| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonia Brar, David Henderson, John Schenck, Earl A Zimmerma. Iron accumulation in the substantia nigra of patients with Alzheimer disease and parkinsonism. Archives of neurology. vol 66. issue 3. 2009-04-15. PMID:19273756. |
preliminary studies have shown an increase in iron accumulation in the substantia nigra but not in the hippocampus in patients with parkinson disease without dementia and the reverse in patients with alzheimer disease (ad) and no parkinsonism. |
2009-04-15 |
2023-08-12 |
Not clear |
| Zhiqun Wang, Cheng Zhao, Lei Yu, Weidong Zhou, Kuncheng L. Regional metabolic changes in the hippocampus and posterior cingulate area detected with 3-Tesla magnetic resonance spectroscopy in patients with mild cognitive impairment and Alzheimer disease. Acta radiologica (Stockholm, Sweden : 1987). vol 50. issue 3. 2009-04-13. PMID:19235582. |
regional metabolic changes in the hippocampus and posterior cingulate area detected with 3-tesla magnetic resonance spectroscopy in patients with mild cognitive impairment and alzheimer disease. |
2009-04-13 |
2023-08-12 |
human |
| W J P Henneman, J D Sluimer, J Barnes, W M van der Flier, I C Sluimer, N C Fox, P Scheltens, H Vrenken, F Barkho. Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures. Neurology. vol 72. issue 11. 2009-04-10. PMID:19289740. |
hippocampal atrophy rates in alzheimer disease: added value over whole brain volume measures. |
2009-04-10 |
2023-08-12 |
Not clear |
| W J P Henneman, J D Sluimer, J Barnes, W M van der Flier, I C Sluimer, N C Fox, P Scheltens, H Vrenken, F Barkho. Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures. Neurology. vol 72. issue 11. 2009-04-10. PMID:19289740. |
to investigate the added value of hippocampal atrophy rates over whole brain volume measurements on mri in patients with alzheimer disease (ad), patients with mild cognitive impairment (mci), and controls. |
2009-04-10 |
2023-08-12 |
Not clear |
| Erik S Carlson, Rhamy Magid, Anna Petryk, Michael K Georgief. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Brain research. vol 1237. 2009-04-09. PMID:18723004. |
the purpose of the present study was threefold: 1) quantitative pcr confirmation of our previous microarray results, demonstrating upregulation of a network of genes leading to beta-amyloid production and implicated in alzheimer disease etiology in iron-deficient anemic rat pups at the time of hippocampal differentiation; 2) investigation of the potential contributions of iron deficiency anemia and iron treatment to this differential gene expression in the hippocampus; and 3) investigation of these genes over a developmental time course in a mouse model where iron deficiency is limited to hippocampus, is not accompanied by anemia and is not repletable. |
2009-04-09 |
2023-08-12 |
mouse |
| Melissa J Alldred, Shaoli Che, Stephen D Ginsber. Terminal continuation (TC) RNA amplification without second strand synthesis. Journal of neuroscience methods. vol 177. issue 2. 2009-04-09. PMID:19026688. |
the modified tc rna amplification method can discriminate single cell gene expression profiles between normal control and alzheimer's disease hippocampal neurons indistinguishable from the original protocol. |
2009-04-09 |
2023-08-12 |
mouse |
| Sterling C Johnson, Taylor W Schmitz, Sanjay Asthana, Mark A Gluck, Catherine Myer. Associative learning over trials activates the hippocampus in healthy elderly but not mild cognitive impairment. Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. vol 15. issue 2. 2009-04-08. PMID:17851984. |
the ability to form associations between choice alternatives and their contingent outcomes is an important aspect of learning that may be sensitive to hippocampal dysfunction in memory disorders of aging such as amnestic mild cognitive impairment (mcia), or early alzheimer disease. |
2009-04-08 |
2023-08-12 |
human |
| Joshua B Owen, Fabio Di Domenico, Rukhsana Sultana, Marzia Perluigi, Chiara Cini, William M Pierce, D Allan Butterfiel. Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD. Journal of proteome research. vol 8. issue 2. 2009-04-06. PMID:19072283. |
proteomics-determined differences in the concanavalin-a-fractionated proteome of hippocampus and inferior parietal lobule in subjects with alzheimer's disease and mild cognitive impairment: implications for progression of ad. |
2009-04-06 |
2023-08-12 |
human |
| Jun Liu, Longxuan Li, William Z Su. HT22 hippocampal neuronal cell line possesses functional cholinergic properties. Life sciences. vol 84. issue 9-10. 2009-04-06. PMID:19135458. |
hippocampal cholinergic hypofunction is known to be involved in the cognitive deficits of alzheimer's disease, but the detailed mechanisms remain to be elucidated. |
2009-04-06 |
2023-08-12 |
mouse |
| Rebekkah W Halford, David W Russel. Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 9. 2009-04-01. PMID:19204288. |
amyloid precursor protein expression and amyloid plaque deposition in the cortex and hippocampus of male and female alzheimer's disease mice between the ages of 3 to 15 months were similar in the presence and absence of cholesterol 24-hydroxylase. |
2009-04-01 |
2023-08-12 |
mouse |
