| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Molinuev. [Memantine: the value of combined therapy]. Revista de neurologia. vol 52. issue 2. 2011-04-29. PMID:21271549. |
the symptomatic treatment of alzheimer's disease is currently carried out using a twofold therapeutic approach involving acetylcholinesterase inhibitors, whose mechanism of action is based on the selective inhibition of this enzyme, and memantine, which acts by blocking the pathological tonic activation of nmda receptors. |
2011-04-29 |
2023-08-12 |
Not clear |
| Lygia Azevedo Marques, Martin Giera, Henk Lingeman, Wilfried Ma Niesse. Analysis of acetylcholinesterase inhibitors: bioanalysis, degradation and metabolism. Biomedical chromatography : BMC. vol 25. issue 1-2. 2011-04-28. PMID:21154892. |
the drugs of choice for the treatment of alzheimer's disease are acetylcholinesterase (ache) inhibitors. |
2011-04-28 |
2023-08-12 |
Not clear |
| Myriam Ouberai, Kristoffer Brannstrom, Monika Vestling, Anders Olofsson, Pascal Dumy, Sabine Chierici, Julian Garci. Clicked tacrine conjugates as acetylcholinesterase and β-amyloid directed compounds. Organic & biomolecular chemistry. vol 9. issue 4. 2011-04-19. PMID:21152577. |
the multifaceted nature of alzheimer's disease (ad) has led to the development of multi-targeted compounds based on the classical ad drug, tacrine, first known to inhibit the acetylcholine-degrading enzyme acetylcholinesterase (ache). |
2011-04-19 |
2023-08-12 |
Not clear |
| Naoko Shimizu, Tsutomu Nakahara, Yuko Kubota, Kenji Sakamoto, Kunio Ishi. Contribution of cyclooxygenase-dependent mechanisms to contractile responses to donepezil in the rat urinary bladder. Pharmacology. vol 86. issue 5-6. 2011-04-11. PMID:20980781. |
donepezil, an inhibitor of acetylcholinesterase, is used to improve cholinergic neurotransmission and cognitive function in alzheimer's disease. |
2011-04-11 |
2023-08-12 |
rat |
| Giuseppe Cirillo, Kai Kraemer, Susanne Fuessel, Francesco Puoci, Manuela Curcio, Umile Gianfranco Spizzirri, Ilaria Altimari, Francesca Iemm. Biological activity of a gallic acid-gelatin conjugate. Biomacromolecules. vol 11. issue 12. 2011-04-11. PMID:21058637. |
in particular, acetylcholinesterase inhibition (ic(50) of 7.1 ± 1.3 mg ml(-1)) implies the conjugate's usefulness in the chemoprevention of alzheimer's disease, while the inhibition of α-amylase (ic(50) of 9.8 ± 1.1 mg ml(-1)) suggests that the conjugate can be a preferred alternative for inhibition of carbohydrate breakdown and control of glycemic index of food products. |
2011-04-11 |
2023-08-12 |
Not clear |
| David Hicks, Danielle John, Natalia Z Makova, Zaineb Henderson, Natalia N Nalivaeva, Anthony J Turne. Membrane targeting, shedding and protein interactions of brain acetylcholinesterase. Journal of neurochemistry. vol 116. issue 5. 2011-03-30. PMID:21214569. |
the early stages of alzheimer's disease are characterized by cholinergic deficits and the preservation of cholinergic function through the use of acetylcholinesterase inhibitors is the basis for current treatments of the disease. |
2011-03-30 |
2023-08-12 |
rat |
| Stefano Dall'Acqua, Filippo Maggi, Paola Minesso, Marina Salvagno, Fabrizio Papa, Sauro Vittori, Gabbriella Innocent. Identification of non-alkaloid acetylcholinesterase inhibitors from Ferulago campestris (Besser) Grecescu (Apiaceae). Fitoterapia. vol 81. issue 8. 2011-03-29. PMID:20713133. |
inhibition of acetylcholinesterase (ache) is still considered as a strategy for the treatment of neurological disorders such as alzheimer's disease. |
2011-03-29 |
2023-08-12 |
Not clear |
| Yukihiro Noda, Akihiro Mouri, Yu Ando, Yukari Waki, Shin-Nosuke Yamada, Akira Yoshimi, Kiyofumi Yamada, Norio Ozaki, Dayong Wang, Toshitaka Nabeshim. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. The international journal of neuropsychopharmacology. vol 13. issue 10. 2011-03-18. PMID:20219155. |
galantamine, a drug used to treat alzheimer's disease, inhibits acetylcholinesterase (ache) and allosterically modulates nicotinic acetylcholine receptors (nachrs) resulting in stimulation of catecholamine neurotransmission. |
2011-03-18 |
2023-08-12 |
mouse |
| Keita Inanaga, Toshihiro Ichiki, Ryohei Miyazaki, Kotaro Takeda, Toru Hashimoto, Hirohide Matsuura, Kenji Sunagaw. Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoprotein E-knockout mice. Atherosclerosis. vol 213. issue 1. 2011-03-07. PMID:20723895. |
donepezil, a reversible acetylcholinesterase inhibitor, improves cognitive function of alzheimer's disease. |
2011-03-07 |
2023-08-12 |
mouse |
| Katherine E Galluzzi, Denah M Appelt, Brian J Bali. Modern care for patients with Alzheimer disease: rationale for early intervention. The Journal of the American Osteopathic Association. vol 110. issue 9 Suppl 8. 2011-03-07. PMID:20926742. |
lacking definitive disease-modifying treatments, modern care for individuals with alzheimer disease is necessarily multimodal, combining the use of approved pharmaceutic agents (ie, acetylcholinesterase inhibitors, n-methyl-d-aspartate receptor antagonists, antipsychotics), lifestyle and behavioral interventions, and components of palliative care. |
