| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nurgun Kucukboyaci, Ilkay Orhan, Bilge Sener, S Ahmad Nawaz, M Iqbal Choudhar. Assessment of enzyme inhibitory and antioxidant activities of lignans from Taxus baccata L. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 65. issue 3-4. 2010-06-03. PMID:20469636. |
compounds 1-5 were evaluated for their acetylcholinesterase (ache), butyrylcholinesterase (bche), and lipoxygenase (lox) inhibitory activities, which play a role in the pathogenesis of alzheimer's disease (ad), by in vitro spectrophotometric methods, while they were also screened for their antioxidant capacity in 2,2-diphenyl-1-picrylhydrazyl (dpph) radical scavenging, ferrous ion-chelating effect, and ferric-reducing antioxidant power (frap) at 125, 250, 500, and 1000 microg ml(-1). |
2010-06-03 |
2023-08-12 |
Not clear |
| F S Senol, I Orhan, G Yilmaz, M Ciçek, B Sene. Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition studies and antioxidant activities of 33 Scutellaria L. taxa from Turkey. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 48. issue 3. 2010-06-02. PMID:20026160. |
therefore, we initiated a study to screen the methanol extracts prepared from the aerial parts of 33 turkish scutellaria species for their acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitory activities, which are the key enzymes taking place in pathogenesis of alzheimer's disease. |
2010-06-02 |
2023-08-12 |
Not clear |
| Howard H Feldman, Tuula Pirttila, Jean François Dartigues, Brian Everitt, Bart Van Baelen, Susanne Schwalen, Shane Kavanag. Treatment with galantamine and time to nursing home placement in Alzheimer's disease patients with and without cerebrovascular disease. International journal of geriatric psychiatry. vol 24. issue 5. 2010-05-26. PMID:18985627. |
this study evaluated patient and treatment (galantamine and other acetylcholinesterase inhibitors (acheis)) factors associated with the time until nursing home placement (nhp) in patients with alzheimer's disease (ad) with and without cerebrovascular disease (cvd). |
2010-05-26 |
2023-08-12 |
Not clear |
| Alessandra Bizzarro, V Guglielmi, R Lomastro, A Valenza, A Lauria, C Marra, M C Silveri, F D Tiziano, C Brahe, C Masull. BuChE K variant is decreased in Alzheimer's disease not in fronto-temporal dementia. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 3. 2010-05-20. PMID:20058037. |
alzheimer's disease (ad) is characterized by a significant reduction in acetylcholinesterase and an increase in butyrylcholinesterase (buche) activity. |
2010-05-20 |
2023-08-12 |
Not clear |
| María-Salud García-Ayllón, Iolanda Riba-Llena, Carol Serra-Basante, Jordi Alom, Rathnam Boopathy, Javier Sáez-Valer. Altered levels of acetylcholinesterase in Alzheimer plasma. PloS one. vol 5. issue 1. 2010-05-20. PMID:20090844. |
altered levels of acetylcholinesterase in alzheimer plasma. |
2010-05-20 |
2023-08-12 |
Not clear |
| Shih-Bin Yeh, Po-Yen Yeh, Carlos H Schenc. Rivastigmine-induced REM sleep behavior disorder (RBD) in a 88-year-old man with Alzheimer's disease. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. vol 6. issue 2. 2010-05-13. PMID:20411699. |
we report the case of an 88-year-old man with alzheimer's disease (ad) of 8 years duration (emerging shortly after the de novo onset of sleeptalking) who developed rem sleep behavior disorder (rbd) after increasing the nightly dose of rivastigmine, an acetylcholinesterase inhibitor, from 1.5 mg to 3 mg (total daily dose, 4.5 mg), as therapy for his dementia. |
2010-05-13 |
2023-08-12 |
Not clear |
| Daniel M Bittne. Combination therapy of acetylcholinesterase inhibitor and vitamin E in Alzheimer disease. Journal of clinical psychopharmacology. vol 29. issue 5. 2010-05-05. PMID:19745661. |
combination therapy of acetylcholinesterase inhibitor and vitamin e in alzheimer disease. |
2010-05-05 |
2023-08-12 |
Not clear |
| Hyun Cho, Jee-Hyun Kwon, Hyun-Jin Seo, Jae-Seung Ki. The short-term effect of acetylcholinesterase inhibitor on the regional cerebral blood flow of Alzheimer's disease. Archives of gerontology and geriatrics. vol 50. issue 2. 2010-04-26. PMID:19398134. |
the short-term effect of acetylcholinesterase inhibitor on the regional cerebral blood flow of alzheimer's disease. |
2010-04-26 |
2023-08-12 |
Not clear |
| Hyun Cho, Jee-Hyun Kwon, Hyun-Jin Seo, Jae-Seung Ki. The short-term effect of acetylcholinesterase inhibitor on the regional cerebral blood flow of Alzheimer's disease. Archives of gerontology and geriatrics. vol 50. issue 2. 2010-04-26. PMID:19398134. |
this study is to investigate changes in regional cerebral blood flow (rcbf) of alzheimer's disease (ad) in short-term treatment with acetylcholinesterase inhibitor (chei). |
2010-04-26 |
2023-08-12 |
Not clear |
| E H Wiig, P Annas, H Basun, N Andreasen, L Lannfelt, H Zetterberg, K Blennow, L Mintho. The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease. Acta neurologica Scandinavica. vol 121. issue 3. 2010-04-26. PMID:19785641. |
