| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huan-Huan Zhao, Ying-Qian Liu, Juan Che. Screening acetylcholinesterase inhibitors from traditional Chinese medicines by paper-immobilized enzyme combined with capillary electrophoresis analysis. Journal of pharmaceutical and biomedical analysis. vol 190. 2021-06-17. PMID:32866747. |
discovering acetylcholinesterase (ache) inhibitors is one of the important ways to develop new drugs for the treatment of alzheimer's disease. |
2021-06-17 |
2023-08-13 |
Not clear |
| Bashir Akhlaq Akhoon, Sushil Choudhary, Harshita Tiwari, Ajay Kumar, Manas Ranjan Barik, Laxmi Rathor, Rakesh Pandey, Amit Nargotr. Discovery of a New Donepezil-like Acetylcholinesterase Inhibitor for Targeting Alzheimer's Disease: Computational Studies with Biological Validation. Journal of chemical information and modeling. vol 60. issue 10. 2021-06-17. PMID:32955256. |
discovery of a new donepezil-like acetylcholinesterase inhibitor for targeting alzheimer's disease: computational studies with biological validation. |
2021-06-17 |
2023-08-13 |
Not clear |
| Bashir Akhlaq Akhoon, Sushil Choudhary, Harshita Tiwari, Ajay Kumar, Manas Ranjan Barik, Laxmi Rathor, Rakesh Pandey, Amit Nargotr. Discovery of a New Donepezil-like Acetylcholinesterase Inhibitor for Targeting Alzheimer's Disease: Computational Studies with Biological Validation. Journal of chemical information and modeling. vol 60. issue 10. 2021-06-17. PMID:32955256. |
so far, donepezil is the only food and drug administration-approved dual-binding site inhibitor of acetylcholinesterase (ache) that can amplify the cholinergic activity and also decrease aβ aggregation in alzheimer patients. |
2021-06-17 |
2023-08-13 |
Not clear |
| Horacio Pérez-Sánchez, Helena den Haan, Alfonso Pérez-Garrido, Jorge Peña-García, Sandipan Chakraborty, Ilkay Erdogan Orhan, Fatma Sezer Senol Deniz, José Manuel Villalgord. Combined Structure and Ligand-Based Design of Selective Acetylcholinesterase Inhibitors. Journal of chemical information and modeling. vol 61. issue 1. 2021-06-17. PMID:33320652. |
acetylcholinesterase is a prime target for therapeutic intervention in alzheimer's disease. |
2021-06-17 |
2023-08-13 |
Not clear |
| Isabelly Fernanda Ferraz de Souza, Thaís Queiroz Dos Santos, Rodrigo Vicentino Placido, Bianca Aparecida Mangerona, Flávia Chiva Carvalho, Vanessa Bergamin Boralli, André Luís Morais Ruela, Gislaine Ribeiro Pereir. The liquid crystalline phase behaviour of a nasal formulation modifies the brain disposition of donepezil in rats in the treatment of Alzheimer's disease. Colloids and surfaces. B, Biointerfaces. vol 203. 2021-06-17. PMID:33798905. |
donepezil is a drug administered orally in the treatment of alzheimer's disease, and with gastrointestinal side effects that are typical of acetylcholinesterase inhibitors. |
2021-06-17 |
2023-08-13 |
rat |
| Gabriella Marucci, Michela Buccioni, Diego Dal Ben, Catia Lambertucci, Rosaria Volpini, Francesco Ament. Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease. Neuropharmacology. vol 190. 2021-06-09. PMID:33035532. |
efficacy of acetylcholinesterase inhibitors in alzheimer's disease. |
2021-06-09 |
2023-08-13 |
Not clear |
| Leila Sadeghi, Reza Yekta, Gholamreza Dehgha. The inhibitory effects of bile acids on catalytic and non‑catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer's disease. Acta neurobiologiae experimentalis. vol 80. issue 2. 2021-06-07. PMID:32602852. |
the inhibitory effects of bile acids on catalytic and non‑catalytic functions of acetylcholinesterase as a therapeutic target in alzheimer's disease. |
