| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Howell, J R Atack, D Dewar, R M McKernan, C Su. Density and pharmacology of alpha5 subunit-containing GABA(A) receptors are preserved in hippocampus of Alzheimer's disease patients. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891610. |
density and pharmacology of alpha5 subunit-containing gaba(a) receptors are preserved in hippocampus of alzheimer's disease patients. |
2000-09-27 |
2023-08-12 |
human |
| O Howell, J R Atack, D Dewar, R M McKernan, C Su. Density and pharmacology of alpha5 subunit-containing GABA(A) receptors are preserved in hippocampus of Alzheimer's disease patients. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891610. |
this pattern of expression was identical in both hippocampus from control and alzheimer's disease subjects. |
2000-09-27 |
2023-08-12 |
human |
| O Howell, J R Atack, D Dewar, R M McKernan, C Su. Density and pharmacology of alpha5 subunit-containing GABA(A) receptors are preserved in hippocampus of Alzheimer's disease patients. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891610. |
furthermore, saturation and competition experiments with [3h]l-655,708 and representative benzodiazepine site ligands revealed that alpha5 receptors in alzheimer's hippocampus have an alpha5beta2/3gamma2 pharmacology and structure as in control human brain.overall, the data reported here provide evidence for a specific expression and relative sparing of alpha5 subunit-containing gamma-aminobutyric acid type-a receptors in the hippocampus of alzheimer's patients. |
2000-09-27 |
2023-08-12 |
human |
| J P Rossiter, L L Anderson, F Yang, G M Col. Caspase-cleaved actin (fractin) immunolabelling of Hirano bodies. Neuropathology and applied neurobiology. vol 26. issue 4. 2000-09-19. PMID:10931367. |
fractin immunohistochemistry was performed on hippocampal sections from alzheimer's disease and control cases containing numerous hirano bodies, in addition to immunolabelling with cm1 antiserum which recognizes activated caspase-3. |
2000-09-19 |
2023-08-12 |
rabbit |
| G Murialdo, F Nobili, A Rollero, M V Gianelli, F Copello, G Rodriguez, A Poller. Hippocampal perfusion and pituitary-adrenal axis in Alzheimer's disease. Neuropsychobiology. vol 42. issue 2. 2000-09-15. PMID:10940758. |
hippocampal perfusion and pituitary-adrenal axis in alzheimer's disease. |
2000-09-15 |
2023-08-12 |
human |
| G Murialdo, F Nobili, A Rollero, M V Gianelli, F Copello, G Rodriguez, A Poller. Hippocampal perfusion and pituitary-adrenal axis in Alzheimer's disease. Neuropsychobiology. vol 42. issue 2. 2000-09-15. PMID:10940758. |
the hippocampus is involved in alzheimer's disease (ad) and regulates the hypothalamus-pituitary-adrenal axis (hpaa). |
2000-09-15 |
2023-08-12 |
human |
| E Salmon, F Collette, C Degueldre, C Lemaire, G Franc. Voxel-based analysis of confounding effects of age and dementia severity on cerebral metabolism in Alzheimer's disease. Human brain mapping. vol 10. issue 1. 2000-09-14. PMID:10843517. |
alzheimer's disease is characterized by early hippocampal lesions, but neuropathological and functional imaging studies have also demonstrated involvement of associative cortices in patients suffering from this illness. |
2000-09-14 |
2023-08-12 |
Not clear |
| I Maurer, S Zierz, H J Mölle. A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients. Neurobiology of aging. vol 21. issue 3. 2000-09-07. PMID:10858595. |
to assess mitochondrial function and test the hypothesis of an underlying oxidative phosphorylation defect in alzheimer disease (ad), we evaluated the activities of mitochondrial respiratory chain enzyme complexes i+iii, complexes ii+iii, complex iv (cytochrome c oxidase, cox), succinate dehydrogenase, and citrate synthase in the frontal cortex, temporal cortex, hippocampus, and cerebellum of 23 ad patients and 13 normal human brains. |
2000-09-07 |
2023-08-12 |
human |
| G P Eckert, N J Cairns, W E Mülle. Piracetam reverses hippocampal membrane alterations in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 7-8. 2000-08-22. PMID:10907734. |
piracetam reverses hippocampal membrane alterations in alzheimer's disease. |
2000-08-22 |
2023-08-12 |
Not clear |
| G P Eckert, N J Cairns, W E Mülle. Piracetam reverses hippocampal membrane alterations in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 7-8. 2000-08-22. PMID:10907734. |
the in vitro effects of piracetam treatment on the fluidity of membranes from the hippocampus of alzheimer's disease patients (ad) and non-demented controls were studied. |
2000-08-22 |
2023-08-12 |
Not clear |
| M J West, C H Kawas, L J Martin, J C Troncos. The CA1 region of the human hippocampus is a hot spot in Alzheimer's disease. Annals of the New York Academy of Sciences. vol 908. 2000-08-17. PMID:10911964. |
