| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R W Verwer, K A Jansen, A A Sluiter, C W Pool, W Kamphorst, D F Swaa. Decreased hippocampal metabolic activity in Alzheimer patients is not reflected in the immunoreactivity of cytochrome oxidase subunits. Experimental neurology. vol 163. issue 2. 2000-07-17. PMID:10833319. |
cytochrome oxidase activity was significantly reduced in all hippocampal areas of alzheimer patients. |
2000-07-17 |
2023-08-12 |
human |
| H Zhu, W Fu, M P Mattso. The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis. Journal of neurochemistry. vol 75. issue 1. 2000-07-17. PMID:10854254. |
we now report that suppression of tert levels and function in embryonic mouse hippocampal neurons in culture using antisense technology and the telomerase inhibitor 3' -azido-2' 3' -dideoxythymidine significantly increases their vulnerability to cell death induced by amyloid beta-peptide, a neurotoxic protein believed to promote neuronal degeneration in alzheimer's disease. |
2000-07-17 |
2023-08-12 |
mouse |
| C Hock, K Heese, C Hulette, C Rosenberg, U Otte. Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Archives of neurology. vol 57. issue 6. 2000-07-13. PMID:10867782. |
region-specific neurotrophin imbalances in alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. |
2000-07-13 |
2023-08-12 |
Not clear |
| M P Laakso, G B Frisoni, M Könönen, M Mikkonen, A Beltramello, C Geroldi, A Bianchetti, M Trabucchi, H Soininen, H J Arone. Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer's disease: a morphometric MRI study. Biological psychiatry. vol 47. issue 12. 2000-07-12. PMID:10862805. |
hippocampus and entorhinal cortex in frontotemporal dementia and alzheimer's disease: a morphometric mri study. |
2000-07-12 |
2023-08-12 |
Not clear |
| M P Laakso, G B Frisoni, M Könönen, M Mikkonen, A Beltramello, C Geroldi, A Bianchetti, M Trabucchi, H Soininen, H J Arone. Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer's disease: a morphometric MRI study. Biological psychiatry. vol 47. issue 12. 2000-07-12. PMID:10862805. |
magnetic resonance imaging (mri) of hippocampal atrophy is a sensitive but not specific method to support the clinical diagnosis of early alzheimer's disease (ad). |
2000-07-12 |
2023-08-12 |
Not clear |
| S Yehuda, S Rabinovitz, R L Carasso, D I Mostofsk. Fatty acid mixture counters stress changes in cortisol, cholesterol, and impair learning. The International journal of neuroscience. vol 101. issue 1-4. 2000-07-07. PMID:10765992. |
it is proposed that induction of intense stress, and the associated increase in cortisol, cholesterol and other corticosteroids may damage hippocampal structures and help account for the cognitive decline witnessed in alzheimer's disease and other age-related conditions. |
2000-07-07 |
2023-08-12 |
rat |
| L de Toledo-Morrell, B Dickerson, M P Sullivan, C Spanovic, R Wilson, D A Bennet. Hemispheric differences in hippocampal volume predict verbal and spatial memory performance in patients with Alzheimer's disease. Hippocampus. vol 10. issue 2. 2000-06-27. PMID:10791835. |
hemispheric differences in hippocampal volume predict verbal and spatial memory performance in patients with alzheimer's disease. |
2000-06-27 |
2023-08-12 |
human |
| D R Thal, M Holzer, U Rüb, G Waldmann, S Günzel, D Zedlick, R Schobe. Alzheimer-related tau-pathology in the perforant path target zone and in the hippocampal stratum oriens and radiatum correlates with onset and degree of dementia. Experimental neurology. vol 163. issue 1. 2000-06-13. PMID:10785448. |
these results indicate that axonal phf-tau pathology in hippocampal pathways presumably is critical for the clinical expression of dementia and may constitute an anatomical substrate of clinically verifiable memory dysfunction in alzheimer's disease. |
2000-06-13 |
2023-08-12 |
Not clear |
| Y Kashiwaya, T Takeshima, N Mori, K Nakashima, K Clarke, R L Veec. D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 10. 2000-06-13. PMID:10805800. |
similarly, a fragment of amyloid protein, abeta(1-42), is lethal to hippocampal cells, producing recent memory deficits characteristic of alzheimer's disease. |
2000-06-13 |
2023-08-12 |
human |
| V I Cohen, B Jin, R C McRee, S F Boulay, E I Cohen, V K Sood, B R Zeeberg, R C Reb. In vitro and in vivo m2 muscarinic subtype selectivity of some dibenzodiazepinones and pyridobenzodiazepinones. Brain research. vol 861. issue 2. 2000-06-06. PMID:10760492. |
