| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexis Ciro, Joon Park, Gary Burkhard, Nicole Yan, Changiz Geul. Biochemical differentiation of cholinesterases from normal and Alzheimer's disease cortex. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:21244353. |
using biochemical assays of acetylcholinesterase and butyrylcholinesterase activities, we demonstrate here that serotonin and bacitracin result in a significantly greater and dose-dependent inhibition of cholinesterases in alzheimer's disease cortex when compared with age-matched controls. |
2012-06-14 |
2023-08-12 |
Not clear |
| Alexis Ciro, Joon Park, Gary Burkhard, Nicole Yan, Changiz Geul. Biochemical differentiation of cholinesterases from normal and Alzheimer's disease cortex. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:21244353. |
we also confirmed significant reduction of acetylcholinesterase activity in alzheimer's disease cortex and increased butyrylcholinesterase activity that only approached significance. |
2012-06-14 |
2023-08-12 |
Not clear |
| Simon Gibbon. An introduction to planar chromatography and its application to natural products isolation. Methods in molecular biology (Clifton, N.J.). vol 864. 2012-06-14. PMID:22367896. |
it also has use in the biological evaluation of organic compounds, particularly in the areas of antimicrobial and antioxidant metabolites and for the evaluation of acetylcholinesterase inhibitors which have utility in the treatment of alzheimer's disease. |
2012-06-14 |
2023-08-12 |
Not clear |
| Mohamed A Lebda, Mahmoud S El-Neweshy, Yasser S El-Saye. Neurohepatic toxicity of subacute manganese chloride exposure and potential chemoprotective effects of lycopene. Neurotoxicology. vol 33. issue 1. 2012-06-04. PMID:22192907. |
mncl(2)-induced lipid peroxidation and perturbation in antioxidant system, increase of acetylcholinesterase, aminotransferases, and decrease alkaline phosphatase, and lactate dehydrogenase activities with hyperglycemia as demonstrated by alzheimer type ii astrocytosis, and periportal hepatic necrosis and apoptosis were prevented by lycopene. |
2012-06-04 |
2023-08-12 |
rat |
| Tânia Melo, Romeu A Videira, Sónia André, Elisabete Maciel, Carla S Francisco, Ana M Oliveira-Campos, Lígia M Rodrigues, Maria R M Domingues, Francisco Peixoto, M Manuel Oliveir. Tacrine and its analogues impair mitochondrial function and bioenergetics: a lipidomic analysis in rat brain. Journal of neurochemistry. vol 120. issue 6. 2012-06-01. PMID:22192081. |
tacrine is an acetylcholinesterase (ache) inhibitor used as a cognitive enhancer in the treatment of alzheimer's disease (ad). |
2012-06-01 |
2023-08-12 |
rat |
| Po-Yuan Chen, Ching-Tsan Tsai, Che-Yen Ou, Wei-Tse Hsu, Mien-De Jhuo, Chieh-Hsi Wu, Tzu-Ching Shih, Tzu-Hurng Cheng, Jing-Gung Chun. Computational analysis of novel drugs designed for use as acetylcholinesterase inhibitors and histamine H3 receptor antagonists for Alzheimer's disease by docking, scoring and de novo evolution. Molecular medicine reports. vol 5. issue 4. 2012-06-01. PMID:22267207. |
computational analysis of novel drugs designed for use as acetylcholinesterase inhibitors and histamine h3 receptor antagonists for alzheimer's disease by docking, scoring and de novo evolution. |
2012-06-01 |
2023-08-12 |
Not clear |
| J Sánchez Morillo, M J Estruch Pérez, G Barber Ballester, V Pertusa Collad. Changes in butyrylcholinesterase activity in patients with Alzheimer disease treated with acetylcholinesterase inhibitors. Neurologia (Barcelona, Spain). vol 26. issue 4. 2012-05-29. PMID:21163208. |
changes in butyrylcholinesterase activity in patients with alzheimer disease treated with acetylcholinesterase inhibitors. |
2012-05-29 |
2023-08-12 |
Not clear |
| Ilkay Erdogan Orhan, Ipek Pesin Suntar, Esra Kupeli Akko. In vitro neuroprotective effects of the leaf and fruit extracts of Juglans regia L. (walnut) through enzymes linked to Alzheimer's disease and antioxidant activity. International journal of food sciences and nutrition. vol 62. issue 8. 2012-05-22. PMID:21627404. |
anticholinesterase activity was determined against acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes vital for alzheimer's disease, at 50, 100 and 200 μg ml(-1). |
2012-05-22 |
2023-08-12 |
Not clear |
| Hongbing Wu, Jianxu Li, Qizhi Zhang, Xiluan Yan, Liangran Guo, Xiaoling Gao, Mingfeng Qiu, Xinguo Jiang, Ren Lai, Hongzhuan Che. A novel small Odorranalectin-bearing cubosomes: preparation, brain delivery and pharmacodynamic study on amyloid-β₂₅₋₃₅-treated rats following intranasal administration. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 80. issue 2. 2012-05-22. PMID:22061263. |
besides, gly14-humanin (s14g-hn) as a model peptide drug was loaded into cubosomes and evaluated for its pharmacodynamics on alzheimer's disease (ad) rats following intranasal administration by morris water maze test and acetylcholinesterase activity determination. |
2012-05-22 |
2023-08-12 |
rat |
| Preet Anand, Baldev Singh, Nirmal Sing. A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 20. issue 3. 2012-05-16. PMID:22257528. |
a review on coumarins as acetylcholinesterase inhibitors for alzheimer's disease. |
