| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen Zhou, Deng Xiao, Yueyang Zhao, Botao Tan, Zhimin Long, Lehua Yu, Guiqiong H. Enhanced Autolysosomal Function Ameliorates the Inflammatory Response Mediated by the NLRP3 Inflammasome in Alzheimer's Disease. Frontiers in aging neuroscience. vol 13. 2021-03-13. PMID:33708103. |
the pathogenesis of alzheimer's disease (ad) involves activation of many nlrp3 inflammatory bodies, which may be related to amyloid β peptide and aggregation of misfolded proteins. |
2021-03-13 |
2023-08-13 |
mouse |
| Mohd Abdullaha, Mehboob Ali, Dilpreet Kour, Ajay Kumar, Sandip B Bharat. Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as new classes of NLRP3 inflammasome inhibitors via ER-β structure based virtual screening. Bioorganic chemistry. vol 95. 2021-03-01. PMID:31869665. |
the overactivity of nlrp3 inflammasome has been implicated in variety of inflammatory diseases including alzheimer's disease. |
2021-03-01 |
2023-08-13 |
mouse |
| Wen-Qiao Qiu, Rong Pan, Yong Tang, Xiao-Gang Zhou, Jian-Ming Wu, Lu Yu, Betty Yuen-Kwan Law, Wei Ai, Chong-Lin Yu, Da-Lian Qin, An-Guo W. Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 130. 2021-02-25. PMID:32768883. |
emerging evidence indicates that the enhancement of microglial autophagy inhibits the nlrp3 inflammasome mediated neuroinflammation in alzheimer's disease (ad). |
2021-02-25 |
2023-08-13 |
mouse |
| Niklas Lonnemann, Shirin Hosseini, Carlo Marchetti, Damaris B Skouras, Davide Stefanoni, Angelo D'Alessandro, Charles A Dinarello, Martin Kort. The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 50. 2021-02-01. PMID:33257576. |
the nlrp3 inflammasome inhibitor olt1177 rescues cognitive impairment in a mouse model of alzheimer's disease. |
2021-02-01 |
2023-08-13 |
mouse |
| Chuan He, Zhong-Sheng Huang, Hong-Ru Chen, Chao-Chao Yu, Xue-Song Wang, Tao Jiang, Li-Hong Kon. [Effect of pretreatment of acupuncture on learning-memory ability and related protein of NLRP3 inflammasome in hippocampus in Alzheimer's disease like rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 12. 2021-02-01. PMID:33415876. |
[effect of pretreatment of acupuncture on learning-memory ability and related protein of nlrp3 inflammasome in hippocampus in alzheimer's disease like rats]. |
2021-02-01 |
2023-08-13 |
rat |
| Chuan He, Zhong-Sheng Huang, Hong-Ru Chen, Chao-Chao Yu, Xue-Song Wang, Tao Jiang, Li-Hong Kon. [Effect of pretreatment of acupuncture on learning-memory ability and related protein of NLRP3 inflammasome in hippocampus in Alzheimer's disease like rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 12. 2021-02-01. PMID:33415876. |
to observe the effect of pretreatment of acupuncture on the expression of nucleotide-binding oligomerization domain-like receptor 3(nlrp3), caspase-1, interleukin1β(il-1β) and the number of activated microglia (mg) in the hippocampus in alzheimer's disease (ad) like rats, so as to explore the mechanism of pretreatment of acupuncture in preventing and treating ad. |
2021-02-01 |
2023-08-13 |
rat |
| Yun Zhang, Zhifang Dong, Weihong Son. NLRP3 inflammasome as a novel therapeutic target for Alzheimer's disease. Signal transduction and targeted therapy. vol 5. issue 1. 2021-01-25. PMID:32296063. |
nlrp3 inflammasome as a novel therapeutic target for alzheimer's disease. |
2021-01-25 |
2023-08-13 |
Not clear |
| Yulia K Komleva, O L Lopatina, Ya V Gorina, A I Chernykh, L V Trufanova, E F Vais, E V Kharitonova, E L Zhukov, L Yu Vahtina, N N Medvedeva, A B Salmin. Expression of NLRP3 Inflammasomes in Neurogenic Niche Contributes to the Effect of Spatial Learning in Physiological Conditions but Not in Alzheimer's Type Neurodegeneration. Cellular and molecular neurobiology. 2021-01-04. PMID:33392919. |
expression of nlrp3 inflammasomes in neurogenic niche contributes to the effect of spatial learning in physiological conditions but not in alzheimer's type neurodegeneration. |
2021-01-04 |
2023-08-13 |
rat |
| Yulia K Komleva, O L Lopatina, Ya V Gorina, A I Chernykh, L V Trufanova, E F Vais, E V Kharitonova, E L Zhukov, L Yu Vahtina, N N Medvedeva, A B Salmin. Expression of NLRP3 Inflammasomes in Neurogenic Niche Contributes to the Effect of Spatial Learning in Physiological Conditions but Not in Alzheimer's Type Neurodegeneration. Cellular and molecular neurobiology. 2021-01-04. PMID:33392919. |
taken together, our data suggest that expression of nlrp3 inflammasomes in cd133+ and psa-ncam+ cells may contribute to stimulation of adult neurogenesis in physiological conditions, whereas alzheimer's type neurodegeneration abolishes stimuli-induced overexpression of nlrp3 within the sgz neurogenic niche. |
2021-01-04 |
2023-08-13 |
rat |
| Ya-Shuo Feng, Zi-Xuan Tan, Lin-Yu Wu, Fang Dong, Feng Zhan. The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease. Ageing research reviews. vol 64. 2020-12-30. PMID:33059089. |
