| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zheng Fu, Xue Li, Yipu Miao, Kenneth M Mer. Conformational analysis and parallel QM/MM X-ray refinement of protein bound anti-Alzheimer drug donepezil. Journal of chemical theory and computation. vol 9. issue 3. 2021-10-21. PMID:23526889. |
the recognition and association of donepezil with acetylcholinesterase (ache) has been extensively studied in the past several decades because of the former's use as a palliative treatment for mild alzheimer disease. |
2021-10-21 |
2023-08-12 |
Not clear |
| Nasimudeen R Jabir, Shazi Shakil, Shams Tabrez, Mohd Shahnawaz Khan, Md Tabish Rehman, Bakrudeen Ali Ahme. In silico screening of glycogen synthase kinase-3β targeted ligands against acetylcholinesterase and its probable relevance to Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 39. issue 14. 2021-10-21. PMID:32588759. |
in silico screening of glycogen synthase kinase-3β targeted ligands against acetylcholinesterase and its probable relevance to alzheimer's disease. |
2021-10-21 |
2023-08-13 |
Not clear |
| Ana Mércia Silva Mascarenhas, Raquel Bianca Marchesine de Almeida, Moysés Fagundes de Araujo Neto, Géssica Oliveira Mendes, Jorddy Neves da Cruz, Cleydson Breno Rodrigues Dos Santos, Mariana Borges Botura, Franco Henrique Andrade Leit. Pharmacophore-based virtual screening and molecular docking to identify promising dual inhibitors of human acetylcholinesterase and butyrylcholinesterase. Journal of biomolecular structure & dynamics. vol 39. issue 16. 2021-10-21. PMID:32705955. |
the dual inhibition of human acetylcholinesterase (hache) and butyrylcholinesterase (hbuche) plays an important role in alzheimer's disease treatment. |
2021-10-21 |
2023-08-13 |
human |
| Noopur Khare, Sanjiv Kumar Maheshwari, Abhimanyu Kumar Jh. Screening and identification of secondary metabolites in the bark of Journal of biomolecular structure & dynamics. vol 39. issue 16. 2021-10-21. PMID:32720564. |
screening and identification of secondary metabolites in the bark of acetylcholinesterase (ache) and butyrylcholinesterase (bche) acts as a promising protein targets for which drug as an inhibitor can be designed to treat alzheimer's disease. |
2021-10-21 |
2023-08-13 |
Not clear |
| Kamilia M Amin, Doaa E Abdel Rahman, Heba Abdelrasheed Allam, Haidy H El-Zoheir. Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer's disease. Bioorganic chemistry. vol 110. 2021-10-12. PMID:33799178. |
design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for alzheimer's disease. |
2021-10-12 |
2023-08-13 |
Not clear |
| Xueyang Jiang, Chang Liu, Manxing Zou, Huanfang Xie, Tailiang Lin, Weiping Lyu, Jian Xu, Yuan Li, Feng Feng, Haopeng Sun, Wenyuan Li. Discovery of 2-(cyclopropanecarboxamido)-N-(5-((1-(4-fluorobenzyl)piperidin-4-yl)methoxy)pyridin-3-yl)isonicotinamide as a potent dual AChE/GSK3β inhibitor for the treatment of Alzheimer's disease: Significantly increasing the level of acetylcholine in the brain without affecting that in intestine. European journal of medicinal chemistry. vol 223. 2021-10-12. PMID:34198150. |
acetylcholinesterase (ache) inhibitors are currently the first-line drugs approved by the fda for the treatment of alzheimer's disease (ad). |
2021-10-12 |
2023-08-13 |
Not clear |
| Khalil El Khatabi, Reda El-Mernissi, Ilham Aanouz, Mohammed Aziz Ajana, Tahar Lakhlifi, Abbas Khan, Dong-Qing Wei, Mohammed Bouachrin. Identification of novel acetylcholinesterase inhibitors through 3D-QSAR, molecular docking, and molecular dynamics simulation targeting Alzheimer's disease. Journal of molecular modeling. vol 27. issue 10. 2021-10-12. PMID:34581863. |
