| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lexiao Li, Saifudeen Ismael, Sanaz Nasoohi, Kazuko Sakata, Francesca-Fang Liao, Michael P McDonald, Tauheed Ishra. Thioredoxin-Interacting Protein (TXNIP) Associated NLRP3 Inflammasome Activation in Human Alzheimer's Disease Brain. Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-22. PMID:30741672. |
thioredoxin-interacting protein (txnip) associated nlrp3 inflammasome activation in human alzheimer's disease brain. |
2020-06-22 |
2023-08-13 |
human |
| Yang Yang, Huanan Wang, Mohammed Kouadir, Houhui Song, Fushan Sh. Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30755589. |
the nlrp3 inflammasome has been implicated in a wide range of diseases, including alzheimer's disease, prion diseases, type 2 diabetes, and some infectious diseases. |
2020-04-06 |
2023-08-13 |
Not clear |
| Xingyi Chen, You Zhou, Jiujiu Y. Exosome-like Nanoparticles from Ginger Rhizomes Inhibited NLRP3 Inflammasome Activation. Molecular pharmaceutics. vol 16. issue 6. 2020-03-16. PMID:31038962. |
the nucleotide-binding domain and leucine-rich repeat-containing family, pyrin domain-containing 3 (nlrp3) inflammasome is a key regulator of innate immune responses, and its aberrant activation is implicated in the pathogenesis of many diseases such as alzheimer's disease and type 2 diabetes. |
2020-03-16 |
2023-08-13 |
Not clear |
| Nedra Mekni, Maria De Rosa, Chiara Cipollina, Maria Rita Gulotta, Giada De Simone, Jessica Lombino, Alessandro Padova, Ugo Perricon. In Silico Insights towards the Identification of NLRP3 Druggable Hot Spots. International journal of molecular sciences. vol 20. issue 20. 2020-02-19. PMID:31600880. |
nlrp3 (nod-like receptor family, pyrin domain-containing protein 3) activation has been linked to several chronic pathologies, including atherosclerosis, type-ii diabetes, fibrosis, rheumatoid arthritis, and alzheimer's disease. |
2020-02-19 |
2023-08-13 |
Not clear |
| Qing-Guo Ren, Wei-Gang Gong, Hong Zhou, Hao Shu, Yan-Juan Wang, Zhi-Jun Zhan. Spatial Training Ameliorates Long-Term Alzheimer's Disease-Like Pathological Deficits by Reducing NLRP3 Inflammasomes in PR5 Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 16. issue 2. 2020-01-09. PMID:30560481. |
spatial training ameliorates long-term alzheimer's disease-like pathological deficits by reducing nlrp3 inflammasomes in pr5 mice. |
2020-01-09 |
2023-08-13 |
mouse |
| Nathan Kelley, Devon Jeltema, Yanhui Duan, Yuan H. The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. International journal of molecular sciences. vol 20. issue 13. 2019-12-11. PMID:31284572. |
however, the aberrant activation of the nlrp3 inflammasome has been linked with several inflammatory disorders, which include cryopyrin-associated periodic syndromes, alzheimer's disease, diabetes, and atherosclerosis. |
2019-12-11 |
2023-08-13 |
Not clear |
| Baban S Thawkar, Ginpreet Kau. Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease. Journal of neuroimmunology. vol 326. 2019-11-29. PMID:30502599. |
the nuclear factor-kappa b (nf- kb) and nlrp3 inflammasome activation by p2x7/nlrp3/caspase 1 pathways are closely linked to alzheimer's disease (ad) via neuroinflammation, therefore it could be a rational strategy to target these proteins to counteract the ad pathology. |
2019-11-29 |
2023-08-13 |
Not clear |
| Carolina Pellegrini, Matteo Fornai, Luca Antonioli, Corrado Blandizzi, Vincenzo Calderon. Phytochemicals as Novel Therapeutic Strategies for NLRP3 Inflammasome-Related Neurological, Metabolic, and Inflammatory Diseases. International journal of molecular sciences. vol 20. issue 12. 2019-11-26. PMID:31200447. |
several lines of evidence point out the relevance of nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain-containing protein 3 (nlrp3) inflammasome as a pivotal player in the pathophysiology of several neurological and psychiatric diseases (i.e., parkinson's disease (pd), alzheimer's disease (ad), multiple sclerosis (ms), amyotrophic lateral sclerosis, and major depressive disorder), metabolic disorders (i.e., obesity and type 2 diabetes) and chronic inflammatory diseases (i.e., intestinal inflammation, arthritis, and gout). |
2019-11-26 |
2023-08-13 |
Not clear |
| Ana Tapia-Abellán, Diego Angosto-Bazarra, Helios Martínez-Banaclocha, Carlos de Torre-Minguela, Jose P Cerón-Carrasco, Horacio Pérez-Sánchez, Juan I Arostegui, Pablo Pelegri. MCC950 closes the active conformation of NLRP3 to an inactive state. Nature chemical biology. vol 15. issue 6. 2019-07-29. PMID:31086329. |
nlrp3 (nod-like receptor pyrin domain-containing protein 3) is an innate immune sensor that contributes to the development of different diseases, including monogenic autoinflammatory syndromes, gout, atherosclerosis, and alzheimer's disease. |
2019-07-29 |
2023-08-13 |
Not clear |
| Jingwei Shang, Toru Yamashita, Yun Zhai, Yumiko Nakano, Ryuta Morihara, Xianghong Li, Feng Tian, Xia Liu, Yong Huang, Xiaowen Shi, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Ab. Acceleration of NLRP3 inflammasome by chronic cerebral hypoperfusion in Alzheimer's disease model mouse. Neuroscience research. vol 143. 2019-07-23. PMID:29885344. |
