| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sukhleen Kaur, Kuhu Sharma, Ankita Sharma, Kamalpreet Kaur Sandha, Syed Mudassir Ali, Riyaz Ahmed, P Ramajayan, Parvinder Pal Singh, Zabeer Ahmed, Ajay Kuma. Fluvoxamine maleate alleviates amyloid-beta load and neuroinflammation in 5XFAD mice to ameliorate Alzheimer disease pathology. Frontiers in immunology. vol 15. 2024-08-13. PMID:39136022. |
alzheimer pathology (ad) is characterized by the deposition of amyloid beta (aβ) and chronic neuroinflammation, with the nlrp3 inflammasome playing a significant role. |
2024-08-13 |
2024-08-16 |
mouse |
| Nastaran Barati, Ali Shojaeian, Mahdi Ramezani, Fereshte Kalhori, Mohammad Sajjad Yavari Bazl, Salman Zafari, Sara Soleimani Asl, Seyedmousa Motavallihagh. Investigating the effect of parasites (toxoplasma gondii RH strain, Leishmania major (MRHO/IR/75/ER), and hydatid cyst) antigens on Alzheimer's disease: An in vivo evaluation. Experimental neurology. 2024-05-12. PMID:38735456. |
nlrp3 expression was increased in all groups compared with the control group, with lower expression in hc group, but significantly decreased in l. major group compared with alzheimer's. |
2024-05-12 |
2024-05-27 |
rat |
| Baban S Thawkar, Ginpreet Kau. Betanin combined with virgin coconut oil inhibits neuroinflammation in aluminum chloride-induced toxicity in rats by regulating NLRP3 inflammasome. Journal of traditional and complementary medicine. vol 14. issue 3. 2024-05-06. PMID:38707915. |
activating nlrp3 (nod-, lrr-, and pyrin domain-containing protein 3) is crucial in the pathogenesis of alzheimer's disease (ad). |
2024-05-06 |
2024-05-08 |
rat |
| Danhui Qin, Caiwei Wang, Rongzhen Yan, Ying Qin, Zhendong Ying, Hongyi Kong, Wei Zhao, Lei Zhang, Hui Son. ZAP facilitates NLRP3 inflammasome activation via promoting the oligomerization of NLRP3. International immunopharmacology. vol 133. 2024-04-25. PMID:38663314. |
the nod-like receptor family protein 3 (nlrp3) inflammasome is a crucial complex for the host to establish inflammatory immune responses and plays vital roles in a series of disorders, including alzheimer's disease and acute peritonitis. |
2024-04-25 |
2024-04-28 |
mouse |
| Qi Yun, Si-Fei Ma, Wei-Ning Zhang, Meng Gu, Jia Wan. FoxG1 as a Potential Therapeutic Target for Alzheimer's Disease: Modulating NLRP3 Inflammasome via AMPK/mTOR Autophagy Pathway. Cellular and molecular neurobiology. vol 44. issue 1. 2024-04-17. PMID:38630150. |
foxg1 as a potential therapeutic target for alzheimer's disease: modulating nlrp3 inflammasome via ampk/mtor autophagy pathway. |
2024-04-17 |
2024-04-19 |
mouse |
| Qi Yun, Si-Fei Ma, Wei-Ning Zhang, Meng Gu, Jia Wan. FoxG1 as a Potential Therapeutic Target for Alzheimer's Disease: Modulating NLRP3 Inflammasome via AMPK/mTOR Autophagy Pathway. Cellular and molecular neurobiology. vol 44. issue 1. 2024-04-17. PMID:38630150. |
an increasing body of research suggests that promoting microglial autophagy hinders the neuroinflammation initiated though the nlrp3 inflammasome activation in alzheimer's disease (ad). |
2024-04-17 |
2024-04-19 |
mouse |
| Róisín M McManus, Eicke Lat. NLRP3 inflammasome signalling in Alzheimer's disease. Neuropharmacology. 2024-04-02. PMID:38565393. |
nlrp3 inflammasome signalling in alzheimer's disease. |
2024-04-02 |
2024-04-05 |
Not clear |
| Gourav Singh, Gauri Shankar, Samir Ranjan Panda, Sunil Kumar, Sanskriti Rai, Himanshu Verma, Prabhat Kumar, Prasanta Kumar Nayak, V G M Naidu, Saripella Srikrishna, Saroj Kumar, Gyan Mod. Design, Synthesis, and Biological Evaluation of Ferulic Acid Template-Based Novel Multifunctional Ligands Targeting NLRP3 Inflammasome for the Management of Alzheimer's Disease. ACS chemical neuroscience. 2024-03-25. PMID:38525886. |
design, synthesis, and biological evaluation of ferulic acid template-based novel multifunctional ligands targeting nlrp3 inflammasome for the management of alzheimer's disease. |
2024-03-25 |
2024-03-27 |
Not clear |
| Bo Hu, Jiaping Zhang, Jie Huang, Bairu Luo, Xiansi Zeng, Jinjing Ji. NLRP3/1-mediated pyroptosis: beneficial clues for the development of novel therapies for Alzheimer's disease. Neural regeneration research. vol 19. issue 11. 2024-03-25. PMID:38526276. |
there is accumulating evidence that nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3 (nlrp3) inflammasome-mediated microglial pyroptosis and nlrp1 inflammasome-mediated neuronal pyroptosis in the brain are closely associated with the pathogenesis of alzheimer's disease. |
2024-03-25 |
2024-03-27 |
Not clear |
