| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Defossez, J C Beauvillain, A Delacourte, M Mazzuc. Alzheimer's disease: a new evidence for common epitopes between microtubule associated protein Tau and paired helical filaments (PHF): demonstration at the electron microscope level by a double immunogold labelling. Virchows Archiv. A, Pathological anatomy and histopathology. vol 413. issue 2. 1988-08-05. PMID:2455379. |
the evidence for these common epitopes was studied on sections of cortex from alzheimer brains after araldite embedding. |
1988-08-05 |
2023-08-11 |
rabbit |
| A Defossez, J C Beauvillain, A Delacourte, M Mazzuc. Alzheimer's disease: a new evidence for common epitopes between microtubule associated protein Tau and paired helical filaments (PHF): demonstration at the electron microscope level by a double immunogold labelling. Virchows Archiv. A, Pathological anatomy and histopathology. vol 413. issue 2. 1988-08-05. PMID:2455379. |
two rabbit immune sera were used: one was raised against phf isolated from alzheimer cortex; the other against tau proteins extracted from bovine cortex. |
1988-08-05 |
2023-08-11 |
rabbit |
| A Najlerahim, D M Bowe. Biochemical measurements in Alzheimer's disease reveal a necessity for improved neuroimaging techniques to study metabolism. The Biochemical journal. vol 251. issue 1. 1988-08-05. PMID:3390157. |
a series of alzheimer's disease and control brains were dissected to determine the extent of atrophy (based on total protein content) and loss of choline acetyltransferase activity in the cerebral cortex from the entire surface of the diseased brains. |
1988-08-05 |
2023-08-11 |
Not clear |
| P Amouyel, A Gégonne, A Delacourte, A Défossez, D Stéheli. Expression of ETS proto-oncogenes in astrocytes in human cortex. Brain research. vol 447. issue 1. 1988-08-03. PMID:3289683. |
recently, a microduplication on chromosome 21 including ets2 locus was described in karyotypically 'normal' down's syndrome and suspected in alzheimer's disease; when testing alzheimer's disease-affected brain cortex sections, no obvious difference was observed with the technique used. |
1988-08-03 |
2023-08-11 |
human |
| A W Procter, S L Lowe, A M Palmer, P T Francis, M M Esiri, G C Stratmann, A Najlerahim, A J Patel, A Hunt, D M Bowe. Topographical distribution of neurochemical changes in Alzheimer's disease. Journal of the neurological sciences. vol 84. issue 2-3. 1988-07-18. PMID:2898011. |
these and the content of edaas and two related amino acids, and choline acetyltransferase (chat) activity have been measured in up to 13 areas of cerebral cortex and the cerebellar cortex from 16 patients with alzheimer's disease and 17 controls. |
1988-07-18 |
2023-08-11 |
human |
| S J Kish, L Schut, J Simmons, J Gilbert, L J Chang, M Rebbeto. Brain acetylcholinesterase activity is markedly reduced in dominantly-inherited olivopontocerebellar atrophy. Journal of neurology, neurosurgery, and psychiatry. vol 51. issue 4. 1988-07-15. PMID:3164041. |
the magnitude of the enzyme reduction in cerebral cortex was equal to or greater than that reported in brain of demented alzheimer's and parkinson's disease patients having loss of ache-containing nucleus basalis cholinergic neurons. |
1988-07-15 |
2023-08-11 |
Not clear |
| N W Kowall, M F Bea. Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: normal anatomy and alterations in Alzheimer's disease. Annals of neurology. vol 23. issue 2. 1988-07-14. PMID:2897822. |
somatostatin and neuropeptide y are two neuropeptides that are of particular interest in alzheimer's disease because they are reported to be depleted in cerebral cortex. |
1988-07-14 |
2023-08-11 |
Not clear |
| A Najlerahim, D M Bowe. Regional weight loss of the cerebral cortex and some subcortical nuclei in senile dementia of the Alzheimer type. Acta neuropathologica. vol 75. issue 5. 1988-07-14. PMID:3376753. |
regional weight loss of the cerebral cortex and some subcortical nuclei in senile dementia of the alzheimer type. |
1988-07-14 |
2023-08-11 |
Not clear |
| A Najlerahim, D M Bowe. Regional weight loss of the cerebral cortex and some subcortical nuclei in senile dementia of the Alzheimer type. Acta neuropathologica. vol 75. issue 5. 1988-07-14. PMID:3376753. |
all the cerebral cortex and some subcortical nuclei from six examples of senile dementia of the alzheimer type (sdat) and six age- and sex-matched controls have been dissected and weighed. |
1988-07-14 |
2023-08-11 |
Not clear |
| D M Armstrong, L B Hersh, F H Gag. Morphologic alterations of cholinergic processes in the neocortex of aged rats. Neurobiology of aging. vol 9. issue 2. 1988-06-24. PMID:3374737. |
the latter structures looked similar to the immunoreactive profiles observed in the cortex of patients with alzheimer's disease and in the rat septum following fimbria-fornix transection. |
