| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Figueiró, J Ilha, D Pochmann, L O Porciúncula, L L Xavier, M Achaval, D S Nunes, E Elisabetsk. Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a nootropic Amazonian herbal (Marapuama). Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 12. 2010-12-15. PMID:20833520. |
the goal of acetylcholinesterase inhibitors (acheis) used to treat alzheimer's patients is an improvement in cholinergic transmission. |
2010-12-15 |
2023-08-12 |
mouse |
| L B Pagliosa, S C Monteiro, K B Silva, J P de Andrade, J Dutilh, J Bastida, M Cammarota, J A S Zuanazz. Effect of isoquinoline alkaloids from two Hippeastrum species on in vitro acetylcholinesterase activity. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 8-9. 2010-12-03. PMID:19969445. |
galanthamine, an important alkaloid isolated from the amaryllidaceae family, is approved for the pharmacological treatment of alzheimer's disease (ad) and acts by inhibiting the acetylcholinesterase (ache) activity. |
2010-12-03 |
2023-08-12 |
Not clear |
| Faviola Alcantara-Gonzalez, Ismael Juarez, Oscar Solis, Isaura Martinez-Tellez, Israel Camacho-Abrego, Eliezer Masliah, Raul Mena, Gonzalo Flore. Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus, and nucleus accumbens in old rats after chronic donepezil administration. Synapse (New York, N.Y.). vol 64. issue 10. 2010-11-30. PMID:20336627. |
donepezil is a potent and selective acetylcholinesterase inhibitor used in the treatment of alzheimer's disease. |
2010-11-30 |
2023-08-12 |
rat |
| Yoshihiko Kakinuma, Mutsuo Furihata, Tsuyoshi Akiyama, Mikihiko Arikawa, Takemi Handa, Rajesh G Katare, Takayuki Sat. Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model. Journal of molecular and cellular cardiology. vol 48. issue 4. 2010-11-16. PMID:19962381. |
donepezil, an acetylcholinesterase inhibitor against alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model. |
2010-11-16 |
2023-08-12 |
mouse |
| Yoshihiko Kakinuma, Mutsuo Furihata, Tsuyoshi Akiyama, Mikihiko Arikawa, Takemi Handa, Rajesh G Katare, Takayuki Sat. Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model. Journal of molecular and cellular cardiology. vol 48. issue 4. 2010-11-16. PMID:19962381. |
therefore, we assessed the hypothesis that the cholinergic modulator donepezil, an acetylcholinesterase inhibitor utilized in alzheimer's disease, exhibits beneficial effects, especially on the acceleration of angiogenesis. |
2010-11-16 |
2023-08-12 |
mouse |
| M Inês Vicente, Pedro F Costa, Pedro A Lim. Galantamine inhibits slowly inactivating K+ currents with a dual dose-response relationship in differentiated N1E-115 cells and in CA1 neurones. European journal of pharmacology. vol 634. issue 1-3. 2010-11-01. PMID:20184872. |
galantamine, one of the major drugs used in alzheimer's disease therapy, is a relatively weak acetylcholinesterase inhibitor and an allosteric potentiating ligand of nicotinic acetylcholine receptors. |
2010-11-01 |
2023-08-12 |
rat |
| Guillaume Bastiat, François Plourde, Aude Motulsky, Alexandra Furtos, Yvan Dumont, Rémi Quirion, Gregor Fuhrmann, Jean-Christophe Lerou. Tyrosine-based rivastigmine-loaded organogels in the treatment of Alzheimer's disease. Biomaterials. vol 31. issue 23. 2010-10-21. PMID:20472283. |
in this work, an injectable subcutaneous organogel system based on safflower oil and a modified-tyrosine organogelator was evaluated in vivo for the delivery of rivastigmine, an acetylcholinesterase (ache) inhibitor used in the treatment of alzheimer's disease. |
2010-10-21 |
2023-08-12 |
Not clear |
| Miroslav Pohanka, Daniel Jun, Kamil Kuc. In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048. Journal of enzyme inhibition and medicinal chemistry. vol 24. issue 3. 2010-10-12. PMID:18825528. |
the presented study is aimed at reactivation of trichlorfon-inhibited butyrylcholinesterase since this enzyme play an important role in alzheimer's disease as deputy for acetylcholinesterase and furthermore it could be applied as a scavenger in case of overdosing. |
2010-10-12 |
2023-08-12 |
Not clear |
| Hailin Zheng, Moussa B H Youdim, Mati Fridki. Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy. ACS chemical biology. vol 5. issue 6. 2010-09-27. PMID:20455574. |
site-activated chelators targeting acetylcholinesterase and monoamine oxidase for alzheimer's therapy. |
2010-09-27 |
2023-08-12 |
Not clear |
| Natalia Wszelaki, Agnieszka Kuciun, Anna Karolina Kis. Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity. Acta pharmaceutica (Zagreb, Croatia). vol 60. issue 1. 2010-09-23. PMID:20228046. |
