| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P J Whitehouse, W W Vale, R M Zweig, H S Singer, R Mayeux, M J Kuhar, D L Price, E B De Souz. Reductions in corticotropin releasing factor-like immunoreactivity in cerebral cortex in Alzheimer's disease, Parkinson's disease, and progressive supranuclear palsy. Neurology. vol 37. issue 6. 1987-07-01. PMID:3495748. |
reductions in corticotropin releasing factor-like immunoreactivity in cerebral cortex in alzheimer's disease, parkinson's disease, and progressive supranuclear palsy. |
1987-07-01 |
2023-08-11 |
Not clear |
| H Braak, E Braa. Argyrophilic grains: characteristic pathology of cerebral cortex in cases of adult onset dementia without Alzheimer changes. Neuroscience letters. vol 76. issue 1. 1987-06-29. PMID:2438598. |
argyrophilic grains: characteristic pathology of cerebral cortex in cases of adult onset dementia without alzheimer changes. |
1987-06-29 |
2023-08-11 |
Not clear |
| B Sauer, H W Dietl, H J Kretschmann, P Mehraei. A quantitative study of the cerebral cortex in Alzheimer's disease and senile dementia using an automatic image analyzing system. Journal fur Hirnforschung. vol 27. issue 6. 1987-06-09. PMID:3571965. |
a quantitative study of the cerebral cortex in alzheimer's disease and senile dementia using an automatic image analyzing system. |
1987-06-09 |
2023-08-11 |
Not clear |
| B Sauer, H W Dietl, H J Kretschmann, P Mehraei. A quantitative study of the cerebral cortex in Alzheimer's disease and senile dementia using an automatic image analyzing system. Journal fur Hirnforschung. vol 27. issue 6. 1987-06-09. PMID:3571965. |
an automatic image analysis system compared the laminar patterns in the straight gyrus of the cerebral cortex of deceased normal patients with those who died with alzheimer's disease and senile dementia. |
1987-06-09 |
2023-08-11 |
Not clear |
| A Fine, K Pittaway, M de Quidt, C Czudek, G P Reynold. Maintenance of cortical somatostatin and monoamine levels in the rat does not require intact cholinergic innervation. Brain research. vol 406. issue 1-2. 1987-06-05. PMID:2436718. |
these results render unlikely the possibility that non-cholinergic neurotransmitter deficits in alzheimer's disease cortex are the consequence of cholinergic degeneration. |
1987-06-05 |
2023-08-11 |
rat |
| H Tago, P L McGeer, E G McGee. Acetylcholinesterase fibers and the development of senile plaques. Brain research. vol 406. issue 1-2. 1987-06-05. PMID:3567634. |
these data provide direct evidence of an association between the cholinergic system of the basal forebrain and the early formation of senile plaques in the cortex in alzheimer's disease. |
1987-06-05 |
2023-08-11 |
rat |
| K J Reinikainen, P J Riekkinen, J Jolkkonen, V M Kosma, H Soinine. Decreased somatostatin-like immunoreactivity in cerebral cortex and cerebrospinal fluid in Alzheimer's disease. Brain research. vol 402. issue 1. 1987-05-14. PMID:3828777. |
decreased somatostatin-like immunoreactivity in cerebral cortex and cerebrospinal fluid in alzheimer's disease. |
1987-05-14 |
2023-08-11 |
Not clear |
| W F Maragos, D C Chu, A B Young, C J D'Amato, J B Penne. Loss of hippocampal [3H]TCP binding in Alzheimer's disease. Neuroscience letters. vol 74. issue 3. 1987-05-08. PMID:3031556. |
we have previously demonstrated a marked loss in n-methyl-d-aspartate (nmda) receptors in the hippocampus and cerebral cortex of patients dying with dementia of the alzheimer type (dat). |
1987-05-08 |
2023-08-11 |
Not clear |
| J A Hardy, D M Mann, P Wester, B Winbla. An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease. Neurobiology of aging. vol 7. issue 6. 1987-05-05. PMID:2882432. |
at the heart of this hypothesis lies a defect in blood brain barrier function and/or structure within the cerebral cortex and this defect may be the cause of the cerebral vessel amyloidosis common in many patients with alzheimer's disease. |
1987-05-05 |
2023-08-11 |
Not clear |
| C E Stokes, J N Hawthorn. Reduced phosphoinositide concentrations in anterior temporal cortex of Alzheimer-diseased brains. Journal of neurochemistry. vol 48. issue 4. 1987-04-22. PMID:3029323. |
the concentrations of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate were also lower in alzheimer cortex, but differences from the control group were not statistically significant. |
1987-04-22 |
2023-08-11 |
Not clear |
| E G McGeer, P L McGeer, H Kamo, H Tago, R Harro. Cortical metabolism, acetylcholinesterase staining and pathological changes in Alzheimer's disease. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 13. issue 4 Suppl. 1987-02-06. PMID:2431752. |