1988-06-24 |
2023-08-11 |
rat |
| P J Whitehouse, A M Martino, M V Wagster, D L Price, R Mayeux, J R Atack, K J Kella. Reductions in [3H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study. Neurology. vol 38. issue 5. 1988-06-02. PMID:3362368. |
in alzheimer's disease (ad) and parkinson's disease (pd), dysfunction in the basal forebrain cholinergic system is accompanied by a consistent loss of presynaptic cholinergic markers in cortex, but changes in cholinergic receptor binding sites are poorly understood. |
1988-06-02 |
2023-08-11 |
human |
| P R Mouton, E M Meyer, A J Dunn, W Millard, G W Arendas. Induction of cortical cholinergic hypofunction and memory retention deficits through intracortical AF64A infusions. Brain research. vol 444. issue 1. 1988-05-31. PMID:3359282. |
since the primary cholinergic innervation to the fp cortex, originating in the nucleus basalis of meynert, appears to become dysfunctional (but not totally degenerative) in alzheimer's disease, cortical af64a infusions may closely reflect this cholinergic dysfunction by 'functionally' eliminating cortical cholinergic terminals. |
1988-05-31 |
2023-08-11 |
rat |
| T Arendt, G Taubert, V Bigl, A Arend. Amyloid deposition in the nucleus basalis of Meynert complex: a topographic marker for degenerating cell clusters in Alzheimer's disease. Acta neuropathologica. vol 75. issue 3. 1988-04-13. PMID:3348080. |
besides a constant involvement of the cerebral cortex and hippocampus, all cases of alzheimer's disease show a large amount of amyloid in the medial septal nucleus, in the diagonal band nucleus and in the substantia innominata which is correlated with neuronal loss in these areas. |
1988-04-13 |
2023-08-11 |
Not clear |
| G H Travis, J G Sutcliff. Phenol emulsion-enhanced DNA-driven subtractive cDNA cloning: isolation of low-abundance monkey cortex-specific mRNAs. Proceedings of the National Academy of Sciences of the United States of America. vol 85. issue 5. 1988-04-01. PMID:2894033. |
two of the lower-abundance mrnas were expressed at levels reduced by a factor of 10 in alzheimer disease relative to normal human cortex. |
1988-04-01 |
2023-08-11 |
human |
| E B De Souza, P J Whitehouse, S E Folstein, D L Price, W W Val. Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease. Brain research. vol 437. issue 2. 1988-03-25. PMID:2893655. |
in contrast to previously reported decreases in crh-ir in the cerebral cortex in alzheimer's disease, parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of crh-ir between controls and huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus. |
1988-03-25 |
2023-08-11 |
Not clear |
| Y Higuchi, T Miyakawa, A Shimoji, S Katsurag. Ultrastructural changes of blood vessels in the cerebral cortex in Alzheimer's disease. The Japanese journal of psychiatry and neurology. vol 41. issue 2. 1988-03-25. PMID:3437617. |
ultrastructural changes of blood vessels in the cerebral cortex in alzheimer's disease. |
1988-03-25 |
2023-08-11 |
Not clear |
| Y Uchida, Y Ihara, M Tomonag. Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats. Biochemical and biophysical research communications. vol 150. issue 3. 1988-03-23. PMID:3342070. |
cell cultures of neonatal rat cerebral cortex in a serum-free medium were used to investigate a lack of neuronotrophic factors in alzheimer's disease (ad) brain. |
1988-03-23 |
2023-08-11 |
rat |
| M L Cohen, T E Golde, M F Usiak, L H Younkin, S G Younki. In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 85. issue 4. 1988-03-21. PMID:3277188. |
our results demonstrate that beta-amyloid mrna is produced by neurons in the nucleus basalis of meynert and cerebral cortex and that nucleus basalis perikarya from alzheimer patients consistently hybridize more beta-amyloid probe than those from controls. |
1988-03-21 |
2023-08-11 |
Not clear |
| S B Zain, M Salim, W G Chou, E M Sajdel-Sulkowska, R E Majocha, C A Marott. Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex. Proceedings of the National Academy of Sciences of the United States of America. vol 85. issue 3. 1988-03-11. PMID:2893379. |
molecular cloning of amyloid cdna derived from mrna of the alzheimer disease brain: coding and noncoding regions of the fetal precursor mrna are expressed in the cortex. |
1988-03-11 |
2023-08-11 |
Not clear |
| H Kawasaki, S Murayama, M Tomonaga, N Izumiyama, H Shimad. Neurofibrillary tangles in human upper cervical ganglia. Morphological study with immunohistochemistry and electron microscopy. Acta neuropathologica. vol 75. issue 2. 1988-03-04. PMID:3434223. |
neurofibrillary tangles (nfts) are one of the main pathological hallmarks of alzheimer's disease or senile dementia, and are seen in the cerebral cortex and some other nuclei in the central nervous system (cns). |
1988-03-04 |
2023-08-11 |
human |