| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Baglietto-Vargas, Ines Moreno-Gonzalez, Raquel Sanchez-Varo, Sebastian Jimenez, Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Manuel Torres, Manuel Romero-Acebal, Diego Ruano, Marisa Vizuete, Javier Vitorica, Antonia Gutierre. Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus. Journal of Alzheimer's disease : JAD. vol 21. issue 1. 2010-11-02. PMID:20413859. |
calretinin interneurons are early targets of extracellular amyloid-beta pathology in ps1/abetapp alzheimer mice hippocampus. |
2010-11-02 |
2023-08-12 |
mouse |
| Manjeet Singh, Ven Murthy, Charles Ramassam. Modulation of hydrogen peroxide and acrolein-induced oxidative stress, mitochondrial dysfunctions and redox regulated pathways by the Bacopa monniera extract: potential implication in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 21. issue 1. 2010-11-02. PMID:20421692. |
in brains of alzheimer's disease (ad) patients, levels of acrolein are significantly higher in vulnerable brain region and, on primary hippocampal culture, it is more toxic than 4-hydroxyl-nonenal. |
2010-11-02 |
2023-08-12 |
human |
| C Köhler, P Bista, J Götz, H Schröde. Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. Brain research. vol 1347. 2010-11-02. PMID:20513372. |
to test the suitability of the pr5 model as a model of alzheimer's disease concerning the cholinergic innervation of the telencephalon, we determined the expression of the human tau transgene and the presence of neurofibrillary changes in the basal nucleus of meynert, the septal nuclei and the diagonal band of broca, sources of cholinergic innervation of the cerebral cortex and hippocampus. |
2010-11-02 |
2023-08-12 |
mouse |
| Jin Hyeong Jhoo, Dong Young Lee, Il Han Choo, Eun Hyun Seo, Jungsu S Oh, Jae Sung Lee, Dong Soo Lee, Shin Gyeom Kim, Jong Chul Youn, Ki Woong Kim, Jong Inn Wo. Discrimination of normal aging, MCI and AD with multimodal imaging measures on the medial temporal lobe. Psychiatry research. vol 183. issue 3. 2010-10-26. PMID:20705437. |
this study aimed to compare the discrimination accuracy of hippocampal volume (hc-vol), parahippocampal cingulum fractional anisotropy (phc-fa), hippocampal glucose metabolism (hc-glu), and any combination of the three measurements among normal control (nc), mild cognitive impairment (mci), and alzheimer's disease (ad). |
2010-10-26 |
2023-08-12 |
human |
| Gry Houeland, Armando Romani, Cristina Marchetti, Gianluca Amato, Simona Capsoni, Antonino Cattaneo, Hélène Mari. Transgenic mice with chronic NGF deprivation and Alzheimer's disease-like pathology display hippocampal region-specific impairments in short- and long-term plasticities. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 39. 2010-10-25. PMID:20881126. |
transgenic mice with chronic ngf deprivation and alzheimer's disease-like pathology display hippocampal region-specific impairments in short- and long-term plasticities. |
2010-10-25 |
2023-08-12 |
mouse |
| Akhlaq A Farooqu. Studies on plasmalogen-selective phospholipase A2 in brain. Molecular neurobiology. vol 41. issue 2-3. 2010-10-08. PMID:20049656. |
activities of plsetn-pla(2) are markedly increased in plasma membrane and synaptosomal plasma membrane fraction prepared from nucleus basalis and hippocampal region of brains from alzheimer disease patients compared to age-matched controls. |
2010-10-08 |
2023-08-12 |
Not clear |
| Richard A Armstron. A spatial pattern analysis of beta-amyloid (Abeta) deposition in the temporal lobe in Alzheimer's disease. Folia neuropathologica. vol 48. issue 2. 2010-10-06. PMID:20602287. |
to determine the factors influencing the distribution of -amyloid (abeta) deposits in alzheimer's disease (ad), the spatial patterns of the diffuse, primitive, and classic a deposits were studied from the superior temporal gyrus (stg) to sector ca4 of the hippocampus in six sporadic cases of the disease. |
2010-10-06 |
2023-08-12 |
Not clear |
| Robin Wolz, Rolf A Heckemann, Paul Aljabar, Joseph V Hajnal, Alexander Hammers, Jyrki Lötjönen, Daniel Ruecker. Measurement of hippocampal atrophy using 4D graph-cut segmentation: application to ADNI. NeuroImage. vol 52. issue 1. 2010-09-30. PMID:20382238. |
the application to hippocampal atrophy measurement in 568 image pairs (baseline and month 12 follow-up) as well as 362 image triplets (baseline, month 12, and month 24) from the alzheimer's disease neuroimaging initiative (adni) confirms previous findings for atrophy in alzheimer's disease (ad) and healthy aging. |
2010-09-30 |
2023-08-12 |
human |
| Ana María Simón, Rakel López de Maturana, Ana Ricobaraza, Luis Escribano, Lucio Schiapparelli, Mar Cuadrado-Tejedor, Alberto Pérez-Mediavilla, Jesús Avila, Joaquín Del Río, Diana Frechill. Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 17. issue 4. 2010-09-22. PMID:19542617. |
early changes in hippocampal eph receptors precede the onset of memory decline in mouse models of alzheimer's disease. |
2010-09-22 |
2023-08-12 |
mouse |
| Zaheer Ul-Haq, Waqasuddin Khan, Saima Kalsoom, Farzana L Ansar. In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of beta-amyloid plaques associated with Alzheimer's disease. Theoretical biology & medical modelling. vol 7. 2010-09-17. PMID:20550720. |
