| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Savaskan, G Olivieri, L Brydon, R Jockers, K Kräuchi, A Wirz-Justice, F Müller-Spah. Cerebrovascular melatonin MT1-receptor alterations in patients with Alzheimer's disease. Neuroscience letters. vol 308. issue 1. 2001-09-13. PMID:11445273. |
the objective of this study was to provide the first immunohistochemical evidence for the localization of vascular mt1 in human control hippocampus compared to alzheimer's disease (ad) patients, since regional blood flow impairments contribute to the neurodegenerative course of the disease. |
2001-09-13 |
2023-08-12 |
human |
| I Kaneko, K Morimoto, T Kub. Drastic neuronal loss in vivo by beta-amyloid racemized at Ser(26) residue: conversion of non-toxic [D-Ser(26)]beta-amyloid 1-40 to toxic and proteinase-resistant fragments. Neuroscience. vol 104. issue 4. 2001-09-13. PMID:11457586. |
it is unclear how and when insoluble beta-amyloid in senile plaques exerts degenerative effects on distant hippocampal neurons in alzheimer's disease. |
2001-09-13 |
2023-08-12 |
rat |
| I Kaneko, K Morimoto, T Kub. Drastic neuronal loss in vivo by beta-amyloid racemized at Ser(26) residue: conversion of non-toxic [D-Ser(26)]beta-amyloid 1-40 to toxic and proteinase-resistant fragments. Neuroscience. vol 104. issue 4. 2001-09-13. PMID:11457586. |
this suggests the in vivo conversion of non-toxic [d-ser(26)]beta-amyloid 1-40 to the toxic and truncated peptides which enhance the susceptibility of neurons to the excitatory amino acid.these results and the presence of [d-ser(26)]beta-amyloid 25-35-like antigens in alzheimer's disease brains suggest that soluble [d-ser(26)]beta-amyloid 1-40, possibly formed during the aging process, is released from senile plaques, and converted by brain proteinases to truncated [d-ser(26)]beta-amyloid 25-35(40)-like peptides, which degenerate hippocampal neurons by enhancing the susceptibility to excitatory amino acids in alzheimer's disease brains. |
2001-09-13 |
2023-08-12 |
rat |
| K Yagyu, K Kitagawa, T Irie, B Wu, X T Zeng, N Hattori, C Inagak. Amyloid beta proteins inhibit Cl(-)-ATPase activity in cultured rat hippocampal neurons. Journal of neurochemistry. vol 78. issue 3. 2001-08-30. PMID:11483660. |
to test its pathophysiological changes in a phosphatidylinositol (pi) metabolism disorder, the effects of neurotoxic factors in alzheimer's disease (ad), amyloid beta proteins (abetas), on the cl(-)-atpase activity were examined using primary cultured rat hippocampal neurons. |
2001-08-30 |
2023-08-12 |
rat |
| E Vaucher, N Aumont, D Pearson, W Rowe, J Poirier, S Ka. Amyloid beta peptide levels and its effects on hippocampal acetylcholine release in aged, cognitively-impaired and -unimpaired rats. Journal of chemical neuroanatomy. vol 21. issue 4. 2001-08-23. PMID:11429273. |
excessive extracellular deposition of amyloid beta (abeta) peptide in neuritic plaques and degeneration of forebrain cholinergic neurones, which innervate the hippocampus and the neocortex, are the invariant characteristic features of alzheimer's disease (ad). |
2001-08-23 |
2023-08-12 |
rat |
| W A Pedersen, D McCullers, C Culmsee, N J Haughey, J P Herman, M P Mattso. Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease. Neurobiology of disease. vol 8. issue 3. 2001-08-16. PMID:11442356. |
we previously reported that mice over-expressing the human amyloid precursor protein gene with the double swedish mutation of familial alzheimer's disease (mtapp), which exhibit progressive deposition of amyloid beta-peptide in hippocampal and cortical brain regions, have an impaired ability to maintain a sustained glucocorticoid response to stress. |
2001-08-16 |
2023-08-12 |
mouse |
| M Grunwald, F Busse, A Hensel, F Kruggel, S Riedel-Heller, H Wolf, T Arendt, H J Gert. Correlation between cortical theta activity and hippocampal volumes in health, mild cognitive impairment, and mild dementia. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. vol 18. issue 2. 2001-07-26. PMID:11435810. |
the results support the assumption about a relationship between hippocampal atrophy and theta power, and may be helpful for a better understanding of the course of alzheimer's disease. |
2001-07-26 |
2023-08-12 |
human |
| U Krügel, V Bigl, K Eschrich, M Big. Deafferentation of the septo-hippocampal pathway in rats as a model of the metabolic events in Alzheimer's disease. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 19. issue 3. 2001-07-19. PMID:11337195. |
changes in the metabolic activity within the brain of patients suffering from alzheimer's disease (ad) were investigated and compared with biochemical alterations in the hippocampus induced by fimbria/fornix transection in the rat. |
2001-07-19 |
2023-08-12 |
human |
| U Krügel, V Bigl, K Eschrich, M Big. Deafferentation of the septo-hippocampal pathway in rats as a model of the metabolic events in Alzheimer's disease. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 19. issue 3. 2001-07-19. PMID:11337195. |
