| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Meier-Ruge, S Abdel-Al, U Schul. [Stereomorphometric studies of capillaries and nerve cells in the normal brain of the aged subject and in Alzheimer's disease]. Presse medicale (Paris, France : 1983). vol 12. issue 48. 1984-02-24. PMID:6228925. |
the morphometric results of the capillary measurements show a 40% increase of the capillary volume in the brain cortex of the alzheimer group compared with the controls. |
1984-02-24 |
2023-08-12 |
human |
| W Meier-Ruge, S Abdel-Al, U Schul. [Stereomorphometric studies of capillaries and nerve cells in the normal brain of the aged subject and in Alzheimer's disease]. Presse medicale (Paris, France : 1983). vol 12. issue 48. 1984-02-24. PMID:6228925. |
these results which are probably localized in cortex represent gross atrophy of the frontal brain in senile dementia of the alzheimer type. |
1984-02-24 |
2023-08-12 |
human |
| T D Bird, S Stranahan, S M Sumi, M Raskin. Alzheimer's disease: choline acetyltransferase activity in brain tissue from clinical and pathological subgroups. Annals of neurology. vol 14. issue 3. 1983-12-20. PMID:6227276. |
there was a tendency for choline acetyltransferase activity to be lower in cortex from patients with early-onset alzheimer's disease compared with cortex from the late-onset group, and this difference was significant in temporal cortex. |
1983-12-20 |
2023-08-12 |
human |
| D F Benson, D E Kuhl, R A Hawkins, M E Phelps, J L Cummings, S Y Tsa. The fluorodeoxyglucose 18F scan in Alzheimer's disease and multi-infarct dementia. Archives of neurology. vol 40. issue 12. 1983-11-23. PMID:6605139. |
patients with alzheimer's dementia showed decreased metabolism in all areas of the brain but with preferential sparing of the primary motor and sensory cortex. |
1983-11-23 |
2023-08-12 |
human |
| C Flicker, R L Dean, D L Watkins, S K Fisher, R T Bartu. Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to the cerebral cortex in the rat. Pharmacology, biochemistry, and behavior. vol 18. issue 6. 1983-10-08. PMID:6889421. |
these results are discussed as they relate to the behavioral role of cholinergic innervation of the cortex, and the development of animal models for disorders involving cortical cholinergic deficiencies, including senile dementia of the alzheimer's type. |
1983-10-08 |
2023-08-12 |
rat |
| R P Friedland, T F Budinger, E Ganz, Y Yano, C A Mathis, B Koss, B A Ober, R H Huesman, S E Derenz. Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with [18F]fluorodeoxyglucose. Journal of computer assisted tomography. vol 7. issue 4. 1983-08-26. PMID:6602819. |
ratios comparing mean counts per resolution element in frontal, temporoparietal, and entire cortex regions in brain sections 10 mm thick obtained 40-70 min following fdg injection showed relatively less fdg uptake in the temporoparietal cortex bilaterally in all the alzheimer subjects (p less than 0.01). |
1983-08-26 |
2023-08-12 |
human |
| R P Friedland, T F Budinger, E Ganz, Y Yano, C A Mathis, B Koss, B A Ober, R H Huesman, S E Derenz. Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with [18F]fluorodeoxyglucose. Journal of computer assisted tomography. vol 7. issue 4. 1983-08-26. PMID:6602819. |
this diminished uptake was due to lowered rates of fdg use and suggests that the metabolic effects of alzheimer disease are most concentrated in the temporoparietal cortex. |
1983-08-26 |
2023-08-12 |
human |
| N M Ng Ying Kin, J Palo, M Haltia, L S Wolf. High levels of brain dolichols in neuronal ceroid-lipofuscinosis and senescence. Journal of neurochemistry. vol 40. issue 5. 1983-05-27. PMID:6834069. |
highly significant elevations of dolichol levels were found in human cerebral cortex of patients with ncl and alzheimer's disease compared with age-matched controls, but the levels were normal in pick's disease. |
1983-05-27 |
2023-08-12 |
human |
| G K Wilcock, M M Esiri, D M Bowen, C C Smit. Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities. Journal of the neurological sciences. vol 57. issue 2-3. 1983-04-21. PMID:7161627. |
we have examined the choline acetyltransferase [cat] activity in autopsy samples of frontal and temporal lobe cortex from 47 patients (31 with alzheimer's disease, 4 with dementia due to cerebrovascular disease and 12 undemented controls) and compared it with the severity of dementia during life and with the numbers of argyrophilic plaques and neurofibrillary tangles in the corresponding areas of cortex in the contralateral cerebral hemisphere. |
1983-04-21 |
