| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Ho Lee, Hong Jun Kim, Jong Uk Kim, Tae Han Yook, Kyeong Han Kim, Joo Young Lee, Gabsik Yan. A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer's and Parkinson's Disease. International journal of molecular sciences. vol 22. issue 3. 2021-09-03. PMID:33525754. |
a novel treatment strategy by natural products in nlrp3 inflammasome-mediated neuroinflammation in alzheimer's and parkinson's disease. |
2021-09-03 |
2023-08-13 |
Not clear |
| Da-Bao Chen, Hua-Wu Gao, Cheng Peng, Shao-Qiang Pei, An-Ran Dai, Xue-Ting Yu, Peng Zhou, Yan Wang, Biao Ca. Quinones as preventive agents in Alzheimer's diseases: focus on NLRP3 inflammasomes. The Journal of pharmacy and pharmacology. vol 72. issue 11. 2021-08-04. PMID:32667050. |
quinones as preventive agents in alzheimer's diseases: focus on nlrp3 inflammasomes. |
2021-08-04 |
2023-08-13 |
Not clear |
| Ya-Shuo Feng, Zi-Xuan Tan, Lin-Yu Wu, Fang Dong, Feng Zhan. The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 138. 2021-07-22. PMID:33667787. |
in this review, we will discuss the mechanisms that are involved in the activation of the nlrp3 inflammasome and its crucial role in the pathology of neurodegenerative disorders, such as alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis. |
2021-07-22 |
2023-08-13 |
Not clear |
| Ya-Jen Chiu, Chih-Hsin Lin, Ming-Chung Lee, Hsiu Mei Hsieh-Li, Chiung-Mei Chen, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Che. Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement. Aging. vol 13. issue 11. 2021-07-21. PMID:34106880. |
formulated chinese medicine shaoyao gancao tang reduces nlrp1 and nlrp3 in alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement. |
2021-07-21 |
2023-08-13 |
mouse |
| Robert B Kargb. Therapeutic Modulation of NLRP3 for Treatment of Cancer, Alzheimer's Disease, and Trauma. ACS medicinal chemistry letters. vol 12. issue 7. 2021-07-17. PMID:34267876. |
therapeutic modulation of nlrp3 for treatment of cancer, alzheimer's disease, and trauma. |
2021-07-17 |
2023-08-13 |
Not clear |
| Mark T Milner, Madhavi Maddugoda, Jürgen Götz, Sabrina S Burgener, Kate Schrode. The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease. Current opinion in immunology. vol 68. 2021-07-13. PMID:33181351. |
the nlrp3 inflammasome triggers sterile neuroinflammation and alzheimer's disease. |
2021-07-13 |
2023-08-13 |
Not clear |
| Mark T Milner, Madhavi Maddugoda, Jürgen Götz, Sabrina S Burgener, Kate Schrode. The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease. Current opinion in immunology. vol 68. 2021-07-13. PMID:33181351. |
dysregulated nlrp3 inflammasome activity, however, drives many conditions including alzheimer's disease (ad). |
2021-07-13 |
2023-08-13 |
Not clear |
| Mehboob Ali, Mehak Gupta, Abubakar Wani, Ankita Sharma, Mohd Abdullaha, Dilpreet Kour, Sushil Choudhary, Sandip B Bharate, Gurdarshan Singh, Ajay Kuma. IIIM-941, a Stilbene Derivative Inhibits NLRP3 Inflammasome Activation by Inducing Autophagy. Frontiers in pharmacology. vol 12. 2021-07-13. PMID:34248643. |
the compounds like iiim-941 can be explored further for the development of therapies against diseases such as alzheimer's disease and parkinson's disease, where hampered autophagy and nlrp3 activation play a crucial role in the pathological development. |
2021-07-13 |
2023-08-13 |
mouse |
| Alexander N R Weber, Zsófia A Bittner, Sangeetha Shankar, Xiao Liu, Tzu-Hsuan Chang, Tengchuan Jin, Ana Tapia-Abellá. Recent insights into the regulatory networks of NLRP3 inflammasome activation. Journal of cell science. vol 133. issue 23. 2021-06-18. PMID:33273068. |
although its activity is essential to fight infection and support tissue homeostasis, the inflammasome complex, which consists of the danger sensor nlrp3, the adaptor apoptosis-associated speck-like protein containing a card (asc; also known as pycard), caspase-1 and probably other regulatory proteins, also bears considerable potential for detrimental inflammation, as observed in human conditions such as gout, heart attack, stroke and alzheimer's disease. |
2021-06-18 |
2023-08-13 |
human |
| Anna Litwiniuk, Wojciech Bik, Małgorzata Kalisz, Agnieszka Baranowska-Bi. Inflammasome NLRP3 Potentially Links Obesity-Associated Low-Grade Systemic Inflammation and Insulin Resistance with Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 11. 2021-06-17. PMID:34070553. |
inflammasome nlrp3 potentially links obesity-associated low-grade systemic inflammation and insulin resistance with alzheimer's disease. |
2021-06-17 |
2023-08-13 |
Not clear |