identification of novel acetylcholinesterase inhibitors through 3d-qsar, molecular docking, and molecular dynamics simulation targeting alzheimer's disease. |
2021-10-12 |
2023-08-13 |
Not clear |
| Khalil El Khatabi, Reda El-Mernissi, Ilham Aanouz, Mohammed Aziz Ajana, Tahar Lakhlifi, Abbas Khan, Dong-Qing Wei, Mohammed Bouachrin. Identification of novel acetylcholinesterase inhibitors through 3D-QSAR, molecular docking, and molecular dynamics simulation targeting Alzheimer's disease. Journal of molecular modeling. vol 27. issue 10. 2021-10-12. PMID:34581863. |
acetylcholinesterase (ache) is a potential target for the development of small molecules as inhibitors for the therapy of alzheimer's disease (ad). |
2021-10-12 |
2023-08-13 |
Not clear |
| Huichen Zhu, Lu Cong, Yi Chen, Shaoyi Chen, Lingke Chen, Zhenling Huang, Jie Zhou, Jie Xiao, Yonglei Huang, Diansan S. Efficiency of donepezil in elderly patients undergoing orthopaedic surgery due to underlying post-operative cognitive dysfunction: study protocol for a multicentre randomised controlled trial. Trials. vol 22. issue 1. 2021-10-12. PMID:34627332. |
our previous study demonstrated that the concentration of choline acetyl transferase in the cerebral spinal fluid was a predictive factor of pocd and that donepezil, which is an acetylcholinesterase inhibitor used in clinical settings for the treatment of alzheimer's disease, can prevent learning and memory impairment after anaesthesia/surgery in aged mice. |
2021-10-12 |
2023-08-13 |
mouse |
| José L Borioni, Valeria Cavallaro, Adriana B Pierini, Ana P Murray, Alicia B Peñéñory, Marcelo Puiatti, Manuela E Garcí. An activity prediction model for steroidal and triterpenoidal inhibitors of Acetylcholinesterase enzyme. Journal of computer-aided molecular design. vol 34. issue 10. 2021-10-08. PMID:32632601. |
particularly, these methods have been important in the design of novel acetylcholinesterase enzyme inhibitors related to alzheimer's disease. |
2021-10-08 |
2023-08-13 |
Not clear |
| Suciati, Debora Poerwantoro, Aty Widyawaruyanti, Kornkanok Ingkanina. Acetylcholinesterase inhibitory activity of extract and fractions from the root of Journal of basic and clinical physiology and pharmacology. vol 32. issue 4. 2021-09-30. PMID:34214376. |
acetylcholinesterase inhibitory activity of extract and fractions from the root of alzheimer's disease (ad) is a degenerative brain disease characterized by confusion, behavior changes, decline in memory and cognitive skills. |
2021-09-30 |
2023-08-13 |
Not clear |
| Ashwani Arya, Rubal Chahal, Rekha Rao, Md Habibur Rahman, Deepak Kaushik, Muhammad Furqan Akhtar, Ammara Saleem, Shaden M A Khalifa, Hesham R El-Seedi, Mohamed Kamel, Ghadeer M Albadrani, Mohamed M Abdel-Daim, Vineet Mitta. Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer's Disease Therapy. Biomolecules. vol 11. issue 3. 2021-09-28. PMID:33669097. |
acetylcholinesterase inhibitory potential of various sesquiterpene analogues for alzheimer's disease therapy. |
2021-09-28 |
2023-08-13 |
Not clear |
| E Shamsi, A Rahati, E Dehghania. A modified binary particle swarm optimization with a machine learning algorithm and molecular docking for QSAR modelling of cholinesterase inhibitors. SAR and QSAR in environmental research. vol 32. issue 9. 2021-09-27. PMID:34494463. |
the acetylcholinesterase (ache) and butyrylcholinesterase (buche) inhibitors play a key role in treating alzheimer's disease. |
2021-09-27 |
2023-08-13 |
Not clear |
| Félix Viñuela, Angeles Barr. Assessment of a Potential Synergistic Effect of Souvenaid® in Mild Alzheimer's Disease Patients on Treatment with Acetylcholinesterase Inhibitors: An Observational, Non-Interventional Study. Journal of Alzheimer's disease : JAD. vol 80. issue 4. 2021-09-17. PMID:33682712. |
