| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zihao Li, Ye Zhang, Meiling Ji, Chenglong Wu, Yanxing Zhang, Senlin J. Targeting ferroptosis in neuroimmune and neurodegenerative disorders for the development of novel therapeutics. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 176. 2024-05-25. PMID:38795640. |
neurodegenerative diseases result from neuronal degeneration or demyelination in the brain or spinal cord, such as alzheimer's disease, parkinson's disease, huntington's disease, and amyotrophic lateral sclerosis. |
2024-05-25 |
2024-05-31 |
Not clear |
| Andrea Salzinger, Vidya Ramesh, Shreya Das Sharma, Siddharthan Chandran, Bhuvaneish Thangaraj Selvara. Neuronal Circuit Dysfunction in Amyotrophic Lateral Sclerosis. Cells. vol 13. issue 10. 2024-05-24. PMID:38786016. |
the primary neural circuit affected in amyotrophic lateral sclerosis (als) patients is the corticospinal motor circuit, originating in upper motor neurons (umns) in the cerebral motor cortex which descend to synapse with the lower motor neurons (lmns) in the spinal cord to ultimately innervate the skeletal muscle. |
2024-05-24 |
2024-05-27 |
human |
| Weijian Chen, Xu Liu, Peiyuan Wan, Zhijie Chen, Yi Che. Anti-artifacts techniques for neural recording front-ends in closed-loop brain-machine interface ICs. Frontiers in neuroscience. vol 18. 2024-05-24. PMID:38784093. |
particularly in the field of neuromedical, the utilization of brain-machine interfaces (bmi) has revolutionized the treatment of neurological diseases such as amyotrophic lateral sclerosis, cerebral palsy, stroke, or spinal cord injury. |
2024-05-24 |
2024-05-27 |
Not clear |
| Ilaria Martinelli, Jessica Mandrioli, Andrea Ghezzi, Elisabetta Zucchi, Giulia Gianferrari, Cecilia Simonini, Francesco Cavallieri, Franco Valzani. Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients: a rare occurrence? Neural regeneration research. vol 20. issue 1. 2024-05-20. PMID:38767482. |
amyotrophic lateral sclerosis (als) is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex, brainstem, and spinal cord. |
2024-05-20 |
2024-05-27 |
human |
| Jiaqi Xin, Sen Huang, Jing Wen, Yunhao Li, Ang Li, Senthil Kumaran Satyanarayanan, Xiaoli Yao, Huanxing S. Drug Screening and Validation Targeting TDP-43 Proteinopathy for Amyotrophic Lateral Sclerosis. Aging and disease. 2024-05-13. PMID:38739934. |
amyotrophic lateral sclerosis (als) stands as a rare, yet severely debilitating disorder marked by the deterioration of motor neurons (mns) within the brain and spinal cord, which is accompanied by degenerated corticobulbar/corticospinal tracts and denervation in skeletal muscles. |
2024-05-13 |
2024-05-27 |
Not clear |
| Sangeetha Gupta, Uma Sharm. Metabolomics of neurological disorders in India. Analytical science advances. vol 2. issue 11-12. 2024-05-08. PMID:38715858. |
the current review mainly focuses on an indian perspective of metabolomics for the identification of metabolites and metabolic alterations serving as potential diagnostic biomarkers for neurological diseases including acute spinal cord injury, amyotrophic lateral sclerosis, tethered cord syndrome, spina bifida, stroke, parkinson's disease, glioblastoma and neurological disorders with inborn errors of metabolism. |
2024-05-08 |
2024-05-27 |
Not clear |
| Abdulkadir Ozkan, Hari K Padmanabhan, Seth L Shipman, Eiman Azim, Priyanka Kumar, Cameron Sadegh, A Nazli Basak, Jeffrey D Mackli. Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors. bioRxiv : the preprint server for biology. 2024-05-07. PMID:38712174. |