the involvement of nlrp3 inflammasome in the treatment of alzheimer's disease. |
2020-12-30 |
2023-08-13 |
Not clear |
| Francesca La Rosa, Marina Saresella, Ivana Marventano, Federica Piancone, Enrico Ripamonti, Nasser Al-Daghri, Chiara Bazzini, Chiara Paola Zoia, Elisa Conti, Carlo Ferrarese, Mario Cleric. Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy. Journal of Alzheimer's disease : JAD. vol 72. issue 2. 2020-11-17. PMID:31594217. |
alzheimer's disease (ad) is associated with the accumulation of amyloid-β (aβ) within senile plaques in the brain and neuroinflammation, possibly driven by the activation of the nlrp3 inflammasome. |
2020-11-17 |
2023-08-13 |
Not clear |
| Kate J Claycombe-Larson, Travis Alvine, Dayong Wu, Nishan S Kalupahana, Naima Moustaid-Moussa, James N Roemmic. Nutrients and Immunometabolism: Role of Macrophage NLRP3. The Journal of nutrition. vol 150. issue 7. 2020-11-13. PMID:32271912. |
studies have demonstrated that macrophages and the nod-, lrr-, and pyrin domain-containing protein 3 (nlrp3) inflammasome are activated in key metabolic tissues to contribute to increased risk for type 2 diabetes mellitus, alzheimer disease, and liver diseases. |
2020-11-13 |
2023-08-13 |
Not clear |
| Kendra L Hanslik, Tyler K Ullan. The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease. Frontiers in neurology. vol 11. 2020-10-22. PMID:33071950. |
the role of microglia and the nlrp3 inflammasome in alzheimer's disease. |
2020-10-22 |
2023-08-13 |
Not clear |
| Hu Li, Xueping Zhang, Mingfu Chen, Jianyan Chen, Tao Gao, Shanglong Ya. Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by c-Fos/NLRP3/caspase-1 cascades. EXCLI journal. vol 17. 2020-10-01. PMID:29743866. |
nod-like receptor 3 (nlrp3) plays critical roles in the initiation of inflammasome-mediated inflammation in microglia, thus becomes an important therapeutic target of alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
human |
| Elif Eren, Nesrin Özöre. The NLRP3 inflammasome: a new player in neurological diseases. Turkish journal of biology = Turk biyoloji dergisi. vol 43. issue 6. 2020-10-01. PMID:31892810. |
besides this central role of nlrp3 in inflammation, recent publications show that the nlrp3 inflammasome is also involved in the physiopathology of several neurological disorders including alzheimer's disease, parkinson's disease, and multiple sclerosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Katharine M von Herrmann, Lucas A Salas, Eileen M Martinez, Alison L Young, Joseph M Howard, Mary S Feldman, Brock C Christensen, Owen M Wilkins, Stephen L Lee, William F Hickey, Matthew C Havrd. NPJ Parkinson's disease. vol 4. 2020-09-30. PMID:30131971. |
nlrp3 inflammasome activity has been associated with alzheimer's disease, and recent reports, from our laboratory and others, indicate that |
2020-09-30 |
2023-08-13 |
Not clear |
| Hua Bai, Qi-Fang Zhang, Juan-Juan Duan, De-Jun Yu, Li-Jie Li. Downregulation of signal transduction and STAT3 expression exacerbates oxidative stress mediated by NLRP3 inflammasome. Neural regeneration research. vol 13. issue 12. 2020-09-29. PMID:30323145. |
activated nucleotide binding to the oligonucleotide receptor protein 3 (nlrp3) inflammasome is possibly involved in the pathogenesis of alzheimer's disease through oxidative stress and neurogenic inflammation. |
2020-09-29 |
2023-08-13 |
Not clear |
| Weigang Cui, Chunli Sun, Yuqi Ma, Songtao Wang, Xianwei Wang, Yinghua Zhan. Inhibition of TLR4 Induces M2 Microglial Polarization and Provides Neuroprotection via the NLRP3 Inflammasome in Alzheimer's Disease. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32508567. |
inhibition of tlr4 induces m2 microglial polarization and provides neuroprotection via the nlrp3 inflammasome in alzheimer's disease. |
2020-09-28 |
2023-08-13 |
mouse |
| Yadi Guan, Fang Ha. Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases. Frontiers in integrative neuroscience. vol 14. 2020-09-28. PMID:32792920. |
here, we reviewed the mechanisms, role, and latest developments regarding the nlrp3 inflammasome with respect to three neurodegenerative diseases: alzheimer's disease (ad), parkinson's disease (pd), and amyotrophic lateral sclerosis (als). |
2020-09-28 |
2023-08-13 |
human |
| Jong-Hoon Lee, Ha Kyeu An, Mun-Gi Sohn, Paul Kivela, Sangsuk O. 4,4'-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor. International journal of molecular sciences. vol 21. issue 17. 2020-08-31. PMID:32824985. |
the nlrp3 (nacht, lrr and pyd domains-containing protein 3) inflammasome is implicated in a variety of human diseases including alzheimer's disease (ad), prion diseases, type 2 diabetes, and numerous infectious diseases. |
2020-08-31 |
2023-08-13 |
human |