assessment of a potential synergistic effect of souvenaid® in mild alzheimer's disease patients on treatment with acetylcholinesterase inhibitors: an observational, non-interventional study. |
2021-09-17 |
2023-08-13 |
Not clear |
| Félix Viñuela, Angeles Barr. Assessment of a Potential Synergistic Effect of Souvenaid® in Mild Alzheimer's Disease Patients on Treatment with Acetylcholinesterase Inhibitors: An Observational, Non-Interventional Study. Journal of Alzheimer's disease : JAD. vol 80. issue 4. 2021-09-17. PMID:33682712. |
we evaluated the efficacy and safety of souvenaid (a multinutrient supplement) in patients with mild alzheimer's disease (ad) in real clinical practice and assessed a potential synergistic effect of acetylcholinesterase (ache) inhibitors. |
2021-09-17 |
2023-08-13 |
Not clear |
| Motahareh Hassanzadeh, Farshid Hassanzadeh, Ghadam Ali Khodarahmi, Mahbobe Rostami, Fateme Azimi, Hamid Nadri, Farshad Homayouni Moghada. Design, synthesis, and bio-evaluation of new isoindoline-1,3-dione derivatives as possible inhibitors of acetylcholinesterase. Research in pharmaceutical sciences. vol 16. issue 5. 2021-09-16. PMID:34522196. |
a significant decrease in acetylcholine level in the brain is common in most patients with alzheimer's disease, therefore acetylcholinesterase (ache) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects. |
2021-09-16 |
2023-08-13 |
Not clear |
| Alberto Castagna, Andrea Fabbo, Ciro Manzo, Roberto Lacava, Carmen Ruberto, Giovanni Ruotol. A Retrospective Study on the Benefits of Combined Citicoline, Memantine, and Acetylcholinesterase Inhibitor Treatments in Older Patients Affected with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459645. |
a retrospective study on the benefits of combined citicoline, memantine, and acetylcholinesterase inhibitor treatments in older patients affected with alzheimer's disease. |
2021-09-15 |
2023-08-13 |
Not clear |
| Alberto Castagna, Andrea Fabbo, Ciro Manzo, Roberto Lacava, Carmen Ruberto, Giovanni Ruotol. A Retrospective Study on the Benefits of Combined Citicoline, Memantine, and Acetylcholinesterase Inhibitor Treatments in Older Patients Affected with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459645. |
in previous studies, combined treatment with memantine and acetylcholinesterase inhibitors (acheis) maintained cognitive function in patients with alzheimer's disease (ad) better than memantine or acheis alone. |
2021-09-15 |
2023-08-13 |
Not clear |
| Boris Nemzer, Diganta Kalita, Nebiyu Abshir. Quantification of Major Bioactive Constituents, Antioxidant Activity, and Enzyme Inhibitory Effects of Whole Coffee Cherries ( Molecules (Basel, Switzerland). vol 26. issue 14. 2021-09-15. PMID:34299581. |
in this study we examined the potential antioxidant activity and enzyme inhibitory effects of whole coffee cherries (wcc) and their two extracts on α-amylase, α-glucosidase and acetylcholinesterase (ache) activities, which are targets for the control of diabetes and alzheimer's diseases. |
2021-09-15 |
2023-08-13 |
Not clear |
| Runcong Guo, Lei Zhou, Xiaoyan Che. Desorption electrospray ionization (DESI) source coupling ion mobility mass spectrometry for imaging fluoropezil (DC20) distribution in rat brain. Analytical and bioanalytical chemistry. vol 413. issue 23. 2021-09-14. PMID:34405263. |
fluoropezil (dc20) is a new selective acetylcholinesterase inhibitor, and it was developed for the treatment of alzheimer's disease patients. |
2021-09-14 |
2023-08-13 |
rat |