| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M M Mesulam, C Geula, M A Morá. Anatomy of cholinesterase inhibition in Alzheimer's disease: effect of physostigmine and tetrahydroaminoacridine on plaques and tangles. Annals of neurology. vol 22. issue 6. 1988-02-26. PMID:3435078. |
the histochemical distribution of cholinesterases in the cerebral cortex and their response to cholinesterase inhibitors such as physostigmine and tetrahydroaminoacridine (tha) were investigated in brains from patients with alzheimer's disease and control subjects. |
1988-02-26 |
2023-08-11 |
human |
| M M Mesulam, C Geula, M A Morá. Anatomy of cholinesterase inhibition in Alzheimer's disease: effect of physostigmine and tetrahydroaminoacridine on plaques and tangles. Annals of neurology. vol 22. issue 6. 1988-02-26. PMID:3435078. |
cholinesterase-containing normal axons (and in some cases cells) were severely depleted in the cerebral cortex of patients with alzheimer's disease. |
1988-02-26 |
2023-08-11 |
human |
| N W Kowall, K S Kosi. Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease. Annals of neurology. vol 22. issue 5. 1988-02-20. PMID:3122646. |
with optimal fixation and histochemical methods, we show the normal axonal location of tau protein in human cerebral cortex and the striking alterations of tau distribution that affect the cortical neuropil in alzheimer's disease. |
1988-02-20 |
2023-08-11 |
human |
| M W Decke. The effects of aging on hippocampal and cortical projections of the forebrain cholinergic system. Brain research. vol 434. issue 4. 1988-02-17. PMID:3319050. |
these observations suggest that unlike alzheimer's disease, normal aging does not reliably produce a degeneration of the cholinergic innervation of the hippocampus and cortex. |
1988-02-17 |
2023-08-11 |
Not clear |
| K Harada, W Krucke, J L Mancardi, T I Mandybu. Alzheimer's tangles in sudanophilic leukodystrophy. Neurology. vol 38. issue 1. 1988-02-16. PMID:3336464. |
the striking, unexpected finding was the presence of numerous alzheimer's tangles containing paired helical filaments in electronmicroscopic examination, not only in the cerebral cortex but also in the brainstem, basal ganglia, and hypothalamus including the nucleus basalis of meynert. |
1988-02-16 |
2023-08-11 |
Not clear |
| K J Kellar, P J Whitehouse, A M Martino-Barrows, K Marcus, D L Pric. Muscarinic and nicotinic cholinergic binding sites in Alzheimer's disease cerebral cortex. Brain research. vol 436. issue 1. 1988-02-16. PMID:3690354. |
muscarinic and nicotinic cholinergic binding sites in alzheimer's disease cerebral cortex. |
1988-02-16 |
2023-08-11 |
Not clear |
| K J Kellar, P J Whitehouse, A M Martino-Barrows, K Marcus, D L Pric. Muscarinic and nicotinic cholinergic binding sites in Alzheimer's disease cerebral cortex. Brain research. vol 436. issue 1. 1988-02-16. PMID:3690354. |
the total population of muscarinic receptors and a subpopulation of muscarinic receptors with high affinity for agonists were measured with [3h]quinuclidinyl benzilate and [3h]acetylcholine, respectively, in homogenates of cerebral cortex from control and alzheimer's disease brains. |
1988-02-16 |
2023-08-11 |
Not clear |
| K J Kellar, P J Whitehouse, A M Martino-Barrows, K Marcus, D L Pric. Muscarinic and nicotinic cholinergic binding sites in Alzheimer's disease cerebral cortex. Brain research. vol 436. issue 1. 1988-02-16. PMID:3690354. |
no significant differences between control and alzheimer's diseased cortex were found in either the total population of receptors or the subpopulation with high affinity for agonists in either the frontal or temporal poles. |
1988-02-16 |
2023-08-11 |
Not clear |
| K J Kellar, P J Whitehouse, A M Martino-Barrows, K Marcus, D L Pric. Muscarinic and nicotinic cholinergic binding sites in Alzheimer's disease cerebral cortex. Brain research. vol 436. issue 1. 1988-02-16. PMID:3690354. |
in contrast to muscarinic sites, binding to nicotinic sites was markedly decreased in alzheimer's disease cortex. |
1988-02-16 |
2023-08-11 |
Not clear |
| K J Kellar, P J Whitehouse, A M Martino-Barrows, K Marcus, D L Pric. Muscarinic and nicotinic cholinergic binding sites in Alzheimer's disease cerebral cortex. Brain research. vol 436. issue 1. 1988-02-16. PMID:3690354. |
autoradiography of [3h]acetylcholine binding to nicotinic sites indicated that in control cortex these sites are more concentrated in laminae iv-vi than in the superficial laminae, and that in alzheimer's disease there is loss of these sites in all cortical laminae. |
