| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D M Jacobowitz, W E Heydor. Two-dimensional gel electrophoresis used in neurobiological studies of proteins in discrete areas of the rat brain. Clinical chemistry. vol 30. issue 12 Pt 1. 1985-01-17. PMID:6499172. |
finally, we developed a possible animal model for studying proteins related to alzheimer's disease by depleting the cholinergic innervation to the cortex and the hippocampus. |
1985-01-17 |
2023-08-12 |
rat |
| A Bignami, D J Selkoe, D Dah. Amyloid-like (Congophilic) neurofibrillary tangles do not react with neurofilament antisera in Alzheimer's cerebral cortex. Acta neuropathologica. vol 64. issue 3. 1984-12-14. PMID:6208743. |
amyloid-like (congophilic) neurofibrillary tangles do not react with neurofilament antisera in alzheimer's cerebral cortex. |
1984-12-14 |
2023-08-12 |
Not clear |
| N Amano, T Matsuishi, K Suzuki, S Yokoi, A Saitoh, S Yagishit. [Ultrastructural study of the neuronal lipofuscin--an autopsy case of familial Alzheimer's disease]. No to shinkei = Brain and nerve. vol 36. issue 7. 1984-11-30. PMID:6487435. |
the neuronal loss, senile plaques and alzheimer's neurofibrillary tangles were found throughout the cerebral cortex. |
1984-11-30 |
2023-08-12 |
Not clear |
| D S Horoupian, L Thal, R Katzman, R D Terry, P Davies, A Hirano, R DeTeresa, P A Fuld, C Petito, J Blas. Dementia and motor neuron disease: morphometric, biochemical, and Golgi studies. Annals of neurology. vol 16. issue 3. 1984-11-21. PMID:6148912. |
in two patients, quantitative studies of selected regions of the cortex using a computerized image analyzer disclosed, as in patients with senile dementia of alzheimer type, a marked reduction in the number of neurons, especially those larger than 90 mu 2. |
1984-11-21 |
2023-08-12 |
Not clear |
| B T Hyman, G W Van Hoesen, A R Damasio, C L Barne. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science (New York, N.Y.). vol 225. issue 4667. 1984-10-16. PMID:6474172. |
examination of temporal lobe structures from alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers ii and iv of the entorhinal cortex. |
1984-10-16 |
2023-08-12 |
Not clear |
| T Arendt, V Bigl, A Tennstedt, A Arend. Correlation between cortical plaque count and neuronal loss in the nucleus basalis in Alzheimer's disease. Neuroscience letters. vol 48. issue 1. 1984-10-15. PMID:6472737. |
in order to substantiate the hypothesis of a cholinergic matrix for neuritic plaque formation in alzheimer's disease (ad), the relationship between the loss of cholinergic neurons in the basal forebrain and formation of neuritic plaques in the cerebral cortex was studied in 5 cases of neuropathologically verified ad. |
1984-10-15 |
2023-08-12 |
Not clear |
| V F Shefe. [Relation between the degree of severity of the dementia and the extent of the manifestation of the pathomorphological changes in the cerebral cortex in senile dementia and Alzheimer's disease]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). vol 84. issue 7. 1984-10-12. PMID:6475406. |
[relation between the degree of severity of the dementia and the extent of the manifestation of the pathomorphological changes in the cerebral cortex in senile dementia and alzheimer's disease]. |
1984-10-12 |
2023-08-12 |
Not clear |
| D M Mann, P O Yates, B Marcyniu. Alzheimer's presenile dementia, senile dementia of Alzheimer type and Down's syndrome in middle age form an age related continuum of pathological changes. Neuropathology and applied neurobiology. vol 10. issue 3. 1984-08-07. PMID:6234474. |
a loss of nerve cells from the nucleus basalis of meynert and the locus caeruleus together with a reduction in nucleolar volume in surviving cells was measured in twenty-two patients with alzheimer's disease who ranged in age from 48-92 years, and in six patients over 50 years of age with down's syndrome who also showed extensive formation of senile plaques and neurofibrillary tangles within their cerebral cortex. |
1984-08-07 |
2023-08-12 |
Not clear |
| I Nakano, A Hiran. Parkinson's disease: neuron loss in the nucleus basalis without concomitant Alzheimer's disease. Annals of neurology. vol 15. issue 5. 1984-07-19. PMID:6732189. |
simultaneously, the cerebral cortex and the nucleus basalis in the patients with parkinson's disease were examined for senile plaques and alzheimer's neurofibrillary tangles. |
1984-07-19 |
2023-08-12 |
human |
| C Fuentes, G Roch, R Mart. [Astrocytic response in alcoholic cirrhotic encephalopathy (immunohistochemical study)]. Zeitschrift fur mikroskopisch-anatomische Forschung. vol 98. issue 1. 1984-06-11. PMID:6372283. |
in human alcoholic cirrhotic encephalopathy, most of astrocytes of the cerebral cortex appear as alzheimer type ii cells. |
1984-06-11 |
2023-08-12 |
human |
| P van den Bosch de Aguilar, C Langhendries-Wéverberg, J Goemaere-Vanneste, J Flament-Durand, J P Brion, A M Couc. Transplantation of human cortex with Alzheimer's disease into rat occipital cortex; a model for the study of Alzheimer disease. Experientia. vol 40. issue 4. 1984-05-30. PMID:6714374. |