the lcmrgl declined in the cerebral cortex with age, but the decrement was significantly greater in the clinically diagnosed alzheimer's cases. |
1987-02-06 |
2023-08-11 |
Not clear |
| E G McGeer, P L McGeer, H Kamo, H Tago, R Harro. Cortical metabolism, acetylcholinesterase staining and pathological changes in Alzheimer's disease. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 13. issue 4 Suppl. 1987-02-06. PMID:2431752. |
acetylcholinesterase (ache) staining of the cerebral cortex in elderly normals and alzheimer's disease cases with a new, highly sensitive method showed that in alzheimer's disease there was an extensive loss of ache-positive fibers with senile plaques frequently incorporating ache-positive fiber debris. |
1987-02-06 |
2023-08-11 |
Not clear |
| J L Cumming. Subcortical dementia. Neuropsychology, neuropsychiatry, and pathophysiology. The British journal of psychiatry : the journal of mental science. vol 149. 1987-02-06. PMID:2878699. |
subcortical dementia contrasts neuropsychologically and anatomically with disorders such as dementia of the alzheimer type that affect primarily the cerebral cortex. |
1987-02-06 |
2023-08-11 |
Not clear |
| A A Sima, A W Clark, N A Sternberger, L A Sternberge. Lewy body dementia without Alzheimer changes. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 13. issue 4 Suppl. 1987-02-06. PMID:3024794. |
three patients with clinical alzheimer's disease were found at postmortem examination to have lewy-bodies and lewy-like bodies in the cerebral cortex and the pigmented brainstem nuclei. |
1987-02-06 |
2023-08-11 |
Not clear |
| P L McGeer, E G McGeer, H Kamo, K Won. Positron emission tomography and the possible origins of cytopathology in Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 10. issue 3-5. 1987-02-06. PMID:3541048. |
the local cerebral metabolic rate for glucose (lcmrgl), as determined by positron emission tomography (pet), declines in the cerebral cortex in alzheimer's disease; the severity of the decline parallels the severity of the dementia and correlates with regional cortical neuronal loss and glial proliferation. |
1987-02-06 |
2023-08-11 |
Not clear |
| P L McGeer, E G McGeer, H Kamo, K Won. Positron emission tomography and the possible origins of cytopathology in Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 10. issue 3-5. 1987-02-06. PMID:3541048. |
the cholinergic cells of the medial basal forebrain show a pathological dropout in alzheimer's disease which accounts for the decline in choline acetyltransferase in the cerebral cortex and hippocampus. |
1987-02-06 |
2023-08-11 |
Not clear |
| K Koshimura, T Kato, I Tohyama, S Nakamura, M Kameyam. Qualitative abnormalities of choline acetyltransferase in Alzheimer type dementia. Journal of the neurological sciences. vol 76. issue 2-3. 1987-02-05. PMID:3794747. |
the maximum activity of choline acetyltransferase (chat), the affinity for choline or acetyl-coa and the isozyme pattern in the cerebral cortex of 5 cases of alzheimer type dementia (atd) and 6 age-matched control subjects were examined post-mortem. |
1987-02-05 |
2023-08-11 |
human |
| C A Tamminga, N L Foster, P Fedio, E D Bird, T N Chas. Alzheimer's disease: low cerebral somatostatin levels correlate with impaired cognitive function and cortical metabolism. Neurology. vol 37. issue 1. 1987-02-03. PMID:2879258. |
loss of somatostatin-containing neurons, especially in the parietal association cortex, may be a critical determinant for alzheimer dementia. |
1987-02-03 |
2023-08-11 |
Not clear |
| D M Mann, N R Eaves, B Marcyniuk, P O Yate. Quantitative changes in cerebral cortical microvasculature in ageing and dementia. Neurobiology of aging. vol 7. issue 5. 1987-01-13. PMID:3785532. |
it is concluded that the extent of the capillary network in the cerebral cortex alters to match the number and activity of functioning nerve cells; changes in quantity of capillary occurring with age or alzheimer's disease may, therefore, secondarily reflect a primary loss of nerve cells and do not form, per se, part of the degenerative process. |
1987-01-13 |
2023-08-11 |
Not clear |
| Y Christe. [Does a pharmacological model of aging exist?]. Presse medicale (Paris, France : 1983). vol 15. issue 31. 1987-01-06. PMID:2947083. |
as for alzheimer's disease for which no natural animal model is known, new studies which involve surgical or chemical destruction of the cholinergic pathways leading to the cortex seem to be particularly promising for a better comprehension of degenerative processes in the neo-cortex. |
1987-01-06 |
2023-08-11 |
Not clear |