| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liana G Apostolova, Paul M Thompson, Amity E Green, Kristy S Hwang, Charleen Zoumalan, Clifford R Jack, Danielle J Harvey, Ronald C Petersen, Leon J Thal, Paul S Aisen, Arthur W Toga, Jeffrey L Cummings, Charles S Decarl. 3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI. Human brain mapping. vol 31. issue 5. 2010-07-08. PMID:20143386. |
sixty percent of the subjects with none to mild hippocampal atrophy rated with the visual medial temporal atrophy rating scale (mta score < 2) and 33.8% of the subjects with moderate to severe (mta > or = 2) hippocampal atrophy converted to alzheimer's disease (ad) during 3-year follow-up. |
2010-07-08 |
2023-08-12 |
human |
| b' Bruno P Imbimbo, Luciana Giardino, Sandra Sivilia, Alessandro Giuliani, Marco Gusciglio, Vladimiro Pietrini, Elda Del Giudice, Antonello D\'Arrigo, Alberta Leon, Gino Villetti, Laura Calz\\xc3\\xa. CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer\'s disease. Journal of Alzheimer\'s disease : JAD. vol 20. issue 1. 2010-07-08. PMID:20164581.' |
chf5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of alzheimer's disease. |
2010-07-08 |
2023-08-12 |
mouse |
| Xiu-Li Shang, Jiu-Han Zhao, Yun-Peng Cao, Yi-Xue Xu. Effects of synaptic plasticity regulated by 17beta-estradiol on learning and memory in rats with Alzheimer's disease. Neuroscience bulletin. vol 26. issue 2. 2010-07-07. PMID:20332818. |
to investigate whether estrogen modulates learning and memory and long-term potentiation (ltp) in the hippocampus of rats with alzheimer's disease (ad). |
2010-07-07 |
2023-08-12 |
rat |
| Orly Lazarov, Robert A Mar. Neurogenesis and Alzheimer's disease: at the crossroads. Experimental neurology. vol 223. issue 2. 2010-07-01. PMID:19699201. |
while a massive and progressive neuronal loss in specific areas such as the hippocampus and cortex unequivocally underlies cognitive deterioration and memory loss in alzheimer's disease, noteworthy alterations take place in the neurogenic microenvironments, namely, the subgranule layer of the dentate gyrus and the subventricular zone. |
2010-07-01 |
2023-08-12 |
Not clear |
| Yui Yamamoto, Norifumi Shioda, Feng Han, Shigeki Moriguchi, Kohji Fukunag. [Donepezil-induced neuroprotection of acetylcholinergic neurons in olfactory bulbectomized mice]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 130. issue 5. 2010-07-01. PMID:20460870. |
in the brain of alzheimer's patients, the cholinergic neurons innervated the hippocampus and cerebral cortex degenerates before accumulation of beta-amyloid protein. |
2010-07-01 |
2023-08-12 |
mouse |
| Lon Whit. Brain lesions at autopsy in older Japanese-American men as related to cognitive impairment and dementia in the final years of life: a summary report from the Honolulu-Asia aging study. Journal of Alzheimer's disease : JAD. vol 18. issue 3. 2010-06-30. PMID:19661625. |
they were: alzheimer lesions (neocortical neurofibrillary tangles and neuritic plaques), microvascular infarcts (microinfarcts and lacunar infarcts), neocortical lewy bodies, hippocampal sclerosis, and generalized brain atrophy. |
2010-06-30 |
2023-08-12 |
human |
| Lon Whit. Brain lesions at autopsy in older Japanese-American men as related to cognitive impairment and dementia in the final years of life: a summary report from the Honolulu-Asia aging study. Journal of Alzheimer's disease : JAD. vol 18. issue 3. 2010-06-30. PMID:19661625. |
about half of the hippocampal sclerosis cases appeared to be linked to alzheimer lesions. |
2010-06-30 |
2023-08-12 |
human |
| Il Han Choo, Dong Young Lee, Jungsu S Oh, Jae Sung Lee, Dong Soo Lee, In Chan Song, Jong Choul Youn, Shin Gyeom Kim, Ki Woong Kim, Jin Hyeong Jhoo, Jong Inn Wo. Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer's disease. Neurobiology of aging. vol 31. issue 5. 2010-06-28. PMID:18687503. |
this study aimed to investigate the atrophy of the posterior cingulate cortex (pcc) and medical temporal lobe (mtl) structures (i.e., the entorhinal cortex (erc) and hippocampus) and the regional disruption of the cingulum bundle in mild cognitive impairment (mci) and alzheimer's disease (ad) patients. |
2010-06-28 |
2023-08-12 |
Not clear |
| Shiv Sharm. Hepatocyte growth factor in synaptic plasticity and Alzheimer's disease. TheScientificWorldJournal. vol 10. 2010-06-24. PMID:20305987. |
this review describes the role of hgf in hippocampal neurons, synaptic plasticity, and the memory impairment condition, alzheimer's disease. |
2010-06-24 |
2023-08-12 |
Not clear |
| Jackalina M Van Kampen, Christopher B Eckma. Agonist-induced restoration of hippocampal neurogenesis and cognitive improvement in a model of cholinergic denervation. Neuropharmacology. vol 58. issue 6. 2010-06-23. PMID:20026137. |
loss of basal forebrain cholinergic innervation of the hippocampus and severe neuronal loss within the hippocampal ca1 region are early hallmarks of alzheimer's disease, and are strongly correlated with cognitive status. |
