| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Macarena S Arrázola, Lorena Varela-Nallar, Marcela Colombres, Enrique M Toledo, Fernando Cruzat, Leonardo Pavez, Rodrigo Assar, Andrés Aravena, Mauricio González, Martín Montecino, Alejandro Maass, Servet Martínez, Nibaldo C Inestros. Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway. Journal of cellular physiology. vol 221. issue 3. 2009-11-13. PMID:19711354. |
we report here that: (a) a bioinformatic analysis of 15,476 promoters of the human genome predicted several wnt target genes, being camkiv a very interesting candidate; (b) camkiv promoter contains tcf/lef transcription motifs similar to those present in wnt target genes; (c) biochemical studies indicate that lithium and the canonical ligand wnt-3a induce camkiv mrna and protein expression levels in rat hippocampal neurons as well as camkiv promoter activity; (d) treatment of hippocampal neurons with wnt-3a increases the binding of beta-catenin to the camkiv promoter: (e) in vivo activation of the wnt signaling improve spatial memory impairment and restores the expression of camkiv in a mice double transgenic model for alzheimer's disease which shows decreased levels of the kinase. |
2009-11-13 |
2023-08-12 |
mouse |
| W J P Henneman, H Vrenken, J Barnes, I C Sluimer, N A Verwey, M A Blankenstein, M Klein, N C Fox, P Scheltens, F Barkhof, W M van der Flie. Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease. Neurology. vol 73. issue 12. 2009-11-13. PMID:19770469. |
baseline csf p-tau levels independently predict progression of hippocampal atrophy in alzheimer disease. |
2009-11-13 |
2023-08-12 |
Not clear |
| W J P Henneman, H Vrenken, J Barnes, I C Sluimer, N A Verwey, M A Blankenstein, M Klein, N C Fox, P Scheltens, F Barkhof, W M van der Flie. Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease. Neurology. vol 73. issue 12. 2009-11-13. PMID:19770469. |
to investigate whether baseline csf biomarkers are associated with hippocampal atrophy rate as a measure of disease progression in patients with alzheimer disease (ad), patients with mild cognitive impairment (mci), and controls, controlling for baseline neuropsychological and mri findings. |
2009-11-13 |
2023-08-12 |
Not clear |
| Oscar Acosta, Pierrick Bourgeat, Maria A Zuluaga, Jurgen Fripp, Olivier Salvado, Sébastien Ourseli. Automated voxel-based 3D cortical thickness measurement in a combined Lagrangian-Eulerian PDE approach using partial volume maps. Medical image analysis. vol 13. issue 5. 2009-11-10. PMID:19648050. |
significant differences in the hippocampus and temporal lobe between healthy controls (nc), mild cognitive impaired (mci) and alzheimer's disease (ad) patients were found on clinical data from the adni database. |
2009-11-10 |
2023-08-12 |
Not clear |
| Pu Chen, Aiguo Shen, Wei Zhao, Seong-Joon Baek, Hua Yuan, Jiming H. Raman signature from brain hippocampus could aid Alzheimer's disease diagnosis. Applied optics. vol 48. issue 24. 2009-11-04. PMID:19696863. |
raman signature from brain hippocampus could aid alzheimer's disease diagnosis. |
2009-11-04 |
2023-08-12 |
rat |
| Pu Chen, Aiguo Shen, Wei Zhao, Seong-Joon Baek, Hua Yuan, Jiming H. Raman signature from brain hippocampus could aid Alzheimer's disease diagnosis. Applied optics. vol 48. issue 24. 2009-11-04. PMID:19696863. |
micro-raman spectroscopy (mrs) is used for the first time to our knowledge to investigate brain hippocampus tissue from alzheimer's disease (ad) infected rats. |
2009-11-04 |
2023-08-12 |
rat |
