| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ezio Giacobini, A Claudio Cuello, Abraham Fishe. Reimagining cholinergic therapy for Alzheimer's disease. Brain : a journal of neurology. 2022-03-15. PMID:35289363. |
restoring the cholinergic system has been a primary means of improving cognition in alzheimer's disease, as four of the six approved therapies are acetylcholinesterase inhibitors (fig 1). |
2022-03-15 |
2023-08-13 |
Not clear |
| Sandra Codony, Caterina Pont, Christian Griñán-Ferré, Ania Di Pede-Mattatelli, Carla Calvó-Tusell, Ferran Feixas, Sílvia Osuna, Júlia Jarné-Ferrer, Marina Naldi, Manuela Bartolini, María Isabel Loza, José Brea, Belén Pérez, Clara Bartra, Coral Sanfeliu, Jordi Juárez-Jiménez, Christophe Morisseau, Bruce D Hammock, Mercè Pallàs, Santiago Vázquez, Diego Muñoz-Torrer. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. Journal of medicinal chemistry. 2022-03-10. PMID:35271276. |
discovery and in vivo proof of concept of a highly potent dual inhibitor of soluble epoxide hydrolase and acetylcholinesterase for the treatment of alzheimer's disease. |
2022-03-10 |
2023-08-13 |
mouse |
| Feng Zhang, Sihui Li, Chao Liu, Kun Fang, Yongmei Jiang, Jianyong Zhang, Jie Lan, Lei Zhu, Hanqing Pang, Gang Wan. Rapid screening for acetylcholinesterase inhibitors in Selaginella doederleinii Hieron by using functionalized magnetic Fe Talanta. vol 243. 2022-03-07. PMID:35255433. |
rapid screening for acetylcholinesterase inhibitors in selaginella doederleinii hieron by using functionalized magnetic fe insufficient acetylcholine (ach) can cause cognitive and memory dysfunction, clinically known as, alzheimer's disease (ad). |
2022-03-07 |
2023-08-13 |
Not clear |
| Sidra Rehman, Usman Ali Ashfaq, Muhammad Sufyan, Imran Shahid, Bushra Ijaz, Mureed Hussai. The Insight of In Silico and In Vitro evaluation of Beta vulgaris phytochemicals against Alzheimer's disease targeting acetylcholinesterase. PloS one. vol 17. issue 3. 2022-03-03. PMID:35239683. |
the insight of in silico and in vitro evaluation of beta vulgaris phytochemicals against alzheimer's disease targeting acetylcholinesterase. |
2022-03-03 |
2023-08-13 |
Not clear |
| Sidra Rehman, Usman Ali Ashfaq, Muhammad Sufyan, Imran Shahid, Bushra Ijaz, Mureed Hussai. The Insight of In Silico and In Vitro evaluation of Beta vulgaris phytochemicals against Alzheimer's disease targeting acetylcholinesterase. PloS one. vol 17. issue 3. 2022-03-03. PMID:35239683. |
super activation of acetylcholinesterase enzyme is associated explicitly with alzheimer's disease (ad) ultimately resulting in senile dementia. |
2022-03-03 |
2023-08-13 |
Not clear |
| Makar Makarian, Michael Gonzalez, Stephanie M Salvador, Shahrokh Lorzadeh, Paula K Hudson, Stevan Peci. Synthesis, kinetic evaluation and molecular docking studies of donepezil-based acetylcholinesterase inhibitors. Journal of molecular structure. vol 1247. 2022-02-28. PMID:35221376. |
in an effort to develop new therapeutic agents to treat alzheimer's disease, a series of donepezil-based analogs were designed, synthesized using an environmentally friendly route, and biologically evaluated for their inhibitory activity against electric eel acetylcholinesterase (ache) enzyme. |
2022-02-28 |
2023-08-13 |
Not clear |
| Abhishek Singh, Parul Gupta, Shubhangini Tiwari, Amit Mishra, Sarika Sing. Guanabenz mitigates the neuropathological alterations and cell death in Alzheimer's disease. Cell and tissue research. 2022-02-23. PMID:35195784. |
alzheimer's disease (ad) pathology is characterized by cognitive impairment, increased acetylcholinesterase (ache) activity, and impaired neuronal communication. |
2022-02-23 |
2023-08-13 |
rat |
| Moussa B H Youdi. Site-activated multi target iron chelators with acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitory activities for Alzheimer's disease therapy. Journal of neural transmission (Vienna, Austria : 1996). 2022-02-22. PMID:35190910. |
site-activated multi target iron chelators with acetylcholinesterase (ache) and monoamine oxidase (mao) inhibitory activities for alzheimer's disease therapy. |
2022-02-22 |
2023-08-13 |
Not clear |
| Yiwen Xiao, Weizhong Liang, De Liu, Zhibin Zhang, Jun Chang, Du Zh. Isolation and acetylcholinesterase inhibitory activity of asterric acid derivatives produced by 3 Biotech. vol 12. issue 3. 2022-02-21. PMID:35186657. |
isolation and acetylcholinesterase inhibitory activity of asterric acid derivatives produced by alzheimer's disease (ad) is a neurodegenerative disease and the fourth leading cause of death after cardiovascular disease, tumors, and stroke. |
2022-02-21 |
2023-08-13 |
Not clear |
| Sukhvir Kaur, Yogita Bansa. Design, molecular Docking, synthesis and evaluation of xanthoxylin hybrids as dual inhibitors of IL-6 and acetylcholinesterase for Alzheimer's disease. Bioorganic chemistry. vol 121. 2022-02-21. PMID:35189442. |
design, molecular docking, synthesis and evaluation of xanthoxylin hybrids as dual inhibitors of il-6 and acetylcholinesterase for alzheimer's disease. |
