| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ema Ozaki, Matthew Campbell, Sarah L Doyl. Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives. Journal of inflammation research. vol 8. 2015-02-05. PMID:25653548. |
the nlrp3 inflammasome has been linked to diseases such as alzheimer's disease, atherosclerosis, metabolic syndrome, and age-related macular degeneration. |
2015-02-05 |
2023-08-13 |
Not clear |
| Niamh Murphy, Belinda Grehan, Marina A Lync. Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10. Neuromolecular medicine. vol 16. issue 1. 2014-10-28. PMID:24197756. |
the pathological peptide of alzheimer's disease, amyloid beta (aβ), induces formation of the nlrp3 inflammasome in a manner dependent on the family of proteases, cathepsins; however, the pathway by which cathepsins induce formation of the inflammasome has not yet been elucidated. |
2014-10-28 |
2023-08-12 |
rat |
| Shen-Bin Liu, Wen-Li Mi, Yan-Qing Wan. Research progress on the NLRP3 inflammasome and its role in the central nervous system. Neuroscience bulletin. vol 29. issue 6. 2014-07-18. PMID:23512739. |
the inflammasome plays an important role in the development of alzheimer's disease and bacterial meningitis, and the nlrp3 inflammasome may become a new target for the prevention and treatment of central nervous system diseases. |
2014-07-18 |
2023-08-12 |
Not clear |
| Meng-Shan Tan, Jin-Tai Yu, Teng Jiang, Xi-Chen Zhu, Lan Ta. The NLRP3 inflammasome in Alzheimer's disease. Molecular neurobiology. vol 48. issue 3. 2014-06-18. PMID:23686772. |
the nlrp3 inflammasome in alzheimer's disease. |
2014-06-18 |
2023-08-12 |
mouse |
| Meng-Shan Tan, Jin-Tai Yu, Teng Jiang, Xi-Chen Zhu, Hui-Fu Wang, Wei Zhang, Ying-Li Wang, Wei Jiang, Lan Ta. NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese. Journal of neuroimmunology. vol 265. issue 1-2. 2014-01-30. PMID:24144834. |
nlrp3 polymorphisms are associated with late-onset alzheimer's disease in han chinese. |
2014-01-30 |
2023-08-12 |
Not clear |
| Meng-Shan Tan, Jin-Tai Yu, Teng Jiang, Xi-Chen Zhu, Hui-Fu Wang, Wei Zhang, Ying-Li Wang, Wei Jiang, Lan Ta. NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese. Journal of neuroimmunology. vol 265. issue 1-2. 2014-01-30. PMID:24144834. |
recently, a wealth of information linking the activation of nlrp3 inflammasome to alzheimer's disease (ad) pathogenesis has emerged. |
2014-01-30 |
2023-08-12 |
Not clear |
| Jian-Quan Shi, Chu-Chu Zhang, Xiu-Lan Sun, Xin-Xin Cheng, Jiang-Bo Wang, Ying-Dong Zhang, Jun Xu, Hai-Qiang Zo. Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activation. CNS neuroscience & therapeutics. vol 19. issue 4. 2013-12-23. PMID:23406388. |
the activation of nuclear factor-kappa b (nf-κb) and nlrp3 inflammasome is involved in neuroinflammation, which is closely linked to alzheimer's disease (ad). |
2013-12-23 |
2023-08-12 |
mouse |
| Tobias Goldmann, Tuan Leng Tay, Marco Prin. Love and death: microglia, NLRP3 and the Alzheimer's brain. Cell research. vol 23. issue 5. 2013-11-26. PMID:23399597. |
love and death: microglia, nlrp3 and the alzheimer's brain. |
2013-11-26 |
2023-08-12 |
Not clear |
| Frederick J Sheedy, Alena Grebe, Katey J Rayner, Parisa Kalantari, Bhama Ramkhelawon, Susan B Carpenter, Christine E Becker, Hasini N Ediriweera, Adam E Mullick, Douglas T Golenbock, Lynda M Stuart, Eicke Latz, Katherine A Fitzgerald, Kathryn J Moor. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nature immunology. vol 14. issue 8. 2013-10-31. PMID:23812099. |
particulate ligands, including cholesterol crystals and amyloid fibrils, induce production of interleukin 1β (il-1β) dependent on the cytoplasmic sensor nlrp3 in atherosclerosis, alzheimer's disease and diabetes. |
2013-10-31 |
2023-08-12 |
mouse |
