| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Farida Begum, Najeeb Ur Rehman, Ajmal Khan, Sajid Iqbal, Rehan Zafar Paracha, Jalal Uddin, Ahmed Al-Harrasi, Muhammad Arif Lodh. 2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer's therapy: Frontiers in pharmacology. vol 13. 2022-09-05. PMID:36059999. |
the present study was designed to evaluate potential inhibitors of acetylcholinesterase that could be used as a therapeutic agent against alzheimer's disease (ad). |
2022-09-05 |
2023-08-14 |
Not clear |
| Kolade O Faloye, Shafi Mahmud, Emmanuel G Fakola, Yemisi M Oyetunde, Sunday J Fajobi, Jeremiah P Ugwo, Ayobami J Olusola, Samson O Famuyiwa, Oluwabukunmi G Olajubutu, Temitope I Oguntade, Ahmad J Obaidulla. Revealing the Acetylcholinesterase Inhibitory Potential of Bioinformatics and biology insights. vol 16. 2022-09-01. PMID:36046175. |
revealing the acetylcholinesterase inhibitory potential of the inhibition of acetylcholinesterase plays a vital role in the treatment of alzheimer disease. |
2022-09-01 |
2023-08-14 |
Not clear |
| M Mani, M Cokulraj, A Dey, M Faisal, A A Alatar, A Alok, M S Shekhawa. Micro-morpho-anatomical transitions at various stages of in vitro development of Crinum malabaricum Lekhak and Yadav: A critically endangered medicinal plant. Plant biology (Stuttgart, Germany). 2022-08-30. PMID:36040406. |
it gained attention as a wild source of acetylcholinesterase inhibiting alkaloid 'galanthamine' to treat alzheimer's and parkinson's disease. |
2022-08-30 |
2023-08-14 |
Not clear |
| Saikat Mitra, Maniza Muni, Nusrat Jahan Shawon, Rajib Das, Talha Bin Emran, Rohit Sharma, Deepak Chandran, Fahadul Islam, Md Jamal Hossain, Sher Zaman Safi, Sherouk Hussein Sweila. Tacrine Derivatives in Neurological Disorders: Focus on Molecular Mechanisms and Neurotherapeutic Potential. Oxidative medicine and cellular longevity. vol 2022. 2022-08-29. PMID:36035218. |
tacrine is a drug used in the treatment of alzheimer's disease as a cognitive enhancer and inhibitor of the enzyme acetylcholinesterase (ache). |
2022-08-29 |
2023-08-14 |
Not clear |
| Robert R Redman, Harry Mackenzie, Kosala N Dissanayake, Michael Eddleston, Richard R Ribcheste. DONEPEZIL INHIBITS NEUROMUSCULAR JUNCTIONAL ACETYLCHOLINESTERASE AND ENHANCES SYNAPTIC TRANSMISSION AND FUNCTION IN ISOLATED SKELETAL MUSCLE. British journal of pharmacology. 2022-08-26. PMID:36028305. |
donepezil, a piperidine antagonist of acetylcholinesterase (ache) prescribed for treatment of alzheimer's disease, has adverse neuromuscular effects in humans, including requirement for higher concentrations of non-depolarising neuromuscular blockers during surgery. |
2022-08-26 |
2023-08-14 |
mouse |
| Rafaqat Hussain, Fazal Rahim, Wajid Rehman, Muhammad Taha, Shoaib Khan, Khalid Zaman, Syed Adnan Ali Shah, Abdul Wadood, Syahrul Imran, Magda Abdellati. New bis-thiazolidinone based chalcone analogues as effective inhibitors of Alzheimer's disease: Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase study. Chemistry & biodiversity. 2022-08-23. PMID:35997224. |
new bis-thiazolidinone based chalcone analogues as effective inhibitors of alzheimer's disease: synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase study. |
2022-08-23 |
2023-08-14 |
Not clear |
| Ezgi Fide, Deniz Yerlikaya, Didem Öz, İbrahim Öztura, Görsev Yene. Normalized Theta but Increased Gamma Activity after Acetylcholinesterase Inhibitor Treatment in Alzheimer's Disease: Preliminary qEEG Study. Clinical EEG and neuroscience. 2022-08-12. PMID:35957592. |
