| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Parul Gupta, Shubhangini Tiwari, Abhishek Singh, Amit Pal, Amit Mishra, Sarika Sing. Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling. The Biochemical journal. vol 478. issue 7. 2021-09-13. PMID:33660768. |
rivastigmine is a clinical drug for patients of alzheimer's disease (ad) exerting its inhibitory effect on acetylcholinesterase activity however, its effect on other disease-related pathological mechanisms are not yet known. |
2021-09-13 |
2023-08-13 |
rat |
| Rosiane Dos Santos, Raquel P Morais-Urano, Rosilene M Marçal, Geraldo H Silva, Mário F C Santo. Acetylcholinesterase and butyrylcholinesterase inhibition by nectriapyrone and tryptophol isolated from endophytic fungus Natural product research. 2021-09-09. PMID:34498969. |
acetylcholinesterase and butyrylcholinesterase inhibition by nectriapyrone and tryptophol isolated from endophytic fungus cholinesterase (che) inhibitors are currently the main drugs used to treat the cognitive symptoms of alzheimer's disease (ad). |
2021-09-09 |
2023-08-13 |
Not clear |
| Mehrdad Sadafi Kohnehshahri, Gholamabbas Chehardoli, Masoomeh Bahiraei, Tahmineh Akbarzadeh, Akram Ranjbar, Arezoo Rastegari, Zahra Najaf. Novel tacrine-based acetylcholinesterase inhibitors as potential agents for the treatment of Alzheimer's disease: Quinolotacrine hybrids. Molecular diversity. 2021-09-07. PMID:34491490. |
novel tacrine-based acetylcholinesterase inhibitors as potential agents for the treatment of alzheimer's disease: quinolotacrine hybrids. |
2021-09-07 |
2023-08-13 |
Not clear |
| Uthaiwan Suttisansanee, Parunya Thiyajai, Parisut Chalermchaiwat, Khanitha Wongwathanarat, Kanchana Pruesapan, Somsri Charoenkiatkul, Piya Temviriyanuku. Phytochemicals and In Vitro Bioactivities of Aqueous Ethanolic Extracts from Common Vegetables in Thai Food. Plants (Basel, Switzerland). vol 10. issue 8. 2021-08-31. PMID:34451608. |
the samples were phytochemically screened and determined their health-promoting bioactivities via antioxidant activities and inhibition of ncd-related enzymes including lipase (obesity), α-amylase and α-glucosidase (diabetes), angiotensin-converting enzyme (hypertension), as well as acetylcholinesterase, butyrylcholinesterase and β-secretase (alzheimer's disease). |
2021-08-31 |
2023-08-13 |
Not clear |
| Faez Saleh Al-Hamed, Stamatis Kouniaris, Iskandar Tamimi, Marie Lordkipanidzé, Sreenath Arekunnath Madathil, Abbas Kezouh, Igor Karp, Belinda Nicolau, Faleh Tamim. Acetylcholinesterase inhibitors and risk of bleeding and acute ischemic events in non-hypertensive Alzheimer's patients. Alzheimer's & dementia (New York, N. Y.). vol 7. issue 1. 2021-08-31. PMID:34458554. |
acetylcholinesterase inhibitors and risk of bleeding and acute ischemic events in non-hypertensive alzheimer's patients. |
2021-08-31 |
2023-08-13 |
Not clear |
| Faez Saleh Al-Hamed, Stamatis Kouniaris, Iskandar Tamimi, Marie Lordkipanidzé, Sreenath Arekunnath Madathil, Abbas Kezouh, Igor Karp, Belinda Nicolau, Faleh Tamim. Acetylcholinesterase inhibitors and risk of bleeding and acute ischemic events in non-hypertensive Alzheimer's patients. Alzheimer's & dementia (New York, N. Y.). vol 7. issue 1. 2021-08-31. PMID:34458554. |
acetylcholinesterase inhibitors (acheis) are commonly used to treat mild to moderate cases of alzheimer disease (ad). |
2021-08-31 |
2023-08-13 |
Not clear |
| Erma Fatiha Muhammad, Ashutosh Kumar, Habibah A Wahab, Kam Y J Zhan. Identification of 1,2,4-Triazolylthioethanone Scaffold for the Design of New Acetylcholinesterase Inhibitors. Molecular informatics. vol 40. issue 8. 2021-08-26. PMID:34060234. |
