| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Serenella Anzilotti, Valeria Valente, Paola Brancaccio, Cristina Franco, Antonella Casamassa, Giovanna Lombardi, Alessandra Palazzi, Andrea Conte, Simona Paladino, Lorella Maria Teresa Canzoniero, Lucio Annunziato, Giovanna Maria Pierantoni, Giuseppe Pignatar. Chronic exposure to l-BMAA cyanotoxin induces cytoplasmic TDP-43 accumulation and glial activation, reproducing an amyotrophic lateral sclerosis-like phenotype in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-20. PMID:37729728. |
amyotrophic lateral sclerosis (als) is a progressive and often fatal neurodegenerative disease characterized by the loss of motor neurons (mns) in spinal cord, motor cortex and brainstem. |
2023-09-20 |
2023-10-07 |
mouse |
| Jin Gao, Mingchen Jiang, Danilo Erricolo, Richard L Magin, Gerardo Morfini, Thomas Royston, Andrew C Larson, Weiguo L. Identifying potential imaging markers for diffusion property changes in a mouse model of amyotrophic lateral sclerosis: Application of the continuous time random walk model to ultrahigh b-value diffusion-weighted MR images of spinal cord tissue. NMR in biomedicine. 2023-09-18. PMID:37721118. |
identifying potential imaging markers for diffusion property changes in a mouse model of amyotrophic lateral sclerosis: application of the continuous time random walk model to ultrahigh b-value diffusion-weighted mr images of spinal cord tissue. |
2023-09-18 |
2023-10-07 |
mouse |
| Matthew J Broadhead, Ani Ayvazian-Hancock, Katherine Doucet, Owen Kantelberg, Lesley Motherwell, Fei Zhu, Seth G N Grant, Mathew H Horrocks, Gareth B Mile. Synaptic expression of TAR-DNA-binding protein 43 in the mouse spinal cord determined using super-resolution microscopy. Frontiers in molecular neuroscience. vol 16. 2023-09-06. PMID:37671010. |
amyotrophic lateral sclerosis (als) is characterised by a loss of motor neurons in the brain and spinal cord that is preceded by early-stage changes in synapses that may be associated with tar-dna-binding protein 43 (tdp-43) pathology. |
2023-09-06 |
2023-10-07 |
mouse |
| Wan Zhou, Renshi X. Current insights in the molecular genetic pathogenesis of amyotrophic lateral sclerosis. Frontiers in neuroscience. vol 17. 2023-08-28. PMID:37638324. |
amyotrophic lateral sclerosis (als) is a progressive and fatal neurodegenerative disease that leads to the massive loss of motor neurons in cerebrum, brain stem and spinal cord. |
2023-08-28 |
2023-09-07 |
Not clear |
| Valentina La Cognata, Agata Grazia D'Amico, Grazia Maugeri, Giovanna Morello, Maria Guarnaccia, Benedetta Magrì, Eleonora Aronica, Daniel L Alkon, Velia D'Agata, Sebastiano Cavallar. The ε-Isozyme of Protein Kinase C (PKCε) Is Impaired in ALS Motor Cortex and Its Pulse Activation by Bryostatin-1 Produces Long Term Survival in Degenerating SOD1-G93A Motor Neuron-like Cells. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37629005. |
amyotrophic lateral sclerosis (als) is a rapidly progressive and ultimately fatal neurodegenerative disease, characterized by a progressive depletion of upper and lower motor neurons (mns) in the brain and spinal cord. |
2023-08-26 |
2023-09-07 |
human |
| Orion P Keifer, Juanmarco Gutierrez, Mark T Butt, Sarah D Cramer, Raymond Bartus, Malu Tansey, Daniel Deaver, Alexandre Betourne, Nicholas M Bouli. Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis. PloS one. vol 18. issue 8. 2023-08-22. PMID:37607205. |
spinal cord and brain concentrations of riluzole after oral and intrathecal administration: a potential new treatment route for amyotrophic lateral sclerosis. |
2023-08-22 |
2023-09-07 |
human |