acetylcholinesterase (ache) inhibitors are widely used for the symptomatic treatment of alzheimer's disease (ad) to enhance central cholinergic transmission. |
2010-09-23 |
2023-08-12 |
Not clear |
| Cláudia Seidl, Beatriz L Correia, Andréa E M Stinghen, Cid A M Santo. Acetylcholinesterase inhibitory activity of uleine from Himatanthus lancifolius. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 65. issue 7-8. 2010-09-21. PMID:20737911. |
application of acetylcholinesterase (ache) inhibitors is the primary treatment for alzheimer's disease. |
2010-09-21 |
2023-08-12 |
Not clear |
| Zaheer Ul-Haq, Waqasuddin Khan, Saima Kalsoom, Farzana L Ansar. In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of beta-amyloid plaques associated with Alzheimer's disease. Theoretical biology & medical modelling. vol 7. 2010-09-17. PMID:20550720. |
inhibition of acetylcholinesterase has successfully been used as a drug target to treat alzheimer's disease but drug resistance shown by butyrylcholinesterase remains a matter of concern in treating alzheimer's disease. |
2010-09-17 |
2023-08-12 |
Not clear |
| V Tumiatti, A Minarini, M L Bolognesi, A Milelli, M Rosini, C Melchiorr. Tacrine derivatives and Alzheimer's disease. Current medicinal chemistry. vol 17. issue 17. 2010-09-08. PMID:20345341. |
to date, the pharmacotherapy of alzheimer's disease (ad) has relied on acetylcholinesterase (ache) inhibitors (acheis) and, more recently, an n-methyl-d-aspartate receptor (nmdar) antagonist. |
2010-09-08 |
2023-08-12 |
Not clear |
| K Sato, R Urbano, C Yu, F Yamasaki, T Sato, J Jordan, D Robertson, A Diedric. The effect of donepezil treatment on cardiovascular mortality. Clinical pharmacology and therapeutics. vol 88. issue 3. 2010-09-08. PMID:20664535. |
the acetylcholinesterase inhibitor donepezil hydrochloride improves cognitive function in patients with alzheimer's disease and vascular dementia. |
2010-09-08 |
2023-08-12 |
Not clear |
| Hay Dvir, Israel Silman, Michal Harel, Terrone L Rosenberry, Joel L Sussma. Acetylcholinesterase: from 3D structure to function. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20138030. |
acetylcholinesterase inhibitors are utilized in the treatment of various neurological disorders, and are the principal drugs approved thus far by the fda for management of alzheimer's disease. |
2010-09-01 |
2023-08-12 |
human |
| Ava J Y Guo, Heidi Q Xie, Roy C Y Choi, Ken Y Z Zheng, Cathy W C Bi, Sherry L Xu, Tina T X Dong, Karl W K Tsi. Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20452337. |
acetylcholinesterase (ache) inhibitors are widely used for the treatment of alzheimer's disease (ad). |
2010-09-01 |
2023-08-12 |
Not clear |
| Harveer Dev, Mark Agius, Rashid Zama. The dramatic effects of Galantamine in a patient with early-onset Alzheimer's disease. Psychiatria Danubina. vol 22. issue 2. 2010-08-27. PMID:20562785. |
she was diagnosed with non-familial early-onset alzheimer's disease (eoad) and started on 8mg daily of the acetylcholinesterase inhibitor galantamine. |
2010-08-27 |
2023-08-12 |
Not clear |
| André Nieoullo. [Acetylcholinesterase inhibitors in Alzheimer's disease: further comments on their mechanisms of action and therapeutic consequences]. Psychologie & neuropsychiatrie du vieillissement. vol 8. issue 2. 2010-08-04. PMID:20525543. |
[acetylcholinesterase inhibitors in alzheimer's disease: further comments on their mechanisms of action and therapeutic consequences]. |
2010-08-04 |
2023-08-12 |
Not clear |
| N M W J de Bruin, J Prickaerts, J H M Lange, S Akkerman, E Andriambeloson, M de Haan, J Wijnen, M van Drimmelen, E Hissink, L Heijink, C G Krus. SLV330, a cannabinoid CB1 receptor antagonist, ameliorates deficits in the T-maze, object recognition and Social Recognition Tasks in rodents. Neurobiology of learning and memory. vol 93. issue 4. 2010-07-30. PMID:20132903. |
the acetylcholinesterase inhibitor (achei) donepezil (aricept, approved for symptomatic treatment of alzheimer's disease) and nicotine were used as reference compounds. |
2010-07-30 |
2023-08-12 |
mouse |
| Wasana Pratchayasakul, Anchalee Pongchaidecha, Nipon Chattipakorn, Siriporn C Chattipakor. Reversible acetylcholinesterase inhibitory effect of Tabernaemontana divaricata extract on synaptic transmission in rat CA1 hippocampus. The Indian journal of medical research. vol 131. 2010-07-29. PMID:20418555. |
acetylcholinesterase inhibitors (ache-is) are used for the treatment of alzheimer's disease (ad). |
2010-07-29 |
2023-08-12 |
rat |