corticospinal neurons (csn) centrally degenerate in amyotrophic lateral sclerosis (als), along with spinal motor neurons, and loss of voluntary motor function in spinal cord injury (sci) results from damage to csn axons. |
2024-05-07 |
2024-05-27 |
Not clear |
| Arsh Ketabforoush, Meifang Wang, Catherine L Smith, William David Arnold, Nicole L Nichol. Assessing Rat Diaphragm Motor Unit Connectivity Outcome Measures as Quantitative Biomarkers of Phrenic Motor Neuron Degeneration and Compensation. Journal of visualized experiments : JoVE. issue 206. 2024-05-06. PMID:38709037. |
loss of ventilatory muscle function is a consequence of motor neuron injury and neurodegeneration (e.g., cervical spinal cord injury and amyotrophic lateral sclerosis, respectively). |
2024-05-06 |
2024-05-08 |
rat |
| Kyrah M Thumbadoo, Birger V Dieriks, Helen C Murray, Molly E V Swanson, Ji Hun Yoo, Nasim F Mehrabi, Clinton Turner, Michael Dragunow, Richard L M Faull, Maurice A Curtis, Teepu Siddique, Christopher E Shaw, Kathy L Newell, Lyndal Henden, Kelly L Williams, Garth A Nicholson, Emma L Scotte. Hippocampal aggregation signatures of pathogenic UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia. Brain : a journal of neurology. 2024-05-04. PMID:38703371. |
pathogenic variants in the ubqln2 gene cause x-linked dominant amyotrophic lateral sclerosis and/or frontotemporal dementia characterised by ubiquilin 2 aggregates in neurons of the motor cortex, hippocampus, and spinal cord. |
2024-05-04 |
2024-05-07 |
Not clear |
| Priya Singh, Paul Belliveau, Jennifer Towle, Andrea Elena Neculau, Lorena Dim. Edaravone Oral Suspension: A Neuroprotective Agent to Treat Amyotrophic Lateral Sclerosis. American journal of therapeutics. vol 31. issue 3. 2024-05-01. PMID:38691665. |
amyotrophic lateral sclerosis (als) is characterized by loss of motor neurons due to degeneration of nerve cells within the brain and spinal cord. |
2024-05-01 |
2024-05-04 |
Not clear |
| Aparna Thulasidharan, Lovleen Garg, Shweta Tendulkar, Girish S Ratnaparkh. Age-dependent dynamics of neuronal VAPB Neurobiology of disease. 2024-04-28. PMID:38679111. |
age-dependent dynamics of neuronal vapb amyotrophic lateral sclerosis (als) is a relentlessly progressive and fatal disease, caused by the degeneration of upper and lower motor neurons within the brain and spinal cord in the ageing human. |
2024-04-28 |
2024-05-01 |
human |
| Sharon Natasha Cox, Claudio Lo Giudice, Anna Lavecchia, Maria Luana Poeta, Matteo Chiara, Ernesto Picardi, Graziano Pesol. Mitochondrial and Nuclear DNA Variants in Amyotrophic Lateral Sclerosis: Enrichment in the Mitochondrial Control Region and Sirtuin Pathway Genes in Spinal Cord Tissue. Biomolecules. vol 14. issue 4. 2024-04-27. PMID:38672428. |
mitochondrial and nuclear dna variants in amyotrophic lateral sclerosis: enrichment in the mitochondrial control region and sirtuin pathway genes in spinal cord tissue. |
2024-04-27 |
2024-04-29 |
human |
| Sharon Natasha Cox, Claudio Lo Giudice, Anna Lavecchia, Maria Luana Poeta, Matteo Chiara, Ernesto Picardi, Graziano Pesol. Mitochondrial and Nuclear DNA Variants in Amyotrophic Lateral Sclerosis: Enrichment in the Mitochondrial Control Region and Sirtuin Pathway Genes in Spinal Cord Tissue. Biomolecules. vol 14. issue 4. 2024-04-27. PMID:38672428. |
amyotrophic lateral sclerosis (als) is a progressive disease with prevalent mitochondrial dysfunctions affecting both upper and lower motor neurons in the motor cortex, brainstem, and spinal cord. |
2024-04-27 |
2024-04-29 |
human |
