| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanja Kovacevic, Michael S Rafii, James B Brewe. High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment. Alzheimer disease and associated disorders. vol 23. issue 2. 2009-07-23. PMID:19474571. |
in addition, most studies that examined mtl atrophy in alzheimer disease have focused only on the hippocampus. |
2009-07-23 |
2023-08-12 |
Not clear |
| Florence Clavaguera, Tristan Bolmont, R Anthony Crowther, Dorothee Abramowski, Stephan Frank, Alphonse Probst, Graham Fraser, Anna K Stalder, Martin Beibel, Matthias Staufenbiel, Mathias Jucker, Michel Goedert, Markus Tolna. Transmission and spreading of tauopathy in transgenic mouse brain. Nature cell biology. vol 11. issue 7. 2009-07-20. PMID:19503072. |
cognitive impairment becomes manifest when inclusions reach the hippocampus, with abundant neocortical tau inclusions and extracellular beta-amyloid deposits being the defining pathological hallmarks of alzheimer's disease. |
2009-07-20 |
2023-08-12 |
mouse |
| Evan Elliott, Offir Laufer, Irith Ginzbur. BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19317853. |
bag-1m is up-regulated in hippocampus of alzheimer's disease patients and associates with tau and app proteins. |
2009-07-16 |
2023-08-12 |
human |
| Zhi-bin Liu, Wen-min Niu, Xiao-hang Yang, Xiao-mei Niu, Yuan Wan. [Effect of "Xiusanzhen" on learning-memory ability and hippocampal ChAT and AChE activity in Alzheimer disease rats]. Zhen ci yan jiu = Acupuncture research. vol 34. issue 1. 2009-07-09. PMID:19526808. |
[effect of "xiusanzhen" on learning-memory ability and hippocampal chat and ache activity in alzheimer disease rats]. |
2009-07-09 |
2023-08-12 |
rat |
| Zhi-bin Liu, Wen-min Niu, Xiao-hang Yang, Xiao-mei Niu, Yuan Wan. [Effect of "Xiusanzhen" on learning-memory ability and hippocampal ChAT and AChE activity in Alzheimer disease rats]. Zhen ci yan jiu = Acupuncture research. vol 34. issue 1. 2009-07-09. PMID:19526808. |
to explore the effect of "xiusanzhen" [bilateral "yingxiang" (li 20) + "yintang" (ex-hn 3)] on learning-memory ability and choline acetyl transferase (chat) and acetyl cholinesterase (ache) activity of hippocampus tissue in alzheimer disease (ad) rats. |
2009-07-09 |
2023-08-12 |
rat |
| Mark T McAuley, Rose Anne Kenny, Thomas B L Kirkwood, Darren J Wilkinson, Janette J L Jones, Veronica M Mille. A mathematical model of aging-related and cortisol induced hippocampal dysfunction. BMC neuroscience. vol 10. 2009-06-30. PMID:19320982. |
the hippocampus is essential for declarative memory synthesis and is a core pathological substrate for alzheimer's disease (ad), the most common aging-related dementing disease. |
2009-06-30 |
2023-08-12 |
Not clear |
| Jun Tang, Min Song, Yanyan Wang, Xiaotang Fan, Haiwei Xu, Yun Ba. Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP(swe)/PS1(DeltaE9) transgenic mouse model of Alzheimer's disease. Biochemical and biophysical research communications. vol 385. issue 3. 2009-06-30. PMID:19463786. |
noggin and bmp4 co-modulate adult hippocampal neurogenesis in the app(swe)/ps1(deltae9) transgenic mouse model of alzheimer's disease. |
2009-06-30 |
2023-08-12 |
mouse |
| Jun Tang, Min Song, Yanyan Wang, Xiaotang Fan, Haiwei Xu, Yun Ba. Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP(swe)/PS1(DeltaE9) transgenic mouse model of Alzheimer's disease. Biochemical and biophysical research communications. vol 385. issue 3. 2009-06-30. PMID:19463786. |