normalized theta but increased gamma activity after acetylcholinesterase inhibitor treatment in alzheimer's disease: preliminary qeeg study. |
2022-08-12 |
2023-08-14 |
human |
| Ezgi Fide, Deniz Yerlikaya, Didem Öz, İbrahim Öztura, Görsev Yene. Normalized Theta but Increased Gamma Activity after Acetylcholinesterase Inhibitor Treatment in Alzheimer's Disease: Preliminary qEEG Study. Clinical EEG and neuroscience. 2022-08-12. PMID:35957592. |
acetylcholinesterase inhibitors (ache-i) are the core treatment of mild to severe alzheimer's disease (ad). |
2022-08-12 |
2023-08-14 |
human |
| Remya R S, N Ramalakshmi, Nalini C N, Niraimathi V, Amuthalakshmi . Design synthesis and In vitro evaluation of Tacrine- Flavone hybrids as Multifunctional Cholinesterase inhibitors for Alzheimer's disease. Current computer-aided drug design. 2022-08-05. PMID:35927818. |
alzheimer's disease(ad) is a multifactorial neurodegenerative disorder.the multifactorial etiology of ad have led to the design of multitarget directed ligands(mtdl) for ad.tacrine an acetylcholinesterase(ache) inhibitor was the first fda approved drug for ad but is discontinued due to hepatotoxicity. |
2022-08-05 |
2023-08-14 |
Not clear |
| Marco Paolino, Mariagrazia Rullo, Samuele Maramai, Modesto de Candia, Leonardo Pisani, Marco Catto, Claudia Mugnaini, Antonella Brizzi, Andrea Cappelli, Massimo Olivucci, Federico Corelli, Cosimo D Altomar. Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors. RSC medicinal chemistry. vol 13. issue 7. 2022-08-04. PMID:35923722. |
to this aim, we designed and synthesized a small library of cinnamic acid-inspired isomeric compounds with light modulated activity able to inhibit acetylcholinesterase (ache) and monoamine oxidase b (mao-b), with remarkable selectivity over butyrylcholinesterase (bche) and mao-a, which have been investigated as the enzyme targets related to alzheimer's disease (ad). |
2022-08-04 |
2023-08-14 |
Not clear |
| Mohan Gupta, Avinash Kumar, Chakrawarti Prasun, Maya S Nair, Suvarna G Kini, Divya Yadav, Sumitra Nai. Design, synthesis, extra-precision docking, and molecular dynamics simulation studies of pyrrolidin-2-one derivatives as potential acetylcholinesterase inhibitors. Journal of biomolecular structure & dynamics. 2022-08-03. PMID:35921217. |
inhibition of acetylcholinesterase (ache) has been widely explored to develop novel molecules for management of alzheimer's disease. |
2022-08-03 |
2023-08-14 |
Not clear |
| Xiao Li, Wei Li, Pingfang Tian, Tianwei Ta. Delineating biosynthesis of Huperzine A, A plant-derived medicine for the treatment of Alzheimer's disease. Biotechnology advances. 2022-08-01. PMID:35914626. |
huperzine a (hupa) is a plant-derived lycopodium alkaloid used for the treatment of alzheimer's disease due to its inhibition against acetylcholinesterase. |
2022-08-01 |
2023-08-14 |
Not clear |
| Yichuang Wu, Xiangdong Su, Jielang Lu, Meifang Wu, Seo Young Yang, Yang Mai, Wenbin Deng, Yongbo Xu. Frontiers in pharmacology. vol 13. 2022-07-28. PMID:35899116. |
current studies have found that butyrylcholinesterase (buche) replaces the biological function of acetylcholinesterase (ache) in the late stage of alzheimer's disease. |
2022-07-28 |
2023-08-14 |
Not clear |
