| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcus Rössler, Rosemarie Zarski, Jürgen Bohl, Thomas G Oh. Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimer's disease. Acta neuropathologica. vol 103. issue 4. 2002-05-07. PMID:11904756. |
stage-dependent and sector-specific neuronal loss in hippocampus during alzheimer's disease. |
2002-05-07 |
2023-08-12 |
human |
| Marcus Rössler, Rosemarie Zarski, Jürgen Bohl, Thomas G Oh. Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimer's disease. Acta neuropathologica. vol 103. issue 4. 2002-05-07. PMID:11904756. |
recent stereological studies documented a severe loss of hippocampal neurons in end-stage alzheimer's disease. |
2002-05-07 |
2023-08-12 |
human |
| Jillian J Kril, Smita Patel, Antony J Harding, Glenda M Hallida. Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation. Acta neuropathologica. vol 103. issue 4. 2002-05-07. PMID:11904757. |
neuron loss from the hippocampus of alzheimer's disease exceeds extracellular neurofibrillary tangle formation. |
2002-05-07 |
2023-08-12 |
Not clear |
| Jillian J Kril, Smita Patel, Antony J Harding, Glenda M Hallida. Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation. Acta neuropathologica. vol 103. issue 4. 2002-05-07. PMID:11904757. |
neurofibrillary tangle (nft) formation in the ca1 region of the hippocampus is one of the early events in the pathogenesis of alzheimer's disease (ad). |
2002-05-07 |
2023-08-12 |
Not clear |
| Klaus Heese, Takahiro Nakayama, Ryuji Hata, Makoto Masumura, Hiroyasu Akatsu, Feng Li, Yasuo Nagai, Takayuki Yamamoto, Kenji Kosaka, Takahiro Suemoto, Tohru Sawad. Characterizing CGI-94 (comparative gene identification-94) which is down-regulated in the hippocampus of early stage Alzheimer's disease brain. The European journal of neuroscience. vol 15. issue 1. 2002-04-25. PMID:11860508. |
characterizing cgi-94 (comparative gene identification-94) which is down-regulated in the hippocampus of early stage alzheimer's disease brain. |
2002-04-25 |
2023-08-12 |
Not clear |
| Georg Grön, Daniel Bittner, Bernd Schmitz, Arthur P Wunderlich, Matthias W Riep. Subjective memory complaints: objective neural markers in patients with Alzheimer's disease and major depressive disorder. Annals of neurology. vol 51. issue 4. 2002-04-18. PMID:11921055. |
contrasting healthy seniors or depressive patients with alzheimer's disease patients revealed superiority of hippocampal activation. |
2002-04-18 |
2023-08-12 |
human |
| Anastazija Gnjec, Justin A Fonte, Craig Atwood, Ralph N Martin. Transition metal chelator therapy--a potential treatment for Alzheimer's disease? Frontiers in bioscience : a journal and virtual library. vol 7. 2002-04-15. PMID:11897554. |
a defining feature of alzheimer's disease (ad) pathology is the presence of amyloid beta known as a-beta (abeta) within neuritic plaques of the hippocampus and neocortex of the brain. |
2002-04-15 |
2023-08-12 |
mouse |
| David L King, Gary W Arendas. Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment. Brain research. vol 926. issue 1-2. 2002-04-04. PMID:11814407. |
regional loss of synapses, particularly within the neocortex and hippocampus, is characteristic of alzheimer's disease (ad) and strongly correlated with extent of cognitive impairment. |
2002-04-04 |
2023-08-12 |
mouse |
| Harald Hampel, Stefan J Teipel, Wolfram Bayer, Gene E Alexander, Robert Schwarz, Mark B Schapiro, Stanley I Rapoport, Hans-Jürgen Mölle. Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease. Journal of the neurological sciences. vol 194. issue 1. 2002-03-29. PMID:11809161. |
age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in alzheimer's disease. |
2002-03-29 |
2023-08-12 |
Not clear |
| Harald Hampel, Stefan J Teipel, Wolfram Bayer, Gene E Alexander, Robert Schwarz, Mark B Schapiro, Stanley I Rapoport, Hans-Jürgen Mölle. Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease. Journal of the neurological sciences. vol 194. issue 1. 2002-03-29. PMID:11809161. |
the specificity of magnetic resonance imaging (mri)-based hippocampal measurements in detecting alzheimer's disease (ad) pathology is reduced by an age-related reduction of the hippocampus volume. |
2002-03-29 |
2023-08-12 |
Not clear |
| Robin A Morton, Frederick M Kuenzi, Stephen M Fitzjohn, Thomas W Rosahl, David Smith, Hui Zheng, Mark Shearman, Graham L Collingridge, Guy R Seabroo. Impairment in hippocampal long-term potentiation in mice under-expressing the Alzheimer's disease related gene presenilin-1. Neuroscience letters. vol 319. issue 1. 2002-03-25. PMID:11814648. |
