarasa, Cristina Cered. Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach. International journal of molecular sciences. vol 21. issue 9. 2021-02-05. PMID:32375302. |
neurodegenerative disorders (i.e., alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis, and spinal cord injury) represent a great problem worldwide and are becoming prevalent because of the increasing average age of the population. |
2021-02-05 |
2023-08-13 |
Not clear |
| Pascual Torres, Daniel Cacabelos, Jèssica Pairada, Kylynda C Bauer, Jordi Boada, Laia Fontdevila, Chiara Rossi, Monica Povedano, Isidre Ferrer, Reinald Pamplona, B Brett Finlay, Manuel Portero-Otín, Victòria Ayal. Gender-Specific Beneficial Effects of Docosahexaenoic Acid Dietary Supplementation in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 17. issue 1. 2021-02-04. PMID:31755041. |
dha concentration decreases in the lumbar spinal cord (lsc) of amyotrophic lateral sclerosis (als) patients and murine preclinical models. |
2021-02-04 |
2023-08-13 |
mouse |
| Mamede de Carvalh. Electrodiagnosis of Amyotrophic Lateral Sclerosis: A Review of Existing Guidelines. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. vol 37. issue 4. 2021-02-02. PMID:33151660. |
amyotrophic lateral sclerosis (als) is characterized by degeneration of upper motor neurons in the motor cortex and lower motor neurons (lmn) in the brainstem and spinal cord, resulting in a progressive functional impairment. |
2021-02-02 |
2023-08-13 |
Not clear |
| Garam Kim, Olivia Gautier, Eduardo Tassoni-Tsuchida, X Rosa Ma, Aaron D Gitle. ALS Genetics: Gains, Losses, and Implications for Future Therapies. Neuron. vol 108. issue 5. 2021-01-27. PMID:32931756. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disorder caused by the loss of motor neurons from the brain and spinal cord. |
2021-01-27 |
2023-08-13 |
human |
| Patrick Oeckl, Patrick Weydt, Dietmar R Thal, Jochen H Weishaupt, Albert C Ludolph, Markus Ott. Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis. Acta neuropathologica. vol 139. issue 1. 2021-01-19. PMID:31701227. |
proteomics in cerebrospinal fluid and spinal cord suggests uchl1, map2 and gpnmb as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis. |
2021-01-19 |
2023-08-13 |
human |
| Motoko Niida-Kawaguchi, Akiyoshi Kakita, Noriko Noguchi, Miku Kazama, Kenta Masui, Yoichiro Kato, Tomoko Yamamoto, Tatsuo Sawada, Kazuo Kitagawa, Kazuhiko Watabe, Noriyuki Shibat. Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 40. issue 2. 2021-01-19. PMID:31883180. |
soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis. |
2021-01-19 |
2023-08-13 |
human |
| Motoko Niida-Kawaguchi, Akiyoshi Kakita, Noriko Noguchi, Miku Kazama, Kenta Masui, Yoichiro Kato, Tomoko Yamamoto, Tatsuo Sawada, Kazuo Kitagawa, Kazuhiko Watabe, Noriyuki Shibat. Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 40. issue 2. 2021-01-19. PMID:31883180. |
previous studies on sporadic amyotrophic lateral sclerosis (sals) demonstrated iron accumulation in the spinal cord and increased glutamate concentration in the cerebrospinal fluid. |
2021-01-19 |
2023-08-13 |
human |