| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashwaq H Bataw. The International journal of neuroscience. vol 134. issue 1. 2024-01-16. PMID:35634646. |
alzheimer's disease (ad) appears as a result of an increase in the accumulation of amyloid beta peptide (aβ) and a decrease in neurotransmitters (acetylcholine) within the brain cells which may be due to increase in acetylcholinesterase (ache) activity and change in expression of apolipoprotein e4 (apoe4) and clusterin (clu) genes. |
2024-01-16 |
2024-01-19 |
Not clear |
| Kunal Bhattacharya, Atanu Bhattacharjee, Manodeep Chakrabort. Assessing the potential of Journal of biomolecular structure & dynamics. 2024-01-11. PMID:38205777. |
assessing the potential of acetylcholinesterase (ache) inhibitors play a crucial role in the treatment of alzheimer's disease. |
2024-01-11 |
2024-01-13 |
Not clear |
| S Scott Sutton, Joseph Magagnoli, Tammy H Cummings, James W Hardin, Jayakrishna Ambat. Alzheimer Disease Treatment With Acetylcholinesterase Inhibitors and Incident Age-Related Macular Degeneration. JAMA ophthalmology. 2024-01-04. PMID:38175625. |
alzheimer disease treatment with acetylcholinesterase inhibitors and incident age-related macular degeneration. |
2024-01-04 |
2024-01-06 |
Not clear |
| S Scott Sutton, Joseph Magagnoli, Tammy H Cummings, James W Hardin, Jayakrishna Ambat. Alzheimer Disease Treatment With Acetylcholinesterase Inhibitors and Incident Age-Related Macular Degeneration. JAMA ophthalmology. 2024-01-04. PMID:38175625. |
alzheimer disease (ad) treatment, acetylcholinesterase inhibitors (acheis), have anti-inflammatory effects and it remains unclear if they modify the risk of amd. |
2024-01-04 |
2024-01-06 |
Not clear |
| Shoaib Manzoor, Moustafa T Gabr, Mohamed S Nafie, Md Kausar Raza, Ashma Khan, Shahid M Nayeem, Reem K Arafa, Nasimul Hod. Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy. ACS chemical neuroscience. 2023-12-27. PMID:38149821. |
discovery of quinolinone hybrids as dual inhibitors of acetylcholinesterase and aβ aggregation for alzheimer's disease therapy. |
2023-12-27 |
2023-12-29 |
Not clear |
| Shoaib Manzoor, Moustafa T Gabr, Mohamed S Nafie, Md Kausar Raza, Ashma Khan, Shahid M Nayeem, Reem K Arafa, Nasimul Hod. Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy. ACS chemical neuroscience. 2023-12-27. PMID:38149821. |
we report herein new quinolinone hybrids as dual inhibitors of acetylcholinesterase (ache) and aβ aggregation that function as multitargeted ligands for alzheimer's disease. |
2023-12-27 |
2023-12-29 |
Not clear |
| James Calva, Maricarmen Silva, Vladimir Moroch. Composition and Anti-Acetylcholinesterase Properties of the Essential Oil of the Ecuadorian Endemic Species Molecules (Basel, Switzerland). vol 28. issue 24. 2023-12-23. PMID:38138598. |
composition and anti-acetylcholinesterase properties of the essential oil of the ecuadorian endemic species alzheimer's disease is a global health problem due to the scarcity of acetylcholinesterase inhibitors, the basis for symptomatic treatment of this disease; this requires new approaches to drug discovery. |
2023-12-23 |
2023-12-25 |
Not clear |
| Bing Zhang, Yu Wang, Donghui Wu, Qilin Zhao, Yaoyao Chen, Yushu Li, Jian Sun, Xiurong Yan. Fluorescent assay for acetylcholinesterase activity and inhibitor screening based on lanthanide organic/inorganic hybrid materials. Analytical methods : advancing methods and applications. 2023-12-20. PMID:38116865. |
it is of great significance for the clinical diagnosis of alzheimer's disease (ad) to achieve the on-site activity evaluation of acetylcholinesterase (ache), the hydrolase of acetylcholine (ach). |
2023-12-20 |
2023-12-23 |
Not clear |
| Farida Begum, Muhammad Yousaf, Sajid Iqbal, Nazif Ullah, Anwar Hussain, Momin Khan, Asaad Khalid, Alanood S Algarni, Ashraf N Abdalla, Ajmal Khan, Muhammad Arif Lodhi, Ahmed Al-Harras. Inhibition of Acetylcholinesterase with Novel 1, 3, 4, Oxadiazole Derivatives: A Kinetic, ACS omega. vol 8. issue 49. 2023-12-19. PMID:38107974. |
inhibition of acetylcholinesterase with novel 1, 3, 4, oxadiazole derivatives: a kinetic, alzheimer's disease (ad) is a neurological disease that disturbs the memory, thinking skills, and behavior of the affected person. |
2023-12-19 |
2023-12-21 |
Not clear |
| Jucheng Xia, Shuanghong Dong, Lili Yang, Fang Wang, Siqi Xing, Jiyu Du, Zeng L. Design, synthesis, and biological evaluation of novel tryptanthrin derivatives as selective acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. Bioorganic chemistry. vol 143. 2023-11-25. PMID:38006789. |
design, synthesis, and biological evaluation of novel tryptanthrin derivatives as selective acetylcholinesterase inhibitors for the treatment of alzheimer's disease. |
2023-11-25 |
2023-11-28 |
Not clear |
