| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Sarazin, B Duboi. [Mild Cognitive Impairment or pre-demential Alzheimer's disease?]. Revue neurologique. vol 158. issue 10 Suppl. 2003-02-21. PMID:12529583. |
a careful analysis of the cognitive impairment helps identify "hippocampal amnesia syndrome" suggestive of the diagnosis of alzheimer's disease. |
2003-02-21 |
2023-08-12 |
human |
| Patrick R Hof, Thierry Bussière, Gabriel Gold, Enikö Kövari, Panteleimon Giannakopoulos, Constantin Bouras, Daniel P Perl, John H Morriso. Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 62. issue 1. 2003-02-11. PMID:12528818. |
the entorhinal cortex and hippocampus are the first cortical regions to be affected by the degenerative cellular process that leads to alzheimer disease (ad) and display a limited degree of neuronal alterations in normal aging. |
2003-02-11 |
2023-08-12 |
Not clear |
| W-H Zheng, S Bastianetto, F Mennicken, W Ma, S Ka. Amyloid beta peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401334. |
the neuropathological features associated with alzheimer's disease (ad) brain include the presence of extracellular neuritic plaques composed of amyloid beta protein (abeta), intracellular neurofibrillary tangles containing phosphorylated tau protein and the loss of basal forebrain cholinergic neurons which innervate regions such as the hippocampus and the cortex. |
2003-02-05 |
2023-08-12 |
rat |
| Catherine E Myers, Alan Kluger, James Golomb, Steven Ferris, Mony J de Leon, Geoffrey Schnirman, Mark A Gluc. Hippocampal atrophy disrupts transfer generalization in nondemented elderly. Journal of geriatric psychiatry and neurology. vol 15. issue 2. 2003-01-31. PMID:12083598. |
specific reductions in hippocampal volume in nondemented elderly individuals with mild cognitive impairment have been shown to correlate with future development of alzheimer's disease (ad). |
2003-01-31 |
2023-08-12 |
human |
| Bo Wu, Kaori Kitagawa, Kyoko Yagyu, Nan-Yan Zhang, Naoki Hattori, Chiyoko Inagak. Phosphatidylinositol and PI-4-monophosphate recover amyloid beta protein-induced inhibition of Cl- -ATPase activity. Life sciences. vol 72. issue 4-5. 2003-01-27. PMID:12467886. |
we previously reported that low concentrations (1-10 nm) of amyloid beta proteins (abetas, abeta1-42, abeta25-35), the neurotoxic peptides in alzheimer's disease, reduced cl- -atpase activity in cultured rat hippocampal neurons without any changes in the activities of na+/k+-atpase or anion-insensitive mg(2+)-atpase, and decreased pi, pip, and pip2 levels in neuronal plasma membranes (journal of neurochemistry 2001, 78, 569-579). |
2003-01-27 |
2023-08-12 |
rat |
| David G Cook, James B Leverenz, Pamela J McMillan, J Jacob Kulstad, Sasha Ericksen, Richard A Roth, Gerard D Schellenberg, Lee-Way Jin, Kristina S Kovacina, Suzanne Craf. Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele. The American journal of pathology. vol 162. issue 1. 2003-01-24. PMID:12507914. |
reduced hippocampal insulin-degrading enzyme in late-onset alzheimer's disease is associated with the apolipoprotein e-epsilon4 allele. |
2003-01-24 |
2023-08-12 |
human |
| Lon White, Helen Petrovitch, John Hardman, James Nelson, Daron G Davis, G Webster Ross, Kamal Masaki, Lenore Launer, William R Markesber. Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Annals of the New York Academy of Sciences. vol 977. 2003-01-21. PMID:12480729. |
an algorithm was developed to assign each decedent to one of six subsets, corresponding to pathologic dominance by microvascular lesions (14% of decedents), alzheimer lesions (12%), hippocampal sclerosis (5%), cortical lewy bodies (5%), codominance by two or more primary processes (9%), or without a dominant pathologic process recognized (55%). |
2003-01-21 |
2023-08-12 |
human |
| Zhi-Xing Yao, Rachel C Brown, Gary Teper, Janet Greeson, Vassilios Papadopoulo. 22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide. Journal of neurochemistry. vol 83. issue 5. 2003-01-16. PMID:12437582. |
22r-hydroxycholesterol, a steroid intermediate in the pathway of pregnenolone formation from cholesterol, was found at lower levels in alzheimer's disease (ad) hippocampus and frontal cortex tissue specimens compared to age-matched controls. |
2003-01-16 |
2023-08-12 |
human |
| Takashi Ishizawa, Li-wen Ko, Natalie Cookson, Peter Davias, Marisol Espinoza, Dennis W Dickso. Selective neurofibrillary degeneration of the hippocampal CA2 sector is associated with four-repeat tauopathies. Journal of neuropathology and experimental neurology. vol 61. issue 12. 2003-01-14. PMID:12484566. |
the ca2 sector of the hippocampus is relatively resistant to neurofibrillary tangles in aging and alzheimer disease; however, some cases have selective neurofibrillary degeneration in ca2 with sparing of the more vulnerable ca1 sector. |