alzheimer's disease, known to be associated with the gradual loss of memory, is characterized by low concentration of acetylcholine in the hippocampus and cortex part of the brain. |
2010-09-17 |
2023-08-12 |
Not clear |
| Sadayuki Hashioka, Andis Klegeris, Claudia Schwab, Sheng Yu, Patrick L McGee. Differential expression of interferon-gamma receptor on human glial cells in vivo and in vitro. Journal of neuroimmunology. vol 225. issue 1-2. 2010-09-16. PMID:20554027. |
to examine the glial expression of ifn-gamma-r in the human cns, immunohistochemistry and quantitative analyses were performed on alzheimer disease hippocampus, parkinson disease substantia nigra, amyotrophic lateral sclerosis spinal cord and corresponding areas from non-neurological cases. |
2010-09-16 |
2023-08-12 |
human |
| Zhi-qiang Xu, Jing Li, Juan Deng, Xiao-jiang Jiang, Hua-dong Zho. [Effects of proBDNF on cell proliferation and differentiation in hippocampal dentate gyrus in Alzheimer' disease rat model]. Zhonghua yi xue za zhi. vol 90. issue 19. 2010-09-09. PMID:20646587. |
[effects of probdnf on cell proliferation and differentiation in hippocampal dentate gyrus in alzheimer' disease rat model]. |
2010-09-09 |
2023-08-12 |
rat |
| Zhi-qiang Xu, Jing Li, Juan Deng, Xiao-jiang Jiang, Hua-dong Zho. [Effects of proBDNF on cell proliferation and differentiation in hippocampal dentate gyrus in Alzheimer' disease rat model]. Zhonghua yi xue za zhi. vol 90. issue 19. 2010-09-09. PMID:20646587. |
to explore the effects of probdnf on cell proliferation and differentiation in hippocampal dentate gyrus in alzheimer' disease (ad) rat model. |
2010-09-09 |
2023-08-12 |
rat |
| Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20363218. |
the data show that nicotine (1mg/kg in base weight) treatment significantly exacerbates cognitive impairment and tau phosphorylation at ser-202 and thr-231 in the hippocampus compared with abeta25-35 injection groups in the abeta rat model of alzheimer's disease. |
2010-09-07 |
2023-08-12 |
rat |
| Vincent Villette, Frédérique Poindessous-Jazat, Axelle Simon, Clément Léna, Elodie Roullot, Brice Bellessort, Jacques Epelbaum, Patrick Dutar, Aline Stépha. Decreased rhythmic GABAergic septal activity and memory-associated theta oscillations after hippocampal amyloid-beta pathology in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 33. 2010-09-03. PMID:20720106. |
the memory deficits associated with alzheimer's disease result to a great extent from hippocampal network dysfunction. |
2010-09-03 |
2023-08-12 |
rat |
| Stefan J Teipel, Michael Ewers, Stefanie Wolf, Frank Jessen, Heike Kölsch, Sönke Arlt, Christian Luckhaus, Peter Schönknecht, Klaus Schmidtke, Isabella Heuser, Lutz Frölich, Gabriele Ende, Johannes Pantel, Jens Wiltfang, Fabian Rakebrandt, Oliver Peters, Christine Born, Johannes Kornhuber, Harald Hampe. Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease. Psychiatry research. vol 182. issue 3. 2010-08-31. PMID:20493672. |
this study assessed the effect of multicentre variability of mri-based hippocampus and amygdala volumetry on the discrimination between patients with alzheimer's disease (ad) and mild cognitive impairment (mci) and on the association of morphological changes with apoe4 genotype and cognition. |
2010-08-31 |
2023-08-12 |
Not clear |
| Nadia Gamboz, Stefania De Vito, Maria A Brandimonte, Stella Pappalardo, Filomena Galeone, Alessandro Iavarone, Sergio Della Sal. Episodic future thinking in amnesic mild cognitive impairment. Neuropsychologia. vol 48. issue 7. 2010-08-24. PMID:20381507. |
amnesic mci is a high-risk factor for alzheimer's disease and is characterized by a selective impairment of episodic memory, likely reflecting hippocampal malfunctioning. |
2010-08-24 |
2023-08-12 |
Not clear |
| Li Shen, Andrew J Saykin, Sungeun Kim, Hiram A Firpi, John D West, Shannon L Risacher, Brenna C McDonald, Tara L McHugh, Heather A Wishart, Laura A Flashma. Comparison of manual and automated determination of hippocampal volumes in MCI and early AD. Brain imaging and behavior. vol 4. issue 1. 2010-08-24. PMID:20454594. |
mri-based hippocampal volume analysis has been extensively employed given its potential as a biomarker for brain disorders such as alzheimer's disease (ad), and accurate and efficient determination of hippocampal volumes from brain images is still a challenging issue. |
2010-08-24 |
2023-08-12 |
human |
| Michael R Foy, Michel Baudry, Garnik K Akopian, Richard F Thompso. Regulation of hippocampal synaptic plasticity by estrogen and progesterone. Vitamins and hormones. vol 82. 2010-08-20. PMID:20472141. |
understanding the nonreproductive functions of estrogen and progesterone in the hippocampus has far-reaching implications not only for our basic understanding of neuroendocrinology and neurobiology, but also for developing better treatment of age-related diseases such as alzheimer's disease. |
2010-08-20 |
2023-08-12 |
Not clear |
| Michelangelo Mancuso, Daniele Orsucci, Annalisa LoGerfo, Valeria Calsolaro, Gabriele Sicilian. Clinical features and pathogenesis of Alzheimer's disease: involvement of mitochondria and mitochondrial DNA. Advances in experimental medicine and biology. vol 685. 2010-08-20. PMID:20687493. |
alzheimer's disease (ad) is a neurodegenerative disorder which results in the irreversible loss of cortical neurons, particularly in the associative neocortex and hippocampus. |
2010-08-20 |
2023-08-12 |
Not clear |