| Laura A Craig, Nancy S Hong, Joelle Kopp, Robert J McDonal. Selective lesion of medial septal cholinergic neurons followed by a mini-stroke impairs spatial learning in rats. Experimental brain research. vol 193. issue 1. 2009-03-31. PMID:18936927. |
reduced levels of hippocampal acetylcholine are a common finding in patients diagnosed with alzheimer's disease, but it remains unclear what role this depletion plays in the development of dementia. |
2009-03-31 |
2023-08-12 |
rat |
| Alan H Nagahara, David A Merrill, Giovanni Coppola, Shingo Tsukada, Brock E Schroeder, Gideon M Shaked, Ling Wang, Armin Blesch, Albert Kim, James M Conner, Edward Rockenstein, Moses V Chao, Edward H Koo, Daniel Geschwind, Eliezer Masliah, Andrea A Chiba, Mark H Tuszynsk. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nature medicine. vol 15. issue 3. 2009-03-30. PMID:19198615. |
here we show broad neuroprotective effects of entorhinal brain-derived neurotrophic factor (bdnf) administration in several animal models of alzheimer's disease, with extension of therapeutic benefits into the degenerating hippocampus. |
2009-03-30 |
2023-08-12 |
mouse |
| R U Ostrovskaya, T A Gudasheva, A P Zaplina, Ju V Vahitova, M H Salimgareeva, R S Jamidanov, S B Seredeni. Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Bulletin of experimental biology and medicine. vol 146. issue 3. 2009-03-30. PMID:19240853. |
published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced alzheimer's disease, but also at the stage of mild cognitive impairment (pre-disease state). |
2009-03-30 |
2023-08-12 |
rat |
| Md Al Rahim, Akira Nakajima, Norihiko Misawa, Kazutoshi Shindo, Kyoko Adachi, Yoshikazu Shizuri, Yasushi Ohizumi, Tohru Yamakun. A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Abeta-inhibition of the cascade in cultured rat CNS neurons. European journal of pharmacology. vol 600. issue 1-3. 2009-03-27. PMID:18948095. |
after treatment with the chalcone-diol at 50 mum prior to treatment with a sublethal concentration of abeta(1-42), the abeta(1-42)-induced inhibition of phosphorylation of pka substrates and creb was prevented in cultured hippocampal neurons, indicating the potential for protection against the abeta-induced impairment of pka/creb signaling observed in alzheimer's disease. |
2009-03-27 |
2023-08-12 |
rat |
| S V Sarantseva, O I Bol'shakova, S I Timoshenko, D I Rodin, M P Vitek, A L Shvartsma. [Studying pathogenesis of Alzheimer's disease in a Drosophila melanogaster model: human APP overexpression in the brain of transgenic flies leads to deficit of the synaptic protein synaptotagmin]. Genetika. vol 45. issue 1. 2009-03-27. PMID:19239106. |
alzheimer's disease (ad) is a progressive neurodegenerative disease whose main pathomorphological sign is synapse degeneration in the cortex and hippocampus. |
2009-03-27 |
2023-08-12 |
human |
| Feng Bai, Zhijun Zhang, David R Watson, Hui Yu, Yongmei Shi, Wanlin Zhu, Liang Wang, Yonggui Yuan, Yun Qia. Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment. Neuroscience letters. vol 450. issue 2. 2009-03-24. PMID:19071194. |
hippocampus displayed progressively gender-associated damage in alzheimer's disease. |
2009-03-24 |
2023-08-12 |
Not clear |
| Arne Herring, Oliver Ambrée, Manuel Tomm, Henrik Habermann, Norbert Sachser, Werner Paulus, Kathy Keyvan. Environmental enrichment enhances cellular plasticity in transgenic mice with Alzheimer-like pathology. Experimental neurology. vol 216. issue 1. 2009-03-20. PMID:19118549. |
alzheimer's disease (ad) is accompanied by hippocampal neuronal loss and abnormal neurogenesis, both of which probably contributing to ad-related cognitive deficits. |
2009-03-20 |
2023-08-12 |
mouse |
| Briony J Catlow, Amanda R Rowe, Courtney R Clearwater, Maggie Mamcarz, Gary W Arendash, Juan Sanchez-Ramo. Effects of environmental enrichment and physical activity on neurogenesis in transgenic PS1/APP mice. Brain research. vol 1256. 2009-03-16. PMID:19135431. |
in view of our prior study showing that enhanced cognitive activity (but not enhanced physical activity) protects tg mice against cognitive impairment, the present results indicate that increased generation and survival of new neurons in the hippocampal dentate gyrus is not involved with the cognitively-protective effects of complete ce in alzheimer's transgenic mice. |
2009-03-16 |
2023-08-12 |
mouse |
| Raksha Urs, Elizabeth Potter, Warren Barker, Jason Appel, David A Loewenstein, Weizhao Zhao, Ranjan Duar. Visual rating system for assessing magnetic resonance images: a tool in the diagnosis of mild cognitive impairment and Alzheimer disease. Journal of computer assisted tomography. vol 33. issue 1. 2009-03-16. PMID:19188789. |
subjects with mild cognitive impairment (mci) and mild alzheimer disease (ad) can be distinguished from elderly subjects with no cognitive impairment (nci) by the degree of atrophy in the entorhinal cortex (erc) and the hippocampus (hpc), quantified by volumetric magnetic resonance image (mri) studies. |
2009-03-16 |
2023-08-12 |
human |
| Ryoichi Kimura, Masuo Ohn. Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model. Neurobiology of disease. vol 33. issue 2. 2009-03-09. PMID:19026746. |
impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5xfad alzheimer mouse model. |
2009-03-09 |
2023-08-12 |
mouse |