| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanjay Arora, Takahisa Kanekiyo, Jagdish Sing. Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer's disease pathology in transgenic mouse model. International journal of biological macromolecules. 2022-04-04. PMID:35378156. |
in animal models of alzheimer's disease (ad), highly invasive bdnf gene therapy using viral vectors has successfully shown enhanced synaptic protein expression, proliferation of neurons and attenuation of amyloidogenic processes. |
2022-04-04 |
2023-08-13 |
mouse |
| Lino Tessarollo, Sudhirkumar Yanpallewa. TrkB Truncated Isoform Receptors as Transducers and Determinants of BDNF Functions. Frontiers in neuroscience. vol 16. 2022-03-24. PMID:35321093. |
bdnf is a critical player in the development of the central (cns) and peripheral (pns) nervous system of vertebrates and its strong pro-survival function on neurons has attracted great interest as a potential therapeutic target for the management of neurodegenerative disorders such as amyotrophic lateral sclerosis (als), huntington, parkinson's and alzheimer's disease. |
2022-03-24 |
2023-08-13 |
Not clear |
| Ya Shao, Tianbo X. A study on the neuroprotective effect of miR-206-3p on Alzheimer's disease mice by regulating brain-derived neurotrophic factor. Annals of translational medicine. vol 10. issue 2. 2022-03-14. PMID:35282109. |
brain-derived neurotrophic factor (bdnf) is involved in the regulation of alzheimer's disease (ad), but the mechanism is not clear. |
2022-03-14 |
2023-08-13 |
mouse |
| Yoshiyasu Fukuyam. [Synthetic Studies on Small Molecule Natural Products with Neurotrophic Activity]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 142. issue 3. 2022-03-01. PMID:35228379. |
neurotrophic factors have been shown to potentially be beneficial for the treatment of neurodegenerative diseases such as alzheimer's disease, because endogenous neurotrophic factors (ngf, bdnf) have been recognized to play critical roles in the promotion of neurogenesis, differentiation, and neuroprotection throughout the development of the central nervous system. |
2022-03-01 |
2023-08-13 |
rat |
| Marco Túlio Cintra, Rafaela Ávila, Ivonne Carolina Bolaños Burgos, Millena Figueiredo Miranda, Mariana Figueiredo Miranda, Anna Luiza Souza, Denise U Gonçalves, Maria Aparecida C Bicalh. P300 evoked potential and serum BDNF level are related to conversion of MCI to Alzheimer's dementia, regarding genetic background. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109228. |
p300 evoked potential and serum bdnf level are related to conversion of mci to alzheimer's dementia, regarding genetic background. |
2022-02-03 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Paul Maruff, Nicolas R Barthélemy, Alison Goate, Jason Hassenstab, Chihiro Sato, Anne M Fagan, Tammie L S Benzinger, Chengjie Xiong, Carlos Cruchaga, Johannes Levin, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Colin L Masters, Stephen Salloway, Peter R Schofield, John C Morris, Randall J Bateman, Eric McDad. Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease. JAMA neurology. 2022-01-31. PMID:35099506. |
association of bdnf val66met with tau hyperphosphorylation and cognition in dominantly inherited alzheimer disease. |
2022-01-31 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Paul Maruff, Nicolas R Barthélemy, Alison Goate, Jason Hassenstab, Chihiro Sato, Anne M Fagan, Tammie L S Benzinger, Chengjie Xiong, Carlos Cruchaga, Johannes Levin, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Colin L Masters, Stephen Salloway, Peter R Schofield, John C Morris, Randall J Bateman, Eric McDad. Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease. JAMA neurology. 2022-01-31. PMID:35099506. |
allelic variation in the brain-derived neurotrophic factor (bdnf) val66met polymorphism moderates increases in cerebrospinal fluid (csf) levels of tau and phosphorylated tau 181 (p-tau181), measured using immunoassay, and cognitive decline in presymptomatic dominantly inherited alzheimer disease (diad). |
2022-01-31 |
2023-08-13 |
Not clear |
| Somayeh Sadrirad, Naser Samadi, Masoud Nikanfar, Zohre B Moayed, Delara Laghousi, Zahra Hasanzade, Nazila F Maroufi, Alireza Nourazaria. Evaluation of the Diagnostic and Predictive Value of Glutamic Acid Decarboxylase, Zinc Transporter 8 Serum Levels in Alzheimer's Disease. Clinical laboratory. vol 68. issue 1. 2022-01-13. PMID:35023669. |
in this regard, serum levels of gada, znt8a, zn, vitamin d, and leukocyte expression of brain-derived neurotrophic factor (bdnf) gene were investigated in alzheimer's patients and control group. |
2022-01-13 |
2023-08-13 |
Not clear |
| N Abanmy, J Alsabhan, P Gard, G Scut. Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer's disease patients. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 29. issue 12. 2022-01-10. PMID:35002376. |
association between the val66met polymorphism (rs6265/g196a) of the bdnf gene and cognitive performance with ssri use in arab alzheimer's disease patients. |
2022-01-10 |
2023-08-13 |
human |
| N Abanmy, J Alsabhan, P Gard, G Scut. Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer's disease patients. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 29. issue 12. 2022-01-10. PMID:35002376. |