transplantation of human cortex with alzheimer's disease into rat occipital cortex; a model for the study of alzheimer disease. |
1984-05-30 |
2023-08-12 |
human |
| P van den Bosch de Aguilar, C Langhendries-Wéverberg, J Goemaere-Vanneste, J Flament-Durand, J P Brion, A M Couc. Transplantation of human cortex with Alzheimer's disease into rat occipital cortex; a model for the study of Alzheimer disease. Experientia. vol 40. issue 4. 1984-05-30. PMID:6714374. |
when human temporal cortex with alzheimer's disease is implanted in the occipital cortex of 7-week-old rats, human cerebral tissue containing abundant tangles induces in the receiver cortex a reactive fibrous gliosis. |
1984-05-30 |
2023-08-12 |
human |
| E K Perry, J R Atack, R H Perry, J A Hardy, P R Dodd, J A Edwardson, G Blessed, B E Tomlinson, A F Fairbair. Intralaminar neurochemical distributions in human midtemporal cortex: comparison between Alzheimer's disease and the normal. Journal of neurochemistry. vol 42. issue 5. 1984-05-17. PMID:6142924. |
intralaminar neurochemical distributions in human midtemporal cortex: comparison between alzheimer's disease and the normal. |
1984-05-17 |
2023-08-12 |
human |
| E K Perry, J R Atack, R H Perry, J A Hardy, P R Dodd, J A Edwardson, G Blessed, B E Tomlinson, A F Fairbair. Intralaminar neurochemical distributions in human midtemporal cortex: comparison between Alzheimer's disease and the normal. Journal of neurochemistry. vol 42. issue 5. 1984-05-17. PMID:6142924. |
further, the enzyme distribution patterns of these cholinergic activities were also disrupted in alzheimer's disease and the activity of cat throughout the cortex was generally reduced to that found in the white matter. |
1984-05-17 |
2023-08-12 |
human |
| E K Perry, J R Atack, R H Perry, J A Hardy, P R Dodd, J A Edwardson, G Blessed, B E Tomlinson, A F Fairbair. Intralaminar neurochemical distributions in human midtemporal cortex: comparison between Alzheimer's disease and the normal. Journal of neurochemistry. vol 42. issue 5. 1984-05-17. PMID:6142924. |
these findings demonstrate the relatively selective nature of microchemical changes occurring in the cortex in alzheimer's disease and suggest that a functional abnormality in cholinergic input to the outer neocortical layers (i-iv) with predominantly receptive and associative functions may be an important feature of the disease. |
1984-05-17 |
2023-08-12 |
human |
| M N Rossor, L L Iversen, G P Reynolds, C Q Mountjoy, M Rot. Neurochemical characteristics of early and late onset types of Alzheimer's disease. British medical journal (Clinical research ed.). vol 288. issue 6422. 1984-05-14. PMID:6142750. |
the alzheimer group exhibited noticeably reduced activity of the cholinergic marker enzyme choline acetyltransferase in the cerebral cortex, but cortical concentrations of noradrenaline, gamma-aminobutyric acid, and somatostatin were also significantly reduced. |
1984-05-14 |
2023-08-12 |
human |
| N Yoshimur. Evidence that paired helical filaments originate from neurofilaments--electron microscope observations of neurites in senile plaques in the brain in Alzheimer's disease. Clinical neuropathology. vol 3. issue 1. 1984-05-11. PMID:6423331. |
neurites in senile plaques in the cerebral cortex from an autopsied case of alzheimer's disease were examined by electron microscope. |
1984-05-11 |
2023-08-12 |
Not clear |
| K Iqbal, T Zaidi, C H Thompson, P A Merz, H M Wisniewsk. Alzheimer paired helical filaments: bulk isolation, solubility, and protein composition. Acta neuropathologica. vol 62. issue 3. 1984-03-23. PMID:6538056. |
the fresh or frozen autopsied cerebral cortex affected with alzheimer neurofibrillary changes is dissociated by homogenization and sieving through nylon bolting cloth and the ant are separated by a combination of sucrose discontinuous density gradient centrifugation, glass bead column chromatography, and sodium dodecyl sulfate (sds) treatment. |
1984-03-23 |
2023-08-12 |
Not clear |
| B Berger, C Alvare. [Pathology of catecholaminergic innervation of the cerebral cortex in Alzheimer's dementia]. Presse medicale (Paris, France : 1983). vol 12. issue 48. 1984-02-24. PMID:6228924. |
[pathology of catecholaminergic innervation of the cerebral cortex in alzheimer's dementia]. |
1984-02-24 |
2023-08-12 |
Not clear |
| B Berger, C Alvare. [Pathology of catecholaminergic innervation of the cerebral cortex in Alzheimer's dementia]. Presse medicale (Paris, France : 1983). vol 12. issue 48. 1984-02-24. PMID:6228924. |
changes in cerebral catecholaminergic pathways in alzheimer type dementia would appear to involve both the noradrenergic and the dopaminergic system in their sub-cortical and cortical distribution, but the essential information currently available involves the noradrenergic innervation of the cerebral cortex. |
1984-02-24 |
2023-08-12 |
Not clear |