| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noriko Takayama, Eizo Iseki, Takayuki Yamamoto, Kenji Kosak. Regional quantitative study of formation process of neurofibrillary tangles in the hippocampus of non-demented elderly brains: comparison with late-onset Alzheimer's disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 22. issue 3. 2002-12-20. PMID:12416553. |
regional quantitative study of formation process of neurofibrillary tangles in the hippocampus of non-demented elderly brains: comparison with late-onset alzheimer's disease brains. |
2002-12-20 |
2023-08-12 |
Not clear |
| Noriko Takayama, Eizo Iseki, Takayuki Yamamoto, Kenji Kosak. Regional quantitative study of formation process of neurofibrillary tangles in the hippocampus of non-demented elderly brains: comparison with late-onset Alzheimer's disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 22. issue 3. 2002-12-20. PMID:12416553. |
we quantitatively investigated the formation process of neurofibrillary tangles (nft) in the hippocampus of 32 brains from non-demented elderly persons using tau-immunohistochemistry, compared with 13 brains from patients with late-onset alzheimer's disease (ad). |
2002-12-20 |
2023-08-12 |
Not clear |
| Vittorio Colangelo, Jill Schurr, Melvyn J Ball, Ricardo Palacios Pelaez, Nicolas G Bazan, Walter J Luki. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. Journal of neuroscience research. vol 70. issue 3. 2002-12-13. PMID:12391607. |
to extend our initial study (alzheimer reports [2000] 3:161-167), rna samples isolated from control and ad hippocampal cornu ammonis 1 (ca1) were analyzed for 12633 gene and expressed sequence tag (est) expression levels using dna microarrays (hg-u95av2 genechips; affymetrix, santa clara, ca). |
2002-12-13 |
2023-08-12 |
human |
| Sébastien Weill-Engerer, Jean-Philippe David, Véronique Sazdovitch, Philippe Liere, Bernard Eychenne, Antoine Pianos, Michael Schumacher, André Delacourte, Etienne-Emile Baulieu, Yvette Akw. Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients. The Journal of clinical endocrinology and metabolism. vol 87. issue 11. 2002-12-09. PMID:12414884. |
to investigate the physiopathological significance of neurosteroids in alzheimer's disease (ad), we compared the concentrations of pregnenolone, pregnenolone sulfate (pregs), dehydroepiandrosterone, dehydroepiandrosterone sulfate (dheas), progesterone, and allopregnanolone, measured by gas chromatography-mass spectrometry, in individual brain regions of ad patients and aged nondemented controls, including hippocampus, amygdala, frontal cortex, striatum, hypothalamus, and cerebellum. |
2002-12-09 |
2023-08-12 |
human |
| Erin D Bigler, David F Tate, Michael J Miller, Sara A Rice, Cory D Hessel, Heath D Earl, Joann T Tschanz, Brenda Plassman, Kathleen A Welsh-Bohme. Dementia, asymmetry of temporal lobe structures, and apolipoprotein E genotype: relationships to cerebral atrophy and neuropsychological impairment. Journal of the International Neuropsychological Society : JINS. vol 8. issue 7. 2002-11-26. PMID:12405544. |
we examined asymmetry of hippocampal volume as well as other temporal lobe structures (temporal lobe, temporal horn of the lateral ventricular system, parahippocampal and fusiform gyri) in 194 subjects from the cache county, utah study, with varying disorders [85 with alzheimer's disease (ad), 59 with some cognitive or neuropsychiatric disorder-referenced as a mixed neuropsychiatric group, 30 with mild ambiguous/mild cognitive impairment (ma/mci) and 20 controls] and apoe genotypes. |
2002-11-26 |
2023-08-12 |
human |
| Xavier Blaizot, Kenichi Meguro, Isabelle Millien, Jean Claude Baron, Chantal Chavoix, A Xavier Blaizo. Correlations between visual recognition memory and neocortical and hippocampal glucose metabolism after bilateral rhinal cortex lesions in the baboon: implications for Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 21. 2002-11-25. PMID:12417640. |
correlations between visual recognition memory and neocortical and hippocampal glucose metabolism after bilateral rhinal cortex lesions in the baboon: implications for alzheimer's disease. |
2002-11-25 |
2023-08-12 |
monkey |
| Li Liu, Sami Ikonen, Taneli Heikkinen, Matti Heikkilä, Jukka Puoliväli, Thomas van Groen, Heikki Tanil. Effects of fimbria-fornix lesion and amyloid pathology on spatial learning and memory in transgenic APP+PS1 mice. Behavioural brain research. vol 134. issue 1-2. 2002-11-19. PMID:12191831. |
ap mice thus appear to have a selective deficit in hippocampal dependent long-term memory, as do alzheimer patients at early stage of the disease. |
2002-11-19 |
2023-08-12 |
mouse |
| Yuan-Yu Hsu, Norbert Schuff, An-Tao Du, Kevin Mark, Xiaoping Zhu, Dawn Hardin, Michael W Weine. Comparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia. Journal of magnetic resonance imaging : JMRI. vol 16. issue 3. 2002-11-19. PMID:12205587. |
to determine whether automatic and manual measurements of hippocampal volume differences on mri between normal aging, cognitive impairment (ci), and alzheimer's disease (ad) yield similar results. |
2002-11-19 |
2023-08-12 |
Not clear |
| Orly Lazarov, Michael Lee, Daniel A Peterson, Sangram S Sisodi. Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 22. 2002-11-18. PMID:12427834. |
a neuropathological hallmark of alzheimer's disease is the deposition of amyloid-beta (abeta) peptides in senile plaques in the hippocampus and cerebral cortex. |