| Shizhen Zhao, Xiaotian Li, Jie Wang, Honggang Wan. The Role of the Effects of Autophagy on NLRP3 Inflammasome in Inflammatory Nervous System Diseases. Frontiers in cell and developmental biology. vol 9. 2021-06-05. PMID:34079796. |
in this review, we sum up recent research about the role of the effects of autophagy on nlrp3 inflammasome in alzheimer's disease, chronic cerebral hypoperfusion, parkinson's disease, depression, cerebral ischemia/reperfusion injury, early brain injury after subarachnoid hemorrhage, and experimental autoimmune encephalomyelitis and analyzed the related mechanism to provide theoretical reference for the future research of inflammatory neurological diseases. |
2021-06-05 |
2023-08-13 |
Not clear |
| Anna Gritsenko, Shi Yu, Fatima Martin-Sanchez, Ines Diaz-Del-Olmo, Eva-Maria Nichols, Daniel M Davis, David Brough, Gloria Lopez-Castejo. Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes Frontiers in immunology. vol 11. 2021-06-03. PMID:33101286. |
priming is dispensable for nlrp3 inflammasome activation in human monocytes interleukin (il)-18 and il-1β are potent pro-inflammatory cytokines that contribute to inflammatory conditions such as rheumatoid arthritis and alzheimer's disease. |
2021-06-03 |
2023-08-13 |
human |
| Yidan Zhang, Yuan Zhao, Jian Zhang, Guofeng Yan. Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32929691. |
mechanisms of nlrp3 inflammasome activation: its role in the treatment of alzheimer's disease. |
2021-06-02 |
2023-08-13 |
mouse |
| Katharine M von Herrmann, Faith L Anderson, Eileen M Martinez, Alison L Young, Matthew C Havrd. Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice. Journal of neuroinflammation. vol 17. issue 1. 2021-05-24. PMID:32680528. |
activity of the proinflammatory nlrp3 inflammasome is implicated in alzheimer's and parkinson's disease and our recent studies in patients suggest that dopaminergic neurons within the degenerating mesencephalon express nlrp3 throughout the progression of pd. |
2021-05-24 |
2023-08-13 |
mouse |
| Heping Shen, Qiaobing Guan, Xiaoling Zhang, Chao Yuan, Zhengye Tan, Liping Zhai, Yanan Hao, Yanling Gu, Chenyang Ha. New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:32032696. |
new mechanism of neuroinflammation in alzheimer's disease: the activation of nlrp3 inflammasome mediated by gut microbiota. |
2021-04-28 |
2023-08-13 |
mouse |
| Marina Saresella, Nicoletta Basilico, Ivana Marventano, Federica Perego, Francesca La Rosa, Federica Piancone, Donatella Taramelli, Helen Banks, Mario Cleric. Leishmania infantum infection reduces the amyloid β Brain, behavior, and immunity. vol 88. 2021-04-06. PMID:32335194. |
leishmania infantum infection reduces the amyloid β activation of the nlrp3 inflammasome has been shown to play a major role in the neuroinflammation that accompanies alzheimer's disease (ad); interventions that down regulate the nlrp3 inflammasome could thus be beneficial in ad. |
2021-04-06 |
2023-08-13 |
Not clear |
| Junling Yang, Leslie Wise, Ken-Ichiro Fukuch. TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease. Frontiers in immunology. vol 11. 2021-03-31. PMID:32391019. |
tlr4 cross-talk with nlrp3 inflammasome and complement signaling pathways in alzheimer's disease. |
2021-03-31 |
2023-08-13 |
Not clear |
| Jonathan A Holbrook, Heledd H Jarosz-Griffiths, Emily Caseley, Samuel Lara-Reyna, James A Poulter, Caroline H Williams-Gray, Daniel Peckham, Michael F McDermot. Neurodegenerative Disease and the NLRP3 Inflammasome. Frontiers in pharmacology. vol 12. 2021-03-30. PMID:33776778. |
dysregulation of the nlrp3 inflammasome has been implicated in the progression of several neurodegenerative disorders, such as alzheimer's disease, parkinson's disease, huntington's disease, amyotrophic lateral sclerosis, and prion diseases. |
2021-03-30 |
2023-08-13 |
Not clear |
| Alexander N R Webe. Targeting the NLRP3 Inflammasome via BTK. Frontiers in cell and developmental biology. vol 9. 2021-03-16. PMID:33718366. |
the nlrp3 inflammasome represents a critical inflammatory machinery driving pathology in many acute (e. g., myocardial infarction or stroke) and chronic (alzheimer's disease, atherosclerosis) human disorders linked to the activity of il-1 cytokines. |
2021-03-16 |
2023-08-13 |
human |
| Wen Zhou, Deng Xiao, Yueyang Zhao, Botao Tan, Zhimin Long, Lehua Yu, Guiqiong H. Enhanced Autolysosomal Function Ameliorates the Inflammatory Response Mediated by the NLRP3 Inflammasome in Alzheimer's Disease. Frontiers in aging neuroscience. vol 13. 2021-03-13. PMID:33708103. |
enhanced autolysosomal function ameliorates the inflammatory response mediated by the nlrp3 inflammasome in alzheimer's disease. |
2021-03-13 |
2023-08-13 |
mouse |