| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Sangerman, A Killilea, R Chronister, M Pappolla, S R Goodma. Alpha-spectrins are major ubiquitinated proteins in rat hippocampal neurons and components of ubiquitinated inclusions in neurodegenerative disorders. Brain research bulletin. vol 54. issue 4. 2001-06-28. PMID:11306193. |
furthermore, we demonstrated by immunohistochemistry that alpha-spectrins are components of the cytoplasmic ubiquitinated inclusions in hippocampal neurons in alzheimer's and parkinson's disease patients. |
2001-06-28 |
2023-08-12 |
rat |
| B A Citron, K S SantaCruz, P J Davies, B W Festof. Intron-exon swapping of transglutaminase mRNA and neuronal Tau aggregation in Alzheimer's disease. The Journal of biological chemistry. vol 276. issue 5. 2001-06-21. PMID:11013236. |
in order to understand the mechanism for insoluble neurotoxic protein polymerization in alzheimer's disease (ad) brain neurons, we examined protein and gene expression for transglutaminase (tgase 2; tissue transglutaminase (ttg)) in hippocampus and isocortex. |
2001-06-21 |
2023-08-12 |
Not clear |
| A M Mathieu-Kia, L Q Fan, M J Kreek, E J Simon, J M Hille. Mu-, delta- and kappa-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer's disease patients. Brain research. vol 893. issue 1-2. 2001-06-21. PMID:11223000. |
image analyses of autoradiographs show, that in comparison to the same areas in control brain, statistically significant reductions in mu-opioid receptor binding occur in the subiculum and hippocampus of alzheimer's disease brains. |
2001-06-21 |
2023-08-12 |
Not clear |
| M Y Aksenov, M V Aksenova, D A Butterfield, J W Geddes, W R Markesber. Protein oxidation in the brain in Alzheimer's disease. Neuroscience. vol 103. issue 2. 2001-06-14. PMID:11246152. |
increased protein oxidation was detected in sections from the hippocampus and parahippocampal gyrus, superior and middle temporal gyri of six alzheimer's disease and six age-matched control human subjects, but not in the cerebellum. |
2001-06-14 |
2023-08-12 |
human |
| L B Yang, R Li, S Meri, J Rogers, Y She. Deficiency of complement defense protein CD59 may contribute to neurodegeneration in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 20. 2001-06-07. PMID:11027207. |
here, we present evidence from elisa assays that cd59 protein levels are significantly decreased in the frontal cortex and hippocampus of alzheimer's disease (ad) compared with nondemented elderly (nd) patients, whereas complement component 9, a final component to form mac, is significantly increased. |
2001-06-07 |
2023-08-12 |
human |
| G Rodriguez, P Vitali, P Calvini, C Bordoni, N Girtler, G Taddei, G Mariani, F Nobil. Hippocampal perfusion in mild Alzheimer's disease. Psychiatry research. vol 100. issue 2. 2001-05-31. PMID:11114492. |
hippocampal perfusion in mild alzheimer's disease. |
2001-05-31 |
2023-08-12 |
human |
| G Rodriguez, P Vitali, P Calvini, C Bordoni, N Girtler, G Taddei, G Mariani, F Nobil. Hippocampal perfusion in mild Alzheimer's disease. Psychiatry research. vol 100. issue 2. 2001-05-31. PMID:11114492. |
perfusion and metabolic studies in patients with alzheimer's disease (ad) have so far yielded conflicting results on the functional status of the hippocampal region, whose deep location in the brain makes it critical to optimize the image-reconstruction technique employed in emission tomography. |
2001-05-31 |
2023-08-12 |
human |
| D Chan, N C Fox, R I Scahill, W R Crum, J L Whitwell, G Leschziner, A M Rossor, J M Stevens, L Cipolotti, M N Rosso. Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease. Annals of neurology. vol 49. issue 4. 2001-05-31. PMID:11310620. |
in alzheimer's disease, there was symmetrical atrophy of the entorhinal cortex, hippocampus, and amygdala, with no evidence of an anteroposterior gradient in the distribution of temporal lobe or hippocampal atrophy. |
2001-05-31 |
2023-08-12 |
human |
| C X Gong, T Lidsky, J Wegiel, I Grundke-Iqbal, K Iqba. Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain. Brain research. Brain research protocols. vol 6. issue 3. 2001-05-24. PMID:11223412. |
selective inhibition of protein phosphatase 2a in these rat brain slices by the treatment with okadaic acid induced hyperphosphorylation of tau at many abnormal sites seen in alzheimer's disease brain and the accumulation of hyperphosphorylated tau in pyramidal neurons of the cortex and hippocampus. |
2001-05-24 |
2023-08-12 |
human |
| N Bogdanovic, P Davidsson, I Volkmann, B Winblad, K Blenno. Growth-associated protein GAP-43 in the frontal cortex and in the hippocampus in Alzheimer's disease: an immunohistochemical and quantitative study. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 4. 2001-05-10. PMID:11215757. |
growth-associated protein gap-43 in the frontal cortex and in the hippocampus in alzheimer's disease: an immunohistochemical and quantitative study. |
