| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
mri of hippocampal volume loss in early alzheimer's disease in relation to apoe genotype and biomarkers. |
2009-10-01 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
hippocampal volume change over time, measured with mri, has huge potential as a marker for alzheimer's disease. |
2009-10-01 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
the objectives of this study were: (i) to test if constant and accelerated hippocampal loss can be detected in alzheimer's disease, mild cognitive impairment and normal ageing over short periods, e.g. |
2009-10-01 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
6-12 months, with mri in the large multicentre setting of the alzheimer's disease neuroimaging initiative (adni); (ii) to determine the extent to which the polymorphism of the apolipoprotein e (apoe) gene modulates hippocampal change; and (iii) to determine if rates of hippocampal loss correlate with cerebrospinal fluid (csf) biomarkers of alzheimer's disease, such as the beta-amyloid (abeta(1-42)) and tau proteins (tau). |
2009-10-01 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
the mild cognitive impairment and alzheimer's disease groups showed hippocampal volume loss over 6 months and accelerated loss over 1 year. |
2009-10-01 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
moreover, increased rates of hippocampal loss were associated with presence of the apoe allele epsilon4 gene in alzheimer's disease and lower csf abeta(1-42) in mild cognitive impairment, irrespective of apoe genotype, whereas relations with tau were only trends. |
2009-10-01 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
the demonstration of considerable hippocampal loss in mild cognitive impairment and alzheimer's disease patients over only 6 months and accelerated loss over 12 months illustrates the power of mri to track morphological brain changes over time in a large multisite setting. |
2009-10-01 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
furthermore, the relations between faster hippocampal loss in the presence of apoe allele epsilon4 and decreased csf abeta(1-42) supports the concept that increased hippocampal loss is an indicator of alzheimer's disease pathology and a potential marker for the efficacy of therapeutic interventions in alzheimer's disease. |
2009-10-01 |
2023-08-12 |
Not clear |
| Feng Bai, Zhijun Zhang, David R Watson, Hui Yu, Yongmei Shi, Yonggui Yua. Abnormal white matter independent of hippocampal atrophy in amnestic type mild cognitive impairment. Neuroscience letters. vol 462. issue 2. 2009-10-01. PMID:19596405. |
hippocampal atrophy is the key marker in the pathogenesis of alzheimer's disease (ad), which is associated with white matter (wm) disruption. |
2009-10-01 |
2023-08-12 |
Not clear |
| Piero Calvini, Andrea Chincarini, Gianluca Gemme, Maria Antonietta Penco, Sandro Squarcia, Flavio Nobili, Guido Rodriguez, Roberto Bellotti, Ezio Catanzariti, Piergiorgio Cerello, Ivan De Mitri, Maria Evelina Fantacc. Automatic analysis of medial temporal lobe atrophy from structural MRIs for the early assessment of Alzheimer disease. Medical physics. vol 36. issue 8. 2009-09-30. PMID:19746807. |
the purpose of this study is to develop a software for the extraction of the hippocampus and surrounding medial temporal lobe (mtl) regions from t1-weighted magnetic resonance (mr) images with no interactive input from the user, to introduce a novel statistical indicator, computed on the intensities in the automatically extracted mtl regions, which measures atrophy, and to evaluate the accuracy of the newly developed intensity-based measure of mtl atrophy to (a) distinguish between patients with alzheimer disease (ad), patients with amnestic mild cognitive impairment (amci), and elderly controls by using established criteria for patients with ad and amci as the reference standard and (b) infer about the clinical outcome of amci patients. |
2009-09-30 |
2023-08-12 |
human |
| Yonggang Shi, Jonathan H Morra, Paul M Thompson, Arthur W Tog. Inverse-consistent surface mapping with Laplace-Beltrami eigen-features. Information processing in medical imaging : proceedings of the ... conference. vol 21. 2009-09-23. PMID:19694286. |
in our experiments, we successfully mapped 890 hippocampal surfaces and report statistically significant maps of atrophy rates between normal controls and patients with mild cognitive impairment (mci) and alzheimer's disease (ad). |
2009-09-23 |
2023-08-12 |
Not clear |