| Sukhvir Kaur, Richa Minhas, Shivam Mishra, Birpal Kaur, Yogita Bansal, Gulshan Bansa. Design, Synthesis and Evaluation of Benzimidazole Hybrids to Inhibit Acetylcholinesterase and COX for Treatment of Alzheimer's Disease. Central nervous system agents in medicinal chemistry. vol 22. issue 1. 2022-07-28. PMID:35899919. |
design, synthesis and evaluation of benzimidazole hybrids to inhibit acetylcholinesterase and cox for treatment of alzheimer's disease. |
2022-07-28 |
2023-08-14 |
Not clear |
| Manoj Koirala, Vahid Karimzadegan, Nuwan Sameera Liyanage, Natacha Mérindol, Isabel Desgagné-Peni. Biotechnological Approaches to Optimize the Production of Amaryllidaceae Alkaloids. Biomolecules. vol 12. issue 7. 2022-07-27. PMID:35883449. |
the two most studied representatives of the family are galanthamine, an acetylcholinesterase inhibitor used as a treatment of alzheimer's disease, and lycorine, displaying potent in vitro and in vivo cytotoxic and antiviral properties. |
2022-07-27 |
2023-08-14 |
Not clear |
| Yara Mashal, Hosam Abdelhady, Arun K Iye. Comparison of Tau and Amyloid-β Targeted Immunotherapy Nanoparticles for Alzheimer's Disease. Biomolecules. vol 12. issue 7. 2022-07-27. PMID:35883556. |
alzheimer's disease (ad) is a rapidly growing global concern associated with the accumulation of amyloid-β plaques and intracellular neurofibrillary tangles in the brain combined with a high acetylcholinesterase activity. |
2022-07-27 |
2023-08-14 |
Not clear |
| Ting Zhang, Xuangao Wu, Heng Yuan, Shaokai Huang, Sunmin Par. Mitigation of Memory Impairment with Fermented Fucoidan and λ-Carrageenan Supplementation through Modulating the Gut Microbiota and Their Metagenome Function in Hippocampal Amyloid-β Infused Rats. Cells. vol 11. issue 15. 2022-07-27. PMID:35892598. |
attenuating acetylcholinesterase and insulin/insulin-like growth factor-1 signaling in the hippocampus is associated with alzheimer's disease (ad) development. |
2022-07-27 |
2023-08-14 |
rat |
| Júlia Jarne-Ferrer, Christian Griñán-Ferré, Aina Bellver-Sanchis, Santiago Vázquez, Diego Muñoz-Torrero, Mercè Pallà. A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer's Disease Mice Models. Pharmaceuticals (Basel, Switzerland). vol 15. issue 8. 2022-07-27. PMID:35893732. |
a combined chronic low-dose soluble epoxide hydrolase and acetylcholinesterase pharmacological inhibition promotes memory reinstatement in alzheimer's disease mice models. |
2022-07-27 |
2023-08-14 |
mouse |
| Ramada R Khasawneh, Ejlal Abu-El-Rub, Ayman Alzu'bi, Gamal T Abdelhady, Hana S Al-Soud. Corpus callosum anatomical changes in Alzheimer patients and the effect of acetylcholinesterase inhibitors on corpus callosum morphometry. PloS one. vol 17. issue 7. 2022-07-27. PMID:35895623. |
corpus callosum anatomical changes in alzheimer patients and the effect of acetylcholinesterase inhibitors on corpus callosum morphometry. |
2022-07-27 |
2023-08-14 |
human |
| Ramada R Khasawneh, Ejlal Abu-El-Rub, Ayman Alzu'bi, Gamal T Abdelhady, Hana S Al-Soud. Corpus callosum anatomical changes in Alzheimer patients and the effect of acetylcholinesterase inhibitors on corpus callosum morphometry. PloS one. vol 17. issue 7. 2022-07-27. PMID:35895623. |
the study also investigated the effect of acetylcholinesterase inhibitors (acheis) on the size of cc and its association with improvement in the alzheimer disease severity scores. |
2022-07-27 |
2023-08-14 |
human |