| Akiko Yamamuro-Tanabe, Yurika Mukai, Wataru Kojima, Siyuan Zheng, Naoko Matsumoto, Shoho Takada, Mao Mizuhara, Yasuhiro Kosuge, Yuki Ishimaru, Yasuhiro Yoshiok. An Increase in Peroxiredoxin 6 Expression Induces Neurotoxic A1 Astrocytes in the Lumbar Spinal Cord of Amyotrophic Lateral Sclerosis Mice Model. Neurochemical research. 2023-08-09. PMID:37556038. |
an increase in peroxiredoxin 6 expression induces neurotoxic a1 astrocytes in the lumbar spinal cord of amyotrophic lateral sclerosis mice model. |
2023-08-09 |
2023-08-16 |
mouse |
| Swetha Ramachandran, Veselin Grozdanov, Bianca Leins, Katharina Kandler, Simon Witzel, Medhanie Mulaw, Albert C Ludolph, Jochen H Weishaupt, Karin M Danze. Low T-cell reactivity to TDP-43 peptides in ALS. Frontiers in immunology. vol 14. 2023-08-07. PMID:37545536. |
dysregulation of the immune system in amyotrophic lateral sclerosis (als) includes changes in t-cells composition and infiltration of t cells in the brain and spinal cord. |
2023-08-07 |
2023-08-14 |
mouse |
| Bruno Costa Gomes, Nuno Peixinho, Rita Pisco, Marta Gromicho, Ana Catarina Pronto-Laborinho, José Rueff, Mamede de Carvalho, António Sebastião Rodrigue. Differential Expression of miRNAs in Amyotrophic Lateral Sclerosis Patients. Molecular neurobiology. 2023-08-02. PMID:37531027. |
amyotrophic lateral sclerosis (als) is a progressive motor neuron disease that affects nerve cells in the brain and spinal cord, causing loss of muscle control, muscle atrophy and in later stages, death. |
2023-08-02 |
2023-08-14 |
Not clear |
| Kawaljit Kaur, Po-Chun Chen, Meng-Wei Ko, Ao Mei, Sara Huerta-Yepez, Dipnarine Maharaj, Subramaniam Malarkannan, Anahid Jewet. Successes and Challenges in Taming the Beast: Cytotoxic Immune Effectors in Amyotrophic Lateral Sclerosis. Critical reviews in immunology. vol 43. issue 1. 2023-07-31. PMID:37522557. |
amyotrophic lateral sclerosis (als) is a neurological disease characterized by the progressive loss of motor neurons in the brain and spinal cord. |
2023-07-31 |
2023-08-14 |
Not clear |
| Yu Huang, Huili Yang, Biying Yang, Yu Zheng, Xiaomei Hou, Guiling Chen, Wenqi Zhang, Xiang Zeng, Baoxin D. Ginsenoside-Rg1 combined with a conditioned medium from induced neuron-like hUCMSCs alleviated the apoptosis in a cell model of ALS through regulating the NF-κB/Bcl-2 pathway. Chinese journal of natural medicines. vol 21. issue 7. 2023-07-30. PMID:37517821. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease affecting both upper and lower motor neurons in the brain and spinal cord. |
2023-07-30 |
2023-08-14 |
human |
| Oumayma Aousji, Simone Feldengut, Stefano Antonucci, Michael Schön, Tobias M Boeckers, Jakob Matschke, Christian Mawrin, Albert C Ludolph, Kelly Del Tredici, Francesco Roselli, Heiko Braa. Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study. Acta neuropathologica communications. vol 11. issue 1. 2023-07-25. PMID:37491361. |
patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study. |
2023-07-25 |
2023-08-14 |
human |
| Ruicheng Yang, Bo Yang, Wei Liu, Chen Tan, Huanchun Chen, Xiangru Wan. Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes. Journal of neuroinflammation. vol 20. issue 1. 2023-07-22. PMID:37481642. |
neuroinflammation has been implicated in the initiation and progression of several central nervous system (cns) disorders, including alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, ischemic stroke, traumatic brain injury, spinal cord injury, viral encephalitis, and bacterial encephalitis. |
2023-07-22 |
2023-08-14 |
Not clear |
| Robert B Kargb. Microbiome-Gut-Brain Axis Modulation: New Approaches in Treatment of Parkinson's Disease and Amyotrophic Lateral Sclerosis. ACS medicinal chemistry letters. vol 14. issue 7. 2023-07-19. PMID:37465304. |