acceleration of nlrp3 inflammasome by chronic cerebral hypoperfusion in alzheimer's disease model mouse. |
2019-07-23 |
2023-08-13 |
mouse |
| Yasmine Sebti, Lise Ferri, Mathilde Zecchin, Justine Beauchamp, Denis Mogilenko, Bart Staels, Hélène Duez, Benoit Pource. The LPS/D-Galactosamine-Induced Fulminant Hepatitis Model to Assess the Role of Ligand-Activated Nuclear Receptors on the NLRP3 Inflammasome Pathway In Vivo. Methods in molecular biology (Clifton, N.J.). vol 1951. 2019-07-15. PMID:30825154. |
activation of nlrp3 by such compounds triggers a sterile inflammatory response that may be involved in numerous pathologies including rheumatoid arthritis, atherosclerosis, diabetes, and alzheimer's disease. |
2019-07-15 |
2023-08-13 |
mouse |
| Jacob Fulp, Liu He, Stefano Toldo, Yuqi Jiang, Ashley Boice, Chunqing Guo, Xia Li, Andrew Rolfe, Dong Sun, Antonio Abbate, Xiang-Yang Wang, Shijun Zhan. Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization. Journal of medicinal chemistry. vol 61. issue 12. 2019-06-18. PMID:29877709. |
in this study, we established the in vivo functional activities of jc124, a previously identified nlrp3 inflammasome inhibitor from our group, in mouse models of alzheimer's disease and acute myocardial infarction. |
2019-06-18 |
2023-08-13 |
mouse |
| S V Pirozhkov, N N Terebilina, P F Litvitski. [A role of inflammasomes in the pathogenesis of neurological and mental diseases]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 118. issue 12. 2019-05-30. PMID:30698567. |
the review discusses the involvement of nlrp3 inflammasome and other their types in the development of the traumatic brain injury, ischemic and hemorrhagic stroke, brain tumors, cns infections, alzheimer's and parkinson's diseases, epilepsy, amyotrophic lateral sclerosis, depressiver, and consequences of alcohol abuse. |
2019-05-30 |
2023-08-13 |
Not clear |
| Jun Yin, Fanpeng Zhao, Jeremy E Chojnacki, Jacob Fulp, William L Klein, Shijun Zhang, Xiongwei Zh. NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 55. issue 3. 2019-05-23. PMID:28255908. |
nlrp3 inflammasome inhibitor ameliorates amyloid pathology in a mouse model of alzheimer's disease. |
2019-05-23 |
2023-08-13 |
mouse |
| Jun Yin, Fanpeng Zhao, Jeremy E Chojnacki, Jacob Fulp, William L Klein, Shijun Zhang, Xiongwei Zh. NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 55. issue 3. 2019-05-23. PMID:28255908. |
the activation of the nlrp3 inflammasome signaling pathway plays an important role in the neuroinflammation in alzheimer's disease (ad). |
2019-05-23 |
2023-08-13 |
mouse |
| Bian-Rong Wang, Jian-Quan Shi, Nian-Nian Ge, Zhou Ou, You-Yong Tian, Teng Jiang, Jun-Shan Zhou, Jun Xu, Ying-Dong Zhan. PM2.5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes NLRP3 inflammasome activation in an in vitro model of Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2019-04-15. PMID:29720213. |
pm2.5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes nlrp3 inflammasome activation in an in vitro model of alzheimer's disease. |
2019-04-15 |
2023-08-13 |
Not clear |
| Alex G Baldwin, Victor S Tapia, Tessa Swanton, Claire S White, James A Beswick, David Brough, Sally Freema. Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome. ChemMedChem. vol 13. issue 4. 2019-01-22. PMID:29331080. |
inappropriate activation of nlrp3 drives a chronic inflammatory response and is implicated in several non-communicable diseases, including gout, atherosclerosis, type ii diabetes and alzheimer's disease. |
2019-01-22 |
2023-08-13 |
Not clear |
| Tao Gong, Yanqing Yang, Tengchuan Jin, Wei Jiang, Rongbin Zho. Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes. Trends in immunology. vol 39. issue 5. 2018-12-28. PMID:29452983. |
accordingly, the dysregulation of nlrp3 inflammasome activation is involved in a variety of human diseases, including gout, diabetes, and alzheimer's disease. |
2018-12-28 |
2023-08-13 |
human |
| Xuan Li, Sarah Thome, Xiaodan Ma, Mamta Amrute-Nayak, Alison Finigan, Lauren Kitt, Leanne Masters, John R James, Yuguang Shi, Guoyu Meng, Ziad Malla. MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Nature communications. vol 8. 2018-12-11. PMID:28656979. |
excessive activation of the nlr family pyrin domain containing 3 (nlrp3) inflammasome is involved in many chronic inflammatory diseases, including cardiovascular and alzheimer's disease. |
2018-12-11 |
2023-08-13 |
Not clear |
| Tiantian Tang, Tao Gong, Wei Jiang, Rongbin Zho. GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics. Trends in pharmacological sciences. vol 39. issue 9. 2018-11-07. PMID:30054020. |
the nlrp3 inflammasome is an intracellular multimeric protein complex which plays an important role in the pathogenesis of various human inflammatory diseases, such as diabetes, alzheimer's disease and atherosclerosis. |
2018-11-07 |
2023-08-13 |
human |