| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mengli Zhang, Cui Wang, Yongqi Wang, Feng Li, Dangqiang Zh. Visual evaluation of acetylcholinesterase inhibition by an easy-to-operate assay based on N-doped carbon nanozyme with high stability and oxidase-like activity. Journal of materials chemistry. B. 2023-04-17. PMID:37067450. |
acetylcholinesterase (ache) is the key enzyme associated with neurotransmission, and thus many drugs have been explored for their inhibitory effect on ache, such as donepezil for alzheimer's disease and organophosphorus pesticides (ops). |
2023-04-17 |
2023-08-14 |
Not clear |
| Qazi Mohammad Sajid Jamal, Mohammad Imran Khan, Ali H Alharbi, Varish Ahmad, Brijesh Singh Yada. Identification of Natural Compounds of the Apple as Inhibitors against Cholinesterase for the Treatment of Alzheimer's Disease: An In Silico Molecular Docking Simulation and ADMET Study. Nutrients. vol 15. issue 7. 2023-04-13. PMID:37049419. |
the key enzymes involved in alzheimer's disease pathways are acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2023-04-13 |
2023-08-14 |
Not clear |
| Nguyen Minh Quang, Hoa Tran Thai, Hoa Le Thi, Nguyen Duc Cuong, Nguyen Quoc Hien, DongQuy Hoang, Vu Thi Bao Ngoc, Vo Ky Minh, Pham Van Ta. Novel Thiosemicarbazone Quantum Dots in the Treatment of Alzheimer's Disease Combining In Silico Models Using Fingerprints and Physicochemical Descriptors. ACS omega. vol 8. issue 12. 2023-04-03. PMID:37008140. |
searching for thiosemicarbazone derivatives with the potential to inhibit acetylcholinesterase for the treatment of alzheimer's disease (ad) is an important current goal. |
2023-04-03 |
2023-08-14 |
Not clear |
| Tuan Xu, Shuaizhang Li, Andrew J Li, Jinghua Zhao, Srilatha Sakamuru, Wenwei Huang, Menghang Xia, Ruili Huan. Identification of Potent and Selective Acetylcholinesterase/Butyrylcholinesterase Inhibitors by Virtual Screening. Journal of chemical information and modeling. 2023-04-03. PMID:37011147. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) play important roles in human neurodegenerative disorders such as alzheimer's disease. |
2023-04-03 |
2023-08-14 |
human |
| Li-Hua Lee, Shu-Ching Wu, Cheng-Feng Ho, Wan-Lin Liang, Yi-Chien Liu, Chia-Ju Cho. White matter hyperintensities in cholinergic pathways may predict poorer responsiveness to acetylcholinesterase inhibitor treatment for Alzheimer's disease. PloS one. vol 18. issue 3. 2023-03-31. PMID:37000849. |
white matter hyperintensities in cholinergic pathways may predict poorer responsiveness to acetylcholinesterase inhibitor treatment for alzheimer's disease. |
2023-03-31 |
2023-08-14 |
Not clear |
| Li-Hua Lee, Shu-Ching Wu, Cheng-Feng Ho, Wan-Lin Liang, Yi-Chien Liu, Chia-Ju Cho. White matter hyperintensities in cholinergic pathways may predict poorer responsiveness to acetylcholinesterase inhibitor treatment for Alzheimer's disease. PloS one. vol 18. issue 3. 2023-03-31. PMID:37000849. |
acetylcholinesterase inhibitor (achei) drug regimens are the mainstay treatment options for patients with alzheimer's disease (ad). |
2023-03-31 |
2023-08-14 |
Not clear |
| Aman Thakur, Bhanu Sharma, Arun Parashar, Vivek Sharma, Ajay Kumar, Vineet Meht. 2D-QSAR, molecular docking and MD simulation based virtual screening of the herbal molecules against Alzheimer's disorder: an approach to predict CNS activity. Journal of biomolecular structure & dynamics. 2023-03-27. PMID:36970779. |
acetylcholinesterase (ache) is one of the key enzyme targets that have been used clinically for the management of alzheimer's disorder (ad). |