this study investigated whether the bdnf gene val66met polymorphism (rs6265/g196a) is associated with cognitive function changes in both alzheimer disease (ad) patients and elderly participants. |
2022-01-10 |
2023-08-13 |
human |
| Zekiye Ceren Arituluk, Jesse Horne, Bishnu Adhikari, Jeffrey Steltzner, Shomit Mansur, Parmanand Ahirwar, Sadanandan E Velu, Nora E Gray, Lukasz M Ciesla, Yuping Ba. Identification of TrkB Binders from Complex Matrices Using a Magnetic Drug Screening Nanoplatform. ACS applied bio materials. vol 4. issue 8. 2022-01-10. PMID:35006910. |
brain-derived neurotrophic factor (bdnf) and its receptor tyrosine receptor kinase b (trkb) have been shown to play an important role in numerous neurological disorders, such as alzheimer's disease. |
2022-01-10 |
2023-08-13 |
Not clear |
| Karin Seidler, Michelle Barro. Intermittent Fasting and Cognitive Performance - Targeting BDNF as Potential Strategy to Optimise Brain Health. Frontiers in neuroendocrinology. 2021-12-20. PMID:34929259. |
aging-related loss of bdnf has been associated with reduced synaptic plasticity, memory and learning as well as increased risk of cognitive impairment and alzheimer's disease. |
2021-12-20 |
2023-08-13 |
human |
| Saeid Fakhraei, Mohammad Reza Almasi, Maghsoud Peeri, Reza Gharakhanlo. The effect of 4-Week rehabilitation by aerobic exercise on hippocampus BDNF and TGF-β1 gene expressions inAβ 1-42-induced rat model of Alzheimer's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 95. 2021-12-20. PMID:34929632. |
the effect of 4-week rehabilitation by aerobic exercise on hippocampus bdnf and tgf-β1 gene expressions inaβ 1-42-induced rat model of alzheimer's disease. |
2021-12-20 |
2023-08-13 |
rat |
| Debora Cutuli, Eugenia Landolfo, Laura Petrosini, Francesca Gelf. Environmental Enrichment Effects on the Brain-Derived Neurotrophic Factor Expression in Healthy Condition, Alzheimer's Disease, and Other Neurodegenerative Disorders. Journal of Alzheimer's disease : JAD. 2021-12-13. PMID:34897089. |
a further purpose of the present review is analyzing the potential of bdnf regulation in coping with neurodegenerative processes characterizing alzheimer's disease (ad), given bdnf expression alterations are described in ad patients. |
2021-12-13 |
2023-08-13 |
Not clear |
| Golo Kronenberg, Karen Gertz, Johanna Schöner, Lars Bertram, Thomas Liman, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Matthias Endres, Rainer Hellwe. BDNF serum concentrations in 2053 participants of the Berlin Aging Study II. Neurobiology of aging. vol 101. 2021-11-30. PMID:33636574. |
multiple linear regression analysis failed to detect significant relationships of digit symbol substitution test score and consortium to establish a registry for alzheimer's disease memory score to bdnf levels. |
2021-11-30 |
2023-08-13 |
human |
| Simone Eggert, Stefan Kins, Kristina Endres, Tanja Brigadsk. Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of Alzheimer's disease. Biological chemistry. vol 403. issue 1. 2021-11-30. PMID:34619027. |
a wealth of evidence, such as reduced mrna and protein level in the brain, cerebrospinal fluid (csf), and blood samples of alzheimer's disease (ad) patients implicates a crucial role of bdnf in the progression of this disease. |
2021-11-30 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Simon M Laws, Stephanie Perin, Robert H Pietrzak, Christopher Fowler, Colin L Masters, Paul Maruf. BDNF VAL66MET polymorphism and memory decline across the spectrum of Alzheimer's disease. Genes, brain, and behavior. vol 20. issue 5. 2021-11-09. PMID:33369083. |
bdnf val66met polymorphism and memory decline across the spectrum of alzheimer's disease. |
2021-11-09 |
2023-08-13 |
human |
| Yen Ying Lim, Simon M Laws, Stephanie Perin, Robert H Pietrzak, Christopher Fowler, Colin L Masters, Paul Maruf. BDNF VAL66MET polymorphism and memory decline across the spectrum of Alzheimer's disease. Genes, brain, and behavior. vol 20. issue 5. 2021-11-09. PMID:33369083. |
the brain-derived neurotrophic factor (bdnf) val66met (rs6265) polymorphism has been shown to moderate the extent to which memory decline manifests in preclinical alzheimer's disease (ad). |
2021-11-09 |
2023-08-13 |
human |
| Madhuparna Banerjee, Rekha R Sheno. Emphasizing roles of BDNF promoters and inducers in Alzheimer's disease for improving impaired cognition and memory. Journal of basic and clinical physiology and pharmacology. 2021-11-09. PMID:34751526. |
emphasizing roles of bdnf promoters and inducers in alzheimer's disease for improving impaired cognition and memory. |
2021-11-09 |
2023-08-13 |
Not clear |
| Madhuparna Banerjee, Rekha R Sheno. Emphasizing roles of BDNF promoters and inducers in Alzheimer's disease for improving impaired cognition and memory. Journal of basic and clinical physiology and pharmacology. 2021-11-09. PMID:34751526. |
in alzheimer's disease (ad), often it is seen that low levels of bdnf are present, which primarily contributes to cognition deficit by regulating long-term potentiation (ltp) and synaptic plasticity. |
2021-11-09 |
2023-08-13 |
Not clear |