2002-11-18 |
2023-08-12 |
mouse |
| Jin G Sheng, Donald L Price, Vassilis E Koliatso. Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 22. 2002-11-18. PMID:12427835. |
the present study was designed to test the hypothesis that app derived from erc neurons is the source of the abeta peptide deposited in the hippocampal dentate gyrus in alzheimer's disease (ad) and in transgenic mice with abeta amyloidosis. |
2002-11-18 |
2023-08-12 |
mouse |
| Valerie A M Vincent, Jason J DeVoss, Heather S Ryan, Greer M Murph. Analysis of neuronal gene expression with laser capture microdissection. Journal of neuroscience research. vol 69. issue 5. 2002-11-15. PMID:12210823. |
as an example, gene expression was quantified in hippocampal neurons from the tg2576 mouse model for alzheimer's disease. |
2002-11-15 |
2023-08-12 |
mouse |
| Kevin A Corcoran, Ye Lu, R Scott Turner, Stephen Mare. Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease. Learning & memory (Cold Spring Harbor, N.Y.). vol 9. issue 5. 2002-11-15. PMID:12359834. |
one of the hallmarks of the pathology in alzheimer's disease is the deposition of amyloid plaques throughout the brain, especially within the hippocampus and amygdala. |
2002-11-15 |
2023-08-12 |
mouse |
| Ottavio V Vitolo, Antonino Sant'Angelo, Vincenzo Costanzo, Fortunato Battaglia, Ottavio Arancio, Michael Shelansk. Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 20. 2002-11-13. PMID:12244210. |
changes in hippocampal function seem critical for cognitive impairment in alzheimer's disease (ad). |
2002-11-13 |
2023-08-12 |
Not clear |
| Yoon Hee Chung, Chung Min Shin, Kyeung Min Joo, Myeung Ju Kim, Choong Ik Ch. Region-specific alterations in insulin-like growth factor receptor type I in the cerebral cortex and hippocampus of aged rats. Brain research. vol 946. issue 2. 2002-11-12. PMID:12137935. |
our first morphological data concerning the differential regulation of igf-i receptors in aged cerebral cortex and hippocampus may provide insights into age-related changes in trophic support as well as basic knowledge required for the study of neurodegenerative diseases such as alzheimer's disease. |
2002-11-12 |
2023-08-12 |
rat |
| Isabelle Millien, Xavier Blaizot, Cyrille Giffard, Florence Mézenge, Ricardo Insausti, Jean-Claude Baron, Chantal Chavoi. Brain glucose hypometabolism after perirhinal lesions in baboons: implications for Alzheimer disease and aging. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 22. issue 10. 2002-11-05. PMID:12368664. |
the authors previously reported that excitotoxic lesions of both the perirhinal and entorhinal cortices in baboons induce remote neocortical and hippocampal hypometabolism reminiscent of that observed in alzheimer disease (ad), suggesting that disconnection may play a role in ad. |
2002-11-05 |
2023-08-12 |
Not clear |
| Nahid K El-Bakri, A Adem, I A Suliman, E Mulugeta, E Karlsson, J U Lindgren, B Winblad, A Isla. Estrogen and progesterone treatment: effects on muscarinic M(4) receptor subtype in the rat brain. Brain research. vol 948. issue 1-2. 2002-10-30. PMID:12383964. |
the effect of estrogen on the hippocampal muscarinic m(4) receptor subtype is a novel finding and may have functional significance for cholinergic receptors especially in relation to postmenopausal memory problems and neurodegenerative disease like alzheimer's disease. |
2002-10-30 |
2023-08-12 |
rat |
| LuGuang Luo, Naohiro Yano, QuanFu Mao, I M D Jackson, E G Stop. Thyrotropin releasing hormone (TRH) in the hippocampus of Alzheimer patients. Journal of Alzheimer's disease : JAD. vol 4. issue 2. 2002-10-29. PMID:12214133. |
thyrotropin releasing hormone (trh) in the hippocampus of alzheimer patients. |
2002-10-29 |
2023-08-12 |
rat |
| Ruth M Dixon, Kevin M Bradley, Marc M Budge, Peter Styles, A David Smit. Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease. Brain : a journal of neurology. vol 125. issue Pt 10. 2002-10-29. PMID:12244089. |
longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in alzheimer's disease. |
2002-10-29 |
2023-08-12 |
human |
| Ruth M Dixon, Kevin M Bradley, Marc M Budge, Peter Styles, A David Smit. Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease. Brain : a journal of neurology. vol 125. issue Pt 10. 2002-10-29. PMID:12244089. |
our objectives were, first, longitudinally to measure absolute concentrations of metabolites in both hippocampi, the sites of early alzheimer's disease, in patients with clinical alzheimer's disease and controls; secondly, to separate the relative contribution of atrophy and metabolite concentration change to overall signal change; and, thirdly, to determine whether metabolite concentrations in the hippocampus relate to cognitive scores. |
2002-10-29 |
2023-08-12 |
human |
| Ruth M Dixon, Kevin M Bradley, Marc M Budge, Peter Styles, A David Smit. Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease. Brain : a journal of neurology. vol 125. issue Pt 10. 2002-10-29. PMID:12244089. |
(1)h mr spectra were acquired from a single voxel (12 x 15 x 25 mm(3) = 4.5 ml) aligned to the long axis of each hippocampus in nine probable or possible alzheimer's disease subjects diagnosed according to the national institute of neurologic and cognitive disorders and stroke (nincds) compared with 14 age-matched nincds-negative alzheimer's disease controls. |
2002-10-29 |
2023-08-12 |
human |