| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A I Kiktenko, N A Uranova, D D Orlovskay. Hippocampal mossy fibers in Alzheimer's disease. Neuroscience and behavioral physiology. vol 26. issue 1. 1996-09-27. PMID:8801462. |
hippocampal mossy fibers in alzheimer's disease. |
1996-09-27 |
2023-08-12 |
Not clear |
| R F Cowburn, B Wiehager, R Ravid, B Winbla. Acetylcholine muscarinic M2 receptor stimulated [35S]GTP gamma S binding shows regional selective changes in Alzheimer's disease postmortem brain. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 1. 1996-09-24. PMID:8731378. |
oxotremorine-m stimulated [35s]gtp gamma s binding was used to assess acetylcholine muscarinic m2 receptor mediated g-protein function in superior frontal cortical, superior temporal cortical and hippocampal membranes from a series of alzheimer's disease and matched control subjects. |
1996-09-24 |
2023-08-12 |
human |
| R F Cowburn, B Wiehager, R Ravid, B Winbla. Acetylcholine muscarinic M2 receptor stimulated [35S]GTP gamma S binding shows regional selective changes in Alzheimer's disease postmortem brain. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 1. 1996-09-24. PMID:8731378. |
in contrast, the maximal level of oxotremorine-m stimulated [35s]gtp gamma s binding over basal was unaltered in alzheimer's disease superior frontal cortex and significantly reduced in alzheimer's disease hippocampus. |
1996-09-24 |
2023-08-12 |
human |
| R F Cowburn, B Wiehager, R Ravid, B Winbla. Acetylcholine muscarinic M2 receptor stimulated [35S]GTP gamma S binding shows regional selective changes in Alzheimer's disease postmortem brain. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 1. 1996-09-24. PMID:8731378. |
neither gq alpha, gi alpha, nor g(o) alpha levels were significantly altered in alzheimer's disease superior frontal cortex or hippocampus. |
1996-09-24 |
2023-08-12 |
human |
| J F Ghersi-Egea, P D Gorevic, J Ghiso, B Frangione, C S Patlak, J D Fenstermache. Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries. Journal of neurochemistry. vol 67. issue 2. 1996-09-19. PMID:8764620. |
in alzheimer's disease, the neuritic or senile amyloid plaques in hippocampus and association cortex, the diffuse plaques in brain areas such as the cerebellum and sensorimotor cortex, and the amyloid deposits in the walls of pial and parenchymal blood vessels are mainly composed of amyloid beta-peptides. |
1996-09-19 |
2023-08-12 |
rat |
| J Ge, N M Barne. Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders. European journal of pharmacology. vol 297. issue 3. 1996-08-08. PMID:8666063. |
the present studies assessed the levels of [125i][sar1,ile8]angiotensin ii-labelled angiotensin at1 and at2 receptor recognition sites in homogenates of various brain areas (including caudate nucleus, putamen, substantia nigra, hippocampus, frontal cortex, temporal cortex and cerebellum) from patients with clinically diagnosed parkinson's disease, huntington's disease and alzheimer's disease and those from age-, sex- and post-mortem delay-matched neurologically and psychiatrically normal patients. |
1996-08-08 |
2023-08-12 |
human |
| D H Cribbs, L S Chen, S M Bende, F M LaFerl. Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain. The American journal of pathology. vol 148. issue 6. 1996-08-08. PMID:8669467. |
neurons in the hippocampus and cerebral cortex, which are severely compromised in alzheimer's disease, showed prominent expression of presenilin-1. |
1996-08-08 |
2023-08-12 |
mouse |
| D Terwel, J Prickaerts, F Meng, J Jolle. Brain enzyme activities after intracerebroventricular injection of streptozotocin in rats receiving acetyl-L-carnitine. European journal of pharmacology. vol 287. issue 1. 1996-08-07. PMID:8666027. |
in this study, enzyme activities previously investigated in alzheimer's disease (peptidases, dehydrogenases and acetyltransferases) were measured in the septum and hippocampus of control and streptozotocin-treated rats. |
1996-08-07 |
2023-08-12 |
rat |
| A Pitkänen, M Laakso, R Kälviäinen, K Partanen, P Vainio, M Lehtovirta, P Riekkinen, H Soinine. Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease. Neurology. vol 46. issue 6. 1996-07-25. PMID:8649578. |
severity of hippocampal atrophy correlates with the prolongation of mri t2 relaxation time in temporal lobe epilepsy but not in alzheimer's disease. |
1996-07-25 |
2023-08-12 |
human |
| A Pitkänen, M Laakso, R Kälviäinen, K Partanen, P Vainio, M Lehtovirta, P Riekkinen, H Soinine. Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease. Neurology. vol 46. issue 6. 1996-07-25. PMID:8649578. |
we analyzed hippocampal volumes and t2 relaxation times by mri from 78 control subjects, 24 patients with temporal lobe epilepsy, and 55 patients with alzheimer's disease (ad). |
1996-07-25 |
2023-08-12 |
human |
| M J de Leon, A Convit, A E George, J Golomb, S de Santi, C Tarshish, H Rusinek, M Bobinski, C Ince, D Miller, H Wisniewsk. In vivo structural studies of the hippocampus in normal aging and in incipient Alzheimer's disease. Annals of the New York Academy of Sciences. vol 777. 1996-06-14. PMID:8624070. |