2003-01-14 |
2023-08-12 |
Not clear |
| F Glöckner, V Meske, T G Oh. Genotype-related differences of hippocampal apolipoprotein E levels only in early stages of neuropathological changes in Alzheimer's disease. Neuroscience. vol 114. issue 4. 2003-01-10. PMID:12379263. |
genotype-related differences of hippocampal apolipoprotein e levels only in early stages of neuropathological changes in alzheimer's disease. |
2003-01-10 |
2023-08-12 |
Not clear |
| J-C Baro. Hippocampal atrophy and neocortical dysfunction in early Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 73. issue 5. 2003-01-10. PMID:12397133. |
hippocampal atrophy and neocortical dysfunction in early alzheimer's disease. |
2003-01-10 |
2023-08-12 |
Not clear |
| G E J Garrido, S S Furuie, C A Buchpiguel, C M C Bottino, O P Almeida, C G Cid, C H P Camargo, C C Castro, M F Glabus, G F Busatt. Relation between medial temporal atrophy and functional brain activity during memory processing in Alzheimer's disease: a combined MRI and SPECT study. Journal of neurology, neurosurgery, and psychiatry. vol 73. issue 5. 2003-01-10. PMID:12397142. |
to investigate the relation between atrophy of the hippocampal region and brain functional patterns during episodic memory processing in alzheimer's disease. |
2003-01-10 |
2023-08-12 |
Not clear |
| Krisztina Horváth, Ferenc Kövér, Norbert Kovács, János Kállai, Ferenc Nag. [Volumetric measurements of the hippocampus and amygdala with MRI in healthy adults]. Orvosi hetilap. vol 143. issue 37. 2003-01-10. PMID:12434631. |
in recent years several studies have shown the utility of the volumetric measurement of the medial temporal lobe structures, especially the amygdala and the hippocampus in temporal lobe epilepsy, memory disorders, alzheimer disease and schizophrenia. |
2003-01-10 |
2023-08-12 |
Not clear |
| E Kienzl, K Jellinger, B Janetzky, H Steindl, J Bergman. A broader horizon of Alzheimer pathogenesis: ALZAS--an early serum biomarker? Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456054. |
reverse transcription-pcr revealed that the transcript of alzas was expressed in cortical and hippocampal regions of human alzheimer disease brain as well as in leukocytes derived from ad patients. |
2003-01-10 |
2023-08-12 |
human |
| M Fahnestock, D Garzon, R M D Holsinger, B Michalsk. Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule? Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456067. |
in alzheimer's disease, bdnf mrna and protein are decreased in basal forebrain cholinergic neuron target tissues such as cortex and hippocampus. |
2003-01-10 |
2023-08-12 |
human |
| Xiang-You Hu, Huai-Yu Zhang, Song Qin, Hao Xu, Dick F Swaab, Jiang-Ning Zho. Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients. Experimental neurology. vol 178. issue 1. 2003-01-08. PMID:12460612. |
increased p75(ntr) expression in hippocampal neurons containing hyperphosphorylated tau in alzheimer patients. |
2003-01-08 |
2023-08-12 |
Not clear |
| Sic L Chan, Katsutoshi Furukawa, Mark P Mattso. Presenilins and APP in neuritic and synaptic plasticity: implications for the pathogenesis of Alzheimer's disease. Neuromolecular medicine. vol 2. issue 2. 2003-01-03. PMID:12428810. |
a key neuropathological hallmark of alzheimer's disease (ad) is the loss of neocortical and hippocampal synapses, which is closely correlated with the degree of memory impairment. |
2003-01-03 |
2023-08-12 |
mouse |
| Tetsuro Mohr. [Studies on the cytological function of the biomembrane and the neurons]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 122. issue 10. 2002-12-24. PMID:12400154. |
the vulnerability of hippocampal neurons to the alzheimer beta-amyloid protein was confirmed in vitro with primary cultured rat hippocampal neurons in the presence of the amyloid protein beta 1-42 or its core fragments. |
2002-12-24 |
2023-08-12 |
human |
| Max Holzer, Ulrich Gärtner, Andrea Stöbe, Wolfgang Härtig, Hildegard Gruschka, Martina K Brückner, Thomas Arend. Inverse association of Pin1 and tau accumulation in Alzheimer's disease hippocampus. Acta neuropathologica. vol 104. issue 5. 2002-12-23. PMID:12410395. |
inverse association of pin1 and tau accumulation in alzheimer's disease hippocampus. |
2002-12-23 |
2023-08-12 |
Not clear |
| Max Holzer, Ulrich Gärtner, Andrea Stöbe, Wolfgang Härtig, Hildegard Gruschka, Martina K Brückner, Thomas Arend. Inverse association of Pin1 and tau accumulation in Alzheimer's disease hippocampus. Acta neuropathologica. vol 104. issue 5. 2002-12-23. PMID:12410395. |
in the present study, we analysed the potential involvement of pin1 in selective vulnerability of hippocampal neurons to neurofibrillary degeneration in alzheimer's disease. |
2002-12-23 |
2023-08-12 |
Not clear |