perturbation of neurogenesis can alter hippocampal function, and previous studies have shown that neurogenesis is dysregulated in alzheimer disease (ad) brain. |
2009-06-30 |
2023-08-12 |
mouse |
| Anja Harmeier, Christian Wozny, Benjamin R Rost, Lisa-Marie Munter, Haiqing Hua, Oleg Georgiev, Michael Beyermann, Peter W Hildebrand, Christoph Weise, Walter Schaffner, Dietmar Schmitz, Gerd Multhau. Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 23. 2009-06-29. PMID:19515926. |
the aggregation of the amyloid-beta (abeta) peptide plays a pivotal role in the pathogenesis of alzheimer's disease, as soluble oligomers are intimately linked to neuronal toxicity and inhibition of hippocampal long-term potentiation (ltp). |
2009-06-29 |
2023-08-12 |
Not clear |
| Yasuhiro Nakata, Noriko Sato, Kiyotaka Nemoto, Osamu Abe, Shoko Shikakura, Kunimasa Arima, Nobuo Furuta, Masatake Uno, Shigeo Hirai, Yoshitaka Masutani, Kuni Ohtomo, A James Barkovich, Shigeki Aok. Diffusion abnormality in the posterior cingulum and hippocampal volume: correlation with disease progression in Alzheimer's disease. Magnetic resonance imaging. vol 27. issue 3. 2009-06-24. PMID:18771871. |
diffusion abnormality in the posterior cingulum and hippocampal volume: correlation with disease progression in alzheimer's disease. |
2009-06-24 |
2023-08-12 |
Not clear |
| Yasuhiro Nakata, Noriko Sato, Kiyotaka Nemoto, Osamu Abe, Shoko Shikakura, Kunimasa Arima, Nobuo Furuta, Masatake Uno, Shigeo Hirai, Yoshitaka Masutani, Kuni Ohtomo, A James Barkovich, Shigeki Aok. Diffusion abnormality in the posterior cingulum and hippocampal volume: correlation with disease progression in Alzheimer's disease. Magnetic resonance imaging. vol 27. issue 3. 2009-06-24. PMID:18771871. |
the purpose of this study was to determine correlations among disease progression, diffusion abnormalities in the posterior cingulum and hippocampal volume in patients with alzheimer's disease (ad). |
2009-06-24 |
2023-08-12 |
Not clear |
| E C Mormino, J T Kluth, C M Madison, G D Rabinovici, S L Baker, B L Miller, R A Koeppe, C A Mathis, M W Weiner, W J Jagus. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain : a journal of neurology. vol 132. issue Pt 5. 2009-06-24. PMID:19042931. |
to explore the importance of this pathology in the absence of dementia, we compared levels of amyloid deposition (via 'pittsburgh compound-b' (pib) positron emission tomography (pet) imaging) to hippocampus volume (hv) and episodic memory (em) in three groups: (i) normal controls (nc) from the berkeley aging cohort (bac nc, n = 20); (ii) normal controls (nc) from the alzheimer's disease neuroimaging initiative (adni nc, n = 17); and (iii) pib+ mild cognitive impairment subjects from the adni (adni pib+ mci, n = 39). |
2009-06-24 |
2023-08-12 |
human |
| Francesc X Guix, Gerard Ill-Raga, Ramona Bravo, Tadashi Nakaya, Gianni de Fabritiis, Mireia Coma, Gian Pietro Miscione, Jordi Villà-Freixa, Toshiharu Suzuki, Xavier Fernàndez-Busquets, Miguel A Valverde, Bart de Strooper, Francisco J Muño. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain : a journal of neurology. vol 132. issue Pt 5. 2009-06-24. PMID:19251756. |
higher levels of nitro-triosephosphate isomerase (p < 0.05) were detected, by western blot, in immunoprecipitates from hippocampus (9 individuals) and frontal cortex (13 individuals) of alzheimer's disease patients, compared with healthy subjects (4 and 9 individuals, respectively). |
2009-06-24 |
2023-08-12 |
mouse |
