| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Erdogan Orhan, G Orhan, E Gurka. An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production. Mini reviews in medicinal chemistry. vol 11. issue 10. 2012-02-15. PMID:21762104. |
cholinesterase enzyme family consisting of acetylcholinesterase (ache) and butrylcholinesterase (bche) is important in pathogenesis of alzheimer's disease (ad), explained by "cholinergic hypothesis". |
2012-02-15 |
2023-08-12 |
Not clear |
| Michela Rosini, Elena Simoni, Manuela Bartolini, Andrea Tarozzi, Riccardo Matera, Andrea Milelli, Patrizia Hrelia, Vincenza Andrisano, Maria Laura Bolognesi, Carlo Melchiorr. Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. European journal of medicinal chemistry. vol 46. issue 11. 2012-02-13. PMID:21924801. |
its structure was previously combined with that of the acetylcholinesterase inhibitor tacrine to give lipocrine (1), a lead compound multitargeted against alzheimer's disease (ad). |
2012-02-13 |
2023-08-12 |
Not clear |
| Daniel Mansour, Remy Wong, Michael Kuskowski, Maurice Dyske. Discontinuation of acetylcholinesterase inhibitor treatment in the nursing home. The American journal of geriatric pharmacotherapy. vol 9. issue 5. 2012-02-01. PMID:21925960. |
dementia treatment guidelines are not consistent in determining how long to continue acetylcholinesterase inhibitor (achei) treatment in patients with alzheimer's disease. |
2012-02-01 |
2023-08-12 |
Not clear |
| Jan Korabecny, Kamil Musilek, Filip Zemek, Anna Horova, Ondrej Holas, Eugenie Nepovimova, Veronika Opletalova, Jana Hroudova, Zdenek Fisar, Young-Sik Jung, Kamil Kuc. Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties. Bioorganic & medicinal chemistry letters. vol 21. issue 21. 2012-01-31. PMID:21920739. |
tacrine (tha) is a potent acetylcholinesterase inhibitor that was used in the treatment of alzheimer's disease for a long time. |
2012-01-31 |
2023-08-12 |
Not clear |
| Iksoo Lee, Bora Ahn, Jaesue Choi, Masao Hattori, Byungsun Min, Kihwan Ba. Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorganic & medicinal chemistry letters. vol 21. issue 21. 2012-01-31. PMID:21924611. |
because new compounds exhibiting specific anti-acetylcholinesterase activity are being sought as possible drug candidates for the treatment of alzheimer's and related neurodegenerative diseases, compounds 1-18 were examined for their inhibitory activities against acetylcholinesterase and butyrylcholinesterase. |
2012-01-31 |
2023-08-12 |
Not clear |
| A Klimkowicz-Mrowiec, M Marona, K Spisak, J Jagiella, P Wolkow, A Szczudlik, A Slowi. Paraoxonase 1 gene polymorphisms do not influence the response to treatment in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 32. issue 1. 2012-01-11. PMID:21829028. |
acetylcholinesterase inhibitors (acheis) are the treatment of choice for patients with alzheimer's disease (ad). |
2012-01-11 |
2023-08-12 |
Not clear |
| N M W J de Bruin, J Prickaerts, A van Loevezijn, J Venhorst, L de Groote, P Houba, O Reneerkens, S Akkerman, C G Krus. Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats. Neurobiology of learning and memory. vol 96. issue 2. 2011-12-27. PMID:21757018. |
the acetylcholinesterase inhibitor (achei) donepezil (aricept®, approved for symptomatic treatment of alzheimer's disease, ad) was used as a positive reference compound. |
2011-12-27 |
2023-08-12 |
rat |
| Aiko Shimada, Hiroshi Hashimoto, Joji Kawabe, Shigeaki Higashiyama, Toshihiro Kai, Kouhei Kataoka, Ryo Tagawa, Youjirou Kawarada, Aki Nakanishi, Koki Inoue, Susumu Shiomi, Nobuo Kiriik. Evaluation of therapeutic response to donepezil by positron emission tomography. Osaka city medical journal. vol 57. issue 1. 2011-12-13. PMID:22106763. |
donepezil hydrochloride (donepezil) is an acetylcholinesterase inhibitor (achei) that is used for the symptomatic treatment of dementia of the alzheimer's type (dat). |
2011-12-13 |
2023-08-12 |
Not clear |
| Kyoung-Ah Kim, Jong Lae Lim, Chin Kim, Ji-Young Par. Pharmacokinetic comparison of orally disintegrating and conventional donepezil formulations in healthy Korean male subjects: a single-dose, randomized, open-label, 2-sequence, 2-period crossover study. Clinical therapeutics. vol 33. issue 7. 2011-11-18. PMID:21723605. |
donepezil is a potent inhibitor of acetylcholinesterase, an enzyme that is targeted in the treatment of alzheimer's disease. |
2011-11-18 |
2023-08-12 |
human |
| Jean Paulo de Andrade, Strahil Berkov, Francesc Viladomat, Carles Codina, José Angelo S Zuanazzi, Jaume Bastid. Alkaloids from Hippeastrum papilio. Molecules (Basel, Switzerland). vol 16. issue 8. 2011-11-18. PMID:21852767. |
galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (razadyne®, reminyl®) for the treatment of alzheimer's disease (ad), is obtained from amaryllidaceae plants, especially those belonging to the genera leucojum, narcissus, lycoris and ungernia. |
2011-11-18 |
2023-08-12 |
