| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J de Belleroche, I M Gardiner, M H Hamilton, N J Birdsal. Analysis of muscarinic receptor concentration and subtypes following lesion of rat substantia innominata. Brain research. vol 340. issue 2. 1985-10-07. PMID:4027649. |
cholinergic neurones located in the nucleus basalis of meynert (nbm) in the substantia innominata (si) of primates are known to project to cerebral cortex and cell loss in nbm is thought to be associated with the cholinergic deficit seen in alzheimer's disease. |
1985-10-07 |
2023-08-11 |
rat |
| D M Mann, P O Yates, B Marcyniu. Changes in Alzheimer's disease in the magnocellular neurones of the supraoptic and paraventricular nuclei of the hypothalamus and their relationship to the noradrenergic deficit. Clinical neuropathology. vol 4. issue 3. 1985-09-09. PMID:3160517. |
this damage to the locus caeruleus and hypothalamic systems is probably responsible for losses of noradrenaline and vasopressin reported in cerebral cortex and hypothalamus; the importance of these changes to the pathogenesis of alzheimer's disease is emphasized. |
1985-09-09 |
2023-08-11 |
Not clear |
| M Globus, B Mildworf, E Melame. Cerebral blood flow and cognitive impairment in Parkinson's disease. Neurology. vol 35. issue 8. 1985-09-05. PMID:4022347. |
since rcbf is also decreased in alzheimer's dementia, it is theoretically possible that both decreases in rcbf and cognitive impairment in parkinsonians are caused by a similar mechanism, eg, reduced metabolic demand or loss of cholinergic neurons innervating cortex and microvessels. |
1985-09-05 |
2023-08-11 |
human |
| D M Mann, P O Yates, B Marcyniu. Correlation between senile plaque and neurofibrillary tangle counts in cerebral cortex and neuronal counts in cortex and subcortical structures in Alzheimer's disease. Neuroscience letters. vol 56. issue 1. 1985-08-12. PMID:4011048. |
correlation between senile plaque and neurofibrillary tangle counts in cerebral cortex and neuronal counts in cortex and subcortical structures in alzheimer's disease. |
1985-08-12 |
2023-08-11 |
Not clear |
| M F Beal, M F Mazurek, V T Tran, G Chattha, E D Bird, J B Marti. Reduced numbers of somatostatin receptors in the cerebral cortex in Alzheimer's disease. Science (New York, N.Y.). vol 229. issue 4710. 1985-08-09. PMID:2861661. |
reduced numbers of somatostatin receptors in the cerebral cortex in alzheimer's disease. |
1985-08-09 |
2023-08-11 |
Not clear |
| N M Borthwick, A Gordon, C M Yate. Reductions in soluble brain proteins in older subjects with Down's syndrome. Journal of the neurological sciences. vol 68. issue 2-3. 1985-07-29. PMID:3159852. |
in older down's syndrome cases, reductions in tubulin and 5 other proteins were observed in cortex which had the neuropathology of alzheimer's disease but not in caudate nucleus. |
1985-07-29 |
2023-08-11 |
human |
| K F Sheu, Y T Kim, J P Blass, M E Weksle. An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain. Annals of neurology. vol 17. issue 5. 1985-07-25. PMID:4004169. |
the activity of the pyruvate dehydrogenase complex (pdhc; ec 1.2.4.1, ec 2.3.1.12, and ec 1.6.4.3) was reduced to about 30% of control values in histologically unaffected occipital cortex of the brains of patients with alzheimer's disease, as well as in histologically affected frontal cortex. |
1985-07-25 |
2023-08-11 |
cattle |
| P R Stanfield, Y Nakajima, K Yamaguch. Substance P raises neuronal membrane excitability by reducing inward rectification. Nature. vol 315. issue 6019. 1985-07-24. PMID:2582270. |
these neurones have previously been shown to respond to substance p3 and are analogous to the nucleus basalis of meynert in man, which gives a diffuse projection to the cerebral cortex and whose degeneration is the likely cause of alzheimer's disease. |
1985-07-24 |
2023-08-11 |
rat |
| R Quirion, J Richard, T V Da. Evidence for the existence of serotonin type-2 receptors on cholinergic terminals in rat cortex. Brain research. vol 333. issue 2. 1985-07-23. PMID:3995301. |
therefore, further investigations on cholinergic-serotonergic interactions in the cortex and their possible involvement in senile dementia of the alzheimer's type appear to be highly relevant. |
1985-07-23 |
2023-08-11 |
rat |
| B Dubois, J J Hauw, M Ruberg, M Serdaru, F Javoy-Agid, Y Agi. [Dementia and Parkinson's disease: biochemical and anatomo-clinical correlation]. Revue neurologique. vol 141. issue 3. 1985-07-19. PMID:4001706. |