| Faisal A Alzahrani, Yasir M Riza, Thamir M Eid, Reema Almotairi, Lea Scherschinski, Jessica Contreras, Muhammed Nadeem, Sylvia E Perez, Sudhanshu P Raikwar, Ruchira M Jha, Mark C Preul, Andrew F Ducruet, Michael T Lawton, Kanchan Bhatia, Naseem Akhter, Saif Ahma. Exosomes in Vascular/Neurological Disorders and the Road Ahead. Cells. vol 13. issue 8. 2024-04-26. PMID:38667285. |
neurodegenerative diseases, such as alzheimer's disease (ad), parkinson's disease (pd), amyotrophic lateral sclerosis (als), huntington's disease (hd), stroke, and aneurysms, are characterized by the abnormal accumulation and aggregation of disease-causing proteins in the brain and spinal cord. |
2024-04-26 |
2024-04-28 |
Not clear |
| David Gonzalez, Xiomara Cuenca, Miguel L Allend. Knockdown of Frontiers in cellular neuroscience. vol 18. 2024-04-22. PMID:38644973. |
knockdown of amyotrophic lateral sclerosis (als) corresponds to a neurodegenerative disorder marked by the progressive degeneration of both upper and lower motor neurons located in the brain, brainstem, and spinal cord. |
2024-04-22 |
2024-04-24 |
mouse |
| Gaurav Deepak Patel, Lichao Liu, Ailian Li, Yun-Hsuan Yang, Chia-Chi Shen, Beate Brand-Saberi, Xuesong Yan. Mesenchymal stem cell-based therapies for treating well-studied neurological disorders: a systematic review. Frontiers in medicine. vol 11. 2024-04-11. PMID:38601118. |
millions of people across the globe are affected by conditions like amyotrophic lateral sclerosis (als), parkinson's disease (pd), multiple sclerosis (ms), spinal cord injury (sci), and traumatic brain injury (tbi), although most occurrences are common in the elderly population. |
2024-04-11 |
2024-04-13 |
Not clear |
| Makoto Urushitani, Hitoshi Warita, Naoki Atsuta, Yuishin Izumi, Osamu Kano, Toshio Shimizu, Yuki Nakayama, Yugo Narita, Hiroyuki Nodera, Takuji Fujita, Koichi Mizoguchi, Mitsuya Morita, Masashi Aok. The clinical practice guideline for the management of amyotrophic lateral sclerosis in Japan-update 2023. Rinsho shinkeigaku = Clinical neurology. 2024-03-24. PMID:38522911. |
amyotrophic lateral sclerosis (als) is an adult-onset intractable motor neuron disease characterized by selective degeneration of cortical neurons in the frontotemporal lobe and motor neurons in the brainstem and spinal cord. |
2024-03-24 |
2024-03-27 |
Not clear |
| Jiaying Shi, Zhaokun Wang, Ming Yi, Shengyu Xie, Xinyue Zhang, Dachang Tao, Yunqiang Liu, Yuan Yan. Evidence based on Mendelian randomization and colocalization analysis strengthens causal relationships between structural changes in specific brain regions and risk of amyotrophic lateral sclerosis. Frontiers in neuroscience. vol 18. 2024-03-20. PMID:38505770. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by the degeneration of motor neurons in the brain and spinal cord with a poor prognosis. |
2024-03-20 |
2024-03-23 |
Not clear |
| LiJun Zhou, RenShi X. Invertebrate genetic models of amyotrophic lateral sclerosis. Frontiers in molecular neuroscience. vol 17. 2024-03-19. PMID:38500677. |
amyotrophic lateral sclerosis (als) is a common adult-onset neurodegenerative disease characterized by the progressive death of motor neurons in the cerebral cortex, brain stem, and spinal cord. |
2024-03-19 |
2024-03-21 |
human |
| Lynn George, BreAnna Cameron, Lauryn Torres-Hernandez, Virginia Montague, Karen Lewis, Heidi Smith, James Fox, Xueshui Guo, Robert G Kal. Titin is a nucleolar protein in neurons. Research square. 2024-03-18. PMID:38496572. |
additionally, we show that the levels of both titin mrna and protein are altered in the spinal cord of sod1g93a mice, a commonly used model of amyotrophic lateral sclerosis, indicating that titin mediated nucleolar events may in fact contribute to the pathobiology of disease. |
2024-03-18 |
2024-03-20 |
mouse |