it is concluded that common metabolic mechanisms may underlie the concurrent degenerative and repair processes in the denervated hippocampus and the diseased alzheimer brain. |
2001-07-19 |
2023-08-12 |
human |
| F Kagitani, S Uchida, H Hotta, A Sat. Effects of nicotine on blood flow and delayed neuronal death following intermittent transient ischemia in rat hippocampus. The Japanese journal of physiology. vol 50. issue 6. 2001-07-12. PMID:11173554. |
a cholinergic neural vasodilative response in the cerebral cortex and hippocampus, independent of metabolic vasodilation, was recently demonstrated by activating the nicotinic acetylcholine receptors (nachrs) via activation of cholinergic neurons originating in the nucleus basalis of meynert and septal complex in the basal forebrain and projecting to the cortex and hippocampus (see reviews by sato a and sato y: neurosci res 14: 242--274, 1992; sato a and sato y: alzheimer dis assoc disord 9: 28--38, 1995). |
2001-07-12 |
2023-08-12 |
rat |
| M Yamada, Y Itoh, N Sodeyama, N Suematsu, E Otomo, M Matsushita, H Mizusaw. Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 12. issue 2. 2001-07-12. PMID:11173884. |
to elucidate the pathogenesis of sd-nft in comparison with alzheimer's disease (ad), we investigated the hippocampal lesions and analyzed the tau gene. |
2001-07-12 |
2023-08-12 |
human |
| A Nebu, M Ikeda, R Fukuhara, K Komori, N Maki, K Hokoishi, K Shigenobu, T Kikuchi, H Tanab. Utility of (99m)Tc-HM-PAO SPECT hippocampal image to diagnose early stages of Alzheimer's disease using semiquantitative analysis. Dementia and geriatric cognitive disorders. vol 12. issue 2. 2001-07-12. PMID:11173889. |
utility of (99m)tc-hm-pao spect hippocampal image to diagnose early stages of alzheimer's disease using semiquantitative analysis. |
2001-07-12 |
2023-08-12 |
Not clear |
| A Nebu, M Ikeda, R Fukuhara, K Komori, N Maki, K Hokoishi, K Shigenobu, T Kikuchi, H Tanab. Utility of (99m)Tc-HM-PAO SPECT hippocampal image to diagnose early stages of Alzheimer's disease using semiquantitative analysis. Dementia and geriatric cognitive disorders. vol 12. issue 2. 2001-07-12. PMID:11173889. |
examination of the utility of (99m)tc-hexamethylpropylene amine oxide ((99m)tc-hm-pao) spect hippocampal image to diagnose early stages of alzheimer's disease (ad) using semiquantitative analysis. |
2001-07-12 |
2023-08-12 |
Not clear |
| M Y Aksenov, W R Markesber. Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer's disease. Neuroscience letters. vol 302. issue 2-3. 2001-07-12. PMID:11290407. |
changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in alzheimer's disease. |
2001-07-12 |
2023-08-12 |
human |
| M Y Aksenov, W R Markesber. Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer's disease. Neuroscience letters. vol 302. issue 2-3. 2001-07-12. PMID:11290407. |
in this report, we compared total and protein-bound thiol levels in the hippocampus and cerebellum of six alzheimer's disease (ad) patients and six age-matched control subjects. |
2001-07-12 |
2023-08-12 |
human |
| E Head, B Y Azizeh, I T Lott, A J Tenner, C W Cotman, D H Cribb. Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome. Neurobiology of disease. vol 8. issue 2. 2001-07-12. PMID:11300721. |
neurons in the hippocampus and entorhinal cortex, but less frequently in frontal cortex, were c1q positive in ds cases with sufficient neuropathology to have a diagnosis of alzheimer's disease. |
2001-07-12 |
2023-08-12 |
Not clear |
| W R Crum, R I Scahill, N C Fo. Automated hippocampal segmentation by regional fluid registration of serial MRI: validation and application in Alzheimer's disease. NeuroImage. vol 13. issue 5. 2001-07-12. PMID:11304081. |
automated hippocampal segmentation by regional fluid registration of serial mri: validation and application in alzheimer's disease. |
2001-07-12 |
2023-08-12 |
human |
| W R Crum, R I Scahill, N C Fo. Automated hippocampal segmentation by regional fluid registration of serial MRI: validation and application in Alzheimer's disease. NeuroImage. vol 13. issue 5. 2001-07-12. PMID:11304081. |
the objective was to validate the measurement of hippocampal volumetric change by fluid registration in alzheimer's disease (ad) against current methodologies. |
2001-07-12 |
2023-08-12 |
human |
| R Hata, M Masumura, H Akatsu, F Li, H Fujita, Y Nagai, T Yamamoto, H Okada, K Kosaka, M Sakanaka, T Sawad. Up-regulation of calcineurin Abeta mRNA in the Alzheimer's disease brain: assessment by cDNA microarray. Biochemical and biophysical research communications. vol 284. issue 2. 2001-07-12. PMID:11394878. |
using this technology, gene expression in the hippocampus containing neurofibrillary tangle-associated lesions from an alzheimer's disease (ad) patient was compared with expression in the parietal cortex from the same patient that lacked these lesions. |
2001-07-12 |
2023-08-12 |
Not clear |
| K T Dineley, M Westerman, D Bui, K Bell, K H Ashe, J D Sweat. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 12. 2001-07-12. PMID:11404397. |
beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to alzheimer's disease. |
2001-07-12 |
2023-08-12 |
Not clear |