2001-05-10 |
2023-08-12 |
human |
| V Vogelsberg-Ragaglia, T Schuck, J Q Trojanowski, V M Le. PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus. Experimental neurology. vol 168. issue 2. 2001-05-10. PMID:11259128. |
pp2a mrna expression is quantitatively decreased in alzheimer's disease hippocampus. |
2001-05-10 |
2023-08-12 |
Not clear |
| V Vogelsberg-Ragaglia, T Schuck, J Q Trojanowski, V M Le. PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus. Experimental neurology. vol 168. issue 2. 2001-05-10. PMID:11259128. |
since abnormal tau phosphorylation may play a role in neurofibrillary tangle (nft) formation in aging and alzheimer's disease (ad), we probed the distribution and abundance of protein phosphatase 2a (pp2a) catalytic (calpha) and regulatory (pr55alpha and gamma, pr61varepsilon and delta) subunit mrna in control and ad hippocampus using in situ hybridization. |
2001-05-10 |
2023-08-12 |
Not clear |
| R Fama, P K Shear, L Marsh, J A Yesavage, J R Tinklenberg, K O Lim, A Pfefferbaum, E V Sulliva. Remote memory for public figures in Alzheimer's disease: relationships to regional cortical and limbic brain volumes. Journal of the International Neuropsychological Society : JINS. vol 7. issue 3. 2001-05-10. PMID:11311039. |
this study examined the relationships between regional cortical and hippocampal brain volumes and components of remote memory (recall, recognition, sequencing, and photo naming of presidential candidates) in 13 individuals with alzheimer's disease (ad). |
2001-05-10 |
2023-08-12 |
Not clear |
| M A Lovell, C Xie, W R Markesber. Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures. Neurobiology of aging. vol 22. issue 2. 2001-05-03. PMID:11182468. |
acrolein is increased in alzheimer's disease brain and is toxic to primary hippocampal cultures. |
2001-05-03 |
2023-08-12 |
human |
| H Wolf, M Grunwald, F Kruggel, S G Riedel-Heller, S Angerhöfer, A Hojjatoleslami, A Hensel, T Arendt, H Gert. Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly. Neurobiology of aging. vol 22. issue 2. 2001-05-03. PMID:11182467. |
we conclude that hippocampal atrophy is sensitive to detect cognitive dysfunction and subjects at risk for alzheimer's disease in the elderly population. |
2001-05-03 |
2023-08-12 |
human |
| C L Grady, M L Furey, P Pietrini, B Horwitz, S I Rapopor. Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease. Brain : a journal of neurology. vol 124. issue Pt 4. 2001-05-03. PMID:11287374. |
these results support the idea of a functional disconnection between the prefrontal cortex and the hippocampus in alzheimer's disease and suggest that memory breakdown in early alzheimer's disease is related to a reduction in the integrated activity within a distributed network that includes these two areas. |
2001-05-03 |
2023-08-12 |
Not clear |
| H Umegaki, N Tamaya, T Shinkai, A Iguch. The metabolism of plasma glucose and catecholamines in Alzheimer's disease. Experimental gerontology. vol 35. issue 9-10. 2001-03-29. PMID:11113615. |
in alzheimer's disease (ad), the most common type of dementia, degeneration of the hippocampal cholinergic system is one of the most robust pathological features. |
2001-03-29 |
2023-08-12 |
human |
| N Durany, T Michel, J Kurt, F F Cruz-Sánchez, J Cervás-Navarro, P Riedere. Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 8. 2001-03-22. PMID:11156744. |
in the present study, we investigated the levels of brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) in post-mortem brain tissue of alzheimer's disease (ad) patients, and we observed a significant increase of bdnf concentration in hippocampus and parietal cortex of ad patients, as well as a negative correlation between nt-3 levels and age in hippocampus and putamen of control subjects, and for bdnf in frontal cortex. |
2001-03-22 |
2023-08-12 |
human |
| J E Holden, B Therrie. The effect of familiarity on distraction and single cue use after hippocampal damage. Biological research for nursing. vol 1. issue 3. 2001-03-22. PMID:11232212. |
spatial disorientation frequently occurs in conditions such as alzheimer's disease that damage the hippocampus, a brain structure necessary for learning and memory. |
2001-03-22 |
2023-08-12 |
rat |
| T Sakurai, B Yang, T Takata, K Yokon. [Exogenous lactate sustains synaptic activity and neuronal viability, but fails to induce long-term potentiation (LTP)]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 37. issue 12. 2001-03-08. PMID:11201184. |
to investigate possible synaptic dysfunction in alzheimer's disease, we examined the effects of exogenous glucose deprivation and replacement of glucose with lactate on the synaptic transmission, synaptic plasticity, and the morphological integrity of hippocampal neurons. |
2001-03-08 |
2023-08-12 |
rat |