| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christiane Reitz, Adam M Brickman, Truman R Brown, Jennifer Manly, Charles DeCarli, Scott A Small, Richard Mayeu. Linking hippocampal structure and function to memory performance in an aging population. Archives of neurology. vol 66. issue 11. 2009-12-16. PMID:19901171. |
hippocampal atrophy and reductions in basal cerebral blood volume (cbv), a hemodynamic correlate of brain function, occur with cognitive impairment in alzheimer disease, but whether these are early or late changes remains unclear. |
2009-12-16 |
2023-08-12 |
Not clear |
| Luca Ferrarini, Giovanni B Frisoni, Michela Pievani, Johan H C Reiber, Rossana Ganzola, Julien Mille. Morphological hippocampal markers for automated detection of Alzheimer's disease and mild cognitive impairment converters in magnetic resonance images. Journal of Alzheimer's disease : JAD. vol 17. issue 3. 2009-12-15. PMID:19433888. |
morphological hippocampal markers for automated detection of alzheimer's disease and mild cognitive impairment converters in magnetic resonance images. |
2009-12-15 |
2023-08-12 |
human |
| Luca Ferrarini, Giovanni B Frisoni, Michela Pievani, Johan H C Reiber, Rossana Ganzola, Julien Mille. Morphological hippocampal markers for automated detection of Alzheimer's disease and mild cognitive impairment converters in magnetic resonance images. Journal of Alzheimer's disease : JAD. vol 17. issue 3. 2009-12-15. PMID:19433888. |
in this study, we investigated the use of hippocampal shape-based markers for automatic detection of alzheimer's disease (ad) and mild cognitive impairment converters (mci-c). |
2009-12-15 |
2023-08-12 |
human |
| Gary W Arendash, Takashi Mori, Chuanhai Cao, Malgorzata Mamcarz, Melissa Runfeldt, Alexander Dickson, Kavon Rezai-Zadeh, Jun Tane, Bruce A Citron, Xiaoyang Lin, Valentina Echeverria, Huntington Potte. Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice. Journal of Alzheimer's disease : JAD. vol 17. issue 3. 2009-12-15. PMID:19581722. |
we have recently shown that alzheimer's disease (ad) transgenic mice given a moderate level of caffeine intake (the human equivalent of 5 cups of coffee per day) are protected from development of otherwise certain cognitive impairment and have decreased hippocampal amyloid-beta (abeta) levels due to suppression of both beta-secretase (bace1) and presenilin 1 (ps1)/gamma-secretase expression. |
2009-12-15 |
2023-08-12 |
mouse |
| Sebastian Mirochnic, Susanne Wolf, Matthias Staufenbiel, Gerd Kemperman. Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease. Hippocampus. vol 19. issue 10. 2009-12-14. PMID:19219917. |
age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the app23 mouse model of alzheimer disease. |
2009-12-14 |
2023-08-12 |
mouse |
| Ilona Zemlyak, Nathan Manley, Inna Vulih-Shultzman, Andrew B Cutler, Kevin Graber, Robert M Sapolsky, Illana Goze. The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy. Journal of neurochemistry. vol 111. issue 5. 2009-12-11. PMID:19799711. |
nap (napvsipq, generic name, davunetide), a neuroprotective peptide in clinical development for neuroprotection against alzheimer's disease and other neurodegenerative indications, has been recently shown to provide protection against kainic acid excitotoxicity in hippocampal neuronal cultures. |
2009-12-11 |
2023-08-12 |
human |
| Jason Appel, Elizabeth Potter, Qian Shen, Gustavo Pantol, Maria T Greig, David Loewenstein, Ranjan Duar. A comparative analysis of structural brain MRI in the diagnosis of Alzheimer's disease. Behavioural neurology. vol 21. issue 1. 2009-12-09. PMID:19847041. |
the gold standard for alzheimer's diagnosis remains histological identification of amyloid plaques and neurofibrillary tangles within the medial temporal lobe, more specifically the entorhinal cortex and hippocampus. |
2009-12-09 |
2023-08-12 |
Not clear |
| G T Stebbins, C M Murph. Diffusion tensor imaging in Alzheimer's disease and mild cognitive impairment. Behavioural neurology. vol 21. issue 1. 2009-12-09. PMID:19847044. |
structural magnetic resonance imaging (mri) studies of alzheimer's disease and mild cognitive impairment (mci) have focused on the hippocampus and entorhinal cortex; gray matter structures in the medial temporal lobe. |
2009-12-09 |
2023-08-12 |
Not clear |
| Yan-Jiang Wang, Anthony Pollard, Jin-Hua Zhong, Xiao-Yan Dong, Xiao-Bing Wu, Hua-Dong Zhou, Xin-Fu Zho. Intramuscular delivery of a single chain antibody gene reduces brain Abeta burden in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 30. issue 3. 2009-12-07. PMID:17686552. |
hippocampus delivery of the scfv gene was effective in reducing the amyloid plaque in the hippocampus of an alzheimer's disease (ad) mouse model. |
2009-12-07 |
2023-08-12 |
mouse |
| Josephine Barnes, Jonathan W Bartlett, Laura A van de Pol, Clement T Loy, Rachael I Scahill, Chris Frost, Paul Thompson, Nick C Fo. A meta-analysis of hippocampal atrophy rates in Alzheimer's disease. Neurobiology of aging. vol 30. issue 11. 2009-12-07. PMID:18346820. |
