| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruth M Dixon, Kevin M Bradley, Marc M Budge, Peter Styles, A David Smit. Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease. Brain : a journal of neurology. vol 125. issue Pt 10. 2002-10-29. PMID:12244089. |
hippocampal volumes also differed significantly between the groups, and decreased significantly over 1 year in the alzheimer's disease group (12%, p = 0.017). |
2002-10-29 |
2023-08-12 |
human |
| Ruth M Dixon, Kevin M Bradley, Marc M Budge, Peter Styles, A David Smit. Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease. Brain : a journal of neurology. vol 125. issue Pt 10. 2002-10-29. PMID:12244089. |
we conclude that (1)hmrs-detectable metabolites can be quantified from the hippocampi of cognitively impaired individuals, and that hippocampal [naa] is significantly reduced in alzheimer's disease, in excess of atrophy. |
2002-10-29 |
2023-08-12 |
human |
| Renato L Marchetti, Cássio M C Bottino, Dionísio Azevedo, Suely K Nagahashi Marie, Cláudio C de Castr. [Reliability of volumetric measures of mesial temporal structures]. Arquivos de neuro-psiquiatria. vol 60. issue 2-B. 2002-10-22. PMID:12131944. |
the development of reliable techniques for volumetric measurement of mesial temporal structures (amygdala, hippocampus and parahippocampal gyrus) on magnetic resonance imaging (mri) can provide data for the study of neuropsychiatric disorders, mainly temporal lobe epilepsy, alzheimer's disease and schizophrenia. |
2002-10-22 |
2023-08-12 |
Not clear |
| Janusz Moryś, Barbara Bobek-Billewicz, Jerzy Dziewiatkowski, Leszek Bidzan, Dorota Ussorowska, Olgierd Narklewic. Changes in the volume of temporal lobe structures related to Alzheimer's type dementia. Folia neuropathologica. vol 40. issue 2. 2002-10-22. PMID:12230256. |
we compared the volumes of the superior temporal gyrus, basolateral temporal area, parahippocampal gyrus, hippocampal head, amygdaloid body and the inferior horn of the lateral ventricle in 29 patients with dementia of alzheimer's type (dat) and in 14 cognitively normal controls. |
2002-10-22 |
2023-08-12 |
Not clear |
| Hong Bi, Chun-I Sz. N-methyl-D-aspartate receptor subunit NR2A and NR2B messenger RNA levels are altered in the hippocampus and entorhinal cortex in Alzheimer's disease. Journal of the neurological sciences. vol 200. issue 1-2. 2002-10-18. PMID:12127670. |
n-methyl-d-aspartate receptor subunit nr2a and nr2b messenger rna levels are altered in the hippocampus and entorhinal cortex in alzheimer's disease. |
2002-10-18 |
2023-08-12 |
human |
| Diego Garzon, Guanhua Yu, Margaret Fahnestoc. A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex. Journal of neurochemistry. vol 82. issue 5. 2002-10-18. PMID:12358753. |
brain-derived neurotrophic factor (bdnf) supports hippocampal, cortical and basal forebrain cholinergic neurons, which lose function in alzheimer's disease. |
2002-10-18 |
2023-08-12 |
human |
| Diego Garzon, Guanhua Yu, Margaret Fahnestoc. A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex. Journal of neurochemistry. vol 82. issue 5. 2002-10-18. PMID:12358753. |
in alzheimer's tissues such as hippocampus and parietal cortex, brain- derived neurotrophic factor mrna is decreased three- to four-fold compared with controls. |
2002-10-18 |
2023-08-12 |
human |
| A Biegon, M Alvarado, T F Budinger, R Grossman, K Hensley, M S West, Y Kotake, M Ono, R A Floy. Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain. Journal of neurochemistry. vol 82. issue 4. 2002-10-18. PMID:12358798. |
loss of nmda receptor function in cortical and hippocampal regions may contribute to the cognitive deficits observed in diseases with a neuroinflammatory component, such as meningitis or alzheimer's disease. |
2002-10-18 |
2023-08-12 |
rat |
| Shi-Jiang Li, Zhu Li, Gaohong Wu, Mei-Jie Zhang, Malgorzata Franczak, Piero G Antuon. Alzheimer Disease: evaluation of a functional MR imaging index as a marker. Radiology. vol 225. issue 1. 2002-10-17. PMID:12355013. |
to measure changes in functional synchrony in the hippocampus in patients with mild cognitive impairment (mci) and alzheimer disease (ad). |
2002-10-17 |
2023-08-12 |
Not clear |
| Lynn A Hyde, Linda S Crni. Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease. Brain research. vol 945. issue 1. 2002-10-07. PMID:12113948. |