| Bo Hu, Jiaping Zhang, Jie Huang, Bairu Luo, Xiansi Zeng, Jinjing Ji. NLRP3/1-mediated pyroptosis: beneficial clues for the development of novel therapies for Alzheimer's disease. Neural regeneration research. vol 19. issue 11. 2024-03-25. PMID:38526276. |
we also describe the structures of nlrp3 and nlrp1 and the role their activation plays in alzheimer's disease. |
2024-03-25 |
2024-03-27 |
Not clear |
| Bo Hu, Jiaping Zhang, Jie Huang, Bairu Luo, Xiansi Zeng, Jinjing Ji. NLRP3/1-mediated pyroptosis: beneficial clues for the development of novel therapies for Alzheimer's disease. Neural regeneration research. vol 19. issue 11. 2024-03-25. PMID:38526276. |
finally, we examine the neuroprotective activity of small-molecule inhibitors, endogenous inhibitor proteins, micrornas, and natural bioactive molecules that target nlrp3 and nlrp1, based on the rationale that inhibiting nlrp3 and nlrp1 inflammasome-mediated pyroptosis can be an effective therapeutic strategy for alzheimer's disease. |
2024-03-25 |
2024-03-27 |
Not clear |
| Eun Young Kim, Jae Hong Im, Jinhe Han, Won-Jea Ch. Structure-based design and synthesis of sulfonylureas as novel NLRP3 inhibitors for Alzheimer's disease. Bioorganic & medicinal chemistry letters. 2024-01-20. PMID:38244940. |
structure-based design and synthesis of sulfonylureas as novel nlrp3 inhibitors for alzheimer's disease. |
2024-01-20 |
2024-01-23 |
Not clear |
| Juraj Velcicky, Philipp Janser, Nina Gommermann, Silke Brenneisen, Slavica Ilic, Eric Vangrevelinghe, Nikolaus Stiefl, Andreas Boettcher, Christelle Arnold, Claire Malinverni, Janet Dawson, Renata Murgasova, Sandrine Desrayaud, Karen Beltz, Alexandra Hinniger, Carien Dekker, Christopher J Farady, Angela Macka. Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors. Journal of medicinal chemistry. 2024-01-04. PMID:38175811. |
the nlrp3 inflammasome has been implicated in a plethora of diseases including gout, type 2 diabetes, atherosclerosis, alzheimer's disease, and cancer. |
2024-01-04 |
2024-01-07 |
Not clear |
| Powsali Ghosh, Ravi Singh, Chayanika Chatterjee, Ashok Kumar, Sushil Kumar Sing. Computational screening of coumarin derivatives as inhibitors of the NACHT domain of NLRP3 inflammasome for the treatment of Alzheimer's disease. Journal of biomolecular structure & dynamics. 2023-12-20. PMID:38116751. |
computational screening of coumarin derivatives as inhibitors of the nacht domain of nlrp3 inflammasome for the treatment of alzheimer's disease. |
2023-12-20 |
2023-12-23 |
Not clear |
| Powsali Ghosh, Ravi Singh, Chayanika Chatterjee, Ashok Kumar, Sushil Kumar Sing. Computational screening of coumarin derivatives as inhibitors of the NACHT domain of NLRP3 inflammasome for the treatment of Alzheimer's disease. Journal of biomolecular structure & dynamics. 2023-12-20. PMID:38116751. |
the nucleotide-binding oligomerization domain (nod)-like receptor (nlr), leucine-rich-repeat (lrr), and pyrin domain containing 3 (nlrp3) is one of the key players in neuroinflammation, which is a major pathological hallmark of alzheimer's disease (ad). |
2023-12-20 |
2023-12-23 |
Not clear |
| Gizem Terzioglu, Tracy L Young-Pears. Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-11-30. PMID:38017562. |
microglial function, inpp5d/ship1 signaling, and nlrp3 inflammasome activation: implications for alzheimer's disease. |
2023-11-30 |
2023-12-07 |
human |
| Gizem Terzioglu, Tracy L Young-Pears. Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-11-30. PMID:38017562. |
microglial function, inpp5d/ship1 signaling, and nlrp3 inflammasome activation: implications for alzheimer's disease. |
2023-11-29 |
2023-12-07 |
human |
| Yanbo Wang, Qingmei Gong, Haiyan Pan, Xiaowei Wang, Ci Ya. Gardenia jasminoides J. Ellis extract attenuates memory impairment in rats with Alzheimer's disease by suppressing NLRP3 inflammasome. Brain research. 2023-11-24. PMID:38000495. |
gardenia jasminoides j. ellis extract attenuates memory impairment in rats with alzheimer's disease by suppressing nlrp3 inflammasome. |
2023-11-24 |
2023-11-28 |
rat |
| Yaoxue Guo, Lixiang Zhan. Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease. In vitro cellular & developmental biology. Animal. 2023-11-22. PMID:37989934. |
ghrelin inhibits nlrp3 inflammasome activation by upregulating autophagy to improve alzheimer's disease. |
2023-11-22 |
2023-11-29 |
mouse |
| Yaoxue Guo, Lixiang Zhan. Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease. In vitro cellular & developmental biology. Animal. 2023-11-22. PMID:37989934. |
nod-like receptor protein 3 (nlrp3) inflammasome, autophagy, and the aggregation of β-amyloid (aβ) are key factors in alzheimer's disease (ad) development. |
2023-11-22 |
2023-11-29 |
mouse |