the ca1 region of the human hippocampus is a hot spot in alzheimer's disease. |
2000-08-17 |
2023-08-12 |
human |
| M J West, C H Kawas, L J Martin, J C Troncos. The CA1 region of the human hippocampus is a hot spot in Alzheimer's disease. Annals of the New York Academy of Sciences. vol 908. 2000-08-17. PMID:10911964. |
data from an ongoing study of differences in the total number of neurons in the five major subdivisions of the hippocampal regions of the brains of patients with alzheimer's disease (ad) and normal age-matched controls confirm an earlier finding from our laboratories of a pronounced loss of ca1 neurons associated with ad. |
2000-08-17 |
2023-08-12 |
human |
| G P Eckert, N J Cairns, A Maras, W F Gattaz, W E Mülle. Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 11. issue 4. 2000-08-16. PMID:10867442. |
cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in alzheimer's disease. |
2000-08-16 |
2023-08-12 |
Not clear |
| I Ferrer, R Blanc. N-myc and c-myc expression in Alzheimer disease, Huntington disease and Parkinson disease. Brain research. Molecular brain research. vol 77. issue 2. 2000-08-11. PMID:10837922. |
the present study examines n-myc and c-myc protein expression with western blotting and single and double-labeling immunohistochemistry in the hippocampus in alzheimer disease (ad), the striatum in huntington disease (hd) and the substantia nigra in parkinson disease (pd). |
2000-08-11 |
2023-08-12 |
human |
| L de Toledo-Morrell, I Goncharova, B Dickerson, R S Wilson, D A Bennet. From healthy aging to early Alzheimer's disease: in vivo detection of entorhinal cortex atrophy. Annals of the New York Academy of Sciences. vol 911. 2000-08-09. PMID:10911878. |
in an attempt to determine the earliest sites of involvement in mild and incipient alzheimer's disease (ad), we compared entorhinal and hippocampal volume in (1) healthy elderly controls, (2) patients with very mild ad, and (3) elderly patients who were evaluated for cognitive complaints, but did not meet criteria for dementia. |
2000-08-09 |
2023-08-12 |
human |
| A Takeuchi, M C Irizarry, K Duff, T C Saido, K Hsiao Ashe, M Hasegawa, D M Mann, B T Hyman, T Iwatsub. Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. The American journal of pathology. vol 157. issue 1. 2000-08-08. PMID:10880403. |
to analyze the relationship between the deposition of amyloid beta peptides (abeta) and neuronal loss in transgenic models of alzheimer's disease (ad), we examined the frontal neocortex (fc) and ca1 portion of hippocampus (ca1) in psapp mice doubly expressing ad-associated mutant presenilin 1 (ps1) and swedish-type mutant beta amyloid precursor protein (appsw) by morphometry of abeta burden and neuronal counts. |
2000-08-08 |
2023-08-12 |
mouse |
| S W Chang, D Zhang, H D Chung, H P Zassenhau. The frequency of point mutations in mitochondrial DNA is elevated in the Alzheimer's brain. Biochemical and biophysical research communications. vol 273. issue 1. 2000-07-27. PMID:10873587. |
using a pcr-based strategy, we found that point mutation frequencies in mitochondrial dna (mtdna) were 2- to 3-fold higher in the parietal gyrus, hippocampus, and cerebellum from subjects with alzheimer's disease (ad) compared to normal controls. |
2000-07-27 |
2023-08-12 |
human |
| L Korbo, M Wes. No loss of hippocampal neurons in AIDS patients. Acta neuropathologica. vol 99. issue 5. 2000-07-17. PMID:10805097. |
the hippocampal region of the brain is an essential component of learning and memory processes and it is severely affected in a number of diseases, including temporal lobe epilepsy and alzheimer's dementia. |
2000-07-17 |
2023-08-12 |
Not clear |
| R W Verwer, K A Jansen, A A Sluiter, C W Pool, W Kamphorst, D F Swaa. Decreased hippocampal metabolic activity in Alzheimer patients is not reflected in the immunoreactivity of cytochrome oxidase subunits. Experimental neurology. vol 163. issue 2. 2000-07-17. PMID:10833319. |
decreased hippocampal metabolic activity in alzheimer patients is not reflected in the immunoreactivity of cytochrome oxidase subunits. |
2000-07-17 |
2023-08-12 |
human |
| R W Verwer, K A Jansen, A A Sluiter, C W Pool, W Kamphorst, D F Swaa. Decreased hippocampal metabolic activity in Alzheimer patients is not reflected in the immunoreactivity of cytochrome oxidase subunits. Experimental neurology. vol 163. issue 2. 2000-07-17. PMID:10833319. |
in the present study we have compared histochemically determined cytochrome oxidase activity with the levels of immunocytochemically stained cytochrome oxidase subunits (co ii and co iv) and atp synthase in the human hippocampus in relation with alzheimer's disease. |
2000-07-17 |
2023-08-12 |
human |