| Letícia Basso, Silvia Cristina Fagundes, Tatiana Staudt, Karini da Rosa, Elizane Langaro, Hamid Omidian, Charise Dallazem Berto. Transdermal Therapeutic Systems for the Treatment of Alzheimer's Disease: A Patent Review. CNS & neurological disorders drug targets. 2023-11-22. PMID:37990896. |
two classes of medications are used to treat alzheimer's disease (ad); donepezil, galantamine, and rivastigmine are acetylcholinesterase inhibitors, and memantine is a non-competitive antagonist of the n-methyl-d-aspartate receptor. |
2023-11-22 |
2023-11-29 |
Not clear |
| Hongtao Du, Jinzhi Song, Fang Ma, Hongxin Gao, Xinyan Zhao, Renjun Mao, Xiaolong He, Yan Ya. Novel harmine derivatives as potent acetylcholinesterase and amyloid beta aggregation dual inhibitors for management of Alzheimer's disease. Journal of enzyme inhibition and medicinal chemistry. vol 38. issue 1. 2023-11-15. PMID:37965884. |
novel harmine derivatives as potent acetylcholinesterase and amyloid beta aggregation dual inhibitors for management of alzheimer's disease. |
2023-11-15 |
2023-11-20 |
Not clear |
| Dajiang Zou, Renzheng Liu, Yangjing Lv, Jianan Guo, Changjun Zhang, Yuanyuan Xi. Latest advances in dual inhibitors of acetylcholinesterase and monoamine oxidase B against Alzheimer's disease. Journal of enzyme inhibition and medicinal chemistry. vol 38. issue 1. 2023-11-13. PMID:37955252. |
latest advances in dual inhibitors of acetylcholinesterase and monoamine oxidase b against alzheimer's disease. |
2023-11-13 |
2023-11-20 |
Not clear |
| Saira Naseem, Samra Khan, Safdar Hussain, Muhammad Usman Mirza, Muhammad Ashraf, Zahid Shafiq, John F Tran. Synthesis, biological evaluation, and molecular docking study of xanthene-linked thiosemicarbazones as cholinesterase inhibitors. Journal of biomolecular structure & dynamics. 2023-11-10. PMID:37948312. |
this study delineates the design and synthesis of a series of xanthene-based thiosemicarbazones that show low μm inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), crucial enzymes associated with, among others, alzheimer's disease (ad) pathology. |
2023-11-10 |
2023-11-20 |
Not clear |
| Pooja Khairnar, Ajit Singh, Kailash Ahirwar, Rahul Shukl. ApoE3 Anchored Liposomal Delivery of Rivastigmine for Brain Delivery: Formulation, Characterization, and In Vivo Pharmacokinetic Evaluation. AAPS PharmSciTech. vol 24. issue 8. 2023-11-09. PMID:37945928. |
rivastigmine hydrogen tartrate (rht) is an acetylcholinesterase (ache) inhibitor used in the management of alzheimer's disease (ad). |
2023-11-09 |
2023-11-20 |
Not clear |
| Xia Mu, Shengwei Yuan, Dinglin Zhang, Rui Lai, Chenyi Liao, Guohui L. Selective modulation of alkali metal ions on acetylcholinesterase. Physical chemistry chemical physics : PCCP. 2023-11-07. PMID:37934509. |
acetylcholinesterase (ache) is an important hydrolase in cholinergic synapses and a candidate target in the treatment of alzheimer's disease. |
2023-11-07 |
2023-11-08 |
human |
| Meng-Chen Wu, Ye-Hui Gao, Chen Zhang, Bo-Tian Ma, Hong-Ru Lin, Jin-Yun Jiang, Meng-Fan Xue, Shan Li, Hong-Bing Wan. Liensinine and neferine exert neuroprotective effects via the autophagy pathway in transgenic Caenorhabditis elegans. BMC complementary medicine and therapies. vol 23. issue 1. 2023-10-30. PMID:37891552. |
it was reported that liensinine and neferine could inhibit the activities of acetylcholinesterase and cross the blood-brain barriers, suggesting their therapeutic potential for the management of alzheimer's disease. |
2023-10-30 |
2023-11-08 |
caenorhabditis_elegans |
| Ayoub Farihi, Mohamed Bouhrim, Fatiha Chigr, Amine Elbouzidi, Noureddine Bencheikh, Hassan Zrouri, Fahd A Nasr, Mohammad Khalid Parvez, Ahmad Alahdab, Ahmed Omar Touhami Aham. Exploring Medicinal Herbs' Therapeutic Potential and Molecular Docking Analysis for Compounds as Potential Inhibitors of Human Acetylcholinesterase in Alzheimer's Disease Treatment. Medicina (Kaunas, Lithuania). vol 59. issue 10. 2023-10-30. PMID:37893530. |
exploring medicinal herbs' therapeutic potential and molecular docking analysis for compounds as potential inhibitors of human acetylcholinesterase in alzheimer's disease treatment. |
2023-10-30 |
2023-11-08 |
human |
| Israa J Hakee. Molecular docking analysis of acetylcholinesterase inhibitors for Alzheimer's disease management. Bioinformation. vol 19. issue 5. 2023-10-27. PMID:37886145. |
molecular docking analysis of acetylcholinesterase inhibitors for alzheimer's disease management. |
2023-10-27 |
2023-11-08 |
Not clear |
| Jia Liu, Wei Ha, Eshbakova Komila Alibekovna, Rui Ma, Yan-Ping Sh. Ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with MnO Nanoscale. 2023-10-20. PMID:37860933. |
ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with mno abnormal expression of acetylcholinesterase (ache) causes alzheimer's disease (ad). |
2023-10-20 |
2023-11-08 |
Not clear |