| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tesfaye Wolde Tefera, Frederik J Steyn, Shyuan T Ngo, Karin Borge. CNS glucose metabolism in Amyotrophic Lateral Sclerosis: a therapeutic target? Cell & bioscience. vol 11. issue 1. 2021-01-15. PMID:33431046. |
amyotrophic lateral sclerosis (als) is a fatal progressive neurodegenerative disorder primarily characterized by selective degeneration of both the upper motor neurons in the brain and lower motor neurons in the brain stem and the spinal cord. |
2021-01-15 |
2023-08-13 |
Not clear |
| Yue-Qing Yang, Yong-Hui Zheng, Chun-Ting Zhang, Wei-Wei Liang, Shu-Yu Wang, Xu-Dong Wang, Ying Wang, Tian-Hang Wang, Hong-Quan Jiang, Hong-Lin Fen. Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis. Neurobiology of disease. vol 134. 2021-01-13. PMID:31676238. |
accumulation of dna damage has been detected in the spinal cord of patients as well as in the g93a mouse model of amyotrophic lateral sclerosis (als). |
2021-01-13 |
2023-08-13 |
mouse |
| Aditya K Padhi, Kam Y J Zhan. Mechanistic insights into the loss-of-function mechanisms of rare human D-amino acid oxidase variants implicated in amyotrophic lateral sclerosis. Scientific reports. vol 10. issue 1. 2021-01-13. PMID:33051492. |
impaired enzymatic activity in d-amino acid oxidase (daao) caused by missense mutations has been shown to trigger amyotrophic lateral sclerosis (als) through an abnormal accumulation of d-serine in the spinal cord. |
2021-01-13 |
2023-08-13 |
human |
| Rachel Waller, Matthew Wyles, Paul R Heath, Mbombe Kazoka, Helen Wollff, Pamela J Shaw, Janine Kirb. Small RNA Sequencing of Sporadic Amyotrophic Lateral Sclerosis Cerebrospinal Fluid Reveals Differentially Expressed miRNAs Related to Neural and Glial Activity. Frontiers in neuroscience. vol 11. 2021-01-09. PMID:29375285. |
amyotrophic lateral sclerosis (als) is a clinical subtype of motor neurone disease (mnd), a fatal neurodegenerative disease involving the loss of both the upper and lower motor neurones from the motor cortex, brainstem, and spinal cord. |
2021-01-09 |
2023-08-13 |
Not clear |
| Byung Woo Kim, Jiwon Ryu, Ye Eun Jeong, Juhyun Kim, Lee J Marti. Human Motor Neurons With SOD1-G93A Mutation Generated From CRISPR/Cas9 Gene-Edited iPSCs Develop Pathological Features of Amyotrophic Lateral Sclerosis. Frontiers in cellular neuroscience. vol 14. 2020-12-18. PMID:33328898. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disorder characterized by gradual degeneration and elimination of motor neurons (mns) in the motor cortex, brainstem, and spinal cord. |
2020-12-18 |
2023-08-13 |
human |
| María José Castellanos-Montiel, Mathilde Chaineau, Thomas M Durca. The Neglected Genes of ALS: Cytoskeletal Dynamics Impact Synaptic Degeneration in ALS. Frontiers in cellular neuroscience. vol 14. 2020-12-08. PMID:33281562. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease that selectively affects motor neurons (mns) of the cortex, brainstem, and spinal cord. |
2020-12-08 |
2023-08-13 |
Not clear |
| Thomas Wimmer, Frank Schreiber, Nathalie Hensiek, Cornelia Garz, Jörn Kaufmann, Judith Machts, Susanne Vogt, Johannes Prudlo, Reinhard Dengler, Susanne Petri, Hans-Jochen Heinze, Peter J Nestor, Stefan Vielhaber, Stefanie Schreibe. The upper cervical spinal cord in ALS assessed by cross-sectional and longitudinal 3T MRI. Scientific reports. vol 10. issue 1. 2020-11-16. PMID:32020025. |
the upper cervical spinal cord is measured in a large longitudinal amyotrophic lateral sclerosis (als) cohort to evaluate its role as a biomarker. |
2020-11-16 |
2023-08-13 |
Not clear |
| Qi Zhou, Lei Zhu, Weiwen Qiu, Yue Liu, Fang Yang, Wenzhi Chen, Renshi X. Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1 International journal of biological sciences. vol 16. issue 2. 2020-11-02. PMID:31929756. |
nicotinamide riboside enhances mitochondrial proteostasis and adult neurogenesis through activation of mitochondrial unfolded protein response signaling in the brain of als sod1 amyotrophic lateral sclerosis (als) is caused by the progressive degeneration of motor neurons in the spinal cord, the brain stem, and the motor cortex. |
2020-11-02 |
2023-08-13 |
human |
| Adriano Britto Chaves-Filho, Isabella Fernanda Dantas Pinto, Lucas Souza Dantas, Andre Machado Xavier, Alex Inague, Rodrigo Lucas Faria, Marisa H G Medeiros, Isaias Glezer, Marcos Yukio Yoshinaga, Sayuri Miyamot. Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31406145. |
alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis. |
2020-10-27 |
2023-08-13 |
human |
| Mohammad Samin Nur Chowdhury, Arindam Dutta, Matthew K Robison, Chris Blais, Gene Brewer, Daniel W Blis. A Generalized Model to Estimate Reaction Time Corresponding to Visual Stimulus Using Single-Trial EEG. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2020. 2020-10-23. PMID:33018639. |
relevant eeg channels were evaluated to localize the part of the brain significantly responsible for rt estimation, followed by the isolation of important features.clinical relevance- electroencephalogram (eeg) signals can be used in brain-computer interfaces (bcis), enabling people with neuromuscular disorders like brainstem stroke, amyotrophic lateral sclerosis, and spinal cord injury to communicate with assistive devices. |