alzheimer's disease (ad) involves selective loss of muscarinic m2, but not m1, subtype receptors in cortical and hippocampal regions of the human brain. |
2000-06-06 |
2023-08-12 |
human |
| R M Holsinger, J Schnarr, P Henry, V T Castelo, M Fahnestoc. Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Brain research. Molecular brain research. vol 76. issue 2. 2000-06-05. PMID:10762711. |
a decrease in brain-derived neurotrophic factor synthesis could have detrimental effects on hippocampal, cortical and basal forebrain cholinergic neurons and may account for their selective vulnerability in alzheimer's disease. |
2000-06-05 |
2023-08-12 |
human |
| M D Kane, W J Lipinski, M J Callahan, F Bian, R A Durham, R D Schwarz, A E Roher, L C Walke. Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 10. 2000-05-25. PMID:10804202. |
to determine whether the deposition of the beta-amyloid peptide (abeta), a key pathological feature of alzheimer's disease (ad), can be induced in vivo, we infused dilute supernatants of autopsy-derived neocortical homogenates from alzheimer's patients unilaterally into the hippocampus and neocortex of 3-month-old beta-amyloid precursor protein (betaapp)-transgenic mice. |
2000-05-25 |
2023-08-12 |
mouse |
| R Vidal, T Revesz, A Rostagno, E Kim, J L Holton, T Bek, M Bojsen-Møller, H Braendgaard, G Plant, J Ghiso, B Frangion. A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 9. 2000-05-24. PMID:10781099. |
neuropathological findings include severe widespread cerebral amyloid angiopathy, hippocampal plaques, and neurofibrillary tangles, similar to alzheimer's disease. |
2000-05-24 |
2023-08-12 |
Not clear |
| M P Laakso, M Lehtovirta, K Partanen, P J Riekkinen, H Soinine. Hippocampus in Alzheimer's disease: a 3-year follow-up MRI study. Biological psychiatry. vol 47. issue 6. 2000-05-16. PMID:10715362. |
hippocampus in alzheimer's disease: a 3-year follow-up mri study. |
2000-05-16 |
2023-08-12 |
Not clear |
| G Emilien, K Beyreuther, C L Masters, J M Maloteau. Prospects for pharmacological intervention in Alzheimer disease. Archives of neurology. vol 57. issue 4. 2000-04-27. PMID:10768617. |
alzheimer disease (ad) involves neuronal degeneration with impaired cholinergic transmission in the cerebral cortex and hippocampus in areas of the brain particularly associated with memory and higher intellectual functioning. |
2000-04-27 |
2023-08-12 |
Not clear |
| M P Laakso, M Hallikainen, T Hänninen, K Partanen, H Soinine. Diagnosis of Alzheimer's disease: MRI of the hippocampus vs delayed recall. Neuropsychologia. vol 38. issue 5. 2000-04-25. PMID:10689035. |
diagnosis of alzheimer's disease: mri of the hippocampus vs delayed recall. |
2000-04-25 |
2023-08-12 |
human |
| M P Laakso, M Hallikainen, T Hänninen, K Partanen, H Soinine. Diagnosis of Alzheimer's disease: MRI of the hippocampus vs delayed recall. Neuropsychologia. vol 38. issue 5. 2000-04-25. PMID:10689035. |
hippocampal volume measurements using magnetic resonance imaging (mri) and assessment of performance in tests of delayed recall are among the most useful aids for diagnosing early alzheimer's disease (ad) on an individual level. |
2000-04-25 |
2023-08-12 |
human |
| H Umegaki, H Ikari, H Nakahata, J Yoshimura, H Endo, T Yamamoto, A Iguch. Low plasma epinephrine in elderly female subjects of dementia of Alzheimer type. Brain research. vol 858. issue 1. 2000-04-25. PMID:10700598. |
one of the robust features of brain pathologies of dementia of alzheimer type (dat) is the impairment of the hippocampus, especially the cholinergic system. |
2000-04-25 |
2023-08-12 |
human |
| J L Gerst, A K Raina, I Pirim, A McShea, P L Harris, S L Siedlak, A Takeda, R B Petersen, M A Smit. Altered cell-matrix associated ADAM proteins in Alzheimer disease. Journal of neuroscience research. vol 59. issue 5. 2000-04-18. PMID:10686596. |
our results show that whereas adam-1 and 2 are found in susceptible hippocampal neurons in alzheimer disease, these proteins were not generally increased in similar neuronal populations in younger or age-matched controls except in association with age-related neurofibrillary alterations. |
2000-04-18 |
2023-08-12 |
Not clear |
| M B Graeber, S Kösel, E Grasbon-Frodl, H J Möller, P Mehraei. Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D. Neurogenetics. vol 1. issue 3. 2000-04-13. PMID:10737127. |
interestingly, alzheimer's histological preparations did not include the hippocampus or entorhinal region. |
2000-04-13 |
2023-08-12 |
Not clear |