| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S G Potkin, R Anand, K Fleming, G Alva, D Keator, D Carreon, J Messina, J C Wu, R Hartman, J H Fallo. Brain metabolic and clinical effects of rivastigmine in Alzheimer's disease. The international journal of neuropsychopharmacology. vol 4. issue 3. 2001-12-04. PMID:11602028. |
in-vivo metabolic measures with positron emission tomography using (18)f-fluorodeoxyglucose (fdg-pet) have demonstrated hypometabolism in temporal, frontal, and hippocampal areas during the early stages of alzheimer's disease (ad). |
2001-12-04 |
2023-08-12 |
Not clear |
| S J Baloyannis, S L Manolidis, L S Manolidi. Synaptic alterations in the vestibulocerebellar system in Alzheimer's disease--a Golgi and electron microscope study. Acta oto-laryngologica. vol 120. issue 2. 2001-12-04. PMID:11603783. |
from the morphological point of view, neurofibrillary degeneration and neuritic plaques, the main hallmarks of alzheimer's disease, are mostly seen in the hippocampus and the cortex of the cerebral hemispheres. |
2001-12-04 |
2023-08-12 |
Not clear |
| X Zhu, C A Rottkamp, A Hartzler, Z Sun, A Takeda, H Boux, S Shimohama, G Perry, M A Smit. Activation of MKK6, an upstream activator of p38, in Alzheimer's disease. Journal of neurochemistry. vol 79. issue 2. 2001-12-04. PMID:11677259. |
we found that mkk6 was not only increased but also specifically associated with granular structures in the susceptible neurons in the hippocampus and cortex of alzheimer's disease patients, but was only weakly diffuse in the cytoplasm in neurons in control cases. |
2001-12-04 |
2023-08-12 |
Not clear |
| X Zhu, C A Rottkamp, A Hartzler, Z Sun, A Takeda, H Boux, S Shimohama, G Perry, M A Smit. Activation of MKK6, an upstream activator of p38, in Alzheimer's disease. Journal of neurochemistry. vol 79. issue 2. 2001-12-04. PMID:11677259. |
in this regard, in hippocampal and cortical regions of individuals with alzheimer's disease, the activated phospho-mkk6 was localized exclusively in association with pathological alterations including neurofibrillary tangles, senile plaques, neuropil threads and granular structures, overlapping with activated p38 mapk suggesting both a functional and mechanic link. |
2001-12-04 |
2023-08-12 |
Not clear |
| N Kitayama, H Matsuda, T Ohnishi, D Kogure, T Asada, M Uno, K Kamijim. Measurements of both hippocampal blood flow and hippocampal gray matter volume in the same individuals with Alzheimer's disease. Nuclear medicine communications. vol 22. issue 5. 2001-11-01. PMID:11388566. |
measurements of both hippocampal blood flow and hippocampal gray matter volume in the same individuals with alzheimer's disease. |
2001-11-01 |
2023-08-12 |
Not clear |
| N Kitayama, H Matsuda, T Ohnishi, D Kogure, T Asada, M Uno, K Kamijim. Measurements of both hippocampal blood flow and hippocampal gray matter volume in the same individuals with Alzheimer's disease. Nuclear medicine communications. vol 22. issue 5. 2001-11-01. PMID:11388566. |
we evaluated both hippocampal blood flow and hippocampal gray matter volume using single photon emission tomography and magnetic resonance imaging in the same individuals with alzheimer's disease (ad) and in age-matched controls. |
2001-11-01 |
2023-08-12 |
Not clear |
| M J de Leon, A Convit, O T Wolf, C Y Tarshish, S DeSanti, H Rusinek, W Tsui, E Kandil, A J Scherer, A Roche, A Imossi, E Thorn, M Bobinski, C Caraos, P Lesbre, D Schlyer, J Poirier, B Reisberg, J Fowle. Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET). Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 19. 2001-11-01. PMID:11526211. |
neuropathology studies show that patients with mild cognitive impairment (mci) and alzheimer's disease typically have lesions of the entorhinal cortex (ec), hippocampus (hip), and temporal neocortex. |
2001-11-01 |
2023-08-12 |
human |
| D Sencakova, N R Graff-Radford, F B Willis, J A Lucas, F Parfitt, R H Cha, P C O'Brien, R C Petersen, C R Jac. Hippocampal atrophy correlates with clinical features of Alzheimer disease in African Americans. Archives of neurology. vol 58. issue 10. 2001-11-01. PMID:11594917. |
hippocampal atrophy correlates with clinical features of alzheimer disease in african americans. |
2001-11-01 |
2023-08-12 |
Not clear |
| H Hanyu, T Asano, H Sakurai, M Takasaki, H Shindo, K Ab. Magnetization transfer measurements of the hippocampus in the early diagnosis of Alzheimer's disease. Journal of the neurological sciences. vol 188. issue 1-2. 2001-10-25. PMID:11489289. |
magnetization transfer measurements of the hippocampus in the early diagnosis of alzheimer's disease. |
2001-10-25 |
2023-08-12 |
human |