| R J Wurtman, M Cansev, I H Ulu. Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides. The journal of nutrition, health & aging. vol 13. issue 3. 2009-11-03. PMID:19262950. |
the loss of cortical and hippocampal synapses is a universal hallmark of alzheimer's disease, and probably underlies its effects on cognition. |
2009-11-03 |
2023-08-12 |
Not clear |
| Claus Kiefer, Lisa Brockhaus, Katja Cattapan-Ludewig, Pietro Ballinari, Yuliya Burren, Gerhard Schroth, Roland Wies. Multi-parametric classification of Alzheimer's disease and mild cognitive impairment: the impact of quantitative magnetization transfer MR imaging. NeuroImage. vol 48. issue 4. 2009-10-30. PMID:19607926. |
in this study we address the question, if disease related quantitative magnetization transfer effects (qmt) within the intra- and extracellular matrices of the hippocampus may aid in the differentiation between clinically diagnosed patients with alzheimer disease (ad), patients with mild cognitive impairment (mci) and healthy controls. |
2009-10-30 |
2023-08-12 |
human |
| Chi-Wei Huang, Chun-Chung Lui, Weng-Neng Chang, Cheng-Hsien Lu, Ya-Ling Wang, Chiung-Chih Chan. Elevated basal cortisol level predicts lower hippocampal volume and cognitive decline in Alzheimer's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 16. issue 10. 2009-10-27. PMID:19570680. |
elevated basal cortisol level predicts lower hippocampal volume and cognitive decline in alzheimer's disease. |
2009-10-27 |
2023-08-12 |
Not clear |
| Chi-Wei Huang, Chun-Chung Lui, Weng-Neng Chang, Cheng-Hsien Lu, Ya-Ling Wang, Chiung-Chih Chan. Elevated basal cortisol level predicts lower hippocampal volume and cognitive decline in Alzheimer's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 16. issue 10. 2009-10-27. PMID:19570680. |
elevated glucocorticoid concentrations, decreased hippocampal volume and frontal atrophy with poor cognitive function have been reported in the elderly but not extensively in alzheimer's disease (ad). |
2009-10-27 |
2023-08-12 |
Not clear |
| Catherine E Myers, Alan Kluger, James Golomb, Mark A Gluck, Steven Ferri. Learning and generalization tasks predict short-term cognitive outcome in nondemented elderly. Journal of geriatric psychiatry and neurology. vol 21. issue 2. 2009-10-20. PMID:18474718. |
it was examined whether prediction accuracy can be improved by adding a discrimination-and-generalization task that has previously been shown to be disrupted in nondemented elderly with hippocampal atrophy, a risk factor for alzheimer disease. |
2009-10-20 |
2023-08-12 |
Not clear |
| Estelle Leclerc, Emmanuel Sturchler, Stefan W Vetter, Claus W Heizman. Crosstalk between calcium, amyloid beta and the receptor for advanced glycation endproducts in Alzheimer's disease. Reviews in the neurosciences. vol 20. issue 2. 2009-10-20. PMID:19774788. |
hallmarks of alzheimer's disease (ad) include the accumulation of amyloid beta peptide (abeta), hyperphosphorylation of tau protein, and increased inflammatory activity in the hippocampus and cerebral cortex. |
2009-10-20 |
2023-08-12 |
Not clear |
| Masahiko Iwakiri, Katsuyoshi Mizukami, Milos D Ikonomovic, Masanori Ishikawa, Eric E Abrahamson, Steven T DeKosky, Takashi Asad. An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 29. issue 3. 2009-10-19. PMID:19019179. |
an immunohistochemical study of gaba a receptor gamma subunits in alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression. |
2009-10-19 |
2023-08-12 |
human |
| Masahiko Iwakiri, Katsuyoshi Mizukami, Milos D Ikonomovic, Masanori Ishikawa, Eric E Abrahamson, Steven T DeKosky, Takashi Asad. An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 29. issue 3. 2009-10-19. PMID:19019179. |