2023-08-12 |
cat |
| G K Wilcock, M M Esiri, D M Bowen, C C Smit. Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities. Journal of the neurological sciences. vol 57. issue 2-3. 1983-04-21. PMID:7161627. |
in the patients with alzheimer's disease the reduction in cat activity was significantly correlated with the severity of dementia and with the numbers of neurofibrillary tangles, but not argyrophilic plaques, present in the corresponding contralateral cortex. |
1983-04-21 |
2023-08-12 |
cat |
| M N Rossor, P C Emson, C Q Mountjoy, M Roth, L L Iverse. Neurotransmitters of the cerebral cortex in senile dementia of Alzheimer type. Experimental brain research. vol Suppl 5. 1983-03-17. PMID:6129994. |
neurotransmitters of the cerebral cortex in senile dementia of alzheimer type. |
1983-03-17 |
2023-08-12 |
Not clear |
| G K Wilcock, M M Esir. Plaques, tangles and dementia. A quantitative study. Journal of the neurological sciences. vol 56. issue 2-3. 1983-02-25. PMID:7175555. |
the temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to alzheimer's disease. |
1983-02-25 |
2023-08-12 |
human |
| S E Hays, S M Pau. CCK receptors and human neurological disease. Life sciences. vol 31. issue 4. 1983-01-19. PMID:6292647. |
cck binding was significantly reduced inthe basal ganglia and cerebral cortex of huntington's patients, but was normal in the temporal and cingulate cortex of patients with alzheimer's disease. |
1983-01-19 |
2023-08-12 |
human |
| L S Wolfe, N M Ng Ying Kin, J Palo, M Halti. Raised levels of cerebral cortex dolichols in Alzheimer's disease. Lancet (London, England). vol 2. issue 8289. 1982-08-26. PMID:6123835. |
raised levels of cerebral cortex dolichols in alzheimer's disease. |
1982-08-26 |
2023-08-12 |
Not clear |
| R G Struble, L C Cork, P J Whitehouse, D L Pric. Cholinergic innervation in neuritic plaques. Science (New York, N.Y.). vol 216. issue 4544. 1982-06-21. PMID:6803359. |
although several studies of alzheimer's disease suggest that the frequency of neuritic plaques in the cerebral cortex is correlated with the severity of dementia and with reduction in presynaptic cholinergic markers in the cortex, the relationship between cholinergic cortical innervation and the pathogenesis of plaques is unknown. |
1982-06-21 |
2023-08-12 |
monkey |
| V F Shefe. [Pathologo-anatomic morphometric diagnosis of senile dementia and Alzheimer's disease]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). vol 82. issue 2. 1982-06-21. PMID:7072428. |
the numbers of senile plaques, neurofibrillar bundles, and neurofibrillar "skeletons" in a certain constant volume of the left temporal pole cortex were calculated in 131 psychically healthy subjects who died at an age of 41 to 101 years, and in 111 subjects who suffered at lifetime from debilitating diseases of the type of senile dementia (dotage) and alzheimer's disease. |
1982-06-21 |
2023-08-12 |
human |
| P J Whitehouse, D L Price, R G Struble, A W Clark, J T Coyle, M R Delo. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science (New York, N.Y.). vol 215. issue 4537. 1982-04-22. PMID:7058341. |
postmortem studies have previously demonstrated profound reduction in the presynaptic markers for cholinergic neurons in the cortex of patients with alzheimer's disease and senile dementia of the alzheimer's type. |
1982-04-22 |
2023-08-12 |
Not clear |
| M N Rossor, L L Iversen, A J Johnson, C Q Mountjoy, M Rot. Cholinergic deficit in frontal cerebral cortex in Alzheimer's disease is age dependent. Lancet (London, England). vol 2. issue 8260-61. 1982-02-22. PMID:6118790. |
cholinergic deficit in frontal cerebral cortex in alzheimer's disease is age dependent. |
1982-02-22 |
2023-08-12 |
Not clear |
| M Röyttä, I Olsson, P Sourander, P Svendse. Infantile bilateral striatal necrosis. Clinical and morphological report of a case and a review of the literature. Acta neuropathologica. vol 55. issue 2. 1982-02-12. PMID:6118994. |
in the damaged regions, accumulations of cells containing sudanophilic lipids were found and alzheimer type ii glial cells, which were also seen in the cortex. |
1982-02-12 |
2023-08-12 |
Not clear |
| J M Powers, W W Schlaepfer, M C Willingham, B J Hal. An immunoperoxidase study of senile cerebral amyloidosis with pathogenetic considerations. Journal of neuropathology and experimental neurology. vol 40. issue 6. 1982-01-28. PMID:6795314. |
samples of human cerebral cortex were obtained from twelve autopsied patients with alzheimer's disease or "normal" aging. |
1982-01-28 |
2023-08-12 |
human |