2011-03-07 |
2023-08-12 |
Not clear |
| Zhe Jin, Liu Yang, Si-Jie Liu, Jian Wang, Shuo Li, Huang-Quan Lin, David Chi Cheong Wan, Chun H. Synthesis and biological evaluation of 3,6-diaryl-7H-thiazolo[3,2-b] [1,2,4]triazin-7-one derivatives as acetylcholinesterase inhibitors. Archives of pharmacal research. vol 33. issue 10. 2011-03-07. PMID:21052939. |
acetylcholinesterase (ache) inhibitors played an important role in developing a cure for alzheimer' s disease. |
2011-03-07 |
2023-08-12 |
Not clear |
| Marcello Giordano, Ligia J Dominguez, Teresa Vitrano, Massimiliano Curatolo, Anna Ferlisi, Anna Di Prima, Mario Belvedere, Mario Barbagall. Combination of intensive cognitive rehabilitation and donepezil therapy in Alzheimer's disease (AD). Archives of gerontology and geriatrics. vol 51. issue 3. 2011-03-03. PMID:19969381. |
acetylcholinesterase inhibitors (acheis) are extensively used in alzheimer's disease (ad) while reality orientation therapy (rot) is a cognitive rehabilitation indicated for mentally deteriorated patients. |
2011-03-03 |
2023-08-12 |
human |
| Eftim Milkani, Christopher R Lambert, W Grant McGimpse. Direct detection of acetylcholinesterase inhibitor binding with an enzyme-based surface plasmon resonance sensor. Analytical biochemistry. vol 408. issue 2. 2011-03-01. PMID:20849808. |
acetylcholinesterase (ache) inhibitors are potentially lethal but also have applications as therapeutic drugs for neurodegenerative diseases such as alzheimer's. |
2011-03-01 |
2023-08-12 |
Not clear |
| K Wesnes, C Edgar, N Andreasen, P Annas, H Basun, L Lannfelt, H Zetterberg, K Blennow, L Mintho. Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer's disease. Acta neurologica Scandinavica. vol 122. issue 4. 2011-02-25. PMID:20047570. |
computerized cognition assessment during acetylcholinesterase inhibitor treatment in alzheimer's disease. |
2011-02-25 |
2023-08-12 |
Not clear |
| Monika M Hedberg, M Victoria Clos, Miriam Ratia, Daniel Gonzalez, Christina Unger Lithner, Pelayo Camps, Diego Muñoz-Torrero, Albert Badia, Lydia Giménez-Llort, Agneta Nordber. Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice. Neuro-degenerative diseases. vol 7. issue 6. 2011-02-17. PMID:20689242. |
several studies implicate acetylcholinesterase (ache) in the pathogenesis of alzheimer's disease (ad), raising the question of whether inhibitors of ache also might act in a disease-modifying manner. |
2011-02-17 |
2023-08-12 |
mouse |
| Qianqian Li, Donglai Wu, Liming Zhang, Yan Zhan. Effects of galantamine on β-amyloid release and beta-site cleaving enzyme 1 expression in differentiated human neuroblastoma SH-SY5Y cells. Experimental gerontology. vol 45. issue 11. 2011-02-03. PMID:20600777. |
galantamine (gal) is an acetylcholinesterase inhibitor and used to treat the symptoms of alzheimer's disease (ad). |
2011-02-03 |
2023-08-12 |
human |
| Lori A Daiello, Brian R Ott, Elena K Festa, Michael Friedman, Lindsay A Miller, William C Heinde. Effects of cholinesterase inhibitors on visual attention in drivers with Alzheimer disease. Journal of clinical psychopharmacology. vol 30. issue 3. 2011-01-25. PMID:20473058. |
we conducted a combined observational cohort and case-control study in patients with alzheimer disease (ad) to assess the effects of acetylcholinesterase inhibitor (chei) treatment on cognitive functions important for driving. |
2011-01-25 |
2023-08-12 |
Not clear |
| Gülsen Tel, Mehmet Oztürk, Mehmet Emin Duru, Mansur Harmandar, Gülaçti Topç. Chemical composition of the essential oil and hexane extract of Salvia chionantha and their antioxidant and anticholinesterase activities. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 48. issue 11. 2011-01-25. PMID:20732375. |
since, acetylcholinesterase and butyrylcholinesterase enzymes are taking place in pathogenesis of alzheimer's disease, in vitro anticholinesterase activity of the essential oil and the extract was also studied spectrophotometrically. |
2011-01-25 |
2023-08-12 |
Not clear |
| Zha-Jun Zhan, Qi Yu, Zhan-Li Wang, Wei-Guang Sha. Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities. Bioorganic & medicinal chemistry letters. vol 20. issue 21. 2011-01-24. PMID:20850311. |
all isolates were evaluated for acetylcholinesterase (ache) inhibition activities, in which compounds 1 and 3 exhibited the same level of activities as galantamine, a marketed cholinesterase inhibitor for the treatment of alzheimer's disease. |
2011-01-24 |
2023-08-12 |
Not clear |
| Yo Sook Ki, Eun Young Park, Heon-Woo Lee, Myung Sook Oh, Young-Wuk Cho, Yunhee Kim Kwon, Ji Hee Moon, Kyung-Tae Le. Donepezil, a potent acetylcholinesterase inhibitor, induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells. Biological & pharmaceutical bulletin. vol 33. issue 6. 2011-01-10. PMID:20522977. |
although donepezil, a potent acetylcholinesterase (ache) inhibitor, has been used to treat alzheimer's disease (ad) due to its neuroprotective effects, its mode of action to inhibit the growth of cancer cells is poorly understood. |
2011-01-10 |
2023-08-12 |
human |