2012-05-16 |
2023-08-12 |
Not clear |
| Preet Anand, Baldev Singh, Nirmal Sing. A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 20. issue 3. 2012-05-16. PMID:22257528. |
acetylcholinesterase (ache) enzyme inhibition is an important target for the management of alzheimer disease (ad) and ache inhibitors are the main stay drugs for its management. |
2012-05-16 |
2023-08-12 |
Not clear |
| Preet Anand, Baldev Sing. Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents. Bioorganic & medicinal chemistry. vol 20. issue 1. 2012-05-08. PMID:22172310. |
the present study was designed to synthesize and evaluate pyrrolo-isoxazole benzoic acid derivatives as potential acetylcholinesterase (ache) inhibitors for the management of alzheimer's disease. |
2012-05-08 |
2023-08-12 |
mouse |
| J A Figueiredo, M I Ismael, J M Pinheiro, A M S Silva, J Justino, F V M Silva, M Goulart, D Mira, M E M Araújo, R Campoy, A P Raute. Facile synthesis of oxo-/thioxopyrimidines and tetrazoles C-C linked to sugars as novel non-toxic antioxidant acetylcholinesterase inhibitors. Carbohydrate research. vol 347. issue 1. 2012-05-04. PMID:22153708. |
acetylcholinesterase inhibition ranged from 20% to 80% for compounds concentration of 100 μg/ml, demonstrating the potential of this family of compounds for the control of alzheimer's disease symptoms. |
2012-05-04 |
2023-08-12 |
human |
| Diansan Su, Yanxing Zhao, Beilei Wang, Huan Xu, Wen Li, Jie Chen, Xiangrui Wan. Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil. PloS one. vol 6. issue 11. 2012-05-03. PMID:22114680. |
we hypothesized that pretreatment with the acetylcholinesterase inhibitor donepezil, which has been approved by the food and drug administration (fda) for the treatment of alzheimer's disease, prevents isoflurane-induced spatial memory impairment in aged mice. |
2012-05-03 |
2023-08-12 |
mouse |
| Michael Bubser, Nellie Byun, Michael R Wood, Carrie K Jone. Muscarinic receptor pharmacology and circuitry for the modulation of cognition. Handbook of experimental pharmacology. issue 208. 2012-04-25. PMID:22222698. |
conversely, both direct-acting muscarinic receptor agonists and indirect-acting muscarinic cholinergic agonists, such as acetylcholinesterase inhibitors, have shown cognition-enhancing properties, including improvements in normal cognitive function, reversal of cognitive deficits induced by muscarinic receptor antagonists, and attenuation of cognitive deficits in psychiatric and neurological disorders, such as alzheimer's disease and schizophrenia. |
2012-04-25 |
2023-08-12 |
Not clear |
| Pekka S Miettinen, Maija Pihlajamäki, Anne M Jauhiainen, Ina M Tarkka, Heidi Gröhn, Eini Niskanen, Tuomo Hänninen, Ritva Vanninen, Hilkka Soinine. Effect of cholinergic stimulation in early Alzheimer's disease - functional imaging during a recognition memory task. Current Alzheimer research. vol 8. issue 7. 2012-04-04. PMID:21592058. |
treatment of alzheimer's disease (ad) with acetylcholinesterase inhibitors (achei) enhances cholinergic activity and alleviates clinical symptoms. |
2012-04-04 |
2023-08-12 |
Not clear |
| Dorothea Kaufmann, Anudeep Kaur Dogra, Michael Win. Myrtenal inhibits acetylcholinesterase, a known Alzheimer target. The Journal of pharmacy and pharmacology. vol 63. issue 10. 2012-03-08. PMID:21899553. |
myrtenal inhibits acetylcholinesterase, a known alzheimer target. |
2012-03-08 |
2023-08-12 |
Not clear |
| Dorothea Kaufmann, Anudeep Kaur Dogra, Michael Win. Myrtenal inhibits acetylcholinesterase, a known Alzheimer target. The Journal of pharmacy and pharmacology. vol 63. issue 10. 2012-03-08. PMID:21899553. |
inhibition of acetylcholinesterase (ache) is a common treatment for early stages of the most general form of dementia, alzheimer's disease. |
2012-03-08 |
2023-08-12 |
Not clear |
| Connor Keller, Ahmadul Kadir, Anton Forsberg, Omar Porras, Agneta Nordber. Long-term effects of galantamine treatment on brain functional activities as measured by PET in Alzheimer's disease patients. Journal of Alzheimer's disease : JAD. vol 24. issue 1. 2012-03-06. PMID:21157026. |
the effects of galantamine (16 to 24 mg/day) treatment on brain functional activities (blood flow and glucose metabolism) were examined in 18 patients with mild alzheimer's disease (ad) in relation to brain acetylcholinesterase (ache) activity and nicotinic receptors and cognitive function. |
2012-03-06 |
2023-08-12 |
Not clear |
| Fatma Sezer Senol, Ilkay Erdogan Orhan, Sinem Aslan Erdem, Murat Kartal, Bilge Sener, Yüksel Kan, Ferhat Celep, Ahmet Kahraman, Musa Doga. Evaluation of cholinesterase inhibitory and antioxidant activities of wild and cultivated samples of sage (Salvia fruticosa) by activity-guided fractionation. Journal of medicinal food. vol 14. issue 11. 2012-03-01. PMID:21663475. |
in this study, we compared the inhibitory activity of dichloromethane, ethyl acetate, and ethanol extracts of 3 wild-grown samples and 1 cultivated sample of s. fruticosa against acetylcholinesterase and butyrylcholinesterase enzymes (which are associated with pathogenesis of alzheimer's disease) by using the spectrophotometric ellman method. |
2012-03-01 |
2023-08-12 |
Not clear |