2021-06-07 |
2023-08-13 |
rat |
| Leila Sadeghi, Reza Yekta, Gholamreza Dehgha. The inhibitory effects of bile acids on catalytic and non‑catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer's disease. Acta neurobiologiae experimentalis. vol 80. issue 2. 2021-06-07. PMID:32602852. |
acetylcholine is a fast-acting neurotransmitter in synapses and neuromuscular junctions that is decreased in alzheimer's disease (ad) by hyper‑activation of acetylcholinesterase (ache), which leads to progressive loss of memory and neurobehavioral abnormalities. |
2021-06-07 |
2023-08-13 |
rat |
| Zhipeng Yu, Huizhuo Ji, Juntong Shen, Ruotong Kan, Wenzhu Zhao, Jianrong Li, Long Ding, Jingbo Li. Identification and molecular docking study of fish roe-derived peptides as potent BACE 1, AChE, and BChE inhibitors. Food & function. vol 11. issue 7. 2021-06-03. PMID:32656560. |
acetylcholinesterase (ache), butyrylcholinesterase (bche), and beta-secretase 1 (bace 1) play vital roles in the development and progression of alzheimer's disease (ad). |
2021-06-03 |
2023-08-13 |
Not clear |
| Yichang Huang, Mhd Wasem Alsabbag. Comparative risk of cardiac arrhythmias associated with acetylcholinesterase inhibitors used in treatment of dementias - A narrative review. Pharmacology research & perspectives. vol 8. issue 4. 2021-06-03. PMID:32691984. |
donepezil, galantamine, and rivastigmine are the three acetylcholinesterase inhibitors (acheis), out of a total of only four medications prescribed in the treatment of alzheimer's disease (ad) and related dementias. |
2021-06-03 |
2023-08-13 |
Not clear |
| Giang Le-Nhat-Thuy, Nga Nguyen Thi, Hai Pham-The, Tuyet Anh Dang Thi, Huong Nguyen Thi, Thu Ha Nguyen Thi, Sa Nguyen Hoang, Tuyen Van Nguye. Synthesis and biological evaluation of novel quinazoline-triazole hybrid compounds with potential use in Alzheimer's disease. Bioorganic & medicinal chemistry letters. vol 30. issue 18. 2021-06-03. PMID:32717612. |
a library of twelve quinazoline-triazole hybrid compounds were designed, synthesized and evaluated as a novel class of acetylcholinesterase inhibitors to treat alzheimer's disease (ad). |
2021-06-03 |
2023-08-13 |
Not clear |
| Rahman Abdizadeh, Farzin Hadizadeh, Tooba Abdizade. Molecular Modeling Studies of Anti-Alzheimer Agents by QSAR, Molecular Docking and Molecular Dynamics Simulations Techniques. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 16. issue 7. 2021-06-02. PMID:31385775. |
acetylcholinesterase (ache), a serine hydrolase, is an important drug target in the treatment of alzheimer's disease (ad). |
2021-06-02 |
2023-08-13 |
Not clear |
| Daniela Corrêa Santos, Ruan Roberto Henriques, Marcos Antonio de Abreu Lopes Junior, André Borges Farias, Thayssa Lisboa do Couto Nogueira, João Victor Fernandes Quimas, Nelilma Correia Romeiro, Leandro Louback da Silva, Andréa Luzia Ferreira de Souz. Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer's disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation. Bioorganic & medicinal chemistry. vol 28. issue 10. 2021-06-01. PMID:32278712. |
acylhydrazones 1a-o, derived from isoniazid, were synthesized and evaluated for myeloperoxidase (mpo) and acetylcholinesterase (ache) inhibition, as well as their antioxidant and metal chelating activities, with the purpose of investigating potential multi-target profiles for the treatment of alzheimer's disease. |
2021-06-01 |
2023-08-13 |
Not clear |
| Moyad Shahwan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Anas Shams. Understanding binding between donepezil and human ferritin: molecular docking and molecular dynamics simulation approach. Journal of biomolecular structure & dynamics. 2021-05-28. PMID:33228460. |