2010-06-23 |
2023-08-12 |
Not clear |
| Nathan A DeCarolis, Amelia J Eisc. Hippocampal neurogenesis as a target for the treatment of mental illness: a critical evaluation. Neuropharmacology. vol 58. issue 6. 2010-06-23. PMID:20060007. |
there are obvious applications and allures of this approach; for example, perhaps stimulating hippocampal neurogenesis would reverse the overt and noncontroversial hippocampal atrophy and functional deficits observed in alzheimer's disease and schizophrenia, or the more controversial hippocampal deficits seen in mdd and ptsd. |
2010-06-23 |
2023-08-12 |
Not clear |
| Andreana C Leskovjan, Ariane Kretlow, Lisa M Mille. Fourier transform infrared imaging showing reduced unsaturated lipid content in the hippocampus of a mouse model of Alzheimer's disease. Analytical chemistry. vol 82. issue 7. 2010-06-23. PMID:20187625. |
fourier transform infrared imaging showing reduced unsaturated lipid content in the hippocampus of a mouse model of alzheimer's disease. |
2010-06-23 |
2023-08-12 |
mouse |
| Masakazu Hashimoto, Nenad Bogdanovic, Inga Volkmann, Mikio Aoki, Bengt Winblad, Lars O Tjernber. Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Abeta42 and Alzheimer's disease neuropathology. Acta neuropathologica. vol 119. issue 5. 2010-06-22. PMID:20198479. |
in alzheimer's disease (ad), purkinje neurons in the cerebellum are spared, while, for instance, pyramidal neurons in the hippocampus are neuropathologically affected. |
2010-06-22 |
2023-08-12 |
human |
| Federica Agosta, Maria Assunta Rocca, Elisabetta Pagani, Martina Absinta, Giuseppe Magnani, Alessandra Marcone, Monica Falautano, Giancarlo Comi, Maria Luisa Gorno-Tempini, Massimo Filipp. Sensorimotor network rewiring in mild cognitive impairment and Alzheimer's disease. Human brain mapping. vol 31. issue 4. 2010-06-21. PMID:19777557. |
this study aimed at elucidating whether (a) brain areas associated with motor function show a change in functional magnetic resonance imaging (fmri) signal in amnestic mild cognitive impairment (amci) and alzheimer's disease (ad), (b) such change is linear over the course of the disease, and (c) fmri changes in amci and ad are driven by hippocampal atrophy, or, conversely, reflect a nonspecific neuronal network rewiring generically associated to brain tissue damage. |
2010-06-21 |
2023-08-12 |
Not clear |
| M W Marlatt, P J Lucasse. Neurogenesis and Alzheimer's disease: Biology and pathophysiology in mice and men. Current Alzheimer research. vol 7. issue 2. 2010-06-21. PMID:19860727. |
not surprising, investigators of alzheimer's disease have also evaluated adult neurogenesis due to its responsiveness to hippocampal damage. |
2010-06-21 |
2023-08-12 |
mouse |
| Takahide Kaji, Sawako Yoshida, Kunji Kawai, Yoshihiro Fuchigami, Wakako Watanabe, Hideo Kubodera, Toshimitsu Kishimot. ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells. Biochemical and biophysical research communications. vol 395. issue 2. 2010-06-21. PMID:20362554. |
the expression of testi4031745 was increased in rectum tumor and alzheimer's disease hippocampus and decreased in kidney tumor and alzheimer's disease frontal lobe. |
2010-06-21 |
2023-08-12 |
human |
| Hisaaki Takahashi, Ivona Brasnjevic, Bart P F Rutten, Nicolien Van Der Kolk, Daniel P Perl, Constantin Bouras, Harry W M Steinbusch, Christoph Schmitz, Patrick R Hof, Dara L Dickstei. Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease. Brain structure & function. vol 214. issue 2-3. 2010-06-15. PMID:20213270. |
hippocampal interneuron loss in an app/ps1 double mutant mouse and in alzheimer's disease. |
2010-06-15 |
2023-08-12 |
mouse |
| Hisaaki Takahashi, Ivona Brasnjevic, Bart P F Rutten, Nicolien Van Der Kolk, Daniel P Perl, Constantin Bouras, Harry W M Steinbusch, Christoph Schmitz, Patrick R Hof, Dara L Dickstei. Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease. Brain structure & function. vol 214. issue 2-3. 2010-06-15. PMID:20213270. |
hippocampal atrophy and neuron loss are commonly found in alzheimer's disease (ad). |
2010-06-15 |
2023-08-12 |
mouse |
| Mei-hong Shen, Qing-qing Tang, Zhong-ren Li, Cheng M. [Effect of electroacupuncture on hippocampal LTP in Alzheimer' s disease rats induced by Abeta(25-35)]. Zhen ci yan jiu = Acupuncture research. vol 35. issue 1. 2010-06-15. PMID:20458898. |
[effect of electroacupuncture on hippocampal ltp in alzheimer' s disease rats induced by abeta(25-35)]. |
2010-06-15 |
2023-08-12 |
rat |
| I K Tsamis, G D Mytilinaios, N S Njau, F D Fotiou, S Glaftsi, V Costa, J S Baloyanni. Properties of CA3 dendritic excrescences in Alzheimer's disease. Current Alzheimer research. vol 7. issue 1. 2010-06-09. PMID:20205674. |
in the present study, these dendritic structures were studied and compared in ca3 area of hippocampus in patients suffered from alzheimer's disease, age matched controls and young individuals. |
2010-06-09 |
2023-08-12 |
human |