1988-02-16 |
2023-08-11 |
Not clear |
| S S Derderian, K R Rajagopal, B Jabbar. Respiratory control in presenile dementia. The American review of respiratory disease. vol 137. issue 1. 1988-02-10. PMID:3337457. |
to evaluate the role of the cerebral cortex in the response to externally added inspiratory flow-resistive load, we studied 7 patients manifesting clinical presenile dementia of the alzheimer's type. |
1988-02-10 |
2023-08-11 |
human |
| A Défossez, A Delacourt. Transformation of degenerating neurofibrils into amyloid substance in Alzheimer's disease: histochemical and immunohistochemical studies. Journal of the neurological sciences. vol 81. issue 1. 1988-01-20. PMID:2445923. |
degenerating neurofibrils (dnf), which are composed of paired helical filaments (phf) and amyloid fibrils (af), are the 2 characteristic pathological fibrillar deposits in alzheimer cortex. |
1988-01-20 |
2023-08-11 |
Not clear |
| A F Arnsten, P S Goldman-Raki. Noradrenergic mechanisms in age-related cognitive decline. Journal of neural transmission. Supplementum. vol 24. 1988-01-19. PMID:2824692. |
the data indicate that noradrenergic mechanisms play an important role in the functioning of the frontal association cortex, and support the rationale for giving alpha-2 agonists to restore this function in alzheimer's patients with profound norepinephrine loss. |
1988-01-19 |
2023-08-11 |
monkey |
| P J Whitehouse, K J Kella. Nicotinic and muscarinic cholinergic receptors in Alzheimer's disease and related disorders. Journal of neural transmission. Supplementum. vol 24. 1988-01-19. PMID:2960781. |
alzheimer's disease (ad) and parkinson's disease (pd) and to a lesser extent progressive supranuclear palsy are characterized by dysfunction of the cholinergic basal forebrain neurons which send projections to cortex and other areas of the telencephalon. |
1988-01-19 |
2023-08-11 |
Not clear |
| V M Vostriko. Electron-cytochemical study of acetylcholinesterase in the cerebral cortex in Alzheimer's disease. Neuroscience and behavioral physiology. vol 17. issue 4. 1987-12-22. PMID:3683828. |
electron-cytochemical study of acetylcholinesterase in the cerebral cortex in alzheimer's disease. |
1987-12-22 |
2023-08-11 |
Not clear |
| G M Cole, P S Timira. Ubiquitin-protein conjugates in Alzheimer's lesions. Neuroscience letters. vol 79. issue 1-2. 1987-12-09. PMID:2823191. |
neuritic plaques and neurofibrillary tangles in sections of alzheimer's cortex contain insoluble aggregates of proteins and are shown here to specifically immunostain with an antiserum to ubiquitin-protein conjugates. |
1987-12-09 |
2023-08-11 |
Not clear |
| A J Cross, P Slater, M Simpson, C Royston, J F Deakin, R H Perry, E K Perr. Sodium dependent D-[3H]aspartate binding in cerebral cortex in patients with Alzheimer's and Parkinson's diseases. Neuroscience letters. vol 79. issue 1-2. 1987-12-09. PMID:2823192. |
sodium dependent d-[3h]aspartate binding in cerebral cortex in patients with alzheimer's and parkinson's diseases. |
1987-12-09 |
2023-08-11 |
Not clear |
| G W Arendash, W J Millard, A J Dunn, E M Meye. Long-term neuropathological and neurochemical effects of nucleus basalis lesions in the rat. Science (New York, N.Y.). vol 238. issue 4829. 1987-12-09. PMID:2890210. |
bilateral lesions of the nucleus basalis magnocellularis increased somatostatin and neuropeptide y in the cortex of the rat by at least 138 and 284 percent, respectively, suggesting a functional interaction between cholinergic and peptidergic neurons that may differ from that in alzheimer's disease. |
1987-12-09 |
2023-08-11 |
rat |
| P L McGeer, S Itagaki, H Tago, E G McGee. Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR. Neuroscience letters. vol 79. issue 1-2. 1987-12-09. PMID:3670729. |
using immunohistochemical procedures with two specific monoclonal antibodies to hla-dr, hla-dr-positive reactive microglia were found in gray matter throughout the cortex of postmortem brains of patients with senile dementia of the alzheimer type (sdat) and were particularly concentrated in the areas of senile plaque formation. |
1987-12-09 |
2023-08-11 |
human |
| S Sorbi, S Piacentini, L Amaducc. Intralaminar distribution of neurotransmitter-related enzymes in cerebral cortex of Alzheimer's disease. Gerontology. vol 33. issue 3-4. 1987-11-20. PMID:3653702. |
intralaminar distribution of neurotransmitter-related enzymes in cerebral cortex of alzheimer's disease. |
1987-11-20 |
2023-08-11 |
human |