2022-02-21 |
2023-08-13 |
mouse |
| Sukhvir Kaur, Yogita Bansa. Design, molecular Docking, synthesis and evaluation of xanthoxylin hybrids as dual inhibitors of IL-6 and acetylcholinesterase for Alzheimer's disease. Bioorganic chemistry. vol 121. 2022-02-21. PMID:35189442. |
interleukin-6 (il-6) and acetylcholinesterase (ache) are two important targets implicated in progression of alzheimer's disease (ad). |
2022-02-21 |
2023-08-13 |
mouse |
| Mariana G Fronza, Manoela Sacramento, Diego Alves, Domenico Praticò, Lucielli Savegnag. 1-(7-Chloroquinolin-4-yl)-N-(4-Methoxybenzyl)-5-Methyl-1H-1,2, 3-Triazole-4- carboxamide Reduces Aβ Formation and Tau Phosphorylation in Cellular Models of Alzheimer's Disease. Neurochemical research. 2022-02-15. PMID:35165799. |
1-(7-chloroquinolin-4-yl)-n-(4-methoxybenzyl)-5-methyl-1h-1,2,3-triazole-4- carboxamide (qtc-4-meobne) is a new multi-target directed ligand (mtdl) rationally designed to have affinity with β-secretase (bace), glycogen synthase kinase 3β (gsk3β) and acetylcholinesterase, which are considered promising targets on the development of disease-modifying therapies against alzheimer's disease (ad). |
2022-02-15 |
2023-08-13 |
human |
| C Johan van der Westhuizen, André Stander, Darren L Riley, Jenny-Lee Panayide. Discovery of Novel Acetylcholinesterase Inhibitors by Virtual Screening, In Vitro Screening, and Molecular Dynamics Simulations. Journal of chemical information and modeling. 2022-02-10. PMID:35139637. |
this study describes the uses of computer-aided drug discovery techniques to identify novel inhibitors of acetylcholinesterase, a target for alzheimer's disease. |
2022-02-10 |
2023-08-13 |
Not clear |
| Xian-Tao L. Alzheimer's disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels. Metabolic brain disease. 2022-01-31. PMID:35098414. |
alzheimer's disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels. |
2022-01-31 |
2023-08-13 |
Not clear |
| Fatima Y Adeowo, Ahmed A Elrashedy, Murtala A Ejalonibu, Isiaka A Lawal, Monsurat M Lawal, Hezekiel M Kumal. Pharmacophore mapping of the crucial mediators of acetylcholinesterase and butyrylcholinesterase dual inhibition in Alzheimer's disease. Molecular diversity. 2022-01-24. PMID:35067751. |
pharmacophore mapping of the crucial mediators of acetylcholinesterase and butyrylcholinesterase dual inhibition in alzheimer's disease. |
2022-01-24 |
2023-08-13 |
human |
| Fatima Y Adeowo, Ahmed A Elrashedy, Murtala A Ejalonibu, Isiaka A Lawal, Monsurat M Lawal, Hezekiel M Kumal. Pharmacophore mapping of the crucial mediators of acetylcholinesterase and butyrylcholinesterase dual inhibition in Alzheimer's disease. Molecular diversity. 2022-01-24. PMID:35067751. |
herein, we applied a pharmacophore modeling approach to screen potent dual inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (buche) aimed at alzheimer's disease (ad) treatment. |
2022-01-24 |
2023-08-13 |
human |
| Y Cañizares-Carmenate, N-H Nam, R Díaz-Amador, N T Thuan, P T P Dung, F Torrens, H Pham-The, F Perez-Gimenez, J A Castillo-Gari. Ligand-based discovery of new potential acetylcholinesterase inhibitors for Alzheimer's disease treatment. SAR and QSAR in environmental research. 2022-01-20. PMID:35048766. |
ligand-based discovery of new potential acetylcholinesterase inhibitors for alzheimer's disease treatment. |
2022-01-20 |
2023-08-13 |
Not clear |
| Jia Liu, Wei Ha, Hai-Xia Zhang, Yan-Ping Sh. Hollow urchin-shaped manganese dioxide microspheres immobilized acetylcholinesterase for rapid screening inhibitors from traditional herbal medicines. Journal of chromatography. A. vol 1665. 2022-01-20. PMID:35051752. |
acetylcholinesterase (ache) is generally considered to be a valuable therapeutic target for alzheimer's disease (ad). |
2022-01-20 |
2023-08-13 |
Not clear |
| Jason Tom Abraham, H Noorul Samsoon Maharifa, S Hemalath. In Silico Molecular Docking Approach Against Enzymes Causing Alzheimer's Disease Using Borassus flabellifer Linn. Applied biochemistry and biotechnology. 2022-01-11. PMID:35013923. |
in this study, we explore the activity of natural compounds isolated through gc-ms analysis from the haustoria of palmyra palm against two major alzheimer's disease-causing enzymes, β-secretase and acetylcholinesterase. |
2022-01-11 |
2023-08-13 |
Not clear |
| Yan-Jun Li, Fu-Qin He, Huan-Huan Zhao, Yun Li, Juan Che. Screening and identification of acetylcholinesterase inhibitors from Terminalia chebula fruits by immobilized enzyme on cellulose filter paper coupled with ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry and molecular docking. Journal of chromatography. A. vol 1663. 2022-01-02. PMID:34974370. |
with the increasing demand of new drugs for the treatment of alzheimer's disease (ad), screening acetylcholinesterase (ache) inhibitors from traditional chinese medicines (tcms) has been proved to be an effective strategy for drug discovery. |
2022-01-02 |
2023-08-13 |
Not clear |