immunohistochemical characterization of the distribution of gaba(a) receptor subunits gamma1/3 and 2 in the hippocampus relative to neurofibrillary tangle (nft) pathology staging was performed in cognitively normal subjects (braak stage i/ii, n = 4) and two groups of alzheimer's disease (ad) patients (braak stage iii/iv, n = 4; braak stage v/vi, n = 8). |
2009-10-19 |
2023-08-12 |
human |
| Emilie Gerardin, Gaël Chételat, Marie Chupin, Rémi Cuingnet, Béatrice Desgranges, Ho-Sung Kim, Marc Niethammer, Bruno Dubois, Stéphane Lehéricy, Line Garnero, Francis Eustache, Olivier Collio. Multidimensional classification of hippocampal shape features discriminates Alzheimer's disease and mild cognitive impairment from normal aging. NeuroImage. vol 47. issue 4. 2009-10-15. PMID:19463957. |
multidimensional classification of hippocampal shape features discriminates alzheimer's disease and mild cognitive impairment from normal aging. |
2009-10-15 |
2023-08-12 |
Not clear |
| Emilie Gerardin, Gaël Chételat, Marie Chupin, Rémi Cuingnet, Béatrice Desgranges, Ho-Sung Kim, Marc Niethammer, Bruno Dubois, Stéphane Lehéricy, Line Garnero, Francis Eustache, Olivier Collio. Multidimensional classification of hippocampal shape features discriminates Alzheimer's disease and mild cognitive impairment from normal aging. NeuroImage. vol 47. issue 4. 2009-10-15. PMID:19463957. |
we describe a new method to automatically discriminate between patients with alzheimer's disease (ad) or mild cognitive impairment (mci) and elderly controls, based on multidimensional classification of hippocampal shape features. |
2009-10-15 |
2023-08-12 |
Not clear |
| Matthias L Schroeter, Timo Stein, Nina Maslowski, Jane Neuman. Neural correlates of Alzheimer's disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients. NeuroImage. vol 47. issue 4. 2009-10-15. PMID:19463961. |
the meta-analysis reveals that early alzheimer's disease affects structurally the (trans-)entorhinal and hippocampal regions, functionally the inferior parietal lobules and precuneus. |
2009-10-15 |
2023-08-12 |
human |
| Tatsuo Kimura, Phuong Thi Hong Nguyen, Son Anh Ho, Anh Hai Tran, Taketoshi Ono, Hisao Nishij. T-817MA, a neurotrophic agent, ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-beta peptide. British journal of pharmacology. vol 157. issue 3. 2009-10-14. PMID:19371351. |
deficient neurogenesis may be responsible for deficient hippocampal functions in neurodegenerative disorders such as alzheimer's disease (ad). |
2009-10-14 |
2023-08-12 |
rat |
| Selma Aybek, Francois Lazeyras, Aline Gronchi-Perrin, Pierre R Burkhard, Jean-Guy Villemure, Francois J G Vingerhoet. Hippocampal atrophy predicts conversion to dementia after STN-DBS in Parkinson's disease. Parkinsonism & related disorders. vol 15. issue 7. 2009-10-12. PMID:19349206. |
hippocampal atrophy (ha) is a known predictor of dementia in alzheimer's disease. |
2009-10-12 |
2023-08-12 |
Not clear |
| Wei-guo Xue, Zhong Zhang, Li-min Bai, Hong Xu, Hai-xia W. [Effect of electroacupuncture on the behavior and the expression of amyloid beta-protein, amyloid precursor protein and ChAT in APP 695 V 717 I transgenic mice]. Zhen ci yan jiu = Acupuncture research. vol 34. issue 3. 2009-10-08. PMID:19761106. |
to observe the effect of electroacupuncture (ea) on the expression of amyloid precursor protein (app) and amyloid beta-protein (abeta) in hippocampal ca 1 area and cerebral cortex in app 695 v717 i transgenic mice, so as to investigate its underlying mechanism in improving alzheimer's disease (ad). |
2009-10-08 |
2023-08-12 |
mouse |