ts65dn mice, a model for down syndrome and alzheimer's disease, have a spontaneous age-related reduction of cholinergic markers in medial septal neurons, hippocampal abnormalities, and an age-related learning deficit in a task that requires an intact hippocampus. |
2002-10-07 |
2023-08-12 |
mouse |
| Yuko Saito, Kenichi Nakahara, Hiroshi Yamanouchi, Shigeo Murayam. Severe involvement of ambient gyrus in dementia with grains. Journal of neuropathology and experimental neurology. vol 61. issue 9. 2002-09-23. PMID:12230325. |
the temporal neocortex and hippocampus were relatively spared in dg, in contrast to alzheimer disease. |
2002-09-23 |
2023-08-12 |
Not clear |
| John H Morrison, Patrick R Ho. Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease. Progress in brain research. vol 136. 2002-09-19. PMID:12143403. |
selective vulnerability of corticocortical and hippocampal circuits in aging and alzheimer's disease. |
2002-09-19 |
2023-08-12 |
monkey |
| John H Morrison, Patrick R Ho. Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease. Progress in brain research. vol 136. 2002-09-19. PMID:12143403. |
alzheimer's disease (ad), a classic neurodegenerative disorder, is characterized by extensive yet selective neuron death in the neocortex and hippocampus that leads to dramatic decline in cognitive abilities and memory. |
2002-09-19 |
2023-08-12 |
monkey |
| Thor D Stein, Jeffrey A Johnso. Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 17. 2002-09-13. PMID:12196559. |
these results suggest that the slow progression and lack of full-fledged alzheimer's disease pathology in the hippocampal neurons of app(sw) mice result from the genetic reprogramming of neural cells to cope with increased levels of abeta. |
2002-09-13 |
2023-08-12 |
mouse |
| C Weis, W A Kaufmann, C Humpe. Lipid-mediated in vivo gene transfer replaces the loss of choline acetyltransferase activity after unilateral fimbria-fornix aspiration. Cell transplantation. vol 10. issue 8. 2002-09-05. PMID:11814110. |
in alzheimer's disease cholinergic neurons degenerate, resulting in loss of hippocampal acetylcholine. |
2002-09-05 |
2023-08-12 |
Not clear |
| S S Sisodia, W Annaert, S H Kim, B De Stroope. Gamma-secretase: never more enigmatic. Trends in neurosciences. vol 24. issue 11 Suppl. 2002-08-28. PMID:11881741. |
it is widely believed that the pathogenesis of alzheimer's disease (ad) is intimately, if not causatively, associated with the deposition of approximately 4 kda beta-amyloid (a beta) peptides in the cerebral cortex and hippocampus of affected individuals. |
2002-08-28 |
2023-08-12 |
Not clear |
| Paola Casolini, Assia Catalani, Anna R Zuena, Luciano Angelucc. Inhibition of COX-2 reduces the age-dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat. Journal of neuroscience research. vol 68. issue 3. 2002-08-21. PMID:12111864. |
however, chronic inflammatory activity occurs in the hippocampus of aged rats as well as in the brain of alzheimer's disease patients. |
2002-08-21 |
2023-08-12 |
rat |
| Clorinda Arias, Teresa Montiel, Ricardo Quiroz-Báez, Lourdes Massie. beta-Amyloid neurotoxicity is exacerbated during glycolysis inhibition and mitochondrial impairment in the rat hippocampus in vivo and in isolated nerve terminals: implications for Alzheimer's disease. Experimental neurology. vol 176. issue 1. 2002-08-16. PMID:12093093. |
beta-amyloid neurotoxicity is exacerbated during glycolysis inhibition and mitochondrial impairment in the rat hippocampus in vivo and in isolated nerve terminals: implications for alzheimer's disease. |
2002-08-16 |
2023-08-12 |
rat |
| Quanbao Wang, Jianzhi Wan. Injection of bradykinin or cyclosporine A to hippocampus induces Alzheimer-like phosphorylation of Tau and abnormal behavior in rats. Chinese medical journal. vol 115. issue 6. 2002-08-13. PMID:12123558. |
to reconstitute an alzheimer's disease model by administering bradykinin (bk) or cyclosporine a (csa) to the rat hippocampus. |
2002-08-13 |
2023-08-12 |
rat |
| Kelly T Dineley, Karen A Bell, Duy Bui, J David Sweat. beta -Amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes. The Journal of biological chemistry. vol 277. issue 28. 2002-08-12. PMID:11983690. |
the alpha7 nicotinic acetylcholine receptor is highly expressed in hippocampus and in cholinergic projection neurons from the basal forebrain, structures that are particularly vulnerable to the ravages of alzheimer's disease. |
2002-08-12 |
2023-08-12 |
xenopus_laevis |