| Cynthia A Massaad, Taneasha M Washington, Robia G Pautler, Eric Klan. Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 32. 2009-09-21. PMID:19666610. |
overexpression of sod-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of alzheimer's disease. |
2009-09-21 |
2023-08-12 |
mouse |
| Vikas Dhikav, Myank Verma, Kuljeet Anan. Is hypertension a predictor of hippocampal atrophy in Alzheimer's disease? International psychogeriatrics. vol 21. issue 4. 2009-09-17. PMID:19426579. |
is hypertension a predictor of hippocampal atrophy in alzheimer's disease? |
2009-09-17 |
2023-08-12 |
Not clear |
| Frédéric Peters, Fabienne Collette, Christian Degueldre, Virginie Sterpenich, Steve Majerus, Eric Salmo. The neural correlates of verbal short-term memory in Alzheimer's disease: an fMRI study. Brain : a journal of neurology. vol 132. issue Pt 7. 2009-09-09. PMID:19433442. |
at the same time, alzheimer's disease patients showed increased activation in several brain areas, including the left parahippocampus and hippocampus, suggesting that alzheimer's disease patients may recruit alternative recognition mechanisms when performing a short-term memory task. |
2009-09-09 |
2023-08-12 |
human |
| R R Schultz, C C de Castro, P H F Bertolucc. Memory with emotional content, brain amygdala and Alzheimer's disease. Acta neurologica Scandinavica. vol 120. issue 2. 2009-09-07. PMID:19154540. |
we studied the performance of alzheimer's disease (ad) patients and elderly controls using a memory battery with emotional content, and we correlated these results with the amygdala and hippocampus volume. |
2009-09-07 |
2023-08-12 |
Not clear |
| Ingemar Björkhem, Angel Cedazo-Minguez, Valerio Leoni, Steve Meane. Oxysterols and neurodegenerative diseases. Molecular aspects of medicine. vol 30. issue 3. 2009-09-07. PMID:19248803. |
in primary cultures of rat hippocampal cells 27-ohc is able to suppress expression of the activity regulated cytoskeleton-associated protein (arc), a protein important in memory consolidation which is reduced in patients with alzheimer's disease (ad). |
2009-09-07 |
2023-08-12 |
rat |
| Fernando J Sepúlveda, Carlos Opazo, Luis G Aguay. Alzheimer beta-amyloid blocks epileptiform activity in hippocampal neurons. Molecular and cellular neurosciences. vol 41. issue 4. 2009-09-07. PMID:19427381. |
alzheimer beta-amyloid blocks epileptiform activity in hippocampal neurons. |
2009-09-07 |
2023-08-12 |
Not clear |
| Michael I Miller, Carey E Priebe, Anqi Qiu, Bruce Fischl, Anthony Kolasny, Timothy Brown, Youngser Park, J Tilak Ratnanather, Evelina Busa, Jorge Jovicich, Peng Yu, Bradford C Dickerson, Randy L Buckne. Collaborative computational anatomy: an MRI morphometry study of the human brain via diffeomorphic metric mapping. Human brain mapping. vol 30. issue 7. 2009-09-03. PMID:18781592. |
the study was conducted on a population of 101 subjects including nondemented control subjects (n = 57) and subjects clinically diagnosed with alzheimer's disease (ad, n = 38) or semantic dementia (n = 6) with imaging data collected at washington university in st. louis, hippocampal structure annotated at the massachusetts general hospital, and anatomical shapes embedded into a metric shape space using large deformation diffeomorphic metric mapping (lddmm) at the johns hopkins university. |
2009-09-03 |
2023-08-12 |
human |
| Takashi Namba, Motoko Maekawa, Shigeki Yuasa, Shinichi Kohsaka, Shigeo Uchin. The Alzheimer's disease drug memantine increases the number of radial glia-like progenitor cells in adult hippocampus. Glia. vol 57. issue 10. 2009-09-02. PMID:19115386. |
the alzheimer's disease drug memantine increases the number of radial glia-like progenitor cells in adult hippocampus. |
2009-09-02 |
2023-08-12 |
mouse |
| Marta Barrachina, Isidre Ferre. DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. Journal of neuropathology and experimental neurology. vol 68. issue 8. 2009-09-01. PMID:19606065. |
dna methylation was analyzed in selected regions of mapt, app, and psen1 in the frontal cortex and hippocampus of controls (n=26) and those with alzheimer disease at stages i to ii (n=17); alzheimer disease at stages iii to iv (n=15); alzheimer disease at stages v to vi (n=12); argyrophilic grain disease (n=10); frontotemporal lobar degeneration linked to tau mutations (n=6); frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions (n=4); frontotemporal lobar degeneration with motor neuron disease (n=3); pick disease (n=3); parkinson disease (n=8); dementia with lewy bodies, pure form (n=5); and dementia with lewy bodies, common form (n=15). |
2009-09-01 |
2023-08-12 |
human |