thirteen of the parkinsonian patients showed signs of intellectual decline (moderate in 8, severe in 5) and neuropathological examination of the cortex revealed in 10 cases large number of alzheimer type senile changes extending beyond the hippocampus. |
1985-07-19 |
2023-08-11 |
human |
| R Spector, A Kornber. Search for DNA alterations in Alzheimer's disease. Neurobiology of aging. vol 6. issue 1. 1985-06-27. PMID:3873626. |
the dna of brain cortex obtained from autopsy specimens of eight patients with alzheimer's disease and eight controls was examined for content of normal and abnormal bases. |
1985-06-27 |
2023-08-11 |
Not clear |
| D C Mash, D D Flynn, L T Potte. Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation. Science (New York, N.Y.). vol 228. issue 4703. 1985-06-20. PMID:3992249. |
loss of m2 muscarine receptors in the cerebral cortex in alzheimer's disease and experimental cholinergic denervation. |
1985-06-20 |
2023-08-11 |
rat |
| D C Mash, D D Flynn, L T Potte. Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation. Science (New York, N.Y.). vol 228. issue 4703. 1985-06-20. PMID:3992249. |
cerebral cortex samples from patients with alzheimer's disease and from rats after experimental cholinergic denervation of the cerebral cortex exhibited reductions in the presynaptic marker choline acetyltransferase activity and in the number of m2 muscarine receptors, with no change in the number of m1 receptors. |
1985-06-20 |
2023-08-11 |
rat |
| R W Jacobs, N Farivar, L L Butche. Alzheimer dementia and reduced nicotinamide adenine dinucleotide (NADH)-diaphorase activity in senile plaques and the basal forebrain. Neuroscience letters. vol 53. issue 1. 1985-06-06. PMID:3838807. |
the activity of reduced nicotinamide adenine dinucleotide (nadh)-diaphorase was examined histochemically in the amygdala, cortex and sublenticular substantia innominata (nucleus basalis of meynert) of patients with alzheimer's disease and senile dementia of the alzheimer type (sdat). |
1985-06-06 |
2023-08-11 |
Not clear |
| S L Marklund, R Adolfsson, C G Gottfries, B Winbla. Superoxide dismutase isoenzymes in normal brains and in brains from patients with dementia of Alzheimer type. Journal of the neurological sciences. vol 67. issue 3. 1985-05-29. PMID:3989575. |
cuzn superoxide dismutase and mn superoxide dismutase were analysed in hypothalamus, nucleus caudatus, hippocampus and cortex gyrus cinguli from 14 patients with dementia of alzheimer type and from 16 controls. |
1985-05-29 |
2023-08-11 |
Not clear |
| S Nakamura, K Koshimura, T Kato, S Yamao, S Iijima, H Nagata, S Miyata, K Fujiyoshi, K Okamoto, H Sug. Neurotransmitters in dementia. Clinical therapeutics. vol 7 Spec No. 1985-05-21. PMID:6152197. |
cat activity was low in the cerebral cortex of patients with senile dementia of alzheimer's type (sdat). |
1985-05-21 |
2023-08-12 |
human |
| D Dawbarn, P C Emso. Neuropeptide Y-like immunoreactivity in neuritic plaques of Alzheimer's disease. Biochemical and biophysical research communications. vol 126. issue 1. 1985-03-20. PMID:3838246. |
alzheimer's disease, a form of senile dementia, is characterized by the presence of neuritic plaques and neurofibrillary tangles throughout the cortex and hippocampus. |
1985-03-20 |
2023-08-11 |
Not clear |
| H P Schmitt, W Emser, C Heime. Familial occurrence of amyotrophic lateral sclerosis, parkinsonism, and dementia. Annals of neurology. vol 16. issue 6. 1985-03-15. PMID:6524873. |
postmortem examination revealed alzheimer's neurofibrillary tangles in the substantia nigra, innominata, locus ceruleus, parahippocampal gyrus, and less frequently in the hippocampus and the cerebral cortex. |
1985-03-15 |
2023-08-12 |
Not clear |
| N W Pedigo, L D Minor, T N Krumre. Cholinergic drug effects and brain muscarinic receptor binding in aged rats. Neurobiology of aging. vol 5. issue 3. 1985-02-21. PMID:6514108. |
cholinergic neurotransmission in cerebral cortex and hippocampus is also severely impaired in a major age-related neurological disorder, alzheimer's disease. |
1985-02-21 |
2023-08-12 |
rat |
| T McDuff, S M Sum. Subcortical degeneration in Alzheimer's disease. Neurology. vol 35. issue 1. 1985-02-05. PMID:3917560. |
although alzheimer's disease is generally considered a degenerative disease that primarily affects the cerebral cortex, subcortical structures such as the substantia innominata and certain brainstem nuclei may be involved. |
1985-02-05 |
2023-08-11 |
Not clear |