acetylcholinesterase (ache) inhibitors are the most effective drugs for alzheimer's disease treatment. |
2021-08-26 |
2023-08-13 |
Not clear |
| María-Ángeles Cortés-Gómez, Esther Llorens-Álvarez, Jordi Alom, Teodoro Del Ser, Jesús Avila, Javier Sáez-Valero, María-Salud García-Aylló. Tau phosphorylation by glycogen synthase kinase 3β modulates enzyme acetylcholinesterase expression. Journal of neurochemistry. vol 157. issue 6. 2021-08-24. PMID:32955735. |
in alzheimer's disease (ad), the enzyme acetylcholinesterase (ache) co-localizes with hyperphosphorylated tau (p-tau) within neurofibrillary tangles. |
2021-08-24 |
2023-08-13 |
mouse |
| Georgiana Uță, Denisa Ștefania Manolescu, Speranța Avra. Therapeutic Properties of Several Chemical Compounds of Salvia officinalis L. in Alzheimer's Disease. Mini reviews in medicinal chemistry. vol 21. issue 12. 2021-08-20. PMID:33390133. |
currently, the pharmacological management of alzheimer's disease is based on several chemical structures, represented by acetylcholinesterase and n-methyl-d-aspartate (nmda) receptor ligands, with still unclear molecular mechanisms and severe side effects. |
2021-08-20 |
2023-08-13 |
Not clear |
| Meghan K Cash, Kenneth Rockwood, John D Fisk, Sultan Darves. Clinicopathological correlations and cholinesterase expression in early-onset familial Alzheimer's disease with the presenilin 1 mutation, Leu235Pro. Neurobiology of aging. vol 103. 2021-08-16. PMID:33789210. |
in sporadic alzheimer's disease (spad), acetylcholinesterase and butyrylcholinesterase, co-regulators of acetylcholine, are associated with β-amyloid plaques and tau neurofibrillary tangles in patterns suggesting a contribution to neurotoxicity. |
2021-08-16 |
2023-08-13 |
Not clear |
| Saravanan Kandasamy, Chitra Loganathan, Penislusshiyan Sakayanathan, Subramani Karthikeyan, Arputharaj David Stephen, Dinesh Kumar Marimuthu, Saravanan Ravichandran, Vignesh Sivalingam, Palvannan Thayumanava. In silico, theoretical biointerface analysis and in vitro kinetic analysis of amine compounds interaction with acetylcholinesterase and butyrylcholinesterase. International journal of biological macromolecules. vol 185. 2021-08-16. PMID:34216669. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are considered important target for drug design against alzheimer's disease. |
2021-08-16 |
2023-08-13 |
Not clear |
| Debanjan Kundu, Vikash Kumar Dube. Potential alternatives to current cholinesterase inhibitors: an Drug development and industrial pharmacy. vol 47. issue 6. 2021-08-13. PMID:34219594. |
we investigated these drugs for possible fundamental interactions with acetylcholinesterase and butyrylcholinesterase as both are critical in the pathophysiology of alzheimer's disease. |
2021-08-13 |
2023-08-13 |
Not clear |
| Fatima Y Adeowo, Murtala A Ejalonibu, Ahmed A Elrashedy, Monsurat M Lawal, Hezekiel M Kumal. Multi-target approach for Alzheimer's disease treatment: computational biomolecular modeling of cholinesterase enzymes with a novel 4- Journal of biomolecular structure & dynamics. vol 39. issue 11. 2021-08-11. PMID:33030113. |
multi-target approach for alzheimer's disease treatment: computational biomolecular modeling of cholinesterase enzymes with a novel 4- the identification of dual inhibitors targeting the active sites of the cholinesterase enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (buche), have lately surfaced as a multi-approach towards alzheimer treatment. |
2021-08-11 |
2023-08-13 |
Not clear |