the stability of aqt processing speed, adas-cog and mmse during acetylcholinesterase inhibitor treatment in alzheimer's disease. |
2010-04-26 |
2023-08-12 |
Not clear |
| E H Wiig, P Annas, H Basun, N Andreasen, L Lannfelt, H Zetterberg, K Blennow, L Mintho. The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease. Acta neurologica Scandinavica. vol 121. issue 3. 2010-04-26. PMID:19785641. |
to explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (achei) in patients with alzheimer's disease (ad). |
2010-04-26 |
2023-08-12 |
Not clear |
| Létitia Jean, Benjamin Thomas, Abdessamad Tahiri-Alaoui, Michael Shaw, David J Vau. Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease. PloS one. vol 2. issue 7. 2010-04-23. PMID:17653279. |
heterologous amyloid seeding: revisiting the role of acetylcholinesterase in alzheimer's disease. |
2010-04-23 |
2023-08-12 |
human |
| Akinori Akaike, Yuki Takada-Takatori, Toshiaki Kume, Yasuhiko Izum. Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19714494. |
donepezil, galanatamine and tacrine, therapeutic acetylcholinesterase (ache) inhibitors currently being used for treatment of alzheimer's disease also protected neuronal cells from glutamate neurotoxicity. |
2010-04-21 |
2023-08-12 |
rat |
| Wolfgang Härtig, Johannes Kacza, Bernd-Reiner Paulke, Jens Grosche, Ute Bauer, Anke Hoffmann, Paul W Elsinghorst, Michael Gütscho. In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. The European journal of neuroscience. vol 31. issue 1. 2010-04-16. PMID:20092557. |
the drastic loss of cholinergic projection neurons in the basal forebrain is a hallmark of alzheimer's disease (ad), and drugs most frequently applied for the treatment of dementia include inhibitors of the acetylcholine-degrading enzyme acetylcholinesterase (ache). |
2010-04-16 |
2023-08-12 |
mouse |
| Aurelia Santoro, Paola Siviero, Nadia Minicuci, Elena Bellavista, Michele Mishto, Fabiola Olivieri, Francesca Marchegiani, Andrea Maria Chiamenti, Luisa Benussi, Roberta Ghidoni, Benedetta Nacmias, Silvia Bagnoli, Andrea Ginestroni, Osvaldo Scarpino, Emidio Feraco, Walter Gianni, Guido Cruciani, Roberto Paganelli, Angelo Di Iorio, Mario Scognamiglio, Luigi Maria Edoardo Grimaldi, Carlo Gabelli, Sandro Sorbi, Giuliano Binetti, Gaetano Crepaldi, Claudio Francesch. Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study. CNS drugs. vol 24. issue 2. 2010-03-16. PMID:20088621. |
acetylcholinesterase inhibitors (acheis) have been used to improve cognitive status and disability in patients with mild to moderate alzheimer's disease (ad). |
2010-03-16 |
2023-08-12 |
Not clear |
| Ahmet Turan Isik, Ergun Bozogl. Acetylcholinesterase inhibition and insulin resistance in late onset Alzheimer's disease. International psychogeriatrics. vol 21. issue 6. 2010-03-02. PMID:19631004. |
acetylcholinesterase inhibition and insulin resistance in late onset alzheimer's disease. |
2010-03-02 |
2023-08-12 |
Not clear |
| Gang Liu, Ping Men, George Perry, Mark A Smit. Nanoparticle and iron chelators as a potential novel Alzheimer therapy. Methods in molecular biology (Clifton, N.J.). vol 610. 2010-02-22. PMID:20013176. |
current therapies for alzheimer disease (ad) such as the acetylcholinesterase inhibitors and the latest nmda receptor inhibitor, namenda, provide moderate symptomatic delay at various stages of the disease, but do not arrest the disease progression or bring in meaningful remission. |
2010-02-22 |
2023-08-12 |
Not clear |
| Ebrahim Barzegari Asadabadi, Parviz Abdolmaleki, Seyyed Mohsen Hosseini Barkooie, Samad Jahandideh, Mohammad Ali Rezae. A combinatorial feature selection approach to describe the QSAR of dual site inhibitors of acetylcholinesterase. Computers in biology and medicine. vol 39. issue 12. 2010-02-05. PMID:19854437. |
regarding the great potential of dual binding site inhibitors of acetylcholinesterase as the future potent drugs of alzheimer's disease, this study was devoted to extraction of the most effective structural features of these inhibitors from among a large number of quantitative descriptors. |
2010-02-05 |
2023-08-12 |
Not clear |
| Jharna R Das, Yousef Tizab. Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells. Neurotoxicity research. vol 16. issue 3. 2010-01-25. PMID:19526284. |
donepezil (aricept) is a reversible non-competitive acetylcholinesterase inhibitor that is approved for use in mild to moderate alzheimer's disease. |
2010-01-25 |
2023-08-12 |
human |
| Ondrej Soukup, Jan Proska, Jiri Binder, Jana Zdarova Karasova, Gunnar Tobin, Daniel Jun, Jan Marek, Kamil Musílek, Josef Fusek, Kamil Kuc. Methylacridinium and its cholinergic properties. Neurotoxicity research. vol 16. issue 4. 2010-01-22. PMID:19565307. |
inhibitors of acetylcholinesterase (ache) are used in the treatment of myasthenia gravis, alzheimer's disease, and in the prophylaxis of poisoning with organophosphates. |
2010-01-22 |
2023-08-12 |
human |