| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Desiree Antequera, Marta Bolos, Carlos Spuch, Consuelo Pascual, Isidro Ferrer, María Isabel Fernandez-Bachiller, María Isabel Rodríguez-Franco, Eva Carr. Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: involvement in hippocampal neuronal loss in Alzheimer's disease. Neurobiology of disease. vol 46. issue 3. 2012-09-14. PMID:22426395. |
several studies have implicated the enzyme acetylcholinesterase (ache) as well as several biometals in the pathogenesis of alzheimer's disease (ad). |
2012-09-14 |
2023-08-12 |
mouse |
| Masashi Kasuya, Kenichi Meguro, Nobuyuki Okamura, Yoshihito Funaki, Hiroyasu Ishikawa, Naofumi Tanaka, Ren Iwata, Kazuhiko Yana. Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study. Alzheimer disease and associated disorders. vol 26. issue 2. 2012-09-13. PMID:21666432. |
greater responsiveness to donepezil in alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil pet study. |
2012-09-13 |
2023-08-12 |
Not clear |
| Ahsan Raza, Aamer Saeed, Aliya Ibrar, Muhammad Muddassar, Aftab Ahmed Khan, Jamshed Iqba. Pharmacological Evaluation and Docking Studies of 3-Thiadiazolyl- and Thioxo-1,2,4-triazolylcoumarin Derivatives as Cholinesterase Inhibitors. ISRN pharmacology. vol 2012. 2012-09-12. PMID:22966467. |
inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche) is considered a promising strategy for the treatment of alzheimer's disease (ad). |
2012-09-12 |
2023-08-12 |
rabbit |
| Hailin Zheng, Tamar Amit, Orit Bar-Am, Mati Fridkin, Moussa B H Youdim, Silvia A Mande. From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 30. issue 1. 2012-09-10. PMID:22387411. |
from anti-parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for alzheimer's disease. |
2012-09-10 |
2023-08-12 |
Not clear |
| Rose-Marie Dröes, Henriëtte G van der Roest, Lisa van Mierlo, Franka J M Meilan. Memory problems in dementia: adaptation and coping strategies and psychosocial treatments. Expert review of neurotherapeutics. vol 11. issue 12. 2012-08-30. PMID:22091600. |
medication developed for alzheimer's disease, for example, acetylcholinesterase inhibitors, can slow down the increase of cognitive impairment for a while. |
2012-08-30 |
2023-08-12 |
Not clear |
| Nadezhda A Kapai, Julia V Bukanova, Elena I Solntseva, Vladimir G Skrebitsk. Donepezil in a narrow concentration range augments control and impaired by beta-amyloid peptide hippocampal LTP in NMDAR-independent manner. Cellular and molecular neurobiology. vol 32. issue 2. 2012-08-29. PMID:21968642. |
acetylcholinesterase (ache) inhibitor donepezil is widely used for the treatment of alzheimer's disease (ad). |
2012-08-29 |
2023-08-12 |
rat |
| David H Smal. Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization. Neuro-degenerative diseases. vol 10. issue 1-4. 2012-08-29. PMID:22301681. |
dysregulation of ca2+ homeostasis in alzheimer's disease: role in acetylcholinesterase production and ampa receptor internalization. |
2012-08-29 |
2023-08-12 |
Not clear |
| Ying Wang, Xi Can Tang, Hai Yan Zhan. Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice. Journal of neuroscience research. vol 90. issue 2. 2012-08-23. PMID:22002568. |
huperzine a (hupa) is a potent acetylcholinesterase inhibitor (achei) used in the treatment of alzheimer's disease (ad). |
2012-08-23 |
2023-08-12 |
mouse |
| Camryn Berk, Marwan Sabbag. Broader considerations of higher doses of donepezil in the treatment of mild, moderate, and severe Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22191061. |
donepezil, a highly selective acetylcholinesterase inhibitor (achei), is approved as a symptomatic treatment mild, moderate, and severe alzheimer's disease (ad). |
2012-08-23 |
2023-08-12 |
human |
| Mona Mehta, Abdu Adem, Marwan Sabbag. New acetylcholinesterase inhibitors for Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22216416. |
new acetylcholinesterase inhibitors for alzheimer's disease. |
2012-08-23 |
2023-08-12 |
Not clear |
| Mona Mehta, Abdu Adem, Marwan Sabbag. New acetylcholinesterase inhibitors for Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22216416. |
acetylcholinesterase (ache) remains a highly viable target for the symptomatic improvement in alzheimer's disease (ad) because cholinergic deficit is a consistent and early finding in ad. |
2012-08-23 |
2023-08-12 |
Not clear |