| Sagheer Ahmed, Sidrah Tariq Khan, Muhammad Kazim Zargaham, Arif Ullah Khan, Saeed Khan, Abrar Hussain, Jalal Uddin, Ajmal Khan, Ahmed Al-Harras. Potential therapeutic natural products against Alzheimer's disease with Reference of Acetylcholinesterase. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 139. 2021-08-11. PMID:33915501. |
potential therapeutic natural products against alzheimer's disease with reference of acetylcholinesterase. |
2021-08-11 |
2023-08-13 |
Not clear |
| Giselle de Andrade Ramos, Andressa Souza de Oliveira, Manuela Bartolini, Marina Naldi, Irene Liparulo, Christian Bergamini, Elisa Uliassi, Ling Wu, Paul E Fraser, Monica Abreu, Alessandra Sofia Kiametis, Ricardo Gargano, Edilberto Rocha Silveira, Guilherme D Brand, Lukas Prchal, Ondřej Soukup, Jan Korábečný, Maria Laura Bolognesi, Luiz Antonio Soares Romeir. Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties. RSC medicinal chemistry. vol 12. issue 7. 2021-08-07. PMID:34355181. |
as part of our efforts to develop sustainable drugs for alzheimer's disease (ad), we have been focusing on the inexpensive and largely available cashew nut shell liquid (cnsl) as a starting material for the identification of new acetylcholinesterase (ache) inhibitors. |
2021-08-07 |
2023-08-13 |
Not clear |
| Chonny Herrera-Acevedo, Camilo Perdomo-Madrigal, Kenyi Herrera-Acevedo, Ericsson Coy-Barrera, Luciana Scotti, Marcus Tullius Scott. Machine learning models to select potential inhibitors of acetylcholinesterase activity from SistematX: a natural products database. Molecular diversity. vol 25. issue 3. 2021-08-06. PMID:34132933. |
the inhibition of acetylcholinesterase is frequently used to treat alzheimer's disease. |
2021-08-06 |
2023-08-13 |
Not clear |
| Miloš Mitić, Tamara Lazarević-Pašt. Does the application of acetylcholinesterase inhibitors in the treatment of Alzheimer's disease lead to depression? Expert opinion on drug metabolism & toxicology. vol 17. issue 7. 2021-08-05. PMID:33999717. |
does the application of acetylcholinesterase inhibitors in the treatment of alzheimer's disease lead to depression? |
2021-08-05 |
2023-08-13 |
Not clear |
| Gourav Choudhir, Satyawati Sharma, P Hariprasa. A combinatorial approach to screen structurally diverse acetylcholinesterase inhibitory plant secondary metabolites targeting Alzheimer's disease. Journal of biomolecular structure & dynamics. 2021-08-05. PMID:34351840. |
a combinatorial approach to screen structurally diverse acetylcholinesterase inhibitory plant secondary metabolites targeting alzheimer's disease. |
2021-08-05 |
2023-08-13 |
Not clear |
| Behnaz Moghadam, Mitra Ashouri, Hossein Roohi, Mohammad Hosein Karimi-Jafar. Computational evidence of new putative allosteric sites in the acetylcholinesterase receptor. Journal of molecular graphics & modelling. vol 107. 2021-08-03. PMID:34246109. |
acetylcholinesterase (ache), with a rigid structure and buried active site at the end of a deep narrow gorge, is interesting enough to solve the paradox between high catalytic activity and unavailability of the active site in treatment of alzheimer's disease (ad). |
2021-08-03 |
2023-08-13 |
Not clear |
| Sin-Eun Kim, Hyung-Ju Seo, Yeojin Jeong, Gyung-Min Lee, Seung-Bae Ji, So-Young Park, Zhexue Wu, Sangkyu Lee, Sunghwan Kim, Kwang-Hyeon Li. In Vitro Metabolism of Donepezil in Liver Microsomes Using Non-Targeted Metabolomics. Pharmaceutics. vol 13. issue 7. 2021-07-27. PMID:34201744. |
donepezil is a reversible acetylcholinesterase inhibitor that is currently the most commonly prescribed drug for the treatment of alzheimer's disease. |
2021-07-27 |
2023-08-13 |
mouse |