2023-03-27 |
2023-08-14 |
Not clear |
| Mohd Imran Khan, Park Taehwan, Yunseong Cho, Marcus Scotti, Renata Priscila Barros de Menezes, Fohad Mabood Husain, Suliman Yousef Alomar, Mohammad Hassan Baig, Jae-June Don. Discovery of novel acetylcholinesterase inhibitors through integration of machine learning with genetic algorithm based Frontiers in neuroscience. vol 16. 2023-03-20. PMID:36937207. |
discovery of novel acetylcholinesterase inhibitors through integration of machine learning with genetic algorithm based alzheimer's disease (ad) is the most studied progressive eurodegenerative disorder, affecting 40-50 million of the global population. |
2023-03-20 |
2023-08-14 |
Not clear |
| Seyyed Majid Bagheri, Mohammad Allahtavakoli, Alireza Morad. Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease. Journal of complementary & integrative medicine. 2023-03-01. PMID:36857494. |
acetylcholinesterase inhibitory activity of ferula plants and their potential for treatment of alzheimer's disease. |
2023-03-01 |
2023-08-14 |
Not clear |
| Seyyed Majid Bagheri, Mohammad Allahtavakoli, Alireza Morad. Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease. Journal of complementary & integrative medicine. 2023-03-01. PMID:36857494. |
one of the current strategies in the treatment of alzheimer's disease is using drugs with acetylcholinesterase (ache) inhibitory property. |
2023-03-01 |
2023-08-14 |
Not clear |
| Seyyed Majid Bagheri, Mohammad Allahtavakoli, Alireza Morad. Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease. Journal of complementary & integrative medicine. 2023-03-01. PMID:36857494. |
numerous studies on various extracts or purified compounds of ferula genus have shown that members of this genus have the inhibitory properties on acetylcholinesterase and can also be effective in improving alzheimer's and amnesia. |
2023-03-01 |
2023-08-14 |
Not clear |
| Zhiyang Zhang, Jianwu Lv, Yu Wang, Hongli Yu, Baolin Guo, Jihang Zhai, Chaojie Wang, Yuan Zhao, Fangfang Fan, Wen Lu. Static Binding and Dynamic Transporting-Based Design of Specific Ring-Chain-Ring Acetylcholinesterase Inhibitor: From Galantamine to Natural Product. Chemistry (Weinheim an der Bergstrasse, Germany). 2023-02-24. PMID:36826395. |
acetylcholinesterase (ache) is a key target for the current symptomatic treatment of alzheimer's disease, and galantamine is a clinical anticholinesterase drug with transiently acting characteristic and good selectivity for ache. the present theoretical-experimental work improves the drug's residence time without reducing inhibition effect, thus provides crucial breakthrough for modifying the inhibitor of ache with better-kinetic behavior. |
2023-02-24 |
2023-08-14 |
Not clear |
| Bo Pang, Lu-Lu Zhang, Bin Li, Feng-Xian Sun, Zhi-Da Wan. The sodium glucose co-transporter 2 inhibitor ertugliflozin for Alzheimer's disease: inhibition of brain insulin signaling disruption-induced tau hyperphosphorylation. Physiology & behavior. 2023-02-22. PMID:36809844. |
an antidiabetic agent sodium glucose co-transporter 2 (sglt2) inhibitor ertugliflozin has been revealed to bind to catalytic anionic site of acetylcholinesterase (ache), which is considered to be associated with the cognitive decline in neurodegenerative diseases, such as alzheimer's disease (ad). |
2023-02-22 |
2023-08-14 |
rat |