| Francesc X Guix, Gerard Ill-Raga, Ramona Bravo, Tadashi Nakaya, Gianni de Fabritiis, Mireia Coma, Gian Pietro Miscione, Jordi Villà-Freixa, Toshiharu Suzuki, Xavier Fernàndez-Busquets, Miguel A Valverde, Bart de Strooper, Francisco J Muño. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain : a journal of neurology. vol 132. issue Pt 5. 2009-06-24. PMID:19251756. |
this finding correlates with the widespread glycation immunostaining in alzheimer's disease cortex and hippocampus from double transgenic mice overexpressing amyloid precursor protein and presenilin 1. |
2009-06-24 |
2023-08-12 |
mouse |
| Wolfgang Härtig, Andreas Reichenbach, Cornelia Voigt, Johannes Boltze, Larysa Bulavina, Martin U Schuhmann, Johannes Seeger, Gerald F Schusser, Christiane Freytag, Jens Grosch. Triple fluorescence labelling of neuronal, glial and vascular markers revealing pathological alterations in various animal models. Journal of chemical neuroanatomy. vol 37. issue 2. 2009-06-22. PMID:19028564. |
moreover, the versatility of the method is verified by its application to sections from old triple transgenic mice with age-dependent beta-amyloidosis and tau hyperphosphorylation in the hippocampus, modelling neuropathological alterations in alzheimer's disease. |
2009-06-22 |
2023-08-12 |
mouse |
| Laurent Lecanu, Laurent Tillement, Georges Rammouz, Jean Paul Tillement, Janet Greeson, Vassilios Papadopoulo. Caprospinol: moving from a neuroactive steroid to a neurotropic drug. Expert opinion on investigational drugs. vol 18. issue 3. 2009-06-18. PMID:19243278. |
we identified 22r-hydroxycholesterol to be present in much lower levels in the hippocampus and frontal cortex of alzheimer's disease than in tissue from age-matched controls. |
2009-06-18 |
2023-08-12 |
Not clear |
| M G Giovannini, F Cerbai, A Bellucci, C Melani, C Grossi, C Bartolozzi, D Nosi, F Casament. Differential activation of mitogen-activated protein kinase signalling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer's disease. Neuroscience. vol 153. issue 3. 2009-06-08. PMID:18406062. |
differential activation of mitogen-activated protein kinase signalling pathways in the hippocampus of crnd8 transgenic mouse, a model of alzheimer's disease. |
2009-06-08 |
2023-08-12 |
mouse |
| Nicolas G Baza. Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease. Journal of lipid research. vol 50 Suppl. 2009-06-05. PMID:19018037. |
moreover, neurotrophins are npd1-synthesis agonists, and npd1 content is decreased in the ca1 region of the hippocampus of alzheimer's patients. |
2009-06-05 |
2023-08-12 |
Not clear |
| Edward D Levin, Abigail Perkins, Terrell Brotherton, Melissa Qazi, Chantal Berez, Janitza Montalvo-Ortiz, Kasey Davis, Paul Williams, N Channelle Christophe. Chronic underactivity of medial frontal cortical beta2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 2. 2009-06-02. PMID:19146909. |
nicotinic receptor decreases in the frontal cortex and hippocampus are important mediators of cognitive impairment in both schizophrenia and alzheimer's disease. |
2009-06-02 |
2023-08-12 |
rat |
| Bei Ding, Ke-Min Chen, Hua-Wei Ling, Fei Sun, Xia Li, Tao Wan, Wei-Min Chai, Huan Zhang, Ying Zhan, Yong-Jing Gua. Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease. Journal of magnetic resonance imaging : JMRI. vol 29. issue 4. 2009-05-28. PMID:19306401. |
correlation of iron in the hippocampus with mmse in patients with alzheimer's disease. |
2009-05-28 |
2023-08-12 |
Not clear |