donepezil is an acetylcholinesterase inhibitor (achei) in use to treat symptomatic patients of mild to moderate alzheimer's disease (ad). |
2021-05-28 |
2023-08-13 |
human |
| Ümit M Koçyiğit, Parham Taslimi, Burak Tüzün, Hasan Yakan, Halit Muğlu, Emre Güze. 1,2,3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies. Journal of biomolecular structure & dynamics. 2021-05-28. PMID:33292060. |
in recent years, acetylcholinesterase (ache) and α-glycosidase (α-gly) inhibition have emerged as a promising and important approach for pharmacological intervention in many diseases such as glaucoma, epilepsy, obesity, cancer, and alzheimer's. |
2021-05-28 |
2023-08-13 |
Not clear |
| Sania Pervaiz, Sadaf Mutahir, Islam Ullah, Muhammad Ashraf, Xiao Liu, Sidrah Tariq, Bao-Jing Zhou, Muhammad Asim Kha. Organocatalyzed Solvent Free and Efficient Synthesis of 2,4,5-Trisubstituted Imidazoles as Potential Acetylcholinesterase Inhibitors for Alzheimer's Disease. Chemistry & biodiversity. vol 17. issue 3. 2021-05-25. PMID:31968151. |
organocatalyzed solvent free and efficient synthesis of 2,4,5-trisubstituted imidazoles as potential acetylcholinesterase inhibitors for alzheimer's disease. |
2021-05-25 |
2023-08-13 |
Not clear |
| Sania Pervaiz, Sadaf Mutahir, Islam Ullah, Muhammad Ashraf, Xiao Liu, Sidrah Tariq, Bao-Jing Zhou, Muhammad Asim Kha. Organocatalyzed Solvent Free and Efficient Synthesis of 2,4,5-Trisubstituted Imidazoles as Potential Acetylcholinesterase Inhibitors for Alzheimer's Disease. Chemistry & biodiversity. vol 17. issue 3. 2021-05-25. PMID:31968151. |
to explore the potential of these compounds against alzheimer's disease, their inhibitory activities against acetylcholinesterase (ache) were evaluated. |
2021-05-25 |
2023-08-13 |
Not clear |
| Teresa Delerue, M Fátima Barroso, Mónica Dias-Teixeira, Maria Figueiredo-González, Cristina Delerue-Matos, Clara Gross. Interactions between Ginkgo biloba L. and Scutellaria baicalensis Georgi in multicomponent mixtures towards cholinesterase inhibition and ROS scavenging. Food research international (Ottawa, Ont.). vol 140. 2021-05-24. PMID:33648175. |
this study gives new insights to understand the type of interactions between ginkgo biloba l. and scutellaria baicalensis georgi, two chinese medicinal plants with well documented neuroprotective effects, on three targets in alzheimer's disease (ad): acetylcholinesterase (ache) and butyrylcholnesterase (buche) inhibition and hydrogen peroxide scavenging. |
2021-05-24 |
2023-08-13 |
Not clear |
| F Sezer Senol Deniz, Gokcen Eren, Ilkay Erdogan Orhan, Bilge Sener, Ufuk Ozgen, Randa Aldaba, Ihsan Cali. Outlining In Vitro and In Silico Cholinesterase Inhibitory Activity of Twenty-Four Natural Products of Various Chemical Classes: Smilagenin, Kokusaginine, and Methyl Rosmarinate as Emboldening Inhibitors. Molecules (Basel, Switzerland). vol 26. issue 7. 2021-05-24. PMID:33916300. |
cholinesterase (che) inhibition is an important treatment strategy for alzheimer's disease (ad) as acetylcholinesterase (ache) and butyrylcholinesterase (bche) are involved in the pathology of ad. |
2021-05-24 |
2023-08-13 |
Not clear |
| Vinay Kumar, Achintya Saha, Kunal Ro. In silico modeling for dual inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes in Alzheimer's disease. Computational biology and chemistry. vol 88. 2021-05-20. PMID:32801088. |
in silico modeling for dual inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (buche) enzymes in alzheimer's disease. |
2021-05-20 |
2023-08-13 |
Not clear |