| Zhong-Duo Yang, Dong-Zhu Duan, Wei-Wei Xue, Xiao-Jun Yao, Shuo L. Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships. Life sciences. vol 90. issue 23-24. 2012-08-16. PMID:22569298. |
inhibition of acetylcholinesterase (ache) is still considered as a strategy for the treatment of neurological disorders such as alzheimer's disease (ad). |
2012-08-16 |
2023-08-12 |
Not clear |
| Jun Wang, Fu Chen, Peng Zheng, Weijuan Deng, Jia Yuan, Bo Peng, Ruochen Wang, Wenjun Liu, Hui Zhao, Yanqing Wang, Gencheng W. Huperzine A ameliorates experimental autoimmune encephalomyelitis via the suppression of T cell-mediated neuronal inflammation in mice. Experimental neurology. vol 236. issue 1. 2012-08-07. PMID:22524989. |
huperzine a (hupa), a sesquiterpene alkaloid and a potent and reversible inhibitor of acetylcholinesterase, possesses potential anti-inflammatory properties and is used for the treatment of certain neurodegenerative diseases such as alzheimer's disease. |
2012-08-07 |
2023-08-12 |
mouse |
| Ayokunle O Ademosun, Ganiyu Obo. Inhibition of acetylcholinesterase activity and Fe2+-induced lipid peroxidation in rat brain in vitro by some citrus fruit juices. Journal of medicinal food. vol 15. issue 5. 2012-08-06. PMID:22400910. |
the inhibition of acetylcholinesterase activity and antioxidant properties of the citrus juices could make them a good dietary means for the management of alzheimer's disease. |
2012-08-06 |
2023-08-12 |
rat |
| Henri Autio, Kert Mätlik, Tomi Rantamäki, Lothar Lindemann, Marius C Hoener, Moses Chao, Urmas Arumäe, Eero Castré. Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21820453. |
acetylcholinesterase inhibitors are first-line therapies for alzheimer's disease. |
2012-08-01 |
2023-08-12 |
mouse |
| Jean-Louis Krau. Why as a medicinal chemist I am not optimistic about the possibility of finding, in a reasonable timeframe, small-molecule drugs capable of curing the evolution of Alzheimer's disease. ChemMedChem. vol 7. issue 3. 2012-07-13. PMID:21990179. |
herein i explain why i feel that new and effective alzheimer's disease (ad) drugs cannot emerge from current developed concepts such as the amyloid pathway, or acetylcholinesterase inhibitors. |
2012-07-13 |
2023-08-12 |
Not clear |
| Cecilia Bartolucci, Jure Stojan, Qian-sheng Yu, Nigel H Greig, Doriano Lamb. Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group. The Biochemical journal. vol 444. issue 2. 2012-07-13. PMID:22390827. |
natural and synthetic carbamates act as pseudo-irreversible inhibitors of ache (acetylcholinesterase) as well as bche (butyrylcholinesterase), two enzymes involved in neuronal function as well as in the development and progression of ad (alzheimer's disease). |
2012-07-13 |
2023-08-12 |
Not clear |
| Wenjun Li, Piero G Antuono, Chunming Xie, Gang Chen, Jennifer L Jones, B Douglas Ward, Malgorzata B Franczak, Joseph S Goveas, Shi-Jiang L. Changes in regional cerebral blood flow and functional connectivity in the cholinergic pathway associated with cognitive performance in subjects with mild Alzheimer's disease after 12-week donepezil treatment. NeuroImage. vol 60. issue 2. 2012-06-29. PMID:22245641. |
acetylcholinesterase inhibitors (acheis), such as donepezil, have been shown to improve cognition in mild to moderate alzheimer's disease (ad) patients. |
2012-06-29 |
2023-08-12 |
human |
| Milena Sorrenti, Laura Catenacci, Giovanna Bruni, Barbara Luppi, Federica Bigucci, Giampiero Bettinett. Solid-state characterization of tacrine hydrochloride. Journal of pharmaceutical and biomedical analysis. vol 63. 2012-06-25. PMID:22326286. |
the present study deals with the physicochemical characterization of solid forms of tacrine monohydrochloride (tcr), a centrally active reversible acetylcholinesterase inhibitor for treating the symptoms of mild to moderate alzheimer's disease, obtained by recrystallization of hot saturated solutions from different solvents. |
2012-06-25 |
2023-08-12 |
Not clear |
| Ryohei Miyazaki, Toshihiro Ichiki, Toru Hashimoto, Jiro Ikeda, Aya Kamiharaguchi, Eriko Narabayashi, Hirohide Matsuura, Kotaro Takeda, Kenji Sunagaw. Acetylcholinesterase inhibitors attenuate angiogenesis. Clinical science (London, England : 1979). vol 123. issue 4. 2012-06-19. PMID:22369073. |
donepezil {(rs)-2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one} is a reversible acetylcholinesterase inhibitor and used for treatment of patients with ad (alzheimer's disease). |
2012-06-19 |
2023-08-12 |
mouse |