| Luciane B Silva, Elenilze F B Ferreira, Maryam, José M Espejo-Román, Glauber V Costa, Josiane V Cruz, Njogu M Kimani, Josivan S Costa, José A H M Bittencourt, Jorddy N Cruz, Joaquín M Campos, Cleydson B R Santo. Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach. Molecules (Basel, Switzerland). vol 28. issue 3. 2023-02-11. PMID:36770702. |
acetylcholinesterase (ache) enzymes play an essential role in the development of alzheimer's disease (ad). |
2023-02-11 |
2023-08-14 |
Not clear |
| Stergiani-Chrysovalanti Peitzika, Eleni Pontik. A Review on Recent Approaches on Molecular Docking Studies of Novel Compounds Targeting Acetylcholinesterase in Alzheimer Disease. Molecules (Basel, Switzerland). vol 28. issue 3. 2023-02-11. PMID:36770750. |
a review on recent approaches on molecular docking studies of novel compounds targeting acetylcholinesterase in alzheimer disease. |
2023-02-11 |
2023-08-14 |
Not clear |
| Eman M Elbaz, Reham M Essam, Kawkab A Ahmed, Maheera H Safwa. Donepezil halts acetic acid-induced experimental colitis in rats and its associated cognitive impairment through regulating inflammatory/oxidative/apoptotic cascades: An add-on to its anti-dementia activity. International immunopharmacology. vol 116. 2023-02-10. PMID:36764270. |
donepezil (don), a centrally acting acetylcholinesterase inhibitor (achei), is approved for the management of alzheimer's disease (ad). |
2023-02-10 |
2023-08-14 |
rat |
| Ha-Ri Kim, Hee-Yeon Shin, Tae-Bin Yim, Geon-Ho Jahng, Chul Jin, Seungwon Kwon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Chang-Nam Ko, Jung-Mi Par. Efficacy of Kami Guibi-tang as an Add-On Therapy to Acetylcholinesterase Inhibitor for Cognitive Function in Mild Alzheimer's Disease: A Pilot Study. Evidence-based complementary and alternative medicine : eCAM. vol 2023. 2023-02-09. PMID:36756039. |
efficacy of kami guibi-tang as an add-on therapy to acetylcholinesterase inhibitor for cognitive function in mild alzheimer's disease: a pilot study. |
2023-02-09 |
2023-08-14 |
Not clear |
| Ha-Ri Kim, Hee-Yeon Shin, Tae-Bin Yim, Geon-Ho Jahng, Chul Jin, Seungwon Kwon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Chang-Nam Ko, Jung-Mi Par. Efficacy of Kami Guibi-tang as an Add-On Therapy to Acetylcholinesterase Inhibitor for Cognitive Function in Mild Alzheimer's Disease: A Pilot Study. Evidence-based complementary and alternative medicine : eCAM. vol 2023. 2023-02-09. PMID:36756039. |
acetylcholinesterase inhibitors (acheis) are the main treatments for mild alzheimer's disease (ad), a degenerative brain disease. |
2023-02-09 |
2023-08-14 |
Not clear |
| Nurten Abacı, F Sezer Senol Deniz, Ramin Ekhteiari Salmas, Fatma Uysal Bayar, Kenan Turgut, Ilkay Erdogan Orha. International journal of environmental health research. 2023-02-05. PMID:36739545. |
was tested against acetylcholinesterase (ic50: 30.62 ± 3.27 and 32.97 ± 2.33 µg/ml for sfu and sft, respectively) and butyrylcholinesterase (ic50: 69.91 ± 1.08 µg/ml and 86.55 ± 1.26 µg/ml), respectively, relevant to alzheimer's disease. |
2023-02-05 |
2023-08-14 |
Not clear |
| Yuqing Chen, Xinyi Zhang, Xiaogang Lu. Enzyme colorimetric cellulose membrane bioactivity strips based on acetylcholinesterase immobilization for inhibitors preliminary screening. Colloids and surfaces. B, Biointerfaces. vol 223. 2023-02-05. PMID:36739673. |
to quickly screen the active pharmaceutical ingredient that can be used as acetylcholinesterase inhibitors (acheis) to treat alzheimer's disease, an enzyme colorimetric cellulose membrane bioactivity strip (cbs) was developed for simple and rapid screening of acheis. |
2023-02-05 |
2023-08-14 |
Not clear |