mitochondrial dysfunction plays a critical role in the disease's progression, while amyotrophic lateral sclerosis (als), or lou gehrig's disease, is a fatal progressive neurodegenerative disease characterized by significant motor neuron loss in the primary motor cortex, brainstem, and spinal cord. |
2023-07-19 |
2023-08-14 |
Not clear |
| Lorella Giovannelli, Elia Bari, Claudio Jommi, Fulvio Tartara, Daniele Armocida, Diego Garbossa, Fabio Cofano, Maria Luisa Torre, Lorena Segal. Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: Risk-benefit profile and next steps for the market access. Bioactive materials. vol 29. 2023-07-17. PMID:37456581. |
this paper provides an overview of the most recent research on the safety and efficacy of msc-derived secretome and extracellular vesicles (evs) in clinical (if available) and preclinical models of alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, huntington's disease, acute ischemic stroke, and spinal cord injury. |
2023-07-17 |
2023-08-14 |
Not clear |
| Mohamed Mounir El Mendili, Annie Verschueren, Jean-Philippe Ranjeva, Maxime Guye, Shahram Attarian, Wafaa Zaaraoui, Aude-Marie Grappero. Association between brain and upper cervical spinal cord atrophy assessed by MRI and disease aggressiveness in amyotrophic lateral sclerosis. Neuroradiology. 2023-07-17. PMID:37458788. |
association between brain and upper cervical spinal cord atrophy assessed by mri and disease aggressiveness in amyotrophic lateral sclerosis. |
2023-07-17 |
2023-08-14 |
Not clear |
| Mohamed Mounir El Mendili, Annie Verschueren, Jean-Philippe Ranjeva, Maxime Guye, Shahram Attarian, Wafaa Zaaraoui, Aude-Marie Grappero. Association between brain and upper cervical spinal cord atrophy assessed by MRI and disease aggressiveness in amyotrophic lateral sclerosis. Neuroradiology. 2023-07-17. PMID:37458788. |
to study the relative contributions of brain and upper cervical spinal cord compartmental atrophy to disease aggressiveness in amyotrophic lateral sclerosis (als). |
2023-07-17 |
2023-08-14 |
Not clear |
| Kurosh Zamiri, Santosh Kesari, Ketema Paul, Sung Hee Hwang, Bruce Hammock, Karolina Elżbieta Kaczor-Urbanowicz, Andrzej Urbanowicz, Lucy Gao, Julian Whitelegge, Milan Fial. Therapy of autoimmune inflammation in sporadic amyotrophic lateral sclerosis: Dimethyl fumarate and H-151 downregulate inflammatory cytokines in the cGAS-STING pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 8. 2023-07-12. PMID:37436778. |
in sporadic amyotrophic lateral sclerosis (sals), il-17a- and granzyme-positive cytotoxic t lymphocytes (ctl), il-17a-positive mast cells, and inflammatory macrophages invade the brain and spinal cord. |
2023-07-12 |
2023-08-14 |
Not clear |
| Karen Lync. Pathogenesis and presentation of ALS: examining reasons for delayed diagnosis and identifying opportunities for improvement. The American journal of managed care. vol 29. issue 7 Suppl. 2023-07-11. PMID:37433091. |
amyotrophic lateral sclerosis (als), or lou gehrig disease, is a progressive, always-fatal neuromuscular disease characterized by motor neuron degeneration in the brain and spinal cord. |
2023-07-11 |
2023-08-14 |
Not clear |
| M Kathryn Brewer, Pascual Torres, Victòria Ayala, Manuel Portero-Otin, Reinald Pamplona, Pol Andrés-Benito, Isidro Ferrer, Joan J Guinovart, Jordi Dura. Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis. Journal of neurochemistry. 2023-07-04. PMID:37401737. |
amyotrophic lateral sclerosis (als) is a devastating neurodegenerative disease characterized by the progressive loss of motor neurons in the spinal cord. |
2023-07-04 |
2023-08-14 |
mouse |