| H Hanyu, T Asano, H Sakurai, M Takasaki, H Shindo, K Ab. Magnetization transfer measurements of the hippocampus in the early diagnosis of Alzheimer's disease. Journal of the neurological sciences. vol 188. issue 1-2. 2001-10-25. PMID:11489289. |
we measured magnetization transfer ratios (mtrs) of the hippocampus in 38 patients with alzheimer's disease (ad), including very mild (clinical dementia rating [cdr] 0.5, n=12), mild (cdr 1, n=14), and moderate stages (cdr 2, n=12), and in 21 healthy elderly control subjects. |
2001-10-25 |
2023-08-12 |
human |
| A Baskys, Y Adamchi. Neuroprotective effects of extracellular glutamate are absent in hippocampal organotypic cultures treated with the amyloid peptide Abeta(25-35). Brain research. vol 907. issue 1-2. 2001-10-04. PMID:11430902. |
hippocampal cells are particularly vulnerable in alzheimer's disease but the cause of cell death is unknown. |
2001-10-04 |
2023-08-12 |
Not clear |
| M J Ramirez, K E Heslop, P T Francis, M Rattra. Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. Brain research. vol 907. issue 1-2. 2001-10-04. PMID:11430905. |
in this study, entorhinal cortex lesions and/or medial septal area cholinergic lesions were used in the rat to mimic some of the principal and earliest affects in alzheimer's disease, namely hippocampal deafferentation. |
2001-10-04 |
2023-08-12 |
human |
| C Shimizu-Okabe, G M Yousef, E P Diamandis, S Yoshida, S Shiosaka, M Fahnestoc. Expression of the kallikrein gene family in normal and Alzheimer's disease brain. Neuroreport. vol 12. issue 12. 2001-10-04. PMID:11522960. |
we examined the expression of the kallikrein genes in human cerebral cortex and hippocampus by rt-pcr and compared their expression between alzheimer's disease (ad) and control tissue. |
2001-10-04 |
2023-08-12 |
human |
| J L Price, A I Ko, M J Wade, S K Tsou, D W McKeel, J C Morri. Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease. Archives of neurology. vol 58. issue 9. 2001-10-04. PMID:11559310. |
to determine whether nondemented subjects with pathological evidence of preclinical alzheimer disease (ad) demonstrate neuronal loss in the entorhinal cortex and hippocampus, and whether the onset of cognitive deficits in ad coincides with the onset of neuronal degeneration. |
2001-10-04 |
2023-08-12 |
human |
| E Savaskan, G Olivieri, F Meier, R Ravid, F Müller-Spah. Hippocampal estrogen beta-receptor immunoreactivity is increased in Alzheimer's disease. Brain research. vol 908. issue 2. 2001-09-27. PMID:11454321. |
hippocampal estrogen beta-receptor immunoreactivity is increased in alzheimer's disease. |
2001-09-27 |
2023-08-12 |
human |
| P Giannakopoulos, G Gold, J P Michel, C Boura. Cellular vulnerability in brain aging and Alzheimer's disease. Clinical correlates and molecular background. Annales de medecine interne. vol 149. issue 4. 2001-09-20. PMID:11490545. |
extensive hippocampal alterations are correlated with age-associated memory impairment, while substantial neurofibrillary tangle formation in neocortical association areas of the temporal lobe is a prerequisite for the development of alzheimer's disease. |
2001-09-20 |
2023-08-12 |
Not clear |
| F Gonzalez-Lima, J D Berndt, J E Valla, D Games, E M Reima. Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease. Neuroreport. vol 12. issue 11. 2001-09-20. PMID:11496113. |
reduced corpus callosum, fornix and hippocampus in pdapp transgenic mouse model of alzheimer's disease. |
2001-09-20 |
2023-08-12 |
mouse |
| F Gonzalez-Lima, J D Berndt, J E Valla, D Games, E M Reima. Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease. Neuroreport. vol 12. issue 11. 2001-09-20. PMID:11496113. |
persons with alzheimer's disease (ad) have progressive reductions in the relative sizes of the corpus callosum and hippocampus. |
2001-09-20 |
2023-08-12 |
mouse |
| K Meguro, C LeMestric, B Landeau, B Desgranges, F Eustache, J C Baro. Relations between hypometabolism in the posterior association neocortex and hippocampal atrophy in Alzheimer's disease: a PET/MRI correlative study. Journal of neurology, neurosurgery, and psychiatry. vol 71. issue 3. 2001-09-20. PMID:11511703. |
relations between hypometabolism in the posterior association neocortex and hippocampal atrophy in alzheimer's disease: a pet/mri correlative study. |
2001-09-20 |
2023-08-12 |
Not clear |
| K Meguro, C LeMestric, B Landeau, B Desgranges, F Eustache, J C Baro. Relations between hypometabolism in the posterior association neocortex and hippocampal atrophy in Alzheimer's disease: a PET/MRI correlative study. Journal of neurology, neurosurgery, and psychiatry. vol 71. issue 3. 2001-09-20. PMID:11511703. |
hippocampal atrophy and hypometabolism in the posterior association neocortex are two well known features of alzheimer's disease. |
2001-09-20 |
2023-08-12 |
Not clear |