Not clear |
| Daniela Galimberti, Elio Scarpin. Disease-modifying treatments for Alzheimer's disease. Therapeutic advances in neurological disorders. vol 4. issue 4. 2011-11-10. PMID:21765871. |
the first drugs developed for alzheimer's disease (ad), acetylcholinesterase inhibitors (achei), increase acetylcholine levels, previously demonstrated to be reduced in ad. |
2011-11-10 |
2023-08-12 |
Not clear |
| María-Salud García-Ayllón, David H Small, Jesús Avila, Javier Sáez-Valer. Revisiting the Role of Acetylcholinesterase in Alzheimer's Disease: Cross-Talk with P-tau and β-Amyloid. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949503. |
revisiting the role of acetylcholinesterase in alzheimer's disease: cross-talk with p-tau and β-amyloid. |
2011-11-10 |
2023-08-12 |
Not clear |
| María-Salud García-Ayllón, David H Small, Jesús Avila, Javier Sáez-Valer. Revisiting the Role of Acetylcholinesterase in Alzheimer's Disease: Cross-Talk with P-tau and β-Amyloid. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949503. |
a common feature in the alzheimer's disease (ad) brain is the presence of acetylcholinesterase (ache) which is commonly associated with β-amyloid plaques and neurofibrillary tangles (nft). |
2011-11-10 |
2023-08-12 |
Not clear |
| L Parnetti, D Chiasserini, U Andreasson, M Ohlson, C Hüls, H Zetterberg, L Minthon, A K Wallin, N Andreasen, V N Talesa, K Blenno. Changes in CSF acetyl- and butyrylcholinesterase activity after long-term treatment with AChE inhibitors in Alzheimer's disease. Acta neurologica Scandinavica. vol 124. issue 2. 2011-11-02. PMID:20880294. |
to measure cerebrospinal fluid (csf) activity of acetylcholinesterase (ache) and butyrylcholinesterase (bche) in patients with alzheimer's disease (ad) participating in randomized clinical trials from three european centers, before and after long-term treatment with different ache inhibitors (acheis). |
2011-11-02 |
2023-08-12 |
Not clear |
| Solomon Habtemaria. The therapeutic potential of Berberis darwinii stem-bark: quantification of berberine and in vitro evidence for Alzheimer's disease therapy. Natural product communications. vol 6. issue 8. 2011-10-21. PMID:21922905. |
herewith, the therapeutic potential of stem-bark of the plant for treating alzheimer's disease was studied using an in vitro acetylcholinesterase inhibition assay. |
2011-10-21 |
2023-08-12 |
Not clear |
| Haiyan Lou, Peihong Fan, Ruth G Perez, Hongxiang Lo. Neuroprotective effects of linarin through activation of the PI3K/Akt pathway in amyloid-β-induced neuronal cell death. Bioorganic & medicinal chemistry. vol 19. issue 13. 2011-10-17. PMID:21652214. |
these findings raise the possibility that linarin may be a potent therapeutic compound against alzheimer's disease acting through both acetylcholinesterase inhibition and neuroprotection. |
2011-10-17 |
2023-08-12 |
rat |
| Vinicius Barreto da Silva, Peterson de Andrade, Daniel Fábio Kawano, Pedro Alves Bezerra Morais, Jonathan Resende de Almeida, Ivone Carvalho, Carlton Anthony Taft, Carlos Henrique Tomich de Paula da Silv. In silico design and search for acetylcholinesterase inhibitors in Alzheimer's disease with a suitable pharmacokinetic profile and low toxicity. Future medicinal chemistry. vol 3. issue 8. 2011-10-12. PMID:21707398. |
in silico design and search for acetylcholinesterase inhibitors in alzheimer's disease with a suitable pharmacokinetic profile and low toxicity. |
2011-10-12 |
2023-08-12 |
Not clear |
| Cidan Shen, Bei Yang, Tao Zhou, Gengli Duan, Yingjia Y. Bioequivalence evaluation of two brands of rivastigmine of different salt forms, an acetylcholinesterase inhibitor for the treatment of Alzheimer's disease, in healthy Beagle dogs. Die Pharmazie. vol 66. issue 8. 2011-09-29. PMID:21901981. |
bioequivalence evaluation of two brands of rivastigmine of different salt forms, an acetylcholinesterase inhibitor for the treatment of alzheimer's disease, in healthy beagle dogs. |
2011-09-29 |
2023-08-12 |
Not clear |
| Jocley Queiroz Araújo, Josélia Alencar Lima, Angelo da Cunha Pinto, Ricardo Bicca de Alencastro, Magaly Girão Albuquerqu. Docking of the alkaloid geissospermine into acetylcholinesterase: a natural scaffold targeting the treatment of Alzheimer's disease. Journal of molecular modeling. vol 17. issue 6. 2011-09-16. PMID:20844909. |
docking of the alkaloid geissospermine into acetylcholinesterase: a natural scaffold targeting the treatment of alzheimer's disease. |
2011-09-16 |
2023-08-12 |
rat |
| Jana Hroudová, Zdenĕk Fisar, Jan Korábečný, Kamil Kuč. In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain. Neuro endocrinology letters. vol 32. issue 3. 2011-09-15. PMID:21712782. |
inhibition of the enzyme acetylcholinesterase (ache) is the main mechanism both of therapeutic action of drugs for the treatment of alzheimer's disease and toxic action of organophosphorus compounds. |
2011-09-15 |
2023-08-12 |
Not clear |