impairment in hippocampal long-term potentiation in mice under-expressing the alzheimer's disease related gene presenilin-1. |
2002-03-25 |
2023-08-12 |
mouse |
| Inna I Kruman, T S Kumaravel, Althaf Lohani, Ward A Pedersen, Roy G Cutler, Yuri Kruman, Norman Haughey, Jaewon Lee, Michele Evans, Mark P Mattso. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 5. 2002-03-22. PMID:11880504. |
folic acid deficiency and homocysteine impair dna repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of alzheimer's disease. |
2002-03-22 |
2023-08-12 |
mouse |
| D S Woodruff-Pa. Eyeblink classical conditioning differentiates normal aging from Alzheimer's disease. Integrative physiological and behavioral science : the official journal of the Pavlovian Society. vol 36. issue 2. 2002-03-14. PMID:11666044. |
alzheimer's disease (ad) profoundly disrupts the hippocampal cholinergic system, and patients with ad consistently perform poorly in eyeblink conditioning. |
2002-03-14 |
2023-08-12 |
Not clear |
| Vanessa M Brown, Alex Ossadtchi, Arshad H Khan, Simon R Cherry, Richard M Leahy, Desmond J Smit. High-throughput imaging of brain gene expression. Genome research. vol 12. issue 2. 2002-03-14. PMID:11827944. |
using microarrays, 24 voxel images of coronal hemisections at the level of the hippocampus of both the normal human brain and alzheimer's disease brain were acquired for 2000 genes. |
2002-03-14 |
2023-08-12 |
human |
| Mina Maki, Noriyuki Matsukawa, Hiroyuki Yuasa, Yasushi Otsuka, Takayuki Yamamoto, Hiroyasu Akatsu, Takashi Okamoto, Ryuzo Ueda, Kosei Ojik. Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 61. issue 2. 2002-03-07. PMID:11853019. |
decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mrna in the hippocampus in alzheimer disease. |
2002-03-07 |
2023-08-12 |
human |
| Mina Maki, Noriyuki Matsukawa, Hiroyuki Yuasa, Yasushi Otsuka, Takayuki Yamamoto, Hiroyasu Akatsu, Takashi Okamoto, Ryuzo Ueda, Kosei Ojik. Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 61. issue 2. 2002-03-07. PMID:11853019. |
to assess whether hcnp-pp is involved in the pathogenesis of alzheimer disease (ad), the expression levels of its mrna in the hippocampus of autopsy brains from patients with dementia (including ad and ischemic vascular dementia) were compared with those of non-demented control subjects. |
2002-03-07 |
2023-08-12 |
human |
| Steven T DeKosky, Milos D Ikonomovic, Scot D Styren, Laurel Beckett, Stephen Wisniewski, David A Bennett, Elizabeth J Cochran, Jeffrey H Kordower, Elliott J Mufso. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Annals of neurology. vol 51. issue 2. 2002-03-01. PMID:11835370. |
in alzheimer's disease (ad), loss of cortical and hippocampal choline acetyltransferase (chat) activity has been correlated with dementia severity and disease duration, and it forms the basis for current therapies. |
2002-03-01 |
2023-08-12 |
human |
| Etsuro Mori, KangUk Lee, Minoru Yasuda, Mamoru Hashimoto, Hiroaki Kazui, Nobutsugu Hirono, Mieko Matsu. Accelerated hippocampal atrophy in Alzheimer's disease with apolipoprotein E epsilon4 allele. Annals of neurology. vol 51. issue 2. 2002-03-01. PMID:11835377. |
accelerated hippocampal atrophy in alzheimer's disease with apolipoprotein e epsilon4 allele. |
2002-03-01 |
2023-08-12 |
human |
| Etsuro Mori, KangUk Lee, Minoru Yasuda, Mamoru Hashimoto, Hiroaki Kazui, Nobutsugu Hirono, Mieko Matsu. Accelerated hippocampal atrophy in Alzheimer's disease with apolipoprotein E epsilon4 allele. Annals of neurology. vol 51. issue 2. 2002-03-01. PMID:11835377. |
the involvement of the apolipoprotein e epsilon4 allele in the progression of hippocampal atrophy has implications for therapeutic approaches in alzheimer's disease and should be taken into consideration in longitudinal studies including clinical drug trials. |
2002-03-01 |
2023-08-12 |
human |
| J G Sheng, R E Mrak, R A Jones, M M Brewer, X Q Zhou, J McGinness, S Woodward, K Bales, S M Paul, B Cordell, W S Griffi. Neuronal DNA damage correlates with overexpression of interleukin-1beta converting enzyme in APPV717F mice. Neurobiology of aging. vol 22. issue 6. 2002-02-28. PMID:11754996. |
transgenic appv717f mice, homozygous for a human minigene encoding the v717f familial alzheimer's disease mutation, develop abeta plaques similar to those seen in alzheimer patients and show evidence of neuronal cell drop out in ca2-3 regions of the hippocampus at 8 months of age and older. |
2002-02-28 |
2023-08-12 |
mouse |