in vivo structural studies of the hippocampus in normal aging and in incipient alzheimer's disease. |
1996-06-14 |
2023-08-12 |
human |
| R K Lee, J Jimenez, A J Cox, R J Wurtma. Metabotropic glutamate receptors regulate APP processing in hippocampal neurons and cortical astrocytes derived from fetal rats. Annals of the New York Academy of Sciences. vol 777. 1996-06-14. PMID:8624110. |
inasmuch as glutamatergic neurons in cortex and hippocampus are known to be damaged in alzheimer's disease, our findings suggest that amyloid formation may be enhanced by the resulting glutamate deficiency and that selective mglur agonists may be useful in facilitating synaptic efficacy and treating the disease. |
1996-06-14 |
2023-08-12 |
human |
| M P Laakso, K Partanen, P Riekkinen, M Lehtovirta, E L Helkala, M Hallikainen, T Hanninen, P Vainio, H Soinine. Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia: An MRI study. Neurology. vol 46. issue 3. 1996-06-13. PMID:8618666. |
hippocampal volumes in alzheimer's disease, parkinson's disease with and without dementia, and in vascular dementia: an mri study. |
1996-06-13 |
2023-08-12 |
human |
| M P Laakso, K Partanen, P Riekkinen, M Lehtovirta, E L Helkala, M Hallikainen, T Hanninen, P Vainio, H Soinine. Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia: An MRI study. Neurology. vol 46. issue 3. 1996-06-13. PMID:8618666. |
hippocampal atrophy detected by volumetric mri is a sensitive feature of early alzheimer's disease (ad), but there are no studies evaluating hippocampal atrophy by mr volumetry in other dementing diseases. |
1996-06-13 |
2023-08-12 |
human |
| A M Cataldo, D J Hamilton, J L Barnett, P A Paskevich, R A Nixo. Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 1. 1996-06-03. PMID:8613784. |
by contrast, in morphometric analyses of alzheimer's disease brains, 80-93% of pyramidal cells in the prefrontal cortex (laminae iii or v) and hippocampus (ca2, ca3) displayed two- to eightfold higher numbers of hydrolase-positive vacuolar compartments than did corresponding cell populations in age-matched normal brains. |
1996-06-03 |
2023-08-12 |
human |
| M Hoshi, A Takashima, K Noguchi, M Murayama, M Sato, S Kondo, Y Saitoh, K Ishiguro, T Hoshino, K Imahor. Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 7. 1996-05-24. PMID:8610107. |
in rat hippocampal culture, betaa exposure activates tau protein kinase i/glycogen synthase kinase 3beta (tpki/gsk-3beta), which phosphorylates tau protein into alzheimer disease-like forms, resulting in neuronal death. |
1996-05-24 |
2023-08-12 |
rat |
| Z Kristofiková, E Fales, E Majer, J Klaschk. (3H)hemicholinium-3 binding sites in postmortem brains of human patients with Alzheimer's disease and multi-infarct dementia. Experimental gerontology. vol 30. issue 2. 1996-04-03. PMID:8591807. |
(3h)hemicholinium-3 ((3h)hch-3), a potent, selective, and competitive inhibitor of the high-affinity choline uptake process was used for the detection of high-affinity choline carriers in the hippocampus (gyrus parahippocampalis), neocortex (gyrus frontalis medius), and cerebellum (lobulus semilunaris inferior) in autopsy samples of people with alzheimer's disease, multi-infarct dementia and from other psychiatric and nonpsychiatric patients. |
1996-04-03 |
2023-08-12 |
human |
| Z Kristofiková, E Fales, E Majer, J Klaschk. (3H)hemicholinium-3 binding sites in postmortem brains of human patients with Alzheimer's disease and multi-infarct dementia. Experimental gerontology. vol 30. issue 2. 1996-04-03. PMID:8591807. |
the density of (3h)hch-3 binding sites was decreased in the hippocampus and neocortex from individuals with multi-infarct dementia and unchanged in the brain tissue from people with alzheimer's disease in comparison with control patients. |
1996-04-03 |
2023-08-12 |
human |
| M Kohzuki, H Onodera, M Yasujima, Y Itoyama, M Kanazawa, T Sato, K Ab. Endothelin receptors in ischemic rat brain and Alzheimer brain. Journal of cardiovascular pharmacology. vol 26 Suppl 3. 1996-03-28. PMID:8587405. |
endothelin (et) binding sites in male wistar rat brains subjected to a 20-min four-vessel occlusion (transient forebrain ischemia model) which induces hippocampal neuron death, and in human brains with alzheimer disease, were mapped by quantitative in vitro autoradiography employing [125i]et-1 as a radioligand. |
1996-03-28 |
2023-08-12 |
human |
| P Giannakopoulos, P R Hof, P G Vallet, A S Giannakopoulos, Y Charnay, C Boura. Quantitative analysis of neuropathologic changes in the cerebral cortex of centenarians. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 4. 1996-03-22. PMID:8588057. |
quantitatively, alzheimer's disease cases showed significantly higher nft densities than cases with no clinical findings of dementia only in the ca1 field of the hippocampus. |
1996-03-22 |
2023-08-12 |
Not clear |