| Yvan Jamilloux, Roberto Pierini, Mathieu Querenet, Carole Juruj, Anne-Laure Fauchais, Marie-Odile Jauberteau, Sophie Jarraud, Gérard Lina, Jérôme Etienne, Craig R Roy, Thomas Henry, Nathalie Davoust, Florence Ade. Inflammasome activation restricts Legionella pneumophila replication in primary microglial cells through flagellin detection. Glia. vol 61. issue 4. 2013-10-28. PMID:23355222. |
one inflammasome receptor, nlrp3, has been characterized in microglial cells and associated with response to infections and in the initiation of neuro-degeneration in an alzheimer's disease model. |
2013-10-28 |
2023-08-12 |
Not clear |
| Michael T Heneka, Markus P Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng, Ellen Gelpi, Annett Halle, Martin Korte, Eicke Latz, Douglas T Golenboc. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. vol 493. issue 7434. 2013-02-13. PMID:23254930. |
nlrp3 is activated in alzheimer's disease and contributes to pathology in app/ps1 mice. |
2013-02-13 |
2023-08-12 |
mouse |
| Michael T Heneka, Markus P Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng, Ellen Gelpi, Annett Halle, Martin Korte, Eicke Latz, Douglas T Golenboc. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. vol 493. issue 7434. 2013-02-13. PMID:23254930. |
however, it remains unknown whether nlrp3 activation contributes to alzheimer's disease in vivo. |
2013-02-13 |
2023-08-12 |
mouse |
| Michael T Heneka, Markus P Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng, Ellen Gelpi, Annett Halle, Martin Korte, Eicke Latz, Douglas T Golenboc. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. vol 493. issue 7434. 2013-02-13. PMID:23254930. |
nlrp3(-/-) or casp1(-/-) mice carrying mutations associated with familial alzheimer's disease were largely protected from loss of spatial memory and other sequelae associated with alzheimer's disease, and demonstrated reduced brain caspase-1 and interleukin-1β activation as well as enhanced amyloid-β clearance. |
2013-02-13 |
2023-08-12 |
mouse |
| Michael T Heneka, Markus P Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng, Ellen Gelpi, Annett Halle, Martin Korte, Eicke Latz, Douglas T Golenboc. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. vol 493. issue 7434. 2013-02-13. PMID:23254930. |
furthermore, nlrp3 inflammasome deficiency skewed microglial cells to an m2 phenotype and resulted in the decreased deposition of amyloid-β in the app/ps1 model of alzheimer's disease. |
2013-02-13 |
2023-08-12 |
mouse |
| Michael T Heneka, Markus P Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng, Ellen Gelpi, Annett Halle, Martin Korte, Eicke Latz, Douglas T Golenboc. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. vol 493. issue 7434. 2013-02-13. PMID:23254930. |
these results show an important role for the nlrp3/caspase-1 axis in the pathogenesis of alzheimer's disease, and suggest that nlrp3 inflammasome inhibition represents a new therapeutic intervention for the disease. |
2013-02-13 |
2023-08-12 |
mouse |
| Parimala R Vajjhala, Ruth E Mirams, Justine M Hil. Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein. The Journal of biological chemistry. vol 287. issue 50. 2013-02-12. PMID:23066025. |
activation of the nlrp3 inflammasome is also associated with common diseases including cardiovascular disease, diabetes, chronic kidney disease, and alzheimer disease. |
2013-02-12 |
2023-08-12 |
Not clear |
| Ioannis Mitroulis, Panagiotis Skendros, Konstantinos Riti. Targeting IL-1beta in disease; the expanding role of NLRP3 inflammasome. European journal of internal medicine. vol 21. issue 3. 2010-08-23. PMID:20493414. |
genetically defined syndromes like cryopyrin-associated periodic syndromes (caps, cryopyrinopathies) and familial mediterranean fever (fmf) or diseases associated with nlrp3 activation by danger signals like gout, pseudogout, alzheimer's disease or type 2 diabetes are included in this group of diseases. |
2010-08-23 |
2023-08-12 |
human |