2020-10-23 |
2023-08-13 |
Not clear |
| Virginie Petel Légaré, Ziyaan A Harji, Christian J Rampal, Xavier Allard-Chamard, Esteban C Rodríguez, Gary A B Armstron. Augmentation of spinal cord glutamatergic synaptic currents in zebrafish primary motoneurons expressing mutant human TARDBP (TDP-43). Scientific reports. vol 9. issue 1. 2020-10-21. PMID:31235725. |
though there is compelling evidence that de-innervation of neuromuscular junctions (nmj) occurs early in amyotrophic lateral sclerosis (als), defects arising at synapses in the spinal cord remain incompletely understood. |
2020-10-21 |
2023-08-13 |
human |
| Ladislava Vymetalova, Tereza Kucirkova, Lucia Knopfova, Veronika Pospisilova, Tomas Kasko, Hana Lejdarova, Eva Makaturova, Petr Kuglik, Veronika Oralova, Eva Matalova, Petr Benes, Zdenek Koristek, Serhiy Forostya. Large-Scale Automated Hollow-Fiber Bioreactor Expansion of Umbilical Cord-Derived Human Mesenchymal Stromal Cells for Neurological Disorders. Neurochemical research. vol 45. issue 1. 2020-10-19. PMID:31828497. |
maladies like amyotrophic lateral sclerosis, alzheimer's disease, stroke or spinal cord injury commonly features astroglia involvement (astrogliosis) with signs of inflammation. |
2020-10-19 |
2023-08-13 |
human |
| Philippe A Parone, Sandrine Da Cruz, Don W Clevelan. Mitochondrial Isolation and Purification from Mouse Spinal Cord. Bio-protocol. vol 3. issue 21. 2020-10-01. PMID:27819013. |
here, we describe a protocol for the isolation of mitochondria from mouse spinal cord, a compartment of the central nervous system that is significantly affected in neuromuscular diseases such as amyotrophic lateral sclerosis. |
2020-10-01 |
2023-08-13 |
mouse |
| Manoj Kumar Jaiswa. Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca Frontiers in cellular neuroscience. vol 10. 2020-10-01. PMID:28111541. |
riluzole but not melatonin ameliorates acute motor neuron degeneration and moderately inhibits sod1-mediated excitotoxicity induced disrupted mitochondrial ca selective motoneurons (mns) degeneration in the brain stem, hypoglossal motoneurons (hmns), and the spinal cord resulting in patients paralysis and eventual death are prominent features of amyotrophic lateral sclerosis (als). |
2020-10-01 |
2023-08-13 |
Not clear |
| Tesfaye W Tefera, Karin Borge. Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments. Frontiers in neuroscience. vol 10. 2020-10-01. PMID:28119559. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease primarily characterized by loss of motor neurons in brain and spinal cord. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kyle Peake, John Manning, Coral-Ann Lewis, Kevin Tran, Fabio Rossi, Charles Kriege. Bone Marrow-Derived Cell Accumulation in the Spinal Cord Is Independent of Peripheral Mobilization in a Mouse Model of Amyotrophic Lateral Sclerosis. Frontiers in neurology. vol 8. 2020-10-01. PMID:28337172. |
bone marrow-derived cell accumulation in the spinal cord is independent of peripheral mobilization in a mouse model of amyotrophic lateral sclerosis. |
2020-10-01 |
2023-08-13 |
mouse |
| Manoj Kumar Jaiswa. Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease. Neural regeneration research. vol 12. issue 5. 2020-10-01. PMID:28616022. |
amyotrophic lateral sclerosis (als) and motor neuron diseases (mnds) are progressive neurodegenerative diseases that affect nerve cells in the brain affecting upper and lower motor neurons (umns/lmns), brain stem and spinal cord. |
2020-10-01 |
2023-08-13 |
human |
| Liyu Chen, Clare Watson, Marco Morsch, Nicholas J Cole, Roger S Chung, Darren N Saunders, Justin J Yerbury, Kara L Vin. Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28912673. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease affecting the upper and lower motor neurons in the motor cortex and spinal cord. |
2020-10-01 |
2023-08-13 |
Not clear |
| Charlotte Veyrat-Durebex, Pascal Reynier, Vincent Procaccio, Rudolf Hergesheimer, Philippe Corcia, Christian R Andres, Hélène Blasc. How Can a Ketogenic Diet Improve Motor Function? Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29434537. |
motor function has also been shown to be improved by kd and/or medium-chain triglyceride diets in rodent models of alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis, and spinal cord injury. |
2020-10-01 |
2023-08-13 |
Not clear |
| Woo Suk Tae, Byung Joo Ham, Sung Bom Pyun, Shin Hyuk Kang, Byung Jo Ki. Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders. Journal of clinical neurology (Seoul, Korea). vol 14. issue 2. 2020-10-01. PMID:29504292. |
further, it summarizes the clinical role of dti in various disease processes such as amyotrophic lateral sclerosis, multiple sclerosis, parkinson's disease, alzheimer's dementia, epilepsy, ischemic stroke, stroke with motor or language impairment, traumatic brain injury, spinal cord injury, and depression. |
2020-10-01 |
2023-08-13 |
Not clear |