a meta-analysis of hippocampal atrophy rates in alzheimer's disease. |
2009-12-07 |
2023-08-12 |
human |
| Josephine Barnes, Jonathan W Bartlett, Laura A van de Pol, Clement T Loy, Rachael I Scahill, Chris Frost, Paul Thompson, Nick C Fo. A meta-analysis of hippocampal atrophy rates in Alzheimer's disease. Neurobiology of aging. vol 30. issue 11. 2009-12-07. PMID:18346820. |
hippocampal atrophy rates are useful in both diagnosing and tracking alzheimer's disease (ad). |
2009-12-07 |
2023-08-12 |
human |
| Carla M Yuede, Scott D Zimmerman, Hongxin Dong, Matthew J Kling, Adam W Bero, David M Holtzman, Benjamin F Timson, John G Csernansk. Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease. Neurobiology of disease. vol 35. issue 3. 2009-12-03. PMID:19524672. |
effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the tg2576 mouse model of alzheimer's disease. |
2009-12-03 |
2023-08-12 |
mouse |
| Carla M Yuede, Scott D Zimmerman, Hongxin Dong, Matthew J Kling, Adam W Bero, David M Holtzman, Benjamin F Timson, John G Csernansk. Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease. Neurobiology of disease. vol 35. issue 3. 2009-12-03. PMID:19524672. |
we examined the effects of voluntary (16 weeks of wheel running) and forced (16 weeks of treadmill running) exercise on memory-related behavior, hippocampal volume, thioflavine-stained plaque number, and soluble abeta levels in brain tissue in the tg2576 mouse model of alzheimer's disease (ad). |
2009-12-03 |
2023-08-12 |
mouse |
| Barbara Biscaro, Olle Lindvall, Christoph Hock, Christine T Ekdahl, Roger M Nitsc. Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 45. 2009-12-02. PMID:19906959. |
the hippocampus is heavily affected by progressive neurodegeneration and beta-amyloid pathology in alzheimer's disease (ad). |
2009-12-02 |
2023-08-12 |
mouse |
| Nicolas G Baza. Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. Prostaglandins, leukotrienes, and essential fatty acids. vol 81. issue 2-3. 2009-11-23. PMID:19520558. |
npd1 was found to be reduced in the alzheimer's disease (ad) cornu ammonis region 1 (ca1) hippocampal region, but not in other areas of the brain. |
2009-11-23 |
2023-08-12 |
human |
| Evelin L Schaeffer, Barbara A Novaes, Emanuelle R da Silva, Heni D Skaf, Alvaro G Mendes-Net. Strategies to promote differentiation of newborn neurons into mature functional cells in Alzheimer brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 7. 2009-11-17. PMID:19596396. |
alzheimer disease (ad) is characterized by neuron loss in the hippocampus (dg and ca1 field), entorhinal cortex, and association neocortex, which underlies the learning and memory deficits. |
2009-11-17 |
2023-08-12 |
Not clear |
| Keun W Park, Hyung H Baik, Byung K Ji. IL-13-induced oxidative stress via microglial NADPH oxidase contributes to death of hippocampal neurons in vivo. Journal of immunology (Baltimore, Md. : 1950). vol 183. issue 7. 2009-11-16. PMID:19752235. |
to our knowledge, the present study is the first to show that il-13 triggers microglial nadph oxidase-derived oxidative stress, leading to the degeneration of hippocampal neurons in vivo, as occurs in cases of alzheimer's disease. |
2009-11-16 |
2023-08-12 |
Not clear |
| Jonathan H Morra, Zhuowen Tu, Liana G Apostolova, Amity E Green, Christina Avedissian, Sarah K Madsen, Neelroop Parikshak, Xue Hua, Arthur W Toga, Clifford R Jack, Norbert Schuff, Michael W Weiner, Paul M Thompso. Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Human brain mapping. vol 30. issue 9. 2009-11-13. PMID:19172649. |
automated 3d mapping of hippocampal atrophy and its clinical correlates in 400 subjects with alzheimer's disease, mild cognitive impairment, and elderly controls. |
2009-11-13 |
2023-08-12 |
human |
| Jonathan H Morra, Zhuowen Tu, Liana G Apostolova, Amity E Green, Christina Avedissian, Sarah K Madsen, Neelroop Parikshak, Xue Hua, Arthur W Toga, Clifford R Jack, Norbert Schuff, Michael W Weiner, Paul M Thompso. Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Human brain mapping. vol 30. issue 9. 2009-11-13. PMID:19172649. |
we used a new method we developed for automated hippocampal segmentation, called the auto context model, to analyze brain mri scans of 400 subjects from the alzheimer's disease neuroimaging initiative. |
2009-11-13 |
2023-08-12 |
human |
| Jonathan H Morra, Zhuowen Tu, Liana G Apostolova, Amity E Green, Christina Avedissian, Sarah K Madsen, Neelroop Parikshak, Xue Hua, Arthur W Toga, Clifford R Jack, Norbert Schuff, Michael W Weiner, Paul M Thompso. Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Human brain mapping. vol 30. issue 9. 2009-11-13. PMID:19172649. |
after training the classifier on 21 hand-labeled expert segmentations, we created binary maps of the hippocampus for three age- and sex-matched groups: 100 subjects with alzheimer's disease (ad), 200 with mild cognitive impairment (mci) and 100 elderly controls (mean age: 75.